Incidental Mutation 'R4450:Or8g34'
ID 328932
Institutional Source Beutler Lab
Gene Symbol Or8g34
Ensembl Gene ENSMUSG00000094745
Gene Name olfactory receptor family 8 subfamily G member 34
Synonyms GA_x6K02T2PVTD-33158015-33158950, MOR171-42, Olfr954, MOR171-53
MMRRC Submission 041711-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R4450 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39372729-39373673 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 39373328 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 200 (M200I)
Ref Sequence ENSEMBL: ENSMUSP00000079205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080329] [ENSMUST00000214818]
AlphaFold Q9EQB6
Predicted Effect probably benign
Transcript: ENSMUST00000080329
AA Change: M200I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000079205
Gene: ENSMUSG00000094745
AA Change: M200I

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2.6e-52 PFAM
Pfam:7TM_GPCR_Srsx 38 264 3e-5 PFAM
Pfam:7tm_1 44 293 1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214818
AA Change: M197I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219910
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 98% (43/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3930402G23Rik T A 8: 10,976,129 (GRCm39) noncoding transcript Het
Acsl6 A G 11: 54,219,229 (GRCm39) D278G probably damaging Het
Adamdec1 C T 14: 68,810,568 (GRCm39) R196Q probably benign Het
Akap13 T A 7: 75,392,508 (GRCm39) F2450L probably damaging Het
Alg11 C A 8: 22,558,095 (GRCm39) A469E probably benign Het
Angel1 A T 12: 86,768,698 (GRCm39) Y262N probably damaging Het
Arhgef18 A G 8: 3,487,097 (GRCm39) E272G probably damaging Het
Bpifb6 A G 2: 153,748,688 (GRCm39) E228G possibly damaging Het
Brca2 T G 5: 150,459,518 (GRCm39) D264E probably damaging Het
Cdca4 T C 12: 112,785,278 (GRCm39) N150S probably benign Het
Cep162 T C 9: 87,107,861 (GRCm39) S510G probably damaging Het
Cldn12 T C 5: 5,558,398 (GRCm39) T10A probably damaging Het
Clip2 C T 5: 134,531,807 (GRCm39) G631D possibly damaging Het
Col19a1 T A 1: 24,361,116 (GRCm39) T625S probably damaging Het
Col6a5 C T 9: 105,781,720 (GRCm39) G1635D unknown Het
Dcp1b A G 6: 119,183,437 (GRCm39) T175A probably benign Het
Eln C T 5: 134,754,635 (GRCm39) probably benign Het
Galnt2 A G 8: 125,022,116 (GRCm39) D14G probably benign Het
Gm9894 T A 13: 67,913,199 (GRCm39) noncoding transcript Het
Herc2 T C 7: 55,877,640 (GRCm39) L4569P probably damaging Het
Iqcm T C 8: 76,356,394 (GRCm39) S176P probably damaging Het
Klhl42 G A 6: 146,993,169 (GRCm39) G47D probably benign Het
Lmo2 T C 2: 103,811,407 (GRCm39) Y147H probably damaging Het
Lzts2 A T 19: 45,012,032 (GRCm39) K154* probably null Het
Map4k3 C T 17: 80,911,411 (GRCm39) probably null Het
Mlc1 A G 15: 88,847,693 (GRCm39) F285S probably benign Het
Myo5a T A 9: 75,074,458 (GRCm39) M789K probably benign Het
Nbeal1 T A 1: 60,306,933 (GRCm39) S319T probably damaging Het
Nsun4 A T 4: 115,908,453 (GRCm39) Y702* probably null Het
Or8b52 A T 9: 38,577,050 (GRCm39) V30E probably benign Het
