Incidental Mutation 'R4425:Or4f14b'
ID 328091
Institutional Source Beutler Lab
Gene Symbol Or4f14b
Ensembl Gene ENSMUSG00000094747
Gene Name olfactory receptor family 4 subfamily F member 14B
Synonyms GA_x6K02T2Q125-72988111-72987173, MOR245-19P, Olfr1307
MMRRC Submission 041144-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R4425 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 111774861-111775799 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 111775534 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 89 (H89R)
Ref Sequence ENSEMBL: ENSMUSP00000097201 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099604] [ENSMUST00000099606]
AlphaFold Q7TQX1
Predicted Effect probably benign
Transcript: ENSMUST00000099604
AA Change: H89R

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000097199
Gene: ENSMUSG00000094747
AA Change: H89R

DomainStartEndE-ValueType
Pfam:7tm_4 38 311 1.5e-36 PFAM
Pfam:7tm_1 49 295 6.5e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000099606
AA Change: H89R

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000097201
Gene: ENSMUSG00000094747
AA Change: H89R

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 2.2e-42 PFAM
Pfam:7tm_1 41 287 6.7e-23 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 T C 11: 94,236,870 (GRCm39) T1456A probably damaging Het
Acad11 T C 9: 103,950,844 (GRCm39) F56S probably damaging Het
Adamts8 A G 9: 30,867,952 (GRCm39) N592S possibly damaging Het
Amh A G 10: 80,642,755 (GRCm39) D313G probably damaging Het
Ampd2 T C 3: 107,994,052 (GRCm39) probably benign Het
Arap3 A G 18: 38,111,653 (GRCm39) L1115P probably damaging Het
Arfgap1 C A 2: 180,622,869 (GRCm39) D327E probably benign Het
Capns2 T A 8: 93,628,252 (GRCm39) I47N possibly damaging Het
Cd163 T C 6: 124,304,862 (GRCm39) S1080P possibly damaging Het
Ceacam10 A T 7: 24,480,433 (GRCm39) Y68F possibly damaging Het
Cep44 G A 8: 56,991,652 (GRCm39) P317S probably benign Het
Cfh A T 1: 140,028,613 (GRCm39) Y688* probably null Het
Chrnb1 A T 11: 69,677,773 (GRCm39) S326R probably damaging Het
Cngb1 C T 8: 96,026,344 (GRCm39) V25M probably damaging Het
Cyp2c50 A T 19: 40,079,136 (GRCm39) N160Y possibly damaging Het
Dalrd3 T C 9: 108,448,800 (GRCm39) probably benign Het
Eef1d C A 15: 75,774,648 (GRCm39) S253I possibly damaging Het
Efl1 G A 7: 82,412,491 (GRCm39) C960Y probably damaging Het
Elmo1 C G 13: 20,784,382 (GRCm39) Y646* probably null Het
Epb41l2 C A 10: 25,382,078 (GRCm39) D701E possibly damaging Het
Fbxl4 T A 4: 22,422,699 (GRCm39) probably null Het
Fhod1 T C 8: 106,063,983 (GRCm39) probably benign Het
Gm8741 G T 17: 35,555,062 (GRCm39) noncoding transcript Het
Igkv10-95 A T 6: 68,657,606 (GRCm39) I21F probably damaging Het
Il10rb C A 16: 91,204,603 (GRCm39) N51K possibly damaging Het
Krt78 T C 15: 101,856,375 (GRCm39) T479A probably benign Het
Lrig3 T C 10: 125,849,273 (GRCm39) S998P probably benign Het
Lrrc8c T A 5: 105,755,755 (GRCm39) M510K probably benign Het
Nfrkb G T 9: 31,311,258 (GRCm39) C369F probably damaging Het
Nphp1 T C 2: 127,630,719 (GRCm39) E19G possibly damaging Het
Or10a5 A C 7: 106,635,698 (GRCm39) E112A probably damaging Het
Ovol3 A T 7: 29,934,789 (GRCm39) probably null Het
Ppp1r16b C T 2: 158,599,174 (GRCm39) T382I probably benign Het
Rims2 T C 15: 39,301,320 (GRCm39) probably null Het
