Incidental Mutation 'R4418:Gpr6'
ID 326946
Institutional Source Beutler Lab
Gene Symbol Gpr6
Ensembl Gene ENSMUSG00000046922
Gene Name G protein-coupled receptor 6
Synonyms
MMRRC Submission 041139-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4418 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 40945973-40948281 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 40946604 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Threonine at position 326 (N326T)
Ref Sequence ENSEMBL: ENSMUSP00000057323 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061796]
AlphaFold Q6YNI2
Predicted Effect probably damaging
Transcript: ENSMUST00000061796
AA Change: N326T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000057323
Gene: ENSMUSG00000046922
AA Change: N326T

DomainStartEndE-ValueType
low complexity region 13 30 N/A INTRINSIC
low complexity region 37 59 N/A INTRINSIC
Pfam:7tm_1 90 330 2.5e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213704
Meta Mutation Damage Score 0.8090 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 95% (72/76)
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930523C07Rik A G 1: 159,872,372 (GRCm39) noncoding transcript Het
Acot12 A G 13: 91,932,524 (GRCm39) T507A possibly damaging Het
Agap2 T G 10: 126,927,519 (GRCm39) C1113W probably damaging Het
Ap3s1-ps2 A T 8: 95,131,921 (GRCm39) noncoding transcript Het
B3gnt3 T C 8: 72,146,413 (GRCm39) R39G probably benign Het
Bahd1 G A 2: 118,753,004 (GRCm39) R757H probably damaging Het
Cdcp3 A T 7: 130,849,194 (GRCm39) D899V possibly damaging Het
Chad C T 11: 94,458,663 (GRCm39) H271Y possibly damaging Het
Chil4 G A 3: 106,111,043 (GRCm39) P284S possibly damaging Het
Col6a1 T A 10: 76,554,239 (GRCm39) K323* probably null Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dclre1c T C 2: 3,453,972 (GRCm39) F285S possibly damaging Het
Dctn2 T G 10: 127,114,234 (GRCm39) M360R probably benign Het
Dele1 T C 18: 38,394,340 (GRCm39) probably null Het
Dgka A T 10: 128,563,963 (GRCm39) L462Q probably damaging Het
Drg2 A C 11: 60,358,972 (GRCm39) K364T probably damaging Het
Dync1li1 T A 9: 114,535,238 (GRCm39) S167R probably damaging Het
Entrep1 T C 19: 23,956,799 (GRCm39) T365A probably benign Het
Fer A T 17: 64,336,286 (GRCm39) D554V possibly damaging Het
Fignl2 A G 15: 100,951,830 (GRCm39) S151P possibly damaging Het
Gbgt1 A G 2: 28,388,420 (GRCm39) Y35C probably damaging Het
Gm6526 T A 14: 43,986,302 (GRCm39) I79K probably damaging Het
H2bc4 C T 13: 23,868,486 (GRCm39) T91M probably damaging Het
Hcn4 C T 9: 58,751,178 (GRCm39) T268M probably benign Het
Hnf4g A G 3: 3,713,154 (GRCm39) M243V possibly damaging Het
Homer1 A G 13: 93,538,577 (GRCm39) E314G probably damaging Het
Hs6st1 T C 1: 36,143,108 (GRCm39) Y348H probably damaging Het
Ifitm6 A T 7: 140,595,984 (GRCm39) I103N probably damaging Het
Ipo5 T G 14: 121,181,305 (GRCm39) C944G possibly damaging Het
Kcnb1 C A 2: 166,947,595 (GRCm39) E418* probably null Het
Kcnk2 G A 1: 188,988,924 (GRCm39) R207C probably damaging Het
Kctd8 T C 5: 69,498,505 (GRCm39) E47G probably damaging Het
Klhdc2 C T 12: 69,354,371 (GRCm39) probably benign Het
Lrrc37 T C 11: 103,509,140 (GRCm39) probably benign Het
Mgat1 A G 11: 49,152,072 (GRCm39) Y185C probably damaging Het
Mmp25 T A 17: 23,863,044 (GRCm39) R122S probably damaging Het
Mrpl39 C A 16: 84,522,012 (GRCm39) probably null Het
Naip6 C T 13: 100,437,108 (GRCm39) A472T probably benign Het
Nek1 T C 8: 61,559,898 (GRCm39) F1007S probably damaging Het
Neto1 T C 18: 86,422,981 (GRCm39) M146T probably benign Het
Opn1sw G A 6: 29,379,423 (GRCm39) R45* probably null Het
