Incidental Mutation 'R4472:Vmn2r30'
ID 330408
Institutional Source Beutler Lab
Gene Symbol Vmn2r30
Ensembl Gene ENSMUSG00000070847
Gene Name vomeronasal 2, receptor 30
Synonyms V2r15
MMRRC Submission 041729-MU
Accession Numbers
Essential gene? Not available question?
Stock # R4472 (G1)
Quality Score 182
Status Not validated
Chromosome 7
Chromosomal Location 7314722-7340530 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 7320091 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 545 (N545S)
Ref Sequence ENSEMBL: ENSMUSP00000134223 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072475] [ENSMUST00000174368]
AlphaFold K7N5W1
Predicted Effect possibly damaging
Transcript: ENSMUST00000072475
AA Change: N545S

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000072296
Gene: ENSMUSG00000070847
AA Change: N545S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 160 469 2.1e-25 PFAM
Pfam:NCD3G 512 565 8.1e-21 PFAM
Pfam:7tm_3 598 833 2.1e-55 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000174368
AA Change: N545S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000134223
Gene: ENSMUSG00000070847
AA Change: N545S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 155 468 1.5e-27 PFAM
Pfam:NCD3G 512 564 7.2e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209644
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 97% (66/68)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001J11Rik A T 9: 39,961,994 (GRCm39) noncoding transcript Het
Accsl T A 2: 93,694,336 (GRCm39) probably null Het
Accsl G T 2: 93,694,337 (GRCm39) probably null Het
Adcy1 G A 11: 7,080,369 (GRCm39) V371M probably damaging Het
Adgrb2 C T 4: 129,902,146 (GRCm39) A509V probably benign Het
Adgrg6 T A 10: 14,312,525 (GRCm39) Q754L probably damaging Het
Agap2 T C 10: 126,927,082 (GRCm39) I1008T probably damaging Het
Aph1c T G 9: 66,735,051 (GRCm39) H150P probably damaging Het
Atcay T C 10: 81,048,361 (GRCm39) R242G possibly damaging Het
Atg2a G A 19: 6,308,985 (GRCm39) V1724M probably damaging Het
Bbs12 T C 3: 37,373,369 (GRCm39) V54A possibly damaging Het
Card14 A G 11: 119,224,784 (GRCm39) M604V possibly damaging Het
Cd28 A T 1: 60,802,393 (GRCm39) H104L probably benign Het
Cntn5 A T 9: 10,048,776 (GRCm39) D262E probably damaging Het
Col6a3 A G 1: 90,749,736 (GRCm39) V366A probably benign Het
Csnk1d G A 11: 120,855,800 (GRCm39) probably benign Het
Dcaf11 T A 14: 55,803,063 (GRCm39) probably benign Het
Dpy19l4 G A 4: 11,304,053 (GRCm39) T119M possibly damaging Het
Eif3f T C 7: 108,540,153 (GRCm39) V316A possibly damaging Het
Fbrsl1 G A 5: 110,526,932 (GRCm39) probably benign Het
Fbxo10 C T 4: 45,043,693 (GRCm39) R710H probably damaging Het
Fbxw9 G A 8: 85,786,829 (GRCm39) D25N probably damaging Het
Gm14295 C T 2: 176,501,386 (GRCm39) T292I possibly damaging Het
Gm4884 C G 7: 40,692,687 (GRCm39) Q219E probably benign Het
Gpr150 A G 13: 76,204,273 (GRCm39) V224A probably benign Het
Hps1 A T 19: 42,750,935 (GRCm39) I355N probably damaging Het
Lmbr1l A G 15: 98,804,178 (GRCm39) S374P probably benign Het
Macf1 A T 4: 123,289,782 (GRCm39) N5458K probably damaging Het
Man1b1 C G 2: 25,222,867 (GRCm39) probably benign Het
Morc3 A G 16: 93,671,645 (GRCm39) probably null Het
Mrgpra4 T C 7: 47,631,539 (GRCm39) T21A probably benign Het
Myo1a G T 10: 127,546,327 (GRCm39) V277L probably benign Het
