Incidental Mutation 'R4367:Or5p79'
ID 325807
Institutional Source Beutler Lab
Gene Symbol Or5p79
Ensembl Gene ENSMUSG00000061000
Gene Name olfactory receptor family 5 subfamily P member 79
Synonyms Olfr507, GA_x6K02T2PBJ9-10951546-10952496, MOR204-7
MMRRC Submission 041673-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R4367 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 108221021-108221971 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 108221096 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 26 (L26F)
Ref Sequence ENSEMBL: ENSMUSP00000078926 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080014]
AlphaFold Q8VG13
Predicted Effect probably benign
Transcript: ENSMUST00000080014
AA Change: L26F

PolyPhen 2 Score 0.266 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000078926
Gene: ENSMUSG00000061000
AA Change: L26F

DomainStartEndE-ValueType
Pfam:7tm_4 34 313 6.1e-52 PFAM
Pfam:7tm_1 44 295 1e-20 PFAM
Meta Mutation Damage Score 0.5410 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adrb2 T C 18: 62,312,127 (GRCm39) I233V probably damaging Het
Alox5 T A 6: 116,437,924 (GRCm39) Y21F possibly damaging Het
Ank2 T C 3: 126,739,798 (GRCm39) T1942A probably benign Het
Aoc1l1 T C 6: 48,953,064 (GRCm39) S330P probably damaging Het
B4galt3 C A 1: 171,101,613 (GRCm39) H196N probably damaging Het
Bckdk C T 7: 127,505,591 (GRCm39) A238V probably benign Het
Casp1 A G 9: 5,299,333 (GRCm39) T21A probably benign Het
Ccdc39 T C 3: 33,880,671 (GRCm39) H432R probably benign Het
Cttnbp2 A C 6: 18,405,248 (GRCm39) C574G probably damaging Het
Cyp1a1 T C 9: 57,607,432 (GRCm39) V20A probably benign Het
Dhx38 C T 8: 110,279,763 (GRCm39) V976I probably damaging Het
Dnah6 A G 6: 73,126,467 (GRCm39) S1287P possibly damaging Het
Dnttip2 T C 3: 122,070,146 (GRCm39) S454P probably damaging Het
Drp2 A T X: 133,335,884 (GRCm39) probably benign Het
Flcn C T 11: 59,694,610 (GRCm39) V121I possibly damaging Het
Fmo1 G C 1: 162,661,217 (GRCm39) Y355* probably null Het
Git2 T A 5: 114,902,727 (GRCm39) H138L probably damaging Het
Gpr162 G A 6: 124,838,658 (GRCm39) probably benign Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Kcnt1 T C 2: 25,797,638 (GRCm39) I881T probably damaging Het
Lama3 T A 18: 12,646,747 (GRCm39) C1754S probably damaging Het
Mpp3 A T 11: 101,914,246 (GRCm39) D116E probably benign Het
Myh11 T C 16: 14,036,747 (GRCm39) D985G probably damaging Het
Necap1 T C 6: 122,864,337 (GRCm39) V273A probably damaging Het
Nlrc5 T C 8: 95,203,192 (GRCm39) S431P probably damaging Het
Nutm2 A T 13: 50,623,920 (GRCm39) T206S probably benign Het
Or2d3 GAACAACAACAA GAACAACAA 7: 106,490,567 (GRCm39) probably benign Het
Or8g19 G A 9: 39,055,725 (GRCm39) A110T probably damaging Het
Phactr2 A G 10: 13,129,564 (GRCm39) S235P probably damaging Het
Podnl1 G A 8: 84,853,897 (GRCm39) R89H probably benign Het
Prpf38b T C 3: 108,818,487 (GRCm39) Y91C probably damaging Het
Radil C T 5: 142,480,560 (GRCm39) A632T probably benign Het
Rpap2 G A 5: 107,749,661 (GRCm39) V62I possibly damaging Het
