Incidental Mutation 'R4453:Zfp286'
ID 329056
Institutional Source Beutler Lab
Gene Symbol Zfp286
Ensembl Gene ENSMUSG00000047342
Gene Name zinc finger protein 286
Synonyms
MMRRC Submission 041152-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R4453 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 62643403-62680288 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 62671030 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 348 (G348R)
Ref Sequence ENSEMBL: ENSMUSP00000055517 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054654] [ENSMUST00000108705] [ENSMUST00000207597]
AlphaFold Q8C0E6
Predicted Effect probably damaging
Transcript: ENSMUST00000054654
AA Change: G348R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000055517
Gene: ENSMUSG00000047342
AA Change: G348R

DomainStartEndE-ValueType
KRAB 50 114 1.2e-17 SMART
ZnF_C2H2 241 263 2.75e-3 SMART
ZnF_C2H2 269 291 2.84e-5 SMART
ZnF_C2H2 296 318 1.03e-2 SMART
ZnF_C2H2 324 346 5.14e-3 SMART
ZnF_C2H2 352 374 4.24e-4 SMART
ZnF_C2H2 380 402 4.79e-3 SMART
ZnF_C2H2 408 430 1.06e-4 SMART
ZnF_C2H2 436 458 1.06e-4 SMART
ZnF_C2H2 464 486 3.95e-4 SMART
ZnF_C2H2 492 514 1.15e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082758
Predicted Effect probably benign
Transcript: ENSMUST00000108705
SMART Domains Protein: ENSMUSP00000104345
Gene: ENSMUSG00000047342

