Incidental Mutation 'R4414:Mapk4'
ID 328084
Institutional Source Beutler Lab
Gene Symbol Mapk4
Ensembl Gene ENSMUSG00000024558
Gene Name mitogen-activated protein kinase 4
Synonyms p63Mapk, A330097D03Rik, Erk3-related
MMRRC Submission 041694-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4414 (G1)
Quality Score 221
Status Validated
Chromosome 18
Chromosomal Location 74061557-74198430 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 74063609 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 538 (F538I)
Ref Sequence ENSEMBL: ENSMUSP00000089462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091851] [ENSMUST00000159162] [ENSMUST00000162863]
AlphaFold Q6P5G0
Predicted Effect possibly damaging
Transcript: ENSMUST00000091851
AA Change: F538I

PolyPhen 2 Score 0.764 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000089462
Gene: ENSMUSG00000024558
AA Change: F538I

DomainStartEndE-ValueType
S_TKc 20 312 3.81e-79 SMART
low complexity region 462 478 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000159162
SMART Domains Protein: ENSMUSP00000123922
Gene: ENSMUSG00000024558

DomainStartEndE-ValueType
Pfam:Pkinase 20 232 2.3e-58 PFAM
Pfam:Pkinase_Tyr 22 232 5.5e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000162863
SMART Domains Protein: ENSMUSP00000124408
Gene: ENSMUSG00000024558

