Incidental Mutation 'R4409:Gm10226'
ID 327831
Institutional Source Beutler Lab
Gene Symbol Gm10226
Ensembl Gene ENSMUSG00000067929
Gene Name predicted gene 10226
Synonyms
MMRRC Submission 041691-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.191) question?
Stock # R4409 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 21910767-21911021 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 21910876 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 37 (C37F)
Ref Sequence ENSEMBL: ENSMUSP00000072002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072133] [ENSMUST00000097384]
AlphaFold O88253
Predicted Effect possibly damaging
Transcript: ENSMUST00000072133
AA Change: C37F

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000072002
Gene: ENSMUSG00000067929
AA Change: C37F

DomainStartEndE-ValueType
ZnF_C2H2 4 26 5.59e-4 SMART
ZnF_C2H2 32 54 2.79e-4 SMART
ZnF_C2H2 60 82 4.17e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000097384
SMART Domains Protein: ENSMUSP00000094996
Gene: ENSMUSG00000073448

DomainStartEndE-ValueType
ZnF_C2H2 4 26 4.54e-4 SMART
ZnF_C2H2 32 54 7.9e-4 SMART
ZnF_C2H2 60 82 7.15e-2 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AAdacl4fm3 A T 4: 144,447,872 (GRCm39) S35T possibly damaging Het
Abcb5 A C 12: 118,836,657 (GRCm39) L1085V probably damaging Het
Adgrf5 T C 17: 43,752,738 (GRCm39) V560A probably damaging Het
Ambp C A 4: 63,070,884 (GRCm39) S65I probably damaging Het
Ash1l A G 3: 88,914,506 (GRCm39) D1712G probably damaging Het
Capn7 T C 14: 31,077,296 (GRCm39) L338P probably damaging Het
Car2 T A 3: 14,960,162 (GRCm39) S105T probably damaging Het
Casr A G 16: 36,320,703 (GRCm39) C482R probably benign Het
Ccdc18 C T 5: 108,368,708 (GRCm39) Q1277* probably null Het
Clca3a1 A G 3: 144,711,788 (GRCm39) F736L probably damaging Het
Col6a1 T C 10: 76,557,334 (GRCm39) H206R probably benign Het
Crybg1 C T 10: 43,874,754 (GRCm39) A785T possibly damaging Het
Cyp2c68 T A 19: 39,727,896 (GRCm39) E85D probably damaging Het
Dnah9 T C 11: 65,976,303 (GRCm39) S1249G possibly damaging Het
E2f1 C G 2: 154,405,942 (GRCm39) G144R probably damaging Het
Fbxw24 A T 9: 109,437,256 (GRCm39) D210E probably damaging Het
Fcgr1 T C 3: 96,191,893 (GRCm39) Y305C probably benign Het
Greb1l A G 18: 10,503,182 (GRCm39) Y411C possibly damaging Het
Grin1 T C 2: 25,200,451 (GRCm39) N224D possibly damaging Het
H2-T5 T A 17: 36,476,742 (GRCm39) H244L possibly damaging Het
Ighmbp2 C T 19: 3,321,536 (GRCm39) V408I probably benign Het
Il1rap G A 16: 26,531,015 (GRCm39) probably null Het
Iqcg A G 16: 32,865,888 (GRCm39) probably null Het
Klhdc3 C T 17: 46,987,944 (GRCm39) G249E probably damaging Het
Lct T C 1: 128,231,963 (GRCm39) M629V probably damaging Het
Macrod2 T G 2: 140,260,777 (GRCm39) H68Q possibly damaging Het
Morn4 T C 19: 42,066,986 (GRCm39) T2A possibly damaging Het
Msc G C 1: 14,825,902 (GRCm39) P24R probably damaging Het
Msh5 T C 17: 35,258,226 (GRCm39) D300G probably damaging Het
