Incidental Mutation 'R4432:Nmur1'
ID 328638
Institutional Source Beutler Lab
Gene Symbol Nmur1
Ensembl Gene ENSMUSG00000026237
Gene Name neuromedin U receptor 1
Synonyms NmU-R, NMU1R, Gpr66, FM-3
MMRRC Submission 041701-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4432 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 86313964-86317083 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 86315287 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 160 (S160P)
Ref Sequence ENSEMBL: ENSMUSP00000148301 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027440] [ENSMUST00000212058] [ENSMUST00000212541] [ENSMUST00000212614]
AlphaFold O55040
Predicted Effect probably damaging
Transcript: ENSMUST00000027440
AA Change: S193P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027440
Gene: ENSMUSG00000026237
AA Change: S193P

DomainStartEndE-ValueType
Pfam:7tm_4 40 231 4.1e-8 PFAM
Pfam:7TM_GPCR_Srsx 48 349 2.6e-8 PFAM
Pfam:7tm_1 54 334 7.8e-50 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212058
AA Change: S216P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000212541
AA Change: S160P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000212614
Meta Mutation Damage Score 0.5073 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 100% (42/42)
MGI Phenotype PHENOTYPE: Homozygous null mice are healthy and viable. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 T C 11: 110,132,414 (GRCm39) M294V probably benign Het
Abcc5 A T 16: 20,186,937 (GRCm39) probably null Het
Acsm4 A C 7: 119,310,610 (GRCm39) E499A probably damaging Het
Adamtsl4 T C 3: 95,589,069 (GRCm39) probably null Het
Ank2 A T 3: 126,741,455 (GRCm39) probably benign Het
Anks6 G A 4: 47,044,905 (GRCm39) Q334* probably null Het
Cadps2 T A 6: 23,626,737 (GRCm39) I155L probably damaging Het
Casp4 G A 9: 5,323,653 (GRCm39) R74H probably damaging Het
Cdk14 A G 5: 5,086,427 (GRCm39) W298R probably damaging Het
Chia1 A G 3: 106,022,641 (GRCm39) N12D probably benign Het
Cibar2 C A 8: 120,901,594 (GRCm39) R37L probably damaging Het
Cyp3a59 A G 5: 146,041,596 (GRCm39) D380G probably benign Het
Dnm2 T C 9: 21,402,600 (GRCm39) probably benign Het
Dnm3 T C 1: 161,819,566 (GRCm39) probably benign Het
Dpp4 A G 2: 62,175,456 (GRCm39) Y660H probably damaging Het
H6pd T G 4: 150,080,215 (GRCm39) Y202S probably damaging Het
Hnrnpa0 T C 13: 58,275,751 (GRCm39) K126R probably benign Het
Insc C T 7: 114,368,290 (GRCm39) probably benign Het
Lrrc45 G A 11: 120,606,047 (GRCm39) probably null Het
Mapkap1 T C 2: 34,509,875 (GRCm39) L263P probably damaging Het
Or4a81 A T 2: 89,619,078 (GRCm39) M206K possibly damaging Het
Or4g7 T A 2: 111,309,757 (GRCm39) C209* probably null Het
Pcdhb15 A G 18: 37,608,565 (GRCm39) N599S probably damaging Het
Pcid2 T C 8: 13,135,421 (GRCm39) D196G probably damaging Het
Pcolce2 T C 9: 95,563,610 (GRCm39) F199L probably damaging Het
Phf11c A T 14: 59,628,384 (GRCm39) N88K possibly damaging Het
Prl8a8 T A 13: 27,694,463 (GRCm39) Y109F probably benign Het
Rasa2 A G 9: 96,424,460 (GRCm39) probably benign Het
Samhd1 T C 2: 156,946,813 (GRCm39) D558G probably damaging Het
Slc1a1 T C 19: 28,880,109 (GRCm39) F263S probably benign Het
Slc27a3 G A 3: 90,294,647 (GRCm39) T408M probably damaging Het
Slc4a7 T A 14: 14,757,323 (GRCm38) N520K probably damaging Het
Szt2 A G 4: 118,241,428 (GRCm39) S1679P probably damaging Het
Trmt9b A T 8: 36,965,632 (GRCm39) I51F probably damaging Het
Vmn1r218 T C 13: 23,321,412 (GRCm39) F173S possibly damaging Het
Vmn2r32 T A 7: 7,482,918 (GRCm39) N19Y probably damaging Het
Other mutations in Nmur1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00391:Nmur1 APN 1 86,314,193 (GRCm39) missense probably damaging 0.99
IGL00494:Nmur1 APN 1 86,314,084 (GRCm39) missense probably benign
IGL01420:Nmur1 APN 1 86,315,113 (GRCm39) missense probably benign 0.01
IGL02505:Nmur1 APN 1 86,314,057 (GRCm39) missense probably benign 0.00
R0391:Nmur1 UTSW 1 86,315,400 (GRCm39) missense probably damaging 0.99
R1235:Nmur1 UTSW 1 86,314,415 (GRCm39) missense probably damaging 1.00
R4213:Nmur1 UTSW 1 86,315,506 (GRCm39) missense probably damaging 1.00
R4583:Nmur1 UTSW 1 86,314,367 (GRCm39) missense possibly damaging 0.90
R4718:Nmur1 UTSW 1 86,315,463 (GRCm39) missense probably damaging 0.99
R6027:Nmur1 UTSW 1 86,315,053 (GRCm39) nonsense probably null
R7025:Nmur1 UTSW 1 86,315,570 (GRCm39) missense possibly damaging 0.94
R7097:Nmur1 UTSW 1 86,315,230 (GRCm39) missense probably damaging 1.00
R7173:Nmur1 UTSW 1 86,314,190 (GRCm39) missense probably benign 0.00
R7436:Nmur1 UTSW 1 86,314,100 (GRCm39) missense probably benign 0.04
R7601:Nmur1 UTSW 1 86,315,741 (GRCm39) missense probably damaging 1.00
R8920:Nmur1 UTSW 1 86,315,577 (GRCm39) missense probably damaging 1.00
R8985:Nmur1 UTSW 1 86,314,103 (GRCm39) missense probably benign 0.00
R9088:Nmur1 UTSW 1 86,315,252 (GRCm39) missense probably benign
R9198:Nmur1 UTSW 1 86,315,256 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AATCCTTCTGTGGGAGGTCTC -3'
(R):5'- AATGTCACAGCCCTGAGTGTG -3'

Sequencing Primer
(F):5'- AGGTCTCCTGGGTTGCTGC -3'
(R):5'- CCCTGAGTGTGGAGCGTTATG -3'
Posted On 2015-07-21