Incidental Mutation 'R4432:Vmn2r32'
| ID |
328653 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r32
|
| Ensembl Gene |
ENSMUSG00000096743 |
| Gene Name |
vomeronasal 2, receptor 32 |
| Synonyms |
V2r5 |
| MMRRC Submission |
041701-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.249)
|
| Stock # |
R4432 (G1)
|
| Quality Score |
121 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
7466968-7482972 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 7482918 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Tyrosine
at position 19
(N19Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092462
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094866]
|
| AlphaFold |
K7N686 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000094866
AA Change: N19Y
PolyPhen 2
Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000092462
Gene: ENSMUSG00000096743
AA Change: N19Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
470 |
3.6e-33 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
8.1e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
9.5e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
100% (42/42) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca6 |
T |
C |
11: 110,132,414 (GRCm39) |
M294V |
probably benign |
Het |
| Abcc5 |
A |
T |
16: 20,186,937 (GRCm39) |
|
probably null |
Het |
| Acsm4 |
A |
C |
7: 119,310,610 (GRCm39) |
E499A |
probably damaging |
Het |
| Adamtsl4 |
T |
C |
3: 95,589,069 (GRCm39) |
|
probably null |
Het |
| Ank2 |
A |
T |
3: 126,741,455 (GRCm39) |
|
probably benign |
Het |
| Anks6 |
G |
A |
4: 47,044,905 (GRCm39) |
Q334* |
probably null |
Het |
| Cadps2 |
T |
A |
6: 23,626,737 (GRCm39) |
I155L |
probably damaging |
Het |
| Casp4 |
G |
A |
9: 5,323,653 (GRCm39) |
R74H |
probably damaging |
Het |
| Cdk14 |
A |
G |
5: 5,086,427 (GRCm39) |
W298R |
probably damaging |
Het |
| Chia1 |
A |
G |
3: 106,022,641 (GRCm39) |
N12D |
probably benign |
Het |
| Cibar2 |
C |
A |
8: 120,901,594 (GRCm39) |
R37L |
probably damaging |
Het |
| Cyp3a59 |
A |
G |
5: 146,041,596 (GRCm39) |
D380G |
probably benign |
Het |
| Dnm2 |
T |
C |
9: 21,402,600 (GRCm39) |
|
probably benign |
Het |
| Dnm3 |
T |
C |
1: 161,819,566 (GRCm39) |
|
probably benign |
Het |
| Dpp4 |
A |
G |
2: 62,175,456 (GRCm39) |
Y660H |
probably damaging |
Het |
| H6pd |
T |
G |
4: 150,080,215 (GRCm39) |
Y202S |
probably damaging |
Het |
| Hnrnpa0 |
T |
C |
13: 58,275,751 (GRCm39) |
K126R |
probably benign |
Het |
| Insc |
C |
T |
7: 114,368,290 (GRCm39) |
|
probably benign |
Het |
| Lrrc45 |
G |
A |
11: 120,606,047 (GRCm39) |
|
probably null |
Het |
| Mapkap1 |
T |
C |
2: 34,509,875 (GRCm39) |
L263P |
probably damaging |
Het |
| Nmur1 |
A |
G |
1: 86,315,287 (GRCm39) |
S160P |
probably damaging |
Het |
| Or4a81 |
A |
T |
2: 89,619,078 (GRCm39) |
M206K |
possibly damaging |
Het |
| Or4g7 |
T |
A |
2: 111,309,757 (GRCm39) |
C209* |
probably null |
Het |
| Pcdhb15 |
A |
G |
18: 37,608,565 (GRCm39) |
N599S |
probably damaging |
Het |
| Pcid2 |
T |
C |
8: 13,135,421 (GRCm39) |
D196G |
probably damaging |
Het |
| Pcolce2 |
T |
C |
9: 95,563,610 (GRCm39) |
F199L |
probably damaging |
Het |
| Phf11c |
A |
T |
14: 59,628,384 (GRCm39) |
N88K |
possibly damaging |
Het |
| Prl8a8 |
T |
A |
13: 27,694,463 (GRCm39) |
Y109F |
probably benign |
Het |
| Rasa2 |
A |
G |
9: 96,424,460 (GRCm39) |
|
probably benign |
Het |
| Samhd1 |
T |
C |