Myo10 A G 15: 25,807,955 (GRCm39) Y1859C probably damaging Het
Nacc1 A G 8: 85,399,673 (GRCm39) *515Q probably null Het
Or1ad6 T A 11: 50,860,223 (GRCm39) I126N probably damaging Het
Or4n5 T A 14: 50,133,230 (GRCm39) T10S probably benign Het
Or5g29 T C 2: 85,421,274 (GRCm39) L130S probably damaging Het
Oxgr1 C T 14: 120,259,572 (GRCm39) V212M possibly damaging Het
P3h2 G C 16: 25,924,040 (GRCm39) R132G possibly damaging Het
Pcdha9 T A 18: 37,132,198 (GRCm39) H422Q probably benign Het
Pcdhga12 A G 18: 37,901,138 (GRCm39) T657A probably damaging Het
Pcx A G 19: 4,660,031 (GRCm39) K442R possibly damaging Het
Pkd2 T C 5: 104,614,750 (GRCm39) silent Het
Plg T G 17: 12,609,150 (GRCm39) C152G probably damaging Het
Plk4 A G 3: 40,760,984 (GRCm39) E438G probably damaging Het
Ryr3 A G 2: 112,560,653 (GRCm39) L3016P probably damaging Het
Sdccag8 T G 1: 176,695,932 (GRCm39) probably null Het
Slc24a1 A T 9: 64,855,506 (GRCm39) M467K probably benign Het
Sorl1 T G 9: 41,946,744 (GRCm39) I856L probably damaging Het
Spag7 T C 11: 70,555,688 (GRCm39) D83G probably damaging Het
Tmem59l A G 8: 70,939,951 (GRCm39) L6S unknown Het
Tmprss11b T C 5: 86,812,137 (GRCm39) N170S probably benign Het
Tnfrsf1b G A 4: 144,950,855 (GRCm39) Q253* probably null Het
Trim12a G A 7: 103,956,201 (GRCm39) A113V probably benign Het
Ttn A G 2: 76,727,987 (GRCm39) probably benign Het
Vmn1r213 A C 13: 23,195,593 (GRCm39) probably benign Het
Vmn1r54 C A 6: 90,246,864 (GRCm39) Y259* probably null Het
Vmn1r55 A G 7: 5,150,075 (GRCm39) V116A probably benign Het
Vmn2r120 T C 17: 57,816,477 (GRCm39) N626S probably damaging Het
Vmn2r58 A G 7: 41,522,051 (GRCm39) F15S possibly damaging Het
Vmn2r73 A T 7: 85,520,768 (GRCm39) V400E probably damaging Het
Zbtb39 A G 10: 127,578,696 (GRCm39) I423M possibly damaging Het
Zfp352 A G 4: 90,113,401 (GRCm39) N514D probably benign Het
Zfp451 A T 1: 33,816,494 (GRCm39) H485Q probably damaging Het
Other mutations in Gm10226
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0032:Gm10226 UTSW 17 21,910,963 (GRCm39) missense possibly damaging 0.92
R1916:Gm10226 UTSW 17 21,910,916 (GRCm39) missense possibly damaging 0.71
R5161:Gm10226 UTSW 17 21,910,834 (GRCm39) missense possibly damaging 0.71
R5367:Gm10226 UTSW 17 21,910,884 (GRCm39) missense possibly damaging 0.86
R6456:Gm10226 UTSW 17 21,910,932 (GRCm39) nonsense probably null
R7776:Gm10226 UTSW 17 21,910,866 (GRCm39) missense possibly damaging 0.71
R9052:Gm10226 UTSW 17 21,910,959 (GRCm39) missense possibly damaging 0.71
R9091:Gm10226 UTSW 17 21,910,866 (GRCm39) missense possibly damaging 0.86
R9270:Gm10226 UTSW 17 21,910,866 (GRCm39) missense possibly damaging 0.86
R9298:Gm10226 UTSW 17 21,910,768 (GRCm39) missense probably null 0.72
Predicted Primers PCR Primer
(F):5'- GGCAAATCTTTTACTACATGCTCAA -3'
(R):5'- AAAGGATTTGTCACAGTCTTTGCA -3'

Sequencing Primer
(F):5'- GTTCATACTGGAGAGAGACCTTAC -3'
(R):5'- GCATTTGTAAGGTTTCTCTCCAG -3'
Posted On 2015-07-07