Osbpl5 A T 7: 143,263,552 (GRCm39) C98* probably null Het
Pacc1 T A 1: 191,080,629 (GRCm39) V283E probably damaging Het
Pcdhb7 C T 18: 37,476,535 (GRCm39) A557V probably benign Het
Pecam1 A G 11: 106,586,748 (GRCm39) F155L possibly damaging Het
Plxna2 C T 1: 194,431,625 (GRCm39) S538F probably damaging Het
Pmfbp1 C A 8: 110,257,265 (GRCm39) Q609K probably benign Het
Pnpo A T 11: 96,831,795 (GRCm39) probably null Het
Ppp2cb G A 8: 34,107,077 (GRCm39) R254Q probably benign Het
Qser1 A T 2: 104,619,766 (GRCm39) S349T probably damaging Het
Rnf167 T A 11: 70,538,743 (GRCm39) W17R probably damaging Het
Rpl21-ps4 A G 14: 11,227,879 (GRCm38) noncoding transcript Het
Rxfp2 A T 5: 149,972,265 (GRCm39) H158L probably benign Het
Ryr3 C T 2: 112,661,569 (GRCm39) C1807Y probably damaging Het
Scaper T A 9: 55,745,464 (GRCm39) E601D probably damaging Het
Secisbp2l A T 2: 125,594,835 (GRCm39) C542S probably benign Het
Slc6a19 A G 13: 73,832,514 (GRCm39) V393A possibly damaging Het
Stil A G 4: 114,866,574 (GRCm39) N176S probably benign Het
Tap1 T A 17: 34,407,353 (GRCm39) probably null Het
Tcl1b3 A T 12: 105,159,844 (GRCm39) Q105L probably damaging Het
Trappc10 G T 10: 78,053,022 (GRCm39) A251D probably damaging Het
Trim43a G T 9: 88,464,206 (GRCm39) C39F probably damaging Het
Ttn A T 2: 76,719,825 (GRCm39) probably benign Het
Vmn2r110 A T 17: 20,803,951 (GRCm39) L208* probably null Het
Vmn2r88 G T 14: 51,655,538 (GRCm39) L583F probably damaging Het
Wasf1 C T 10: 40,812,578 (GRCm39) H456Y unknown Het
Zfp120 A G 2: 149,960,105 (GRCm39) I73T possibly damaging Het
Zfp990 T C 4: 145,263,298 (GRCm39) C99R possibly damaging Het
Other mutations in Gpr6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Gpr6 APN 10 40,946,812 (GRCm39) missense probably damaging 0.99
IGL01010:Gpr6 APN 10 40,947,147 (GRCm39) missense probably benign
IGL01098:Gpr6 APN 10 40,946,739 (GRCm39) missense probably damaging 1.00
IGL01323:Gpr6 APN 10 40,947,555 (GRCm39) missense possibly damaging 0.96
R1153:Gpr6 UTSW 10 40,946,833 (GRCm39) missense probably damaging 1.00
R1154:Gpr6 UTSW 10 40,946,833 (GRCm39) missense probably damaging 1.00
R1622:Gpr6 UTSW 10 40,947,288 (GRCm39) missense probably damaging 1.00
R1628:Gpr6 UTSW 10 40,947,544 (GRCm39) missense possibly damaging 0.96
R1638:Gpr6 UTSW 10 40,946,530 (GRCm39) missense probably benign 0.02
R1935:Gpr6 UTSW 10 40,947,477 (GRCm39) missense probably benign 0.02
R1936:Gpr6 UTSW 10 40,947,477 (GRCm39) missense probably benign 0.02
R2108:Gpr6 UTSW 10 40,946,649 (GRCm39) missense possibly damaging 0.79
R2129:Gpr6 UTSW 10 40,947,168 (GRCm39) missense possibly damaging 0.50
R4024:Gpr6 UTSW 10 40,947,264 (GRCm39) missense probably damaging 1.00
R4237:Gpr6 UTSW 10 40,946,604 (GRCm39) missense probably damaging 1.00
R4703:Gpr6 UTSW 10 40,947,037 (GRCm39) missense probably damaging 1.00
R4814:Gpr6 UTSW 10 40,947,258 (GRCm39) missense possibly damaging 0.94
R6821:Gpr6 UTSW 10 40,947,004 (GRCm39) missense probably benign 0.04
R7190:Gpr6 UTSW 10 40,946,956 (GRCm39) missense probably damaging 1.00
R7573:Gpr6 UTSW 10 40,946,868 (GRCm39) missense probably damaging 0.99
R7574:Gpr6 UTSW 10 40,946,652 (GRCm39) missense possibly damaging 0.47
R7611:Gpr6 UTSW 10 40,946,875 (GRCm39) missense probably benign 0.02
R8011:Gpr6 UTSW 10 40,946,911 (GRCm39) missense probably benign 0.01
R9416:Gpr6 UTSW 10 40,946,944 (GRCm39) missense possibly damaging 0.86
Predicted Primers PCR Primer
(F):5'- TCATCAGCAGGCACCTTGAC -3'
(R):5'- CACCAGATCGCTTTGCAAC -3'

Sequencing Primer
(F):5'- TTGACGCTCACCAAAGGCTG -3'
(R):5'- CAGATCGCTTTGCAACAGCATTG -3'
Posted On 2015-07-07