Incidental Mutation 'R4445:Or51t4'
ID |
329837 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Or51t4
|
Ensembl Gene |
ENSMUSG00000045824 |
Gene Name |
olfactory receptor family 51 subfamily T member 4 |
Synonyms |
GA_x6K02T2PBJ9-5659738-5660748, MOR14-9, Olfr574 |
MMRRC Submission |
041151-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.175)
|
Stock # |
R4445 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
102597674-102598714 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 102598005 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Leucine to Proline
at position 101
(L101P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000147694
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000052997]
[ENSMUST00000211329]
[ENSMUST00000213477]
[ENSMUST00000216420]
|
AlphaFold |
F8VQ18 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000052997
AA Change: L111P
PolyPhen 2
Score 0.848 (Sensitivity: 0.83; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000095815 Gene: ENSMUSG00000045824 AA Change: L111P
Domain | Start | End | E-Value | Type |
low complexity region
|
14 |
31 |
N/A |
INTRINSIC |
Pfam:7tm_4
|
44 |
323 |
3.8e-96 |
PFAM |
Pfam:7TM_GPCR_Srsx
|
48 |
195 |
1.2e-8 |
PFAM |
Pfam:7tm_1
|
54 |
305 |
2e-17 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000211329
AA Change: L101P
PolyPhen 2
Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000213477
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000216420
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.5%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 53 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adgrg6 |
A |
G |
10: 14,285,507 (GRCm39) |
S1160P |
probably damaging |
Het |
Adgrl1 |
T |
C |
8: 84,661,489 (GRCm39) |
L962P |
probably damaging |
Het |
Arl6 |
A |
T |
16: 59,444,676 (GRCm39) |
I51K |
probably damaging |
Het |
Calcoco1 |
A |
G |
15: 102,624,175 (GRCm39) |
|
probably null |
Het |
Cd59a |
A |
G |
2: 103,941,163 (GRCm39) |
Q47R |
probably benign |
Het |
Cdkl2 |
G |
A |
5: 92,168,168 (GRCm39) |
T342I |
probably benign |
Het |
Cfap45 |
G |
A |
1: 172,362,794 (GRCm39) |
V262M |
probably benign |
Het |
Chd8 |
A |
T |
14: 52,441,984 (GRCm39) |
|
probably null |
Het |
Cntnap2 |
C |
T |
6: 46,736,785 (GRCm39) |
T737I |
probably benign |
Het |
Cplane1 |
A |
G |
15: 8,281,672 (GRCm39) |
D2837G |
unknown |
Het |
Crot |
T |
C |
5: 9,023,643 (GRCm39) |
H415R |
probably damaging |
Het |
Cyp17a1 |
A |
G |
19: 46,656,462 (GRCm39) |
F411L |
probably damaging |
Het |
Cyp4a12a |
G |
A |
4: 115,183,980 (GRCm39) |
|
probably null |
Het |
Cysltr2 |
G |
A |
14: 73,267,333 (GRCm39) |
H126Y |
possibly damaging |
Het |
Ddx56 |
A |
T |
11: 6,215,770 (GRCm39) |
|
probably null |
Het |
Dync2i1 |
G |
A |
12: 116,171,335 (GRCm39) |
A967V |
probably damaging |
Het |
Elmod1 |
T |
A |
9: 53,841,413 (GRCm39) |
D93V |
