Incidental Mutation 'R4433:Or1e25'
ID 328713
Institutional Source Beutler Lab
Gene Symbol Or1e25
Ensembl Gene ENSMUSG00000060335
Gene Name olfactory receptor family 1 subfamily E member 25
Synonyms GA_x6K02T2P1NL-3739520-3740032, Olfr384, Olfr386, GA_x6K02T2P1NL-3773152-3774090, MOR135-5
MMRRC Submission 041147-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.165) question?
Stock # R4433 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 73493408-73494346 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73493712 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 102 (Y102C)
Ref Sequence ENSEMBL: ENSMUSP00000148997 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072993] [ENSMUST00000214228]
AlphaFold Q7TRX8
Predicted Effect probably damaging
Transcript: ENSMUST00000072993
AA Change: Y102C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072758
Gene: ENSMUSG00000060335
AA Change: Y102C

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-60 PFAM
Pfam:7TM_GPCR_Srsx 35 305 5.6e-9 PFAM
Pfam:7tm_1 41 290 1.4e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214228
AA Change: Y102C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.4347 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 A T 16: 20,186,937 (GRCm39) probably null Het
Acsm2 A G 7: 119,153,732 (GRCm39) H14R unknown Het
Adamtsl4 T C 3: 95,589,069 (GRCm39) probably null Het
Ak5 A G 3: 152,361,517 (GRCm39) I135T probably damaging Het
Alk G T 17: 72,206,236 (GRCm39) S1038* probably null Het
Ank2 A T 3: 126,741,455 (GRCm39) probably benign Het
Ap2m1 A T 16: 20,362,134 (GRCm39) H414L possibly damaging Het
Atp13a5 A T 16: 29,100,842 (GRCm39) M649K probably damaging Het
Atp4a G A 7: 30,419,650 (GRCm39) R671Q probably benign Het
Calhm6 T A 10: 34,003,827 (GRCm39) T27S probably damaging Het
Cdc25b A G 2: 131,033,618 (GRCm39) S186G probably benign Het
Ceacam16 A G 7: 19,587,514 (GRCm39) V418A possibly damaging Het
Cntnap3 A C 13: 64,926,667 (GRCm39) S568A possibly damaging Het
Col24a1 G T 3: 145,020,144 (GRCm39) V172F possibly damaging Het
Dynlt4 C T 4: 116,985,320 (GRCm39) R48C probably damaging Het
Eef2 CCC CCCC 10: 81,014,602 (GRCm39) probably null Het
Esp36 T A 17: 38,729,847 (GRCm39) T15S unknown Het
Fat2 A T 11: 55,200,466 (GRCm39) H869Q possibly damaging Het
Fat3 A G 9: 15,942,448 (GRCm39) V1308A probably damaging Het
Gimap3 T C 6: 48,742,880 (GRCm39) T17A possibly damaging Het
Hnrnpr A G 4: 136,044,459 (GRCm39) K13R probably benign Het
Hycc1 A C 5: 24,184,579 (GRCm39) C218G possibly damaging Het
Kdr A G 5: 76,104,585 (GRCm39) M1133T possibly damaging Het
Mgarp A G 3: 51,303,681 (GRCm39) probably benign Het
Neto2 G A 8: 86,367,712 (GRCm39) T337I probably damaging Het
Nfib C T 4: 82,416,672 (GRCm39) R137Q probably damaging Het
Nherf4 T C 9: 44,159,285 (GRCm39) *499W probably null Het
Nr3c2 A G 8: 77,944,096 (GRCm39) E890G probably damaging Het
Nsun4 A G 4: 115,897,327 (GRCm39) V228A possibly damaging Het
Nt5c1a T A 4: 123,109,689 (GRCm39) S263T probably benign Het
Ntm A T 9: 28,923,516 (GRCm39) Y45* probably null Het
Nts A G 10: 102,320,888 (GRCm39) V67A probably benign Het
Or1e19 A T 11: 73,316,537 (GRCm39) S91T possibly damaging Het
Or4g7 T A 2: 111,309,757 (GRCm39) C209* probably null Het
Or51ag1 T A 7: 103,155,346 (GRCm39) K269M probably benign Het
Ostm1 C A 10: 42,555,119 (GRCm39) A47E probably benign Het