Sdf2 C T 11: 78,141,863 (GRCm39) T66I probably damaging Het
Specc1 T C 11: 62,009,356 (GRCm39) S371P probably damaging Het
Suco T C 1: 161,674,799 (GRCm39) E416G probably damaging Het
Sys1 T C 2: 164,303,315 (GRCm39) W10R probably damaging Het
Tars3 C T 7: 65,332,567 (GRCm39) T556M probably damaging Het
Tcirg1 C T 19: 3,949,069 (GRCm39) D407N probably damaging Het
Tefm G T 11: 80,031,156 (GRCm39) L27I probably benign Het
Tenm2 A G 11: 35,918,225 (GRCm39) I1845T probably benign Het
Tfam A T 10: 71,069,233 (GRCm39) I119N probably damaging Het
Tle1 ACAGGTTTCTTCAGGTTTCTT ACAGGTTTCTT 4: 72,036,400 (GRCm39) probably benign Het
Trpm6 T C 19: 18,804,889 (GRCm39) I947T probably damaging Het
Ubqlnl C T 7: 103,798,925 (GRCm39) V191M probably benign Het
Usp54 T C 14: 20,611,202 (GRCm39) T1205A probably benign Het
Vmn2r25 T C 6: 123,805,496 (GRCm39) R454G probably damaging Het
Xylb T C 9: 119,217,781 (GRCm39) V477A probably benign Het
Other mutations in Or5p79
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01066:Or5p79 APN 7 108,221,064 (GRCm39) missense probably damaging 1.00
IGL01979:Or5p79 APN 7 108,221,648 (GRCm39) missense probably benign 0.09
IGL02373:Or5p79 APN 7 108,221,310 (GRCm39) missense probably benign 0.11
IGL02754:Or5p79 APN 7 108,221,880 (GRCm39) missense possibly damaging 0.94
IGL03008:Or5p79 APN 7 108,221,490 (GRCm39) missense probably damaging 0.99
R0305:Or5p79 UTSW 7 108,221,792 (GRCm39) missense probably benign 0.01
R0584:Or5p79 UTSW 7 108,221,622 (GRCm39) missense probably benign 0.00
R0611:Or5p79 UTSW 7 108,221,494 (GRCm39) missense possibly damaging 0.72
R0947:Or5p79 UTSW 7 108,221,879 (GRCm39) missense probably benign 0.02
R1488:Or5p79 UTSW 7 108,221,696 (GRCm39) missense probably damaging 1.00
R1808:Or5p79 UTSW 7 108,221,817 (GRCm39) missense possibly damaging 0.87
R3763:Or5p79 UTSW 7 108,221,924 (GRCm39) missense probably damaging 1.00
R4369:Or5p79 UTSW 7 108,221,096 (GRCm39) missense probably benign 0.27
R4371:Or5p79 UTSW 7 108,221,096 (GRCm39) missense probably benign 0.27
R4609:Or5p79 UTSW 7 108,221,711 (GRCm39) missense probably benign 0.35
R5389:Or5p79 UTSW 7 108,221,924 (GRCm39) missense probably damaging 1.00
R6499:Or5p79 UTSW 7 108,221,713 (GRCm39) missense probably benign 0.02
R6684:Or5p79 UTSW 7 108,221,141 (GRCm39) missense probably damaging 0.98
R7531:Or5p79 UTSW 7 108,221,269 (GRCm39) missense probably benign 0.06
R7555:Or5p79 UTSW 7 108,221,933 (GRCm39) missense probably damaging 1.00
R7893:Or5p79 UTSW 7 108,221,844 (GRCm39) missense probably damaging 1.00
R8415:Or5p79 UTSW 7 108,221,163 (GRCm39) missense probably damaging 1.00
R8444:Or5p79 UTSW 7 108,221,027 (GRCm39) missense probably benign 0.00
R8904:Or5p79 UTSW 7 108,221,919 (GRCm39) missense probably damaging 0.98
R9635:Or5p79 UTSW 7 108,221,654 (GRCm39) missense probably benign 0.00
R9795:Or5p79 UTSW 7 108,221,869 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- AGTGAGTGTTTGATGTACTACCC -3'
(R):5'- TGACAAGCATATTGGGTGTGACAG -3'

Sequencing Primer
(F):5'- AGTGTTTGATGTACTACCCAATTATG -3'
(R):5'- TGACAGAAGATGAAATGCCTATGTC -3'
Posted On 2015-07-06