Incidental Mutation 'R4354:Pga5'
ID |
327464 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Pga5
|
Ensembl Gene |
ENSMUSG00000024738 |
Gene Name |
pepsinogen 5, group I |
Synonyms |
1110035E17Rik, Pepf, pepsinogen A5 |
MMRRC Submission |
041107-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.067)
|
Stock # |
R4354 (G1)
|
Quality Score |
221 |
Status
|
Validated
|
Chromosome |
19 |
Chromosomal Location |
10646321-10655435 bp(-) (GRCm39) |
Type of Mutation |
critical splice donor site (1 bp from exon) |
DNA Base Change (assembly) |
C to T
at 10652190 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000025647
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025647]
|
AlphaFold |
Q9D106 |
Predicted Effect |
probably null
Transcript: ENSMUST00000025647
|
SMART Domains |
Protein: ENSMUSP00000025647 Gene: ENSMUSG00000024738
Domain | Start | End | E-Value | Type |
Pfam:A1_Propeptide
|
16 |
44 |
1.1e-13 |
PFAM |
Pfam:Asp
|
73 |
386 |
1.1e-112 |
PFAM |
Pfam:TAXi_N
|
74 |
229 |
7.6e-12 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225016
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225135
|
Meta Mutation Damage Score |
0.9363 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
Validation Efficiency |
97% (37/38) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 31 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930578I06Rik |
C |
T |
14: 64,210,658 (GRCm39) |
R190H |
probably benign |
Het |
Abca8b |
A |
C |
11: 109,862,518 (GRCm39) |
S416A |
probably benign |
Het |
Abcb4 |
A |
T |
5: 8,968,771 (GRCm39) |
N370I |
probably benign |
Het |
Abi3bp |
T |
C |
16: 56,353,314 (GRCm39) |
F81S |
probably benign |
Het |
Ablim1 |
C |
T |
19: 57,143,710 (GRCm39) |
C83Y |
probably damaging |
Het |
Adamtsl1 |
A |
T |
4: 86,074,921 (GRCm39) |
H96L |
probably damaging |
Het |
Alms1-ps1 |
C |
T |
6: 85,732,617 (GRCm39) |
|
noncoding transcript |
Het |
AU040320 |
A |
G |
4: 126,748,192 (GRCm39) |
|
probably benign |
Het |
Chd1 |
T |
A |
17: 17,610,263 (GRCm39) |
H472Q |
probably benign |
Het |
Chgb |
A |
T |
2: 132,635,864 (GRCm39) |
D602V |
probably damaging |
Het |
Fhdc1 |
C |
A |
3: 84,352,133 (GRCm39) |
V1031F |
probably benign |
Het |
Gpa33 |
A |
G |
1: 165,991,404 (GRCm39) |
T212A |
possibly damaging |
Het |
Hspg2 |
C |
A |
4: 137,196,222 (GRCm39) |
A17E |
probably benign |
Het |
Irf7 |
T |
C |
7: 140,845,183 (GRCm39) |
R8G |
probably damaging |
Het |
Kcnv1 |
G |
A |
15: 44,977,840 (GRCm39) |
T66M |
probably damaging |
Het |
Loxhd1 |
T |
C |
18: 77,483,123 (GRCm39) |
Y1235H |
probably damaging |
Het |
Mon2 |
T |
C |
10: 122,862,888 (GRCm39) |
T680A |
probably benign |
Het |
Nab1 |
A |
T |
1: 52,529,855 (GRCm39) |
L14Q |
probably damaging |
Het |
Neu4 |
C |
T |
1: 93,952,279 (GRCm39) |
T216I |
probably damaging |
Het |
Nle1 |
A |
G |
11: 82,797,257 (GRCm39) |
C152R |
possibly damaging |
Het |
Nprl3 |
T |
A |
11: 32,184,906 (GRCm39) |
M368L |
probably benign |
Het |
Nudt9 |
A |
G |
5: 104,205,977 (GRCm39) |
K129E |
probably damaging |
Het |
Or5c1 |
T |
C |
2: 37,221,888 (GRCm39) |
L43P |
