Incidental Mutation 'R4367:Radil'
ID 325796
Institutional Source Beutler Lab
Gene Symbol Radil
Ensembl Gene ENSMUSG00000029576
Gene Name Ras association and DIL domains
Synonyms D930005D10Rik
MMRRC Submission 041673-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4367 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 142470594-142536853 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 142480560 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 632 (A632T)
Ref Sequence ENSEMBL: ENSMUSP00000106412 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063635] [ENSMUST00000085758] [ENSMUST00000110784] [ENSMUST00000110785]
AlphaFold Q69Z89
Predicted Effect probably benign
Transcript: ENSMUST00000063635
AA Change: A632T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000064539
Gene: ENSMUSG00000029576
AA Change: A632T

DomainStartEndE-ValueType
RA 61 164 1.68e-15 SMART
Blast:FHA 265 332 2e-25 BLAST
low complexity region 344 354 N/A INTRINSIC
low complexity region 550 560 N/A INTRINSIC
DIL 634 743 6.19e-34 SMART
low complexity region 950 964 N/A INTRINSIC
PDZ 979 1056 3.86e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000085758
AA Change: A661T

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000082910
Gene: ENSMUSG00000029576
AA Change: A661T

DomainStartEndE-ValueType
RA 90 193 1.68e-15 SMART
Blast:FHA 294 361 2e-25 BLAST
low complexity region 373 383 N/A INTRINSIC
low complexity region 579 589 N/A INTRINSIC
DIL 663 772 6.19e-34 SMART
low complexity region 979 993 N/A INTRINSIC
PDZ 1008 1085 3.86e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110784
AA Change: A392T

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000106411
Gene: ENSMUSG00000029576
AA Change: A392T

DomainStartEndE-ValueType
Blast:FHA 25 92 3e-25 BLAST
low complexity region 104 114 N/A INTRINSIC
low complexity region 310 320 N/A INTRINSIC
DIL 394 503 6.19e-34 SMART
low complexity region 710 724 N/A INTRINSIC
PDZ 739 816 3.86e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110785
AA Change: A632T

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000106412
Gene: ENSMUSG00000029576
AA Change: A632T