Sh3rf3 T C 10: 58,919,398 (GRCm39) V505A probably benign Het
Shkbp1 T C 7: 27,042,727 (GRCm39) N570S probably benign Het
Slc35f4 C T 14: 49,556,307 (GRCm39) V149I possibly damaging Het
Snx27 A G 3: 94,469,330 (GRCm39) F4L probably benign Het
Syvn1 C T 19: 6,099,951 (GRCm39) probably benign Het
Tagap1 G A 17: 7,223,511 (GRCm39) S395L probably benign Het
Tcstv2b C A 13: 120,373,908 (GRCm39) L127F probably damaging Het
Tek A G 4: 94,751,904 (GRCm39) T1014A probably damaging Het
Top2a A G 11: 98,892,231 (GRCm39) I1077T probably benign Het
Tpo T C 12: 30,154,015 (GRCm39) Y230C probably damaging Het
Trav12-2 A G 14: 53,854,332 (GRCm39) Q102R possibly damaging Het
Ttn G A 2: 76,733,430 (GRCm39) probably benign Het
Vmn1r183 A T 7: 23,754,973 (GRCm39) I259F probably benign Het
Vmn1r228 T C 17: 20,996,861 (GRCm39) E219G probably damaging Het
Vsig8 G T 1: 172,390,714 (GRCm39) G254V probably damaging Het
Vwa8 A G 14: 79,320,246 (GRCm39) I1086V probably benign Het
Zfp423 G A 8: 88,509,601 (GRCm39) H123Y probably damaging Het
Zfp811 A T 17: 33,016,521 (GRCm39) C506* probably null Het
Other mutations in Or4f14b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01501:Or4f14b APN 2 111,774,863 (GRCm39) makesense probably null
IGL01947:Or4f14b APN 2 111,775,339 (GRCm39) missense probably benign 0.26
IGL02373:Or4f14b APN 2 111,775,178 (GRCm39) missense probably benign 0.01
IGL02682:Or4f14b APN 2 111,775,285 (GRCm39) missense probably damaging 1.00
R0714:Or4f14b UTSW 2 111,774,898 (GRCm39) missense probably benign 0.01
R1670:Or4f14b UTSW 2 111,775,264 (GRCm39) missense probably damaging 1.00
R1730:Or4f14b UTSW 2 111,775,633 (GRCm39) missense probably benign 0.45
R1733:Or4f14b UTSW 2 111,775,625 (GRCm39) missense probably benign 0.13
R1773:Or4f14b UTSW 2 111,775,204 (GRCm39) missense possibly damaging 0.55
R1783:Or4f14b UTSW 2 111,775,633 (GRCm39) missense probably benign 0.45
R2180:Or4f14b UTSW 2 111,775,348 (GRCm39) missense probably benign 0.39
R2197:Or4f14b UTSW 2 111,775,658 (GRCm39) missense possibly damaging 0.64
R2207:Or4f14b UTSW 2 111,775,270 (GRCm39) missense probably damaging 1.00
R2377:Or4f14b UTSW 2 111,774,988 (GRCm39) missense probably damaging 1.00
R4595:Or4f14b UTSW 2 111,774,997 (GRCm39) missense possibly damaging 0.86
R4859:Or4f14b UTSW 2 111,775,156 (GRCm39) missense probably damaging 0.98
R4910:Or4f14b UTSW 2 111,775,423 (GRCm39) missense possibly damaging 0.69
R5167:Or4f14b UTSW 2 111,775,447 (GRCm39) missense probably damaging 1.00
R5537:Or4f14b UTSW 2 111,775,393 (GRCm39) missense probably damaging 1.00
R6328:Or4f14b UTSW 2 111,775,739 (GRCm39) missense probably null 0.41
R6877:Or4f14b UTSW 2 111,775,184 (GRCm39) missense probably benign 0.16
R7011:Or4f14b UTSW 2 111,775,031 (GRCm39) missense probably benign 0.01
R7177:Or4f14b UTSW 2 111,775,501 (GRCm39) missense probably damaging 1.00
R7937:Or4f14b UTSW 2 111,774,875 (GRCm39) missense probably benign 0.00
R8792:Or4f14b UTSW 2 111,775,073 (GRCm39) missense probably damaging 1.00
R9290:Or4f14b UTSW 2 111,774,967 (GRCm39) missense possibly damaging 0.91
R9358:Or4f14b UTSW 2 111,775,429 (GRCm39) missense probably benign 0.31
Predicted Primers PCR Primer
(F):5'- AAAACAAGATGCATGTCCTCG -3'
(R):5'- TTTGTGTTCCTGGGACTCAC -3'

Sequencing Primer
(F):5'- CATGTCCTCGGGCTCATAATGG -3'
(R):5'- CTGGGACTCACCAACTCTTG -3'
Posted On 2015-07-07