Incidental Mutation 'R4411:Tas2r136'
ID327910
Institutional Source Beutler Lab
Gene Symbol Tas2r136
Ensembl Gene ENSMUSG00000053217
Gene Nametaste receptor, type 2, member 136
SynonymsTas2r36, mt2r52
MMRRC Submission 041693-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #R4411 (G1)
Quality Score225
Status Validated
Chromosome6
Chromosomal Location132777179-132778162 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 132778009 bp
ZygosityHeterozygous
Amino Acid Change Valine to Leucine at position 52 (V52L)
Ref Sequence ENSEMBL: ENSMUSP00000070791 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065532]
Predicted Effect probably damaging
Transcript: ENSMUST00000065532
AA Change: V52L

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000070791
Gene: ENSMUSG00000053217
AA Change: V52L

DomainStartEndE-ValueType
Pfam:TAS2R 23 317 8.4e-68 PFAM
Meta Mutation Damage Score 0.222 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 95% (62/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,151,955 I423V probably benign Het
Abl2 T C 1: 156,630,082 V306A possibly damaging Het
Adcy4 T C 14: 55,769,443 Y1006C probably damaging Het
Adprhl1 T C 8: 13,246,114 K144E probably benign Het
Arid5b T C 10: 68,096,689 R885G probably damaging Het
Atp9a A T 2: 168,661,933 V613E probably damaging Het
Atxn7l1 G T 12: 33,194,887 probably benign Het
Brd8 C A 18: 34,623,444 probably benign Het
Bsnd C T 4: 106,486,671 R146H probably benign Het
C4b C T 17: 34,728,864 R1659H probably damaging Het
Duox1 G A 2: 122,337,634 R1080H probably benign Het
Eml2 T C 7: 19,182,401 probably null Het
Fbxo44 G A 4: 148,153,608 R221C probably damaging Het
Frem1 T C 4: 82,963,244 D166G probably damaging Het
Galnt5 T C 2: 57,999,195 L269P probably benign Het
Gigyf2 A G 1: 87,436,860 E954G probably damaging Het
Gpc6 T C 14: 117,951,178 V408A probably benign Het
Hspg2 A G 4: 137,562,224 T3832A probably benign Het
Ift88 A G 14: 57,477,979 N493S probably damaging Het
Ighv1-76 A T 12: 115,848,111 C41S probably damaging Het
Igkv12-46 G A 6: 69,764,946 T16I probably benign Het
Igkv3-9 G T 6: 70,588,563 V49F probably damaging Het
Isoc2b A T 7: 4,849,434 probably benign Het
Lcp2 T A 11: 34,087,173 probably benign Het
Lmntd1 A G 6: 145,427,277 probably null Het
Mdm2 A T 10: 117,709,789 probably null Het
Mrgprx3-ps T C 7: 47,309,998 noncoding transcript Het
Msh2 T C 17: 87,717,604 S637P probably damaging Het
Myo5b T C 18: 74,698,274 F765S possibly damaging Het
Nav2 T A 7: 49,398,109 N91K probably benign Het
Ndor1 G A 2: 25,248,480 P363S probably benign Het
Npr3 G C 15: 11,905,149 T164R probably benign Het
Pcdhb5 T C 18: 37,321,997 S477P possibly damaging Het
Pde3b GTGATGATGATGATGATGATGATGATG GTGATGATGATGATGATGATGATG 7: 114,534,749 probably benign Het
Pnpla7 G A 2: 25,051,704 W13* probably null Het
Pnpla8 T C 12: 44,283,442 V41A probably benign Het
Prdm2 A T 4: 143,133,670 S1017T probably benign Het
Prdm5 T A 6: 65,901,787 Y108* probably null Het
Rab34 T A 11: 78,188,766 probably null Het
Smpd5 G T 15: 76,294,912 R160L possibly damaging Het
Srrm2 A G 17: 23,810,468 probably benign Het
Taf5 T A 19: 47,071,014 V199D probably damaging Het
Tas2r114 C T 6: 131,689,622 V148I probably benign Het
Tex43 A G 18: 56,594,648 T65A probably benign Het
Tnfrsf25 G A 4: 152,118,386 probably benign Het
Tpd52l1 T C 10: 31,379,319 T11A possibly damaging Het
Trmt1l G A 1: 151,452,154 E472K probably benign Het
Ttc17 T C 2: 94,342,753 K766E probably damaging Het
Ttc37 A G 13: 76,127,504 E410G possibly damaging Het
Ttn C T 2: 76,730,289 R29256Q probably damaging Het
Ttn T C 2: 76,742,070 I26160V probably damaging Het
Ubxn6 A T 17: 56,069,303 V311E probably damaging Het
Usp2 T C 9: 44,091,063 S351P probably damaging Het
Usp7 C A 16: 8,708,914 D187Y probably damaging Het
Vmn1r115 C T 7: 20,844,282 R235K probably benign Het
Vmn2r50 A C 7: 10,050,308 F80V probably damaging Het
Vmn2r58 T A 7: 41,861,936 K481M possibly damaging Het
Vmn2r86 A G 10: 130,452,600 I344T possibly damaging Het
Zfp455 A T 13: 67,207,325 N219I probably damaging Het
Other mutations in Tas2r136
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00678:Tas2r136 APN 6 132777198 missense probably damaging 1.00
IGL02414:Tas2r136 APN 6 132777531 missense possibly damaging 0.87
IGL02662:Tas2r136 APN 6 132777708 missense probably damaging 1.00
R0607:Tas2r136 UTSW 6 132777412 missense probably benign 0.09
R0785:Tas2r136 UTSW 6 132777927 missense probably benign
R1727:Tas2r136 UTSW 6 132777790 missense possibly damaging 0.63
R2101:Tas2r136 UTSW 6 132777532 missense probably benign 0.09
R2975:Tas2r136 UTSW 6 132778009 missense probably damaging 1.00
R3080:Tas2r136 UTSW 6 132778009 missense probably damaging 1.00
R3746:Tas2r136 UTSW 6 132777237 missense probably damaging 0.97
R3749:Tas2r136 UTSW 6 132777237 missense probably damaging 0.97
R3750:Tas2r136 UTSW 6 132777237 missense probably damaging 0.97
R4362:Tas2r136 UTSW 6 132778009 missense probably damaging 1.00
R4413:Tas2r136 UTSW 6 132778009 missense probably damaging 1.00
R4803:Tas2r136 UTSW 6 132777492 missense probably damaging 1.00
R5283:Tas2r136 UTSW 6 132777411 missense probably damaging 0.99
R5343:Tas2r136 UTSW 6 132778080 missense probably benign 0.00
R5738:Tas2r136 UTSW 6 132777744 missense probably damaging 1.00
R5872:Tas2r136 UTSW 6 132777331 missense possibly damaging 0.46
R6770:Tas2r136 UTSW 6 132777382 missense probably benign 0.03
R7326:Tas2r136 UTSW 6 132777906 missense possibly damaging 0.65
Predicted Primers PCR Primer
(F):5'- GCTGAGTATATTTGCAAGCCATG -3'
(R):5'- AATGAAGACCACATGAATCAGTGTG -3'

Sequencing Primer
(F):5'- GGTTGGTTACTATCCAGACAACAC -3'
(R):5'- CAGTGTGTTCATGAAATCACAGCC -3'
Posted On2015-07-07