Incidental Mutation 'R4428:Olfml2a'
ID 328257
Institutional Source Beutler Lab
Gene Symbol Olfml2a
Ensembl Gene ENSMUSG00000046618
Gene Name olfactomedin-like 2A
Synonyms photomedin-1, 4932431K08Rik
MMRRC Submission 041698-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R4428 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 38821992-38850597 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 38831755 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 111 (M111I)
Ref Sequence ENSEMBL: ENSMUSP00000058761 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057279]
AlphaFold Q8BHP7
Predicted Effect probably damaging
Transcript: ENSMUST00000057279
AA Change: M111I

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000058761
Gene: ENSMUSG00000046618
AA Change: M111I

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
internal_repeat_1 39 66 2.55e-7 PROSPERO
internal_repeat_1 78 105 2.55e-7 PROSPERO
coiled coil region 168 189 N/A INTRINSIC
low complexity region 212 228 N/A INTRINSIC
low complexity region 252 271 N/A INTRINSIC
low complexity region 302 320 N/A INTRINSIC
low complexity region 367 407 N/A INTRINSIC
OLF 426 681 8.73e-69 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119289
Meta Mutation Damage Score 0.1098 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,056,182 (GRCm39) probably benign Het
Abcc1 T A 16: 14,263,164 (GRCm39) V708E probably damaging Het
Bag4 C T 8: 26,259,516 (GRCm39) A228T probably benign Het
Ccdc18 A G 5: 108,283,943 (GRCm39) Y82C probably benign Het
Cd82 T C 2: 93,250,214 (GRCm39) Y266C probably damaging Het
Chrna4 A G 2: 180,670,413 (GRCm39) S448P probably damaging Het
Cldn8 A C 16: 88,359,619 (GRCm39) M102R probably damaging Het
Cmpk1 T C 4: 114,820,559 (GRCm39) E180G probably benign Het
Dock8 T C 19: 25,177,863 (GRCm39) I2066T probably damaging Het
Dock8 T C 19: 25,042,754 (GRCm39) V112A probably benign Het
Fgf3 T C 7: 144,394,444 (GRCm39) V86A probably damaging Het
Frem2 A G 3: 53,561,759 (GRCm39) I916T probably benign Het
Gsk3b T A 16: 38,014,298 (GRCm39) L252Q probably damaging Het
Kif18a A G 2: 109,118,466 (GRCm39) T94A probably damaging Het
Klhdc1 T A 12: 69,315,000 (GRCm39) probably benign Het
Klhl25 T A 7: 75,515,162 (GRCm39) F23I probably damaging Het
Mapk7 T C 11: 61,380,055 (GRCm39) D701G possibly damaging Het
Mbd5 A T 2: 49,169,776 (GRCm39) Q47L possibly damaging Het
Nrcam A G 12: 44,623,558 (GRCm39) D1049G possibly damaging Het
Or3a1c T C 11: 74,046,025 (GRCm39) F15S probably damaging Het
Pld2 A T 11: 70,432,160 (GRCm39) H93L probably damaging Het
Pomgnt2 T C 9: 121,811,320 (GRCm39) E487G possibly damaging Het
Psg17 G T 7: 18,550,717 (GRCm39) N379K probably benign Het
Rfk T A 19: 17,375,959 (GRCm39) H84Q possibly damaging Het
Scn8a A G 15: 100,881,784 (GRCm39) Y617C probably damaging Het
Sema3d T C 5: 12,498,087 (GRCm39) F31S probably benign Het
Shq1 T C 6: 100,647,889 (GRCm39) Y45C probably damaging Het
Siglecg C T 7: 43,067,350 (GRCm39) P639L possibly damaging Het
Skp2 A T 15: 9,117,034 (GRCm39) N325K probably benign Het