DomainStartEndE-ValueType
RA 61 164 1.68e-15 SMART
Blast:FHA 265 332 2e-25 BLAST
low complexity region 344 354 N/A INTRINSIC
low complexity region 550 560 N/A INTRINSIC
DIL 634 743 6.19e-34 SMART
low complexity region 973 987 N/A INTRINSIC
PDZ 1002 1079 3.86e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139824
Meta Mutation Damage Score 0.0706 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adrb2 T C 18: 62,312,127 (GRCm39) I233V probably damaging Het
Alox5 T A 6: 116,437,924 (GRCm39) Y21F possibly damaging Het
Ank2 T C 3: 126,739,798 (GRCm39) T1942A probably benign Het
Aoc1l1 T C 6: 48,953,064 (GRCm39) S330P probably damaging Het
B4galt3 C A 1: 171,101,613 (GRCm39) H196N probably damaging Het
Bckdk C T 7: 127,505,591 (GRCm39) A238V probably benign Het
Casp1 A G 9: 5,299,333 (GRCm39) T21A probably benign Het
Ccdc39 T C 3: 33,880,671 (GRCm39) H432R probably benign Het
Cttnbp2 A C 6: 18,405,248 (GRCm39) C574G probably damaging Het
Cyp1a1 T C 9: 57,607,432 (GRCm39) V20A probably benign Het
Dhx38 C T 8: 110,279,763 (GRCm39) V976I probably damaging Het
Dnah6 A G 6: 73,126,467 (GRCm39) S1287P possibly damaging Het
Dnttip2 T C 3: 122,070,146 (GRCm39) S454P probably damaging Het
Drp2 A T X: 133,335,884 (GRCm39) probably benign Het
Flcn C T 11: 59,694,610 (GRCm39) V121I possibly damaging Het
Fmo1 G C 1: 162,661,217 (GRCm39) Y355* probably null Het
Git2 T A 5: 114,902,727 (GRCm39) H138L probably damaging Het
Gpr162 G A 6: 124,838,658 (GRCm39) probably benign Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Kcnt1 T C 2: 25,797,638 (GRCm39) I881T probably damaging Het
Lama3 T A 18: 12,646,747 (GRCm39) C1754S probably damaging Het
Mpp3 A T 11: 101,914,246 (GRCm39) D116E probably benign Het
Myh11 T C 16: 14,036,747 (GRCm39) D985G probably damaging Het
Necap1 T C 6: 122,864,337 (GRCm39) V273A probably damaging Het
Nlrc5 T C 8: 95,203,192 (GRCm39) S431P probably damaging Het
Nutm2 A T 13: 50,623,920 (GRCm39) T206S probably benign Het
Or2d3 GAACAACAACAA GAACAACAA 7: 106,490,567 (GRCm39) probably benign Het
Or5p79 C T 7: 108,221,096 (GRCm39) L26F probably benign Het
Or8g19 G A 9: 39,055,725 (GRCm39) A110T probably damaging Het
Phactr2 A G 10: 13,129,564 (GRCm39) S235P probably damaging Het
Podnl1 G A 8: 84,853,897 (GRCm39) R89H probably benign Het
Prpf38b T C 3: 108,818,487 (GRCm39) Y91C probably damaging Het
Rpap2 G A 5: 107,749,661 (GRCm39) V62I possibly damaging Het
Sdf2 C T 11: 78,141,863 (GRCm39) T66I probably damaging Het
Specc1 T C 11: 62,009,356 (GRCm39) S371P probably damaging Het
Suco T C 1: 161,674,799 (GRCm39) E416G probably damaging Het
Sys1 T C 2: 164,303,315 (GRCm39) W10R probably damaging Het
Tars3 C T 7: 65,332,567 (GRCm39) T556M probably damaging Het
Tcirg1 C T 19: 3,949,069 (GRCm39) D407N probably damaging Het
Tefm G T 11: 80,031,156 (GRCm39) L27I probably benign Het
Tenm2 A G 11: 35,918,225 (GRCm39) I1845T probably benign Het
Tfam A T 10: 71,069,233 (GRCm39) I119N probably damaging Het
Tle1 ACAGGTTTCTTCAGGTTTCTT ACAGGTTTCTT 4: 72,036,400 (GRCm39) probably benign Het
Trpm6 T C 19: 18,804,889 (GRCm39) I947T probably damaging Het
Ubqlnl C T 7: 103,798,925 (GRCm39) V191M probably benign Het
Usp54 T C 14: 20,611,202 (GRCm39) T1205A probably benign Het
Vmn2r25 T C 6: 123,805,496 (GRCm39) R454G probably damaging Het
Xylb T C 9: 119,217,781 (GRCm39) V477A probably benign Het
Other mutations in Radil
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Radil APN 5 142,483,677 (GRCm39) missense probably damaging 0.99
IGL01359:Radil APN 5 142,529,468 (GRCm39) missense probably damaging 0.98
IGL01714:Radil APN 5 142,529,152 (GRCm39) unclassified probably benign
IGL02086:Radil APN 5 142,529,576 (GRCm39) missense probably benign 0.28