Nkain4 C G 2: 180,596,415 (GRCm39) M1I probably null Het
Nktr T C 9: 121,577,962 (GRCm39) probably benign Het
Nrxn3 T C 12: 90,171,515 (GRCm39) S276P probably damaging Het
Oas2 A T 5: 120,879,220 (GRCm39) D373E possibly damaging Het
Or8g37 T A 9: 39,731,870 (GRCm39) *312R probably null Het
Oser1 T A 2: 163,257,500 (GRCm39) E11V probably null Het
Oser1 C T 2: 163,257,501 (GRCm39) E11K probably damaging Het
Pacsin3 A G 2: 91,093,288 (GRCm39) probably null Het
Pcdh20 T C 14: 88,706,434 (GRCm39) S289G probably benign Het
Phlpp1 A G 1: 106,314,176 (GRCm39) D1183G probably damaging Het
Pign T C 1: 105,575,945 (GRCm39) K232E probably benign Het
Polk A G 13: 96,630,413 (GRCm39) S383P probably damaging Het
Prom2 C A 2: 127,382,111 (GRCm39) R101L probably benign Het
Rest T C 5: 77,429,027 (GRCm39) V482A probably benign Het
Rexo1 A T 10: 80,378,492 (GRCm39) S476T probably damaging Het
Rnf31 T A 14: 55,840,777 (GRCm39) Y1015N probably damaging Het
Spata3 T C 1: 85,954,152 (GRCm39) Y305H probably benign Het
Sv2a G A 3: 96,099,810 (GRCm39) V587M probably benign Het
Synj1 A G 16: 90,766,069 (GRCm39) probably null Het
Syt17 A G 7: 118,036,040 (GRCm39) probably null Het
Taf2 T C 15: 54,922,276 (GRCm39) D337G possibly damaging Het
Tcaf1 A C 6: 42,656,248 (GRCm39) S243A probably benign Het
Tmem9 A G 1: 135,955,234 (GRCm39) T123A probably benign Het
Trav4-4-dv10 T C 14: 53,921,187 (GRCm39) probably benign Het
Trbv15 G A 6: 41,118,493 (GRCm39) R83Q probably damaging Het
Trim27 A G 13: 21,374,056 (GRCm39) I268V probably benign Het
Tubgcp6 T A 15: 88,987,857 (GRCm39) S1031C probably damaging Het
Vmn1r89 C A 7: 12,953,799 (GRCm39) H110Q probably benign Het
Wls G A 3: 159,603,020 (GRCm39) M144I probably benign Het
Yme1l1 T C 2: 23,076,344 (GRCm39) probably null Het
Zeb2 A T 2: 44,913,023 (GRCm39) L56Q probably damaging Het
Other mutations in Vmn2r30
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01797:Vmn2r30 APN 7 7,337,195 (GRCm39) missense probably benign
IGL02114:Vmn2r30 APN 7 7,340,408 (GRCm39) missense possibly damaging 0.62
IGL02429:Vmn2r30 APN 7 7,337,243 (GRCm39) missense possibly damaging 0.95
IGL03214:Vmn2r30 APN 7 7,337,259 (GRCm39) missense probably benign 0.00
R1723:Vmn2r30 UTSW 7 7,337,259 (GRCm39) missense probably benign 0.00
R5409:Vmn2r30 UTSW 7 7,315,547 (GRCm39) missense probably damaging 1.00
R5979:Vmn2r30 UTSW 7 7,315,334 (GRCm39) missense probably damaging 0.99
R6035:Vmn2r30 UTSW 7 7,337,350 (GRCm39) missense probably benign 0.34
R6035:Vmn2r30 UTSW 7 7,337,350 (GRCm39) missense probably benign 0.34
R6336:Vmn2r30 UTSW 7 7,337,307 (GRCm39) missense probably benign 0.03
R6904:Vmn2r30 UTSW 7 7,315,547 (GRCm39) missense probably damaging 1.00
R7124:Vmn2r30 UTSW 7 7,337,183 (GRCm39) missense probably benign 0.05
R8415:Vmn2r30 UTSW 7 7,315,359 (GRCm39) missense probably damaging 0.98
R8558:Vmn2r30 UTSW 7 7,315,655 (GRCm39) missense possibly damaging 0.61
R9267:Vmn2r30 UTSW 7 7,340,432 (GRCm39) missense possibly damaging 0.83
R9744:Vmn2r30 UTSW 7 7,315,284 (GRCm39) missense possibly damaging 0.91
V8831:Vmn2r30 UTSW 7 7,337,148 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAGGCTCCAGGCATGTTTG -3'
(R):5'- GCATTTCCAATATTCAGTTCTGGC -3'

Sequencing Primer
(F):5'- CTCCAGGCATGTTTGTTTGC -3'
(R):5'- CCAGACTGGTCTACAAAGTGAGTTC -3'
Posted On 2015-07-21