Incidental Mutation 'R4420:Hsf5'
ID 327060
Institutional Source Beutler Lab
Gene Symbol Hsf5
Ensembl Gene ENSMUSG00000070345
Gene Name heat shock transcription factor family member 5
Synonyms LOC327992
MMRRC Submission 041141-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.203) question?
Stock # R4420 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 87507990-87550368 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 87548130 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 604 (H604Q)
Ref Sequence ENSEMBL: ENSMUSP00000091488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093956]
AlphaFold Q5ND04
Predicted Effect probably benign
Transcript: ENSMUST00000093956
AA Change: H604Q

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000091488
Gene: ENSMUSG00000070345
AA Change: H604Q

DomainStartEndE-ValueType
HSF 11 153 2.35e-9 SMART
Blast:HSF 163 423 1e-149 BLAST
low complexity region 442 457 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 96% (53/55)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef17 G A 7: 100,531,515 (GRCm39) probably benign Het
Atp1b1 T C 1: 164,281,127 (GRCm39) T53A probably damaging Het
Carmil3 A G 14: 55,731,045 (GRCm39) Q104R probably damaging Het
Casz1 T G 4: 149,033,375 (GRCm39) N1382K possibly damaging Het
Chfr T A 5: 110,318,746 (GRCm39) C585* probably null Het
Chp2 T C 7: 121,821,161 (GRCm39) F174S probably damaging Het
Dclre1c A T 2: 3,434,782 (GRCm39) probably null Het
Dnah6 A G 6: 73,168,462 (GRCm39) V487A probably benign Het
Dnah9 T C 11: 66,009,575 (GRCm39) R771G probably benign Het
Duox1 G A 2: 122,157,607 (GRCm39) A578T probably benign Het
Elp3 G A 14: 65,818,240 (GRCm39) A140V probably damaging Het
Fbrsl1 T C 5: 110,526,852 (GRCm39) H387R possibly damaging Het
Gnat3 T C 5: 18,204,799 (GRCm39) S151P probably damaging Het
Gucy1a2 T A 9: 3,634,640 (GRCm39) L228H probably damaging Het
Gzmn A T 14: 56,403,463 (GRCm39) H215Q probably benign Het
Heg1 A T 16: 33,547,805 (GRCm39) E864V probably benign Het
Hoxb9 T C 11: 96,162,807 (GRCm39) V147A probably benign Het
Hus1 T C 11: 8,950,133 (GRCm39) E196G probably damaging Het
Il12rb2 G T 6: 67,293,394 (GRCm39) probably null Het
Irs1 T C 1: 82,266,171 (GRCm39) S682G possibly damaging Het
Jcad T C 18: 4,676,032 (GRCm39) S1265P probably benign Het
Kdm1b C T 13: 47,216,553 (GRCm39) R308W probably damaging Het
Matk A G 10: 81,098,291 (GRCm39) S361G possibly damaging Het
Mroh5 TGGAG TG 15: 73,654,923 (GRCm39) probably benign Het
Nceh1 A G 3: 27,295,798 (GRCm39) D353G probably damaging Het
Nqo1 C T 8: 108,118,749 (GRCm39) probably null Het
Or5t7 A G 2: 86,507,263 (GRCm39) V138A possibly damaging Het
Pcdh7 T C 5: 58,286,512 (GRCm39) I1196T probably benign Het
Pla2g4d A G 2: 120,114,644 (GRCm39) V29A probably benign Het
Ppfibp1 T A 6: 146,927,736 (GRCm39) Y794* probably null Het
Prdx5 C A 19: 6,885,332 (GRCm39) probably null Het
Psme4 C T 11: 30,762,028 (GRCm39) T456I possibly damaging Het
Ptprd A T 4: 75,957,614 (GRCm39) S923R possibly damaging Het