probably damaging |
Het |
Epb41l2 |
T |
C |
10: 25,319,701 (GRCm39) |
L178P |
possibly damaging |
Het |
Flacc1 |
A |
T |
1: 58,706,080 (GRCm39) |
I263K |
possibly damaging |
Het |
Galnt10 |
T |
A |
11: 57,674,517 (GRCm39) |
V502D |
probably damaging |
Het |
Gm11735 |
T |
C |
11: 116,629,888 (GRCm39) |
|
noncoding transcript |
Het |
H4c12 |
T |
C |
13: 21,934,513 (GRCm39) |
T55A |
possibly damaging |
Het |
Homer3 |
G |
A |
8: 70,742,793 (GRCm39) |
|
probably null |
Het |
Igsf9b |
A |
G |
9: 27,245,548 (GRCm39) |
T1172A |
probably benign |
Het |
Ip6k3 |
A |
G |
17: 27,364,076 (GRCm39) |
I324T |
probably benign |
Het |
Klkb1 |
C |
T |
8: 45,730,092 (GRCm39) |
S263N |
probably benign |
Het |
Lrit3 |
A |
T |
3: 129,582,180 (GRCm39) |
C602* |
probably null |
Het |
Lyst |
T |
C |
13: 13,884,149 (GRCm39) |
S2986P |
probably benign |
Het |
Mapkapk5 |
T |
C |
5: 121,663,291 (GRCm39) |
T445A |
probably benign |
Het |
Mms19 |
A |
T |
19: 41,952,372 (GRCm39) |
M119K |
possibly damaging |
Het |
Myo7a |
T |
C |
7: 97,715,611 (GRCm39) |
D63G |
probably damaging |
Het |
Nscme3l |
A |
T |
19: 5,553,022 (GRCm39) |
V253D |
probably damaging |
Het |
Nsun2 |
G |
A |
13: 69,777,840 (GRCm39) |
|
probably null |
Het |
Or13a24 |
C |
A |
7: 140,154,302 (GRCm39) |
P79T |
probably damaging |
Het |
Or1ak2 |
T |
G |
2: 36,827,563 (GRCm39) |
L144R |
probably damaging |
Het |
Or2ag1b |
T |
A |
7: 106,288,353 (GRCm39) |
Y195F |
possibly damaging |
Het |
Pabpc2 |
T |
C |
18: 39,907,253 (GRCm39) |
F173L |
probably damaging |
Het |
Rngtt |
A |
G |
4: 33,499,035 (GRCm39) |
I531V |
probably benign |
Het |
Sacs |
A |
G |
14: 61,442,135 (GRCm39) |
M1394V |
probably benign |
Het |
Setd1b |
G |
T |
5: 123,286,167 (GRCm39) |
E404D |
unknown |
Het |
Slc25a54 |
G |
A |
3: 109,005,984 (GRCm39) |
R164H |
probably benign |
Het |
Slc2a13 |
A |
G |
15: 91,234,223 (GRCm39) |
V371A |
possibly damaging |
Het |
Spag9 |
C |
G |
11: 93,988,079 (GRCm39) |
L798V |
possibly damaging |
Het |
Tbce |
A |
T |
13: 14,172,980 (GRCm39) |
S484T |
possibly damaging |
Het |
Tcf12 |
C |
T |
9: 71,776,345 (GRCm39) |
R399Q |
probably damaging |
Het |
Ttn |
A |
G |
2: 76,615,177 (GRCm39) |
V16847A |
probably benign |
Het |
Ttn |
A |
G |
2: 76,687,210 (GRCm39) |
|
probably benign |
Het |
Vmn1r11 |
T |
G |
6: 57,114,515 (GRCm39) |
L23V |
probably benign |
Het |
Vmn2r59 |
C |
T |
7: 41,691,874 (GRCm39) |
C541Y |
probably damaging |
Het |
Vmn2r82 |
A |
C |
10: 79,214,874 (GRCm39) |
T286P |
possibly damaging |
Het |
Vps13c |
T |
G |
9: 67,889,777 (GRCm39) |
|
probably null |
Het |
Ypel1 |
A |
T |
16: 16,921,464 (GRCm39) |
Y73* |
probably null |
Het |
Zdhhc6 |
T |
C |
19: 55,291,169 (GRCm39) |
I349V |
probably benign |
Het |
|
Other mutations in Or51t4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01154:Or51t4
|
APN |
7 |
102,598,046 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01732:Or51t4
