Incidental Mutation 'R4404:Zdhhc15'
ID 326776
Institutional Source Beutler Lab
Gene Symbol Zdhhc15
Ensembl Gene ENSMUSG00000033906
Gene Name zinc finger, DHHC domain containing 15
Synonyms 6030457O13Rik
MMRRC Submission 041133-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R4404 (G1)
Quality Score 222
Status Not validated
Chromosome X
Chromosomal Location 103580575-103714670 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 103604294 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 322 (R322*)
Ref Sequence ENSEMBL: ENSMUSP00000047615 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042070]
AlphaFold Q8BGJ0
Predicted Effect probably null
Transcript: ENSMUST00000042070
AA Change: R322*
SMART Domains Protein: ENSMUSP00000047615
Gene: ENSMUSG00000033906
AA Change: R322*

DomainStartEndE-ValueType
transmembrane domain 19 41 N/A INTRINSIC
transmembrane domain 56 73 N/A INTRINSIC
Pfam:zf-DHHC 125 250 2.4e-36 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
PHENOTYPE: Male chimeras hemizygous for a gene trapped allele exhibit a severe developmental delay and neural tube defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc188 A G 16: 18,036,284 (GRCm39) Q153R probably damaging Het
Cimap3 G A 3: 105,908,684 (GRCm39) P7L probably benign Het
Dop1a T A 9: 86,404,866 (GRCm39) L1721* probably null Het
Fcsk T A 8: 111,616,933 (GRCm39) T406S probably benign Het
Fer A T 17: 64,248,284 (GRCm39) probably null Het
Gprc6a T C 10: 51,504,639 (GRCm39) I68M probably benign Het
Gria4 A T 9: 4,464,489 (GRCm39) probably null Het
Gtf3c4 T C 2: 28,716,761 (GRCm39) D813G probably damaging Het
Hars2 G T 18: 36,918,989 (GRCm39) C83F probably damaging Het
Htr6 A G 4: 138,789,513 (GRCm39) S251P probably benign Het
Igsf10 T C 3: 59,236,972 (GRCm39) T1070A probably benign Het
Il22ra1 A T 4: 135,464,742 (GRCm39) E149D possibly damaging Het
Lama3 G A 18: 12,715,588 (GRCm39) M1681I probably benign Het
Loxhd1 G A 18: 77,518,828 (GRCm39) G1878D probably damaging Het
Mcc G A 18: 44,892,365 (GRCm39) T83M probably benign Het
Nol11 A T 11: 107,064,551 (GRCm39) C468S probably damaging Het
Nomo1 A G 7: 45,706,092 (GRCm39) N482S probably benign Het
Npy5r C T 8: 67,134,644 (GRCm39) V50I probably benign Het
Or8g21 T C 9: 38,905,865 (GRCm39) I289V possibly damaging Het
Pam T C 1: 97,782,446 (GRCm39) probably benign Het
Pank4 C T 4: 155,064,613 (GRCm39) T724I probably benign Het
Pramel34 T A 5: 93,785,572 (GRCm39) H236L possibly damaging Het
Sertm1 C T 3: 54,806,746 (GRCm39) C93Y probably damaging Het
Slc22a2 A G 17: 12,833,651 (GRCm39) T444A probably damaging Het
Trpm7 C A 2: 126,675,635 (GRCm39) L489F probably damaging Het
Ubqlnl C T 7: 103,798,925 (GRCm39) V191M probably benign Het
Usp25 A C 16: 76,912,341 (GRCm39) K1020T probably damaging Het
Vmn2r76 T C 7: 85,877,511 (GRCm39) T511A probably benign Het
Other mutations in Zdhhc15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01118:Zdhhc15 APN X 103,641,712 (GRCm39) missense probably benign 0.00
IGL01295:Zdhhc15 APN X 103,588,519 (GRCm39) splice site probably null
IGL01707:Zdhhc15 APN X 103,609,422 (GRCm39) missense probably damaging 0.99
R4407:Zdhhc15 UTSW X 103,604,294 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACCTTTGCCACCCATATTTGTTA -3'
(R):5'- CCAAAGCCACAATCATATCTCATTT -3'

Sequencing Primer
(F):5'- GTTAAACAAATACTTTCCCTCCTCC -3'
(R):5'- TGCCACCACTCAGGATATTTAG -3'
Posted On 2015-07-07