DomainStartEndE-ValueType
KRAB 50 114 1.2e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139798
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140072
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145474
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152602
Predicted Effect probably benign
Transcript: ENSMUST00000207597
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149230
Meta Mutation Damage Score 0.5875 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano7 A G 1: 93,322,075 (GRCm39) D361G probably damaging Het
Atp10a TGGCGGCGGC TGGCGGC 7: 58,308,248 (GRCm39) probably benign Het
Ccdc86 G T 19: 10,925,883 (GRCm39) P239T probably damaging Het
Ces2h G A 8: 105,741,288 (GRCm39) probably null Het
Ckap5 T A 2: 91,379,190 (GRCm39) S43R probably damaging Het
Cpne6 G A 14: 55,750,054 (GRCm39) V62M probably damaging Het
Dmbt1 T C 7: 130,642,664 (GRCm39) C161R probably damaging Het
Dnajc10 T C 2: 80,176,967 (GRCm39) S641P probably damaging Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Grm2 G A 9: 106,531,078 (GRCm39) T137I probably damaging Het
Gusb A G 5: 130,027,324 (GRCm39) V327A possibly damaging Het
Helz C T 11: 107,563,455 (GRCm39) Q1631* probably null Het
Hspa1a A G 17: 35,189,269 (GRCm39) Y545H probably benign Het
Hus1 A T 11: 8,956,035 (GRCm39) M166K probably damaging Het
Kcnh1 C A 1: 192,187,825 (GRCm39) T762K probably damaging Het
Limd1 C A 9: 123,309,359 (GRCm39) Q353K possibly damaging Het
Lipe T A 7: 25,097,115 (GRCm39) K276I probably damaging Het
Ntpcr G A 8: 126,462,929 (GRCm39) V49I probably benign Het
Or6c70 T C 10: 129,710,530 (GRCm39) N32S probably null Het
Ppp1r1c A G 2: 79,538,575 (GRCm39) I20V possibly damaging Het
Prdm13 G T 4: 21,679,464 (GRCm39) A342E unknown Het
Prkd3 C A 17: 79,290,975 (GRCm39) R180L probably damaging Het
Prune2 T C 19: 17,099,274 (GRCm39) F1593L probably benign Het
Rims2 T A 15: 39,155,603 (GRCm39) C95S probably damaging Het
Stard9 A G 2: 120,528,272 (GRCm39) M1510V probably benign Het
Taf12 A G 4: 132,010,306 (GRCm39) I92V probably benign Het
Tma16 C T 8: 66,936,823 (GRCm39) probably null Het
Tssk5 G A 15: 76,258,743 (GRCm39) R48C probably benign Het
Wwtr1 T C 3: 57,482,680 (GRCm39) probably null Het
Zfp473 T A 7: 44,382,678 (GRCm39) T552S probably damaging Het
Zzef1 T C 11: 72,763,465 (GRCm39) F1371L probably benign Het
Other mutations in Zfp286
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02659:Zfp286 APN 11 62,674,563 (GRCm39) missense possibly damaging 0.54
IGL02745:Zfp286 APN 11 62,671,700 (GRCm39) missense probably damaging 1.00
IGL02826:Zfp286 APN 11 62,678,786 (GRCm39) missense probably damaging 0.99
R0233:Zfp286 UTSW 11 62,671,219 (GRCm39) missense possibly damaging 0.75
R0233:Zfp286 UTSW 11 62,671,219 (GRCm39) missense possibly damaging 0.75
R0318:Zfp286 UTSW 11 62,675,788 (GRCm39) missense probably damaging 1.00
R1954:Zfp286 UTSW 11 62,674,534 (GRCm39) missense possibly damaging 0.46
R1994:Zfp286 UTSW 11 62,670,646 (GRCm39) missense probably damaging 1.00
R2186:Zfp286 UTSW 11 62,671,287 (GRCm39) missense probably damaging 0.97
R4258:Zfp286 UTSW 11 62,671,896 (GRCm39) missense probably benign 0.07
R4327:Zfp286 UTSW 11 62,670,844 (GRCm39) missense probably damaging 1.00
R4479:Zfp286 UTSW 11 62,671,030 (GRCm39) missense probably damaging 1.00
R4647:Zfp286 UTSW 11 62,674,559 (GRCm39) nonsense probably null
R4667:Zfp286 UTSW 11 62,671,428 (GRCm39) missense probably benign 0.00
R4883:Zfp286 UTSW 11 62,671,455 (GRCm39) missense probably benign 0.01
R4978:Zfp286 UTSW 11 62,679,754 (GRCm39) critical splice donor site probably null
R5120:Zfp286 UTSW 11 62,671,551 (GRCm39) missense probably benign 0.40
R5533:Zfp286 UTSW 11 62,671,796 (GRCm39) intron probably benign
R7236:Zfp286 UTSW 11 62,674,496 (GRCm39) critical splice donor site probably null
R7464:Zfp286 UTSW 11 62,671,627 (GRCm39) missense probably benign 0.00
R8065:Zfp286 UTSW 11 62,644,345 (GRCm39) missense unknown
R8067:Zfp286 UTSW 11 62,644,345 (GRCm39) missense unknown
R8716:Zfp286 UTSW 11 62,671,817 (GRCm39) missense unknown
R9351:Zfp286 UTSW 11 62,670,801 (GRCm39) missense probably damaging 0.97
Z1186:Zfp286 UTSW 11 62,678,795 (GRCm39) missense probably benign
Z1186:Zfp286 UTSW 11 62,675,782 (GRCm39) missense probably damaging 1.00
Z1187:Zfp286 UTSW 11 62,678,795 (GRCm39) missense probably benign
Z1187:Zfp286 UTSW 11 62,675,782 (GRCm39) missense probably damaging 1.00
Z1188:Zfp286 UTSW 11 62,675,782 (GRCm39) missense probably damaging 1.00
Z1188:Zfp286 UTSW 11 62,678,795 (GRCm39) missense probably benign
Z1189:Zfp286 UTSW 11 62,678,795 (GRCm39) missense probably benign
Z1189:Zfp286 UTSW 11 62,675,782 (GRCm39) missense probably damaging 1.00
Z1190:Zfp286 UTSW 11 62,678,795 (GRCm39) missense probably benign
Z1190:Zfp286 UTSW 11 62,675,782 (GRCm39) missense probably damaging 1.00
Z1191:Zfp286 UTSW 11 62,678,795 (GRCm39) missense probably benign
Z1191:Zfp286 UTSW 11 62,675,782 (GRCm39) missense probably damaging 1.00
Z1192:Zfp286 UTSW 11 62,678,795 (GRCm39) missense probably benign
Z1192:Zfp286 UTSW 11 62,675,782 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAGGGGCTGCTCTTGAAG -3'
(R):5'- CGCTTGGGAAAAGACTGAAG -3'

Sequencing Primer
(F):5'- TGCAAAATTTGAGCTCCGGC -3'
(R):5'- GTTCGGTACTTATCCGACACCAGAG -3'
Posted On 2015-07-21