DomainStartEndE-ValueType
Pfam:Pkinase 20 192 1.7e-41 PFAM
Pfam:Pkinase_Tyr 22 189 5.9e-25 PFAM
Meta Mutation Damage Score 0.2282 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
PHENOTYPE: Mice homozygous for a knock-out allele are viabel and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503E14Rik T A 14: 44,406,690 (GRCm39) M120L probably benign Het
Aco2 A G 15: 81,773,584 (GRCm39) probably null Het
Acss1 A G 2: 150,501,823 (GRCm39) S115P possibly damaging Het
Ank2 A T 3: 127,019,411 (GRCm39) probably null Het
AU041133 C T 10: 81,987,316 (GRCm39) T323M probably damaging Het
Bdp1 T C 13: 100,167,369 (GRCm39) D2215G probably damaging Het
Bod1l G A 5: 41,977,870 (GRCm39) T1148I probably benign Het
Celsr1 C T 15: 85,847,334 (GRCm39) V1468I probably benign Het
Celsr1 A G 15: 85,812,200 (GRCm39) V2065A probably damaging Het
Cep89 A G 7: 35,115,822 (GRCm39) probably benign Het
Cfap58 A G 19: 47,941,480 (GRCm39) K283E possibly damaging Het
Cog5 C T 12: 31,710,853 (GRCm39) Q78* probably null Het
Col20a1 C T 2: 180,643,043 (GRCm39) R796C possibly damaging Het
Dnah7b A T 1: 46,165,840 (GRCm39) T502S probably benign Het
Dnm1l A G 16: 16,160,559 (GRCm39) probably null Het
Dse A T 10: 34,028,632 (GRCm39) F819L probably benign Het
Eloa G T 4: 135,738,553 (GRCm39) L136I possibly damaging Het
Eloa T A 4: 135,738,576 (GRCm39) H128L probably benign Het
Fbxl6 T C 15: 76,421,924 (GRCm39) E205G possibly damaging Het
Golim4 T G 3: 75,802,347 (GRCm39) N287T probably benign Het
Gpx8 T A 13: 113,179,682 (GRCm39) K206N possibly damaging Het
Iqgap3 G T 3: 88,004,293 (GRCm39) V460F probably benign Het
Kcne4 A T 1: 78,795,651 (GRCm39) M100L probably benign Het
Kmt2a A T 9: 44,721,077 (GRCm39) probably benign Het
Ktn1 G A 14: 47,962,387 (GRCm39) W1117* probably null Het
Lad1 A G 1: 135,756,484 (GRCm39) D364G probably benign Het
Lmln T G 16: 32,930,220 (GRCm39) I559S probably benign Het
Mlxipl A G 5: 135,166,253 (GRCm39) probably benign Het
Mmrn1 T C 6: 60,921,570 (GRCm39) L9P probably damaging Het
Mnat1 G A 12: 73,228,601 (GRCm39) R155H probably damaging Het
Mtmr11 T C 3: 96,075,207 (GRCm39) probably benign Het
Naaladl1 T C 19: 6,165,581 (GRCm39) L745P probably damaging Het
Obsl1 A T 1: 75,467,546 (GRCm39) D1409E probably benign Het
Oit3 T C 10: 59,263,925 (GRCm39) Y403C probably damaging Het
Pla2g4e A T 2: 120,013,194 (GRCm39) H375Q probably benign Het
Prodh2 G A 7: 30,205,877 (GRCm39) V238M probably damaging Het
Rdh14 G A 12: 10,441,231 (GRCm39) probably null Het
Rho G A 6: 115,912,191 (GRCm39) V76I probably benign Het
Rock1 A T 18: 10,080,514 (GRCm39) M1010K probably damaging Het
Ros1 A G 10: 52,038,800 (GRCm39) probably null Het
Sim1 A T 10: 50,857,708 (GRCm39) D486V probably benign Het
Spmip6 T C 4: 41,505,574 (GRCm39) T183A possibly damaging Het
Src A G 2: 157,306,573 (GRCm39) D192G probably damaging Het
Stox1 T C 10: 62,495,348 (GRCm39) N975S probably benign Het
Tmem145 A G 7: 25,006,554 (GRCm39) Y54C probably damaging Het
Try4 C T 6: 41,281,905 (GRCm39) P164S possibly damaging Het
Vegfc A T 8: 54,634,130 (GRCm39) N270Y probably benign Het
Other mutations in Mapk4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02396:Mapk4 APN 18 74,067,068 (GRCm39) splice site probably null
IGL02621:Mapk4 APN 18 74,103,346 (GRCm39) missense probably damaging 1.00
IGL03068:Mapk4 APN 18 74,103,415 (GRCm39) missense probably damaging 1.00
R0041:Mapk4 UTSW 18 74,068,109 (GRCm39) missense probably damaging 1.00
R0519:Mapk4 UTSW 18 74,103,392 (GRCm39) missense probably damaging 1.00
R0636:Mapk4 UTSW 18 74,063,525 (GRCm39) missense probably benign
R0918:Mapk4 UTSW 18 74,103,408 (GRCm39) missense probably damaging 1.00
R1654:Mapk4 UTSW 18 74,064,010 (GRCm39) missense probably damaging 1.00
R2913:Mapk4 UTSW 18 74,068,236 (GRCm39) missense probably benign 0.34
R2914:Mapk4 UTSW 18 74,068,236 (GRCm39) missense probably benign 0.34
R4089:Mapk4 UTSW 18 74,063,530 (GRCm39) missense probably damaging 1.00
R4487:Mapk4 UTSW 18 74,064,046 (GRCm39) missense probably damaging 1.00
R4792:Mapk4 UTSW 18 74,070,321 (GRCm39) missense probably damaging 0.98
R5445:Mapk4 UTSW 18 74,064,073 (GRCm39) missense probably benign 0.00
R5597:Mapk4 UTSW 18 74,070,341 (GRCm39) missense probably benign 0.12
R5654:Mapk4 UTSW 18 74,103,365 (GRCm39) missense probably damaging 1.00
R6700:Mapk4 UTSW 18 74,063,882 (GRCm39) missense probably damaging 1.00
R6793:Mapk4 UTSW 18 74,063,539 (GRCm39) missense probably damaging 1.00
R7200:Mapk4 UTSW 18 74,063,990 (GRCm39) missense possibly damaging 0.92
R7335:Mapk4 UTSW 18 74,070,338 (GRCm39) missense possibly damaging 0.75
R8010:Mapk4 UTSW 18 74,063,647 (GRCm39) missense probably benign 0.04
R8269:Mapk4 UTSW 18 74,063,622 (GRCm39) missense probably damaging 0.99
R8736:Mapk4 UTSW 18 74,103,396 (GRCm39) missense probably benign 0.01
Z1176:Mapk4 UTSW 18 74,070,255 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCTGCTAACCCCAACGCAG -3'
(R):5'- AGCAAGCCTCTTTCTGGAG -3'

Sequencing Primer
(F):5'- CAGCTTTCTGGATGGGGATCC -3'
(R):5'- AGCCTCTTTCTGGAGATTGCACAG -3'
Posted On 2015-07-07