2: 156,946,813 (GRCm39) |
D558G |
probably damaging |
Het |
| Slc1a1 |
T |
C |
19: 28,880,109 (GRCm39) |
F263S |
probably benign |
Het |
| Slc27a3 |
G |
A |
3: 90,294,647 (GRCm39) |
T408M |
probably damaging |
Het |
| Slc4a7 |
T |
A |
14: 14,757,323 (GRCm38) |
N520K |
probably damaging |
Het |
| Szt2 |
A |
G |
4: 118,241,428 (GRCm39) |
S1679P |
probably damaging |
Het |
| Trmt9b |
A |
T |
8: 36,965,632 (GRCm39) |
I51F |
probably damaging |
Het |
| Vmn1r218 |
T |
C |
13: 23,321,412 (GRCm39) |
F173S |
possibly damaging |
Het |
|
| Other mutations in Vmn2r32 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02140:Vmn2r32
|
APN |
7 |
7,479,696 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02333:Vmn2r32
|
APN |
7 |
7,467,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02406:Vmn2r32
|
APN |
7 |
7,479,709 (GRCm39) |
missense |
probably benign |
|
|
IGL02428:Vmn2r32
|
APN |
7 |
7,477,283 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02484:Vmn2r32
|
APN |
7 |
7,467,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03277:Vmn2r32
|
APN |
7 |
7,477,251 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL03366:Vmn2r32
|
APN |
7 |
7,467,029 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1055:Vmn2r32
|
UTSW |
7 |
7,477,326 (GRCm39) |
nonsense |
probably null |
|
|
R1695:Vmn2r32
|
UTSW |
7 |
7,466,991 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2172:Vmn2r32
|
UTSW |
7 |
7,477,614 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2262:Vmn2r32
|
UTSW |
7 |
7,477,618 (GRCm39) |
missense |
probably benign |
|
|
R3150:Vmn2r32
|
UTSW |
7 |
7,475,554 (GRCm39) |
missense |
probably benign |
|
|
R4362:Vmn2r32
|
UTSW |
7 |
7,482,857 (GRCm39) |
nonsense |
probably null |
|
|
R4851:Vmn2r32
|
UTSW |
7 |
7,482,953 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4949:Vmn2r32
|
UTSW |
7 |
7,467,083 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5990:Vmn2r32
|
UTSW |
7 |
7,482,809 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6083:Vmn2r32
|
UTSW |
7 |
7,467,209 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6084:Vmn2r32
|
UTSW |
7 |
7,467,209 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6116:Vmn2r32
|
UTSW |
7 |
7,467,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6263:Vmn2r32
|
UTSW |
7 |
7,479,691 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6889:Vmn2r32
|
UTSW |
7 |
7,475,573 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7286:Vmn2r32
|
UTSW |
7 |
7,482,807 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7390:Vmn2r32
|
UTSW |
7 |
7,482,851 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7412:Vmn2r32
|
UTSW |
7 |
7,477,212 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7508:Vmn2r32
|
UTSW |
7 |
7,470,373 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8812:Vmn2r32
|
UTSW |
7 |
7,477,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8968:Vmn2r32
|
UTSW |
7 |
7,477,204 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9331:Vmn2r32
|
UTSW |
7 |
7,467,402 (GRCm39) |
nonsense |
probably null |
|
|
R9358:Vmn2r32
|
UTSW |
7 |
7,477,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r32
|
UTSW |
7 |
7,477,160 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCTAATCTTCATTCTCAGAGCAC -3'
(R):5'- AAGTTTCTTCCAGGGCTCAGG -3'
Sequencing Primer
(F):5'- ATCTTCATTCTCAGAGCACTCAAG -3'
(R):5'- TTTCTTCCAGGGCTCAGGAGAAAC -3'
|
| Posted On |
2015-07-21 |
Incidental Mutation