probably damaging |
Het |
Pdzd8 |
T |
C |
19: 59,333,913 (GRCm39) |
D36G |
probably benign |
Het |
Pold3 |
T |
C |
7: 99,749,824 (GRCm39) |
K47E |
possibly damaging |
Het |
Ptgir |
A |
G |
7: 16,640,794 (GRCm39) |
M29V |
possibly damaging |
Het |
Rab3gap1 |
A |
G |
1: 127,843,378 (GRCm39) |
I251V |
probably benign |
Het |
Susd2 |
G |
T |
10: 75,475,562 (GRCm39) |
F447L |
probably damaging |
Het |
Tbc1d7 |
T |
C |
13: 43,323,344 (GRCm39) |
K16E |
probably damaging |
Het |
Tlr8 |
T |
G |
X: 166,025,868 (GRCm39) |
Q994P |
probably damaging |
Het |
Ube2j1 |
T |
C |
4: 33,049,682 (GRCm39) |
Y227H |
probably benign |
Het |
|
Other mutations in Pga5 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01660:Pga5
|
APN |
19 |
10,652,456 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02037:Pga5
|
APN |
19 |
10,654,065 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02069:Pga5
|
APN |
19 |
10,646,763 (GRCm39) |
missense |
possibly damaging |
0.76 |
IGL02197:Pga5
|
APN |
19 |
10,649,277 (GRCm39) |
splice site |
probably benign |
|
IGL02871:Pga5
|
APN |
19 |
10,649,144 (GRCm39) |
splice site |
probably benign |
|
R0238:Pga5
|
UTSW |
19 |
10,646,817 (GRCm39) |
missense |
probably damaging |
1.00 |
R0238:Pga5
|
UTSW |
19 |
10,646,817 (GRCm39) |
missense |
probably damaging |
1.00 |
R0239:Pga5
|
UTSW |
19 |
10,646,817 (GRCm39) |
missense |
probably damaging |
1.00 |
R0239:Pga5
|
UTSW |
19 |
10,646,817 (GRCm39) |
missense |
probably damaging |
1.00 |
R1573:Pga5
|
UTSW |
19 |
10,651,201 (GRCm39) |
missense |
probably benign |
0.13 |
R1941:Pga5
|
UTSW |
19 |
10,646,820 (GRCm39) |
splice site |
probably null |
|
R4568:Pga5
|
UTSW |
19 |
10,649,216 (GRCm39) |
missense |
probably damaging |
1.00 |
R5119:Pga5
|
UTSW |
19 |
10,654,053 (GRCm39) |
missense |
probably benign |
0.00 |
R5738:Pga5
|
UTSW |
19 |
10,647,024 (GRCm39) |
missense |
probably benign |
0.05 |
R5864:Pga5
|
UTSW |
19 |
10,652,513 (GRCm39) |
missense |
probably damaging |
1.00 |
R6176:Pga5
|
UTSW |
19 |
10,649,149 (GRCm39) |
splice site |
probably null |
|
R6270:Pga5
|
UTSW |
19 |
10,652,225 (GRCm39) |
missense |
probably benign |
|
R6990:Pga5
|
UTSW |
19 |
10,646,779 (GRCm39) |
missense |
probably benign |
0.03 |
R8056:Pga5
|
UTSW |
19 |
10,654,161 (GRCm39) |
splice site |
probably benign |
|
R8348:Pga5
|
UTSW |
19 |
10,649,173 (GRCm39) |
missense |
probably damaging |
1.00 |
R8448:Pga5
|
UTSW |
19 |
10,649,173 (GRCm39) |
missense |
probably damaging |
1.00 |
R8510:Pga5
|
UTSW |
19 |
10,655,308 (GRCm39) |
missense |
possibly damaging |
0.73 |
R9352:Pga5
|
UTSW |
19 |
10,646,897 (GRCm39) |
missense |
probably damaging |
1.00 |
R9382:Pga5
|
UTSW |
19 |
10,646,897 (GRCm39) |
missense |
probably damaging |
1.00 |
R9383:Pga5
|
UTSW |
19 |
10,646,897 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Pga5
|
UTSW |
19 |
10,646,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AAGGAGCTACAAATCTGAGCC -3'
(R):5'- ATCTATTGCTCCAGCCCAGC -3'
Sequencing Primer
(F):5'- GCTACAAATCTGAGCCTTGGG -3'
(R):5'- GTGAGCACTCTGATCCGACCTAC -3'
|
Posted On |
2015-07-07 |