Osbpl5 T A 7: 143,248,643 (GRCm39) T640S probably benign Het
Plaat1 C T 16: 29,046,976 (GRCm39) T165M possibly damaging Het
Rangrf A T 11: 68,866,010 (GRCm39) probably benign Het
Rnpc3 T C 3: 113,404,786 (GRCm39) probably benign Het
Ros1 C T 10: 51,954,038 (GRCm39) G1867D probably damaging Het
Slc11a1 C A 1: 74,424,694 (GRCm39) probably benign Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Speer3 C G 5: 13,846,394 (GRCm39) A238G possibly damaging Het
Syt6 A G 3: 103,492,961 (GRCm39) H156R probably benign Het
Tln2 C T 9: 67,251,347 (GRCm39) probably null Het
Trim58 T C 11: 58,542,191 (GRCm39) W384R probably benign Het
Wwc2 A G 8: 48,321,702 (GRCm39) Y471H unknown Het
Other mutations in Or8g34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02704:Or8g34 APN 9 39,373,579 (GRCm39) missense probably damaging 0.98
IGL02793:Or8g34 APN 9 39,372,802 (GRCm39) missense probably benign 0.09
IGL02964:Or8g34 APN 9 39,373,077 (GRCm39) missense possibly damaging 0.88
IGL02979:Or8g34 APN 9 39,372,819 (GRCm39) missense probably benign 0.02
R0041:Or8g34 UTSW 9 39,372,772 (GRCm39) missense probably benign 0.34
R0153:Or8g34 UTSW 9 39,372,967 (GRCm39) missense probably damaging 0.99
R0269:Or8g34 UTSW 9 39,373,090 (GRCm39) missense probably damaging 1.00
R0426:Or8g34 UTSW 9 39,372,889 (GRCm39) missense probably damaging 1.00
R0731:Or8g34 UTSW 9 39,372,828 (GRCm39) missense probably damaging 1.00
R1800:Or8g34 UTSW 9 39,373,410 (GRCm39) missense probably damaging 1.00
R2340:Or8g34 UTSW 9 39,373,105 (GRCm39) missense probably damaging 1.00
R2901:Or8g34 UTSW 9 39,373,234 (GRCm39) missense probably damaging 0.97
R2912:Or8g34 UTSW 9 39,373,512 (GRCm39) missense probably damaging 1.00
R2939:Or8g34 UTSW 9 39,373,226 (GRCm39) missense probably benign 0.02
R2940:Or8g34 UTSW 9 39,373,226 (GRCm39) missense probably benign 0.02
R3081:Or8g34 UTSW 9 39,373,226 (GRCm39) missense probably benign 0.02
R3765:Or8g34 UTSW 9 39,372,920 (GRCm39) nonsense probably null
R4515:Or8g34 UTSW 9 39,373,527 (GRCm39) nonsense probably null
R4786:Or8g34 UTSW 9 39,373,137 (GRCm39) missense probably benign 0.16
R4961:Or8g34 UTSW 9 39,373,183 (GRCm39) missense probably damaging 1.00
R5219:Or8g34 UTSW 9 39,373,563 (GRCm39) missense probably benign 0.09
R5602:Or8g34 UTSW 9 39,373,326 (GRCm39) missense probably benign 0.00
R5887:Or8g34 UTSW 9 39,372,787 (GRCm39) missense probably damaging 1.00
R5950:Or8g34 UTSW 9 39,373,633 (GRCm39) missense probably benign 0.01
R6943:Or8g34 UTSW 9 39,373,159 (GRCm39) missense probably benign 0.05
R7567:Or8g34 UTSW 9 39,373,173 (GRCm39) missense possibly damaging 0.92
R8817:Or8g34 UTSW 9 39,373,387 (GRCm39) missense probably damaging 1.00
R9251:Or8g34 UTSW 9 39,373,668 (GRCm39) missense probably benign
X0060:Or8g34 UTSW 9 39,373,570 (GRCm39) missense probably damaging 1.00
Z1177:Or8g34 UTSW 9 39,372,997 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TGCCATCTGTAACCCCTTGG -3'
(R):5'- CACAAATGCTGTAGAACCATAGAAG -3'

Sequencing Primer
(F):5'- ACCCCTTGGTTTACAATATAGCCATG -3'
(R):5'- TGCTGTAGAACCATAGAAGACAGC -3'
Posted On 2015-07-21