IGL02250:Radil APN 5 142,529,529 (GRCm39) missense probably damaging 1.00
IGL02296:Radil APN 5 142,492,218 (GRCm39) missense probably benign 0.10
IGL02890:Radil APN 5 142,529,463 (GRCm39) missense probably damaging 1.00
IGL02978:Radil APN 5 142,480,674 (GRCm39) missense probably benign 0.00
IGL03131:Radil APN 5 142,481,097 (GRCm39) missense probably damaging 1.00
R0362:Radil UTSW 5 142,529,582 (GRCm39) missense probably benign 0.00
R0389:Radil UTSW 5 142,529,226 (GRCm39) missense probably damaging 0.98
R0426:Radil UTSW 5 142,483,628 (GRCm39) missense probably damaging 1.00
R1753:Radil UTSW 5 142,481,091 (GRCm39) missense probably damaging 1.00
R2168:Radil UTSW 5 142,492,718 (GRCm39) missense probably benign 0.00
R3055:Radil UTSW 5 142,481,161 (GRCm39) missense possibly damaging 0.77
R3177:Radil UTSW 5 142,492,611 (GRCm39) missense probably damaging 1.00
R3277:Radil UTSW 5 142,492,611 (GRCm39) missense probably damaging 1.00
R3851:Radil UTSW 5 142,492,752 (GRCm39) missense probably damaging 1.00
R4043:Radil UTSW 5 142,479,988 (GRCm39) missense probably benign 0.31
R4245:Radil UTSW 5 142,529,546 (GRCm39) missense probably damaging 1.00
R4697:Radil UTSW 5 142,472,556 (GRCm39) missense probably benign
R4798:Radil UTSW 5 142,470,918 (GRCm39) missense probably benign 0.39
R4948:Radil UTSW 5 142,470,994 (GRCm39) missense probably benign 0.02
R5407:Radil UTSW 5 142,493,970 (GRCm39) missense probably damaging 1.00
R5784:Radil UTSW 5 142,473,268 (GRCm39) missense possibly damaging 0.88
R5918:Radil UTSW 5 142,473,357 (GRCm39) missense probably benign 0.43
R5943:Radil UTSW 5 142,471,213 (GRCm39) missense probably damaging 1.00
R6112:Radil UTSW 5 142,529,399 (GRCm39) missense probably damaging 1.00
R6147:Radil UTSW 5 142,483,695 (GRCm39) missense probably benign 0.01
R6174:Radil UTSW 5 142,472,870 (GRCm39) missense probably benign
R6241:Radil UTSW 5 142,480,697 (GRCm39) missense probably damaging 1.00
R6874:Radil UTSW 5 142,492,557 (GRCm39) missense probably damaging 1.00
R6881:Radil UTSW 5 142,472,672 (GRCm39) missense probably benign 0.00
R7056:Radil UTSW 5 142,480,109 (GRCm39) nonsense probably null
R7134:Radil UTSW 5 142,471,304 (GRCm39) missense probably damaging 1.00
R7167:Radil UTSW 5 142,471,260 (GRCm39) splice site probably null
R7374:Radil UTSW 5 142,471,235 (GRCm39) missense probably damaging 1.00
R7482:Radil UTSW 5 142,472,518 (GRCm39) missense probably benign
R7607:Radil UTSW 5 142,492,368 (GRCm39) missense probably damaging 0.99
R7607:Radil UTSW 5 142,480,550 (GRCm39) missense probably damaging 0.98
R7777:Radil UTSW 5 142,529,303 (GRCm39) missense probably damaging 1.00
R7779:Radil UTSW 5 142,473,320 (GRCm39) missense probably benign 0.03
R8047:Radil UTSW 5 142,480,695 (GRCm39) missense probably damaging 1.00
R8123:Radil UTSW 5 142,473,375 (GRCm39) missense probably damaging 0.99
R8418:Radil UTSW 5 142,480,676 (GRCm39) missense probably benign 0.23
R8525:Radil UTSW 5 142,474,256 (GRCm39) missense probably damaging 1.00
R8708:Radil UTSW 5 142,471,204 (GRCm39) missense probably damaging 1.00
R8827:Radil UTSW 5 142,493,859 (GRCm39) missense probably damaging 1.00
R9181:Radil UTSW 5 142,480,722 (GRCm39) missense probably damaging 1.00
R9315:Radil UTSW 5 142,474,254 (GRCm39) missense probably damaging 0.98
R9462:Radil UTSW 5 142,471,220 (GRCm39) missense probably damaging 1.00
R9545:Radil UTSW 5 142,492,392 (GRCm39) missense probably benign
R9694:Radil UTSW 5 142,473,378 (GRCm39) missense probably damaging 1.00
X0058:Radil UTSW 5 142,473,269 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- AGCTTTTGTCCTACCCTGGG -3'
(R):5'- CATCTCTGTCAGTGGCTCTTGG -3'

Sequencing Primer
(F):5'- GGTTTTGAGCCATCCTACCACAG -3'
(R):5'- GGGGTTCTCTCTCCCTGCAG -3'
Posted On 2015-07-06