Otol1 G A 3: 69,925,881 (GRCm39) V19M probably benign Het
Pcdhb15 A G 18: 37,608,565 (GRCm39) N599S probably damaging Het
Pcdhgb1 T C 18: 37,814,304 (GRCm39) I265T probably damaging Het
Pex14 T C 4: 149,045,967 (GRCm39) E321G possibly damaging Het
Phactr3 C A 2: 177,924,925 (GRCm39) R251S probably damaging Het
Pkdcc C T 17: 83,528,570 (GRCm39) T313M probably benign Het
Plce1 A T 19: 38,755,745 (GRCm39) E1911V probably damaging Het
Ptprv G T 1: 135,042,308 (GRCm39) noncoding transcript Het
Rab36 G A 10: 74,880,328 (GRCm39) V63I probably damaging Het
Rhob A G 12: 8,549,533 (GRCm39) Y34H possibly damaging Het
Slc27a3 G A 3: 90,294,647 (GRCm39) T408M probably damaging Het
Slc9c1 A T 16: 45,419,829 (GRCm39) I1000F possibly damaging Het
Tcf7 G T 11: 52,152,442 (GRCm39) P36T probably benign Het
Tcf7l1 C G 6: 72,765,752 (GRCm39) E62Q probably damaging Het
Tll2 A G 19: 41,109,787 (GRCm39) S326P probably benign Het
Tubgcp4 A G 2: 121,014,954 (GRCm39) N288S probably benign Het
Zfhx3 G A 8: 109,682,269 (GRCm39) R3236H unknown Het
Zfp764l1 T G 7: 126,992,174 (GRCm39) Q87P possibly damaging Het
Zgrf1 A G 3: 127,355,727 (GRCm39) T318A probably benign Het
Other mutations in Or1e25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01476:Or1e25 APN 11 73,494,056 (GRCm39) missense probably damaging 1.00
IGL01767:Or1e25 APN 11 73,493,858 (GRCm39) missense probably benign
IGL02296:Or1e25 APN 11 73,493,532 (GRCm39) missense probably damaging 1.00
IGL02327:Or1e25 APN 11 73,493,981 (GRCm39) missense probably damaging 1.00
IGL02740:Or1e25 APN 11 73,493,657 (GRCm39) missense probably benign 0.41
H8562:Or1e25 UTSW 11 73,494,273 (GRCm39) missense probably damaging 1.00
R0594:Or1e25 UTSW 11 73,494,218 (GRCm39) missense probably benign 0.03
R2038:Or1e25 UTSW 11 73,494,239 (GRCm39) missense probably damaging 1.00
R2127:Or1e25 UTSW 11 73,493,631 (GRCm39) missense possibly damaging 0.78
R2844:Or1e25 UTSW 11 73,494,209 (GRCm39) missense probably benign 0.12
R2846:Or1e25 UTSW 11 73,494,209 (GRCm39) missense probably benign 0.12
R3877:Or1e25 UTSW 11 73,493,979 (GRCm39) missense probably damaging 1.00
R4193:Or1e25 UTSW 11 73,494,243 (GRCm39) missense probably damaging 1.00
R4824:Or1e25 UTSW 11 73,493,426 (GRCm39) missense possibly damaging 0.61
R4851:Or1e25 UTSW 11 73,493,883 (GRCm39) missense probably damaging 1.00
R5285:Or1e25 UTSW 11 73,493,767 (GRCm39) nonsense probably null
R5326:Or1e25 UTSW 11 73,494,030 (GRCm39) missense possibly damaging 0.94
R5542:Or1e25 UTSW 11 73,494,030 (GRCm39) missense possibly damaging 0.94
R5662:Or1e25 UTSW 11 73,494,005 (GRCm39) missense probably benign 0.03
R6489:Or1e25 UTSW 11 73,494,265 (GRCm39) missense probably damaging 1.00
R6770:Or1e25 UTSW 11 73,493,804 (GRCm39) missense probably benign 0.04
R7131:Or1e25 UTSW 11 73,493,562 (GRCm39) missense possibly damaging 0.78
R7313:Or1e25 UTSW 11 73,493,810 (GRCm39) missense probably damaging 0.99
R7754:Or1e25 UTSW 11 73,494,332 (GRCm39) nonsense probably null
R8393:Or1e25 UTSW 11 73,494,261 (GRCm39) missense probably damaging 1.00
R9190:Or1e25 UTSW 11 73,493,877 (GRCm39) missense probably benign 0.36
R9628:Or1e25 UTSW 11 73,493,864 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATGTACCTCACCACTGTCCTGG -3'
(R):5'- GACAATCTTGCCAAGAGTAGGG -3'

Sequencing Primer
(F):5'- TCACCACTGTCCTGGGGAAC -3'
(R):5'- ATCTTGCCAAGAGTAGGGTGTGTAAC -3'
Posted On 2015-07-21