|
APN |
7 |
102,598,446 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02185:Or51t4
|
APN |
7 |
102,597,721 (GRCm39) |
missense |
probably damaging |
0.96 |
PIT4382001:Or51t4
|
UTSW |
7 |
102,598,656 (GRCm39) |
missense |
probably benign |
|
PIT4520001:Or51t4
|
UTSW |
7 |
102,597,921 (GRCm39) |
missense |
probably damaging |
1.00 |
R0765:Or51t4
|
UTSW |
7 |
102,597,939 (GRCm39) |
missense |
probably damaging |
1.00 |
R1616:Or51t4
|
UTSW |
7 |
102,597,721 (GRCm39) |
missense |
probably damaging |
0.96 |
R2041:Or51t4
|
UTSW |
7 |
102,598,170 (GRCm39) |
missense |
probably damaging |
0.98 |
R2079:Or51t4
|
UTSW |
7 |
102,598,702 (GRCm39) |
missense |
probably benign |
0.00 |
R2261:Or51t4
|
UTSW |
7 |
102,598,464 (GRCm39) |
missense |
probably damaging |
1.00 |
R2263:Or51t4
|
UTSW |
7 |
102,598,464 (GRCm39) |
missense |
probably damaging |
1.00 |
R2513:Or51t4
|
UTSW |
7 |
102,598,700 (GRCm39) |
missense |
probably benign |
|
R2903:Or51t4
|
UTSW |
7 |
102,598,661 (GRCm39) |
missense |
probably benign |
0.05 |
R4512:Or51t4
|
UTSW |
7 |
102,597,945 (GRCm39) |
missense |
probably damaging |
1.00 |
R4513:Or51t4
|
UTSW |
7 |
102,597,945 (GRCm39) |
missense |
probably damaging |
1.00 |
R4528:Or51t4
|
UTSW |
7 |
102,598,013 (GRCm39) |
missense |
probably damaging |
1.00 |
R4904:Or51t4
|
UTSW |
7 |
102,598,272 (GRCm39) |
missense |
probably damaging |
1.00 |
R5935:Or51t4
|
UTSW |
7 |
102,598,017 (GRCm39) |
missense |
probably benign |
0.01 |
R6784:Or51t4
|
UTSW |
7 |
102,597,722 (GRCm39) |
missense |
possibly damaging |
0.91 |
R6889:Or51t4
|
UTSW |
7 |
102,597,975 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7082:Or51t4
|
UTSW |
7 |
102,598,455 (GRCm39) |
missense |
probably damaging |
1.00 |
R7125:Or51t4
|
UTSW |
7 |
102,598,386 (GRCm39) |
missense |
probably damaging |
0.99 |
R7549:Or51t4
|
UTSW |
7 |
102,597,798 (GRCm39) |
missense |
possibly damaging |
0.92 |
R7564:Or51t4
|
UTSW |
7 |
102,598,473 (GRCm39) |
missense |
probably damaging |
1.00 |
R7947:Or51t4
|
UTSW |
7 |
102,598,278 (GRCm39) |
missense |
probably damaging |
1.00 |
R8460:Or51t4
|
UTSW |
7 |
102,598,531 (GRCm39) |
nonsense |
probably null |
|
R8518:Or51t4
|
UTSW |
7 |
102,597,804 (GRCm39) |
missense |
probably damaging |
1.00 |
R8859:Or51t4
|
UTSW |
7 |
102,598,373 (GRCm39) |
missense |
probably damaging |
1.00 |
R9116:Or51t4
|
UTSW |
7 |
102,598,527 (GRCm39) |
missense |
possibly damaging |
0.87 |
R9327:Or51t4
|
UTSW |
7 |
102,597,687 (GRCm39) |
missense |
probably benign |
0.00 |
R9408:Or51t4
|
UTSW |
7 |
102,598,443 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Or51t4
|
UTSW |
7 |
102,597,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGGTCTCTACACCATTGCAC -3'
(R):5'- TTGGAAGGACACACTCTTCACAG -3'
Sequencing Primer
(F):5'- CCATTGCACTCTTAGGAAACAG -3'
(R):5'- TCTTCACAGCCATAACTGAAGG -3'
|
Posted On |
2015-07-21 |