Incidental Mutation 'R4351:Prb1b'
ID 328508
Institutional Source Beutler Lab
Gene Symbol Prb1b
Ensembl Gene ENSMUSG00000107874
Gene Name proline-rich protein BstNI subfamily 1B
Synonyms MP5, Prpmp5
MMRRC Submission 041106-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R4351 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 132288553-132291706 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 132290624 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Serine at position 25 (Y25S)
Ref Sequence ENSEMBL: ENSMUSP00000047347 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048686]
AlphaFold E9PXN1
Predicted Effect unknown
Transcript: ENSMUST00000048686
AA Change: Y25S
SMART Domains Protein: ENSMUSP00000047347
Gene: ENSMUSG00000107874
AA Change: Y25S

DomainStartEndE-ValueType
Pfam:Pro-rich 1 136 2.2e-36 PFAM
Pfam:Pro-rich 84 169 6.1e-17 PFAM
Pfam:Pro-rich 131 182 2.5e-10 PFAM
Pfam:Pro-rich 171 228 4.7e-10 PFAM
Pfam:Pro-rich 222 290 1.1e-11 PFAM
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 98% (42/43)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 C T 6: 128,557,349 (GRCm39) A115T probably benign Het
Aak1 A G 6: 86,912,519 (GRCm39) probably null Het
Abtb2 T A 2: 103,513,738 (GRCm39) D382E possibly damaging Het
Adamts1 T A 16: 85,599,234 (GRCm39) D122V probably benign Het
Adcy6 A T 15: 98,502,041 (GRCm39) V191E probably benign Het
Adh1 A G 3: 137,986,258 (GRCm39) T82A probably benign Het
Ak6 C T 13: 100,792,111 (GRCm39) Q185* probably null Het
Aldh6a1 A G 12: 84,490,535 (GRCm39) Y27H probably benign Het
Apob A G 12: 8,043,054 (GRCm39) M812V probably benign Het
Arhgef10 C A 8: 15,041,145 (GRCm39) S748* probably null Het
Brd3 A T 2: 27,347,028 (GRCm39) Y369N probably damaging Het
Cracdl A G 1: 37,663,993 (GRCm39) F635S probably benign Het
Dhh A G 15: 98,796,099 (GRCm39) probably benign Het
Disp1 A G 1: 182,881,542 (GRCm39) V200A probably benign Het
Dvl3 T C 16: 20,344,394 (GRCm39) Y257H possibly damaging Het
Dzip1 T C 14: 119,120,938 (GRCm39) D673G probably benign Het
Evx1 A G 6: 52,290,846 (GRCm39) D6G probably damaging Het
Garin1b C G 6: 29,320,800 (GRCm39) I141M probably damaging Het
Gfy T C 7: 44,827,040 (GRCm39) E352G probably benign Het
Hars2 A G 18: 36,919,231 (GRCm39) E123G probably damaging Het
Hsd17b4 A T 18: 50,275,701 (GRCm39) D115V probably damaging Het
Lyn G A 4: 3,789,796 (GRCm39) R443H probably damaging Het
Mecom C A 3: 30,020,887 (GRCm39) V452L possibly damaging Het
Nckap1l A G 15: 103,395,246 (GRCm39) T909A probably damaging Het
Ncor1 A G 11: 62,301,644 (GRCm39) probably null Het
Nrp2 A G 1: 62,777,576 (GRCm39) D127G probably damaging Het
Or2v2 A G 11: 49,004,530 (GRCm39) S8P probably damaging Het
Or8g52 T A 9: 39,630,865 (GRCm39) M114K probably damaging Het
Ptch1 C T 13: 63,682,143 (GRCm39) R537H probably damaging Het
Rabgap1 A G 2: 37,373,794 (GRCm39) T269A probably benign Het
Rnf31 AAC A 14: 55,838,555 (GRCm39) probably null Het
Sptbn5 T C 2: 119,913,680 (GRCm39) noncoding transcript Het
Sst A G 16: 23,708,565 (GRCm39) S89P probably damaging Het
Tm2d3 A G 7: 65,344,939 (GRCm39) Y49C probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Wdr81 A G 11: 75,332,638 (GRCm39) L1921P probably damaging Het
Other mutations in Prb1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01392:Prb1b APN 6 132,289,383 (GRCm39) missense unknown
IGL02259:Prb1b APN 6 132,289,637 (GRCm39) missense unknown
IGL02434:Prb1b APN 6 132,289,339 (GRCm39) missense unknown
IGL03238:Prb1b APN 6 132,289,308 (GRCm39) missense unknown
R0971:Prb1b UTSW 6 132,290,618 (GRCm39) missense unknown
R1900:Prb1b UTSW 6 132,291,661 (GRCm39) missense unknown
R3800:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R3951:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R3952:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R3981:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R4083:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R4348:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R4352:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R4353:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R6190:Prb1b UTSW 6 132,289,692 (GRCm39) missense unknown
R7001:Prb1b UTSW 6 132,289,527 (GRCm39) missense unknown
R9023:Prb1b UTSW 6 132,289,174 (GRCm39) frame shift probably null
R9028:Prb1b UTSW 6 132,289,618 (GRCm39) missense unknown
R9193:Prb1b UTSW 6 132,288,996 (GRCm39) missense unknown
R9256:Prb1b UTSW 6 132,288,972 (GRCm39) missense unknown
R9388:Prb1b UTSW 6 132,289,437 (GRCm39) missense unknown
R9644:Prb1b UTSW 6 132,289,218 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AAGCCTAGCTTCGAGTTCTTCC -3'
(R):5'- ATGTCTCCCTGAAGTTGTGG -3'

Sequencing Primer
(F):5'- GCCCTGCTGTAAAGTCAATG -3'
(R):5'- TCTCCCTGAAGTTGTGGTAATG -3'
Posted On 2015-07-07