Samd12 G A 15: 53,723,655 (GRCm39) R13W probably damaging Het
Slc35f4 A T 14: 49,551,034 (GRCm39) probably benign Het
Smc1b A G 15: 84,997,031 (GRCm39) Y530H probably damaging Het
Spata2l T C 8: 123,960,768 (GRCm39) T174A possibly damaging Het
Sugct C T 13: 17,627,130 (GRCm39) C241Y probably damaging Het
Tarbp1 G T 8: 127,173,819 (GRCm39) A965D possibly damaging Het
Tas1r3 A G 4: 155,946,789 (GRCm39) V272A probably damaging Het
Tas2r117 T A 6: 132,780,312 (GRCm39) L150* probably null Het
Trip10 C T 17: 57,562,448 (GRCm39) P322L probably benign Het
Wdfy3 A C 5: 102,058,850 (GRCm39) H1487Q probably damaging Het
Wdr95 G A 5: 149,456,131 (GRCm39) V8M probably damaging Het
Zc3h15 C A 2: 83,488,356 (GRCm39) A98E probably damaging Het
Zfp763 T G 17: 33,237,455 (GRCm39) K563N probably benign Het
Zmym2 G A 14: 57,194,335 (GRCm39) D1198N probably damaging Het
Zp1 C T 19: 10,892,124 (GRCm39) probably null Het
Other mutations in Hsf5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Hsf5 APN 11 87,513,922 (GRCm39) missense probably damaging 0.99
IGL01726:Hsf5 APN 11 87,526,951 (GRCm39) missense probably benign 0.22
IGL02480:Hsf5 APN 11 87,522,483 (GRCm39) missense possibly damaging 0.67
IGL02572:Hsf5 APN 11 87,522,521 (GRCm39) splice site probably benign
IGL03113:Hsf5 APN 11 87,548,190 (GRCm39) missense probably benign 0.03
R0015:Hsf5 UTSW 11 87,548,161 (GRCm39) missense probably benign
R0015:Hsf5 UTSW 11 87,548,161 (GRCm39) missense probably benign
R1381:Hsf5 UTSW 11 87,528,995 (GRCm39) missense probably benign
R1807:Hsf5 UTSW 11 87,548,168 (GRCm39) missense probably benign 0.04
R1838:Hsf5 UTSW 11 87,526,881 (GRCm39) missense probably benign 0.45
R2187:Hsf5 UTSW 11 87,529,010 (GRCm39) missense possibly damaging 0.51
R3930:Hsf5 UTSW 11 87,522,508 (GRCm39) missense probably damaging 1.00
R3931:Hsf5 UTSW 11 87,522,508 (GRCm39) missense probably damaging 1.00
R4423:Hsf5 UTSW 11 87,522,460 (GRCm39) missense probably damaging 0.99
R4744:Hsf5 UTSW 11 87,513,617 (GRCm39) missense probably benign 0.02
R4795:Hsf5 UTSW 11 87,526,446 (GRCm39) missense probably benign 0.18
R5862:Hsf5 UTSW 11 87,513,817 (GRCm39) missense probably damaging 0.96
R6232:Hsf5 UTSW 11 87,508,120 (GRCm39) missense probably benign 0.05
R6234:Hsf5 UTSW 11 87,508,120 (GRCm39) missense probably benign 0.05
R6609:Hsf5 UTSW 11 87,526,779 (GRCm39) missense probably damaging 0.99
R7821:Hsf5 UTSW 11 87,528,954 (GRCm39) missense probably benign 0.04
R7989:Hsf5 UTSW 11 87,526,450 (GRCm39) missense probably benign 0.07
R9299:Hsf5 UTSW 11 87,526,770 (GRCm39) missense probably benign
R9419:Hsf5 UTSW 11 87,528,935 (GRCm39) missense probably benign 0.02
R9752:Hsf5 UTSW 11 87,513,709 (GRCm39) missense probably benign 0.22
Z1177:Hsf5 UTSW 11 87,528,959 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGCTCCTGGGTGTGCTTTAAAG -3'
(R):5'- ATCTGGACTGAACAGTTGGAGTG -3'

Sequencing Primer
(F):5'- CTGAAGGCATGTCTGTTGA -3'
(R):5'- GATGTCACGGCTGTCAC -3'
Posted On 2015-07-07