Sost G A 11: 101,857,670 (GRCm39) P44S probably damaging Het
Sp8 T A 12: 118,812,938 (GRCm39) S264R possibly damaging Het
Sun1 T C 5: 139,220,230 (GRCm39) probably benign Het
Tardbp A G 4: 148,709,659 (GRCm39) V54A possibly damaging Het
Tert T A 13: 73,775,594 (GRCm39) F115Y probably damaging Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Tmem68 A T 4: 3,569,534 (GRCm39) I52K probably benign Het
Trhde A T 10: 114,339,028 (GRCm39) L594Q probably damaging Het
Umps A C 16: 33,781,956 (GRCm39) V322G probably damaging Het
Vmn2r109 T C 17: 20,773,286 (GRCm39) D445G probably benign Het
Vmn2r22 T C 6: 123,614,817 (GRCm39) T258A possibly damaging Het
Vmn2r4 C T 3: 64,322,590 (GRCm39) G43E probably damaging Het
Other mutations in Olfml2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01098:Olfml2a APN 2 38,837,226 (GRCm39) critical splice acceptor site probably null
IGL02367:Olfml2a APN 2 38,844,680 (GRCm39) missense probably benign 0.15
IGL03140:Olfml2a APN 2 38,837,303 (GRCm39) missense probably damaging 1.00
R0559:Olfml2a UTSW 2 38,849,832 (GRCm39) missense probably damaging 1.00
R0781:Olfml2a UTSW 2 38,849,765 (GRCm39) missense probably damaging 0.99
R1110:Olfml2a UTSW 2 38,849,765 (GRCm39) missense probably damaging 0.99
R1187:Olfml2a UTSW 2 38,849,825 (GRCm39) missense probably damaging 1.00
R1626:Olfml2a UTSW 2 38,841,275 (GRCm39) missense probably damaging 1.00
R1634:Olfml2a UTSW 2 38,850,231 (GRCm39) missense probably benign 0.03
R2127:Olfml2a UTSW 2 38,831,699 (GRCm39) missense probably damaging 1.00
R2987:Olfml2a UTSW 2 38,837,306 (GRCm39) missense probably damaging 0.97
R4564:Olfml2a UTSW 2 38,850,306 (GRCm39) missense probably benign 0.40
R4609:Olfml2a UTSW 2 38,847,733 (GRCm39) missense probably damaging 0.98
R4667:Olfml2a UTSW 2 38,839,022 (GRCm39) missense probably damaging 0.99
R4703:Olfml2a UTSW 2 38,841,250 (GRCm39) missense probably damaging 1.00
R4827:Olfml2a UTSW 2 38,850,033 (GRCm39) missense probably damaging 1.00
R5588:Olfml2a UTSW 2 38,850,047 (GRCm39) missense probably damaging 1.00
R5879:Olfml2a UTSW 2 38,850,242 (GRCm39) missense probably damaging 1.00
R6063:Olfml2a UTSW 2 38,841,155 (GRCm39) missense probably benign 0.03
R6484:Olfml2a UTSW 2 38,849,780 (GRCm39) missense probably damaging 1.00
R6788:Olfml2a UTSW 2 38,850,238 (GRCm39) nonsense probably null
R7345:Olfml2a UTSW 2 38,850,139 (GRCm39) missense probably damaging 1.00
R7474:Olfml2a UTSW 2 38,850,273 (GRCm39) missense probably damaging 0.98
R7971:Olfml2a UTSW 2 38,831,794 (GRCm39) splice site probably null
R8073:Olfml2a UTSW 2 38,847,766 (GRCm39) missense probably damaging 1.00
R8846:Olfml2a UTSW 2 38,850,255 (GRCm39) missense probably damaging 1.00
R9108:Olfml2a UTSW 2 38,831,753 (GRCm39) missense probably benign 0.10
R9425:Olfml2a UTSW 2 38,847,721 (GRCm39) missense probably damaging 1.00
Z1177:Olfml2a UTSW 2 38,850,296 (GRCm39) missense possibly damaging 0.69
Predicted Primers PCR Primer
(F):5'- GGTATTCAGTGACCTGGACCAG -3'
(R):5'- GGCATATGAAGTGAATTGGGTC -3'

Sequencing Primer
(F):5'- CAGGTTCGGATGACCTCAGAG -3'
(R):5'- CATACCCAGGATGGTGAGTGATTC -3'
Posted On 2015-07-07