Incidental Mutation 'R4400:Olfr292'
ID326585
Institutional Source Beutler Lab
Gene Symbol Olfr292
Ensembl Gene ENSMUSG00000060688
Gene Nameolfactory receptor 292
SynonymsGA_x6K02T2NHDJ-9425121-9424195, MOR220-2
MMRRC Submission 041131-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #R4400 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location86688330-86697507 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 86694590 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 45 (I45V)
Ref Sequence ENSEMBL: ENSMUSP00000079060 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080165]
Predicted Effect probably benign
Transcript: ENSMUST00000080165
AA Change: I45V

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000079060
Gene: ENSMUSG00000060688
AA Change: I45V

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 2.6e-48 PFAM
Pfam:7tm_1 39 288 2.7e-22 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp4b A G 8: 13,388,810 F189L probably damaging Het
Atp8a1 A T 5: 67,764,878 Y372N probably benign Het
Bves T C 10: 45,369,293 V354A probably benign Het
Cd79b A T 11: 106,312,010 Y195* probably null Het
Cog6 A C 3: 53,012,941 D131E probably benign Het
Elp3 C T 14: 65,548,090 E421K possibly damaging Het
Fbxw28 A T 9: 109,328,310 F237Y probably damaging Het
Fezf1 T C 6: 23,247,710 N122S probably benign Het
Galnt2 A G 8: 124,324,303 K157E probably damaging Het
Git2 T C 5: 114,733,909 E141G possibly damaging Het
Gm26888 T C 11: 119,154,027 silent Het
Gnrhr T C 5: 86,182,249 probably null Het
Hoxd13 A T 2: 74,670,015 D300V probably damaging Het
Hspg2 G A 4: 137,548,122 A2748T probably benign Het
Hyal2 A G 9: 107,570,853 N235S probably damaging Het
Itgam T G 7: 128,081,658 L253R probably damaging Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 52,725,906 probably benign Het
Matr3 A T 18: 35,583,916 K591N possibly damaging Het
Mep1a T A 17: 43,475,006 I731F possibly damaging Het
Mkl1 G A 15: 81,020,923 Q103* probably null Het
Muc5b A G 7: 141,861,387 D2690G possibly damaging Het
Nlrc5 A G 8: 94,494,353 Q1140R probably benign Het
Olfr205 C T 16: 59,328,598 V304I probably benign Het
Olfr711 A G 7: 106,972,002 L114P probably damaging Het
Plcl1 T C 1: 55,715,577 F1028L probably damaging Het
Plpp2 A G 10: 79,527,493 V106A possibly damaging Het
Prpf8 A G 11: 75,490,702 T255A possibly damaging Het
Shoc2 A G 19: 54,031,229 I568V probably benign Het
Spopl C T 2: 23,517,945 V241M probably damaging Het
Ssrp1 A T 2: 85,037,941 D9V probably damaging Het
Strn3 A T 12: 51,648,100 D293E possibly damaging Het
Tbx3 G T 5: 119,680,571 D404Y probably damaging Het
Tdrd7 T C 4: 46,005,540 S416P possibly damaging Het
Trim60 G T 8: 65,001,212 Y128* probably null Het
Tspoap1 T C 11: 87,775,603 S947P probably damaging Het
Ttn A T 2: 76,782,395 S17113R probably damaging Het
Ubqln1 T A 13: 58,193,388 N183I probably damaging Het
Ubr4 A G 4: 139,461,856 N3917D possibly damaging Het
Ucp2 A G 7: 100,499,350 *310W probably null Het
Wdr76 A G 2: 121,528,833 M218V probably damaging Het
Zranb3 A C 1: 127,956,655 L998R possibly damaging Het
Zxdc G A 6: 90,369,810 G51E probably damaging Het
Other mutations in Olfr292
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01575:Olfr292 APN 7 86695293 missense probably benign 0.10
IGL01751:Olfr292 APN 7 86694789 missense probably benign
IGL02417:Olfr292 APN 7 86694819 missense probably damaging 1.00
IGL02534:Olfr292 APN 7 86694731 missense probably benign 0.17
IGL02830:Olfr292 APN 7 86695174 missense probably damaging 1.00
R0281:Olfr292 UTSW 7 86694860 missense probably benign 0.00
R0423:Olfr292 UTSW 7 86695226 missense possibly damaging 0.95
R0555:Olfr292 UTSW 7 86695308 missense probably damaging 1.00
R0609:Olfr292 UTSW 7 86694876 missense possibly damaging 0.85
R0662:Olfr292 UTSW 7 86694630 missense possibly damaging 0.88
R1710:Olfr292 UTSW 7 86695110 missense probably benign 0.00
R2144:Olfr292 UTSW 7 86695280 missense probably damaging 0.98
R4615:Olfr292 UTSW 7 86694728 missense probably damaging 1.00
R4762:Olfr292 UTSW 7 86695121 missense probably benign 0.01
R4785:Olfr292 UTSW 7 86694528 missense probably damaging 1.00
R4823:Olfr292 UTSW 7 86694588 missense probably damaging 0.99
R4908:Olfr292 UTSW 7 86695187 missense probably benign 0.00
R4983:Olfr292 UTSW 7 86694479 missense probably benign 0.01
R5010:Olfr292 UTSW 7 86694585 missense possibly damaging 0.95
R5024:Olfr292 UTSW 7 86694881 missense probably benign 0.05
R5157:Olfr292 UTSW 7 86695232 missense probably benign 0.19
R5627:Olfr292 UTSW 7 86695139 missense possibly damaging 0.93
R6327:Olfr292 UTSW 7 86694552 missense probably benign 0.09
R6375:Olfr292 UTSW 7 86695059 missense probably benign 0.01
R6775:Olfr292 UTSW 7 86695149 missense probably benign 0.02
R7257:Olfr292 UTSW 7 86694804 missense probably damaging 0.99
R7383:Olfr292 UTSW 7 86694752 missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- AGTTTCAAGAGAAATGCTAGCG -3'
(R):5'- GGCCATCGTGGTAAGGAATTG -3'

Sequencing Primer
(F):5'- TCAAGAGAAATGCTAGCGATTTATC -3'
(R):5'- GCCATCGTGGTAAGGAATTGAATCTC -3'
Posted On2015-07-07