Incidental Mutation 'R4489:Cnga2'
ID 330657
Institutional Source Beutler Lab
Gene Symbol Cnga2
Ensembl Gene ENSMUSG00000005864
Gene Name cyclic nucleotide gated channel alpha 2
Synonyms Cnca, Cncg4, OCNC1
MMRRC Submission 041745-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4489 (G1)
Quality Score 222
Status Validated
Chromosome X
Chromosomal Location 71035455-71053824 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 71049733 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 133 (F133I)
Ref Sequence ENSEMBL: ENSMUSP00000006020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006020]
AlphaFold Q62398
Predicted Effect possibly damaging
Transcript: ENSMUST00000006020
AA Change: F133I

PolyPhen 2 Score 0.576 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000006020
Gene: ENSMUSG00000005864
AA Change: F133I

DomainStartEndE-ValueType
low complexity region 11 24 N/A INTRINSIC
low complexity region 62 79 N/A INTRINSIC
low complexity region 113 129 N/A INTRINSIC
Pfam:Ion_trans 142 385 2.8e-30 PFAM
cNMP 456 580 4.54e-23 SMART
PDB:3SWY|C 599 642 2e-9 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145642
Meta Mutation Damage Score 0.1095 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 94% (50/53)
MGI Phenotype FUNCTION: This gene encodes a transmembrane protein that is a subunit of the nucleotide-gated olfactory ion channel. Knock out of this gene affects development of the olfactory epithelium and olfactory bulb. [provided by RefSeq, May 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality within 2 days of birth, growth retardation, and abnormal olfactory neuron response to forskolin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 A G 15: 91,062,486 (GRCm39) V484A probably damaging Het
Ank3 C T 10: 69,734,086 (GRCm39) A754V probably damaging Het
Ano1 T C 7: 144,165,479 (GRCm39) N582S probably benign Het
Arnt2 T A 7: 83,924,553 (GRCm39) T425S probably benign Het
Bltp1 A T 3: 37,058,082 (GRCm39) Q3224L probably null Het
Cand2 A G 6: 115,766,427 (GRCm39) D344G probably damaging Het
Clta T G 4: 44,032,417 (GRCm39) F198V probably damaging Het
Csmd2 G A 4: 128,275,738 (GRCm39) V826M possibly damaging Het
Dnah11 C T 12: 117,880,631 (GRCm39) V3830I probably benign Het
Fhl4 T C 10: 84,934,319 (GRCm39) D154G possibly damaging Het
Gbp4 T A 5: 105,269,773 (GRCm39) T352S probably damaging Het
Gigyf2 A G 1: 87,368,548 (GRCm39) D1076G probably damaging Het
Gm21370 T A 13: 120,488,378 (GRCm39) Y57F probably benign Het
Gm6489 A G 1: 31,326,320 (GRCm39) noncoding transcript Het
Grm6 T C 11: 50,750,816 (GRCm39) S660P probably damaging Het
Hectd4 T G 5: 121,424,320 (GRCm39) I660R possibly damaging Het
Homer3 G A 8: 70,742,793 (GRCm39) probably null Het
Htr1b A T 9: 81,513,592 (GRCm39) D338E probably benign Het
Kifbp A G 10: 62,398,806 (GRCm39) probably benign Het
Lrp1b T C 2: 40,551,501 (GRCm39) probably benign Het
Lzts1 T A 8: 69,588,347 (GRCm39) K536N possibly damaging Het
Mrpl22 T A 11: 58,063,928 (GRCm39) N49K probably benign Het
Mzt1 T C 14: 99,273,926 (GRCm39) *42W probably null Het
Nkx3-2 T G 5: 41,919,304 (GRCm39) Q228P probably damaging Het
Nufip2 T G 11: 77,577,055 (GRCm39) M1R probably null Het
Obscn G A 11: 58,922,417 (GRCm39) T5921M possibly damaging Het
Or4c116 T C 2: 88,941,916 (GRCm39) probably null Het
Or52e7 T C 7: 104,684,510 (GRCm39) F35S probably benign Het
Pcdha11 C A 18: 37,139,969 (GRCm39) Q533K possibly damaging Het
Pgm5 T C 19: 24,793,809 (GRCm39) E285G probably benign Het
Plxna2 C T 1: 194,431,625 (GRCm39) S538F probably damaging Het
Potefam1 A G 2: 111,051,047 (GRCm39) Y250H probably benign Het
Rgs21 T C 1: 144,395,613 (GRCm39) T92A possibly damaging Het
Rgsl1 T A 1: 153,703,282 (GRCm39) Y123F probably benign Het
Rnf13 A C 3: 57,728,010 (GRCm39) K230T probably damaging Het
Sgf29 T C 7: 126,263,110 (GRCm39) S29P possibly damaging Het
Smchd1 T C 17: 71,714,230 (GRCm39) T878A probably benign Het
Specc1 T G 11: 62,042,653 (GRCm39) probably null Het
Tg A T 15: 66,579,791 (GRCm39) Q1532L probably damaging Het
Timm44 A C 8: 4,316,654 (GRCm39) S297A possibly damaging Het
Txndc9 G T 1: 38,034,871 (GRCm39) S11* probably null Het
Uggt1 C T 1: 36,185,749 (GRCm39) W1478* probably null Het
Washc3 T C 10: 88,051,893 (GRCm39) V87A probably benign Het
Xlr5b T C X: 72,201,504 (GRCm39) probably null Het
Other mutations in Cnga2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02512:Cnga2 APN X 71,052,531 (GRCm39) missense probably damaging 1.00
IGL02633:Cnga2 APN X 71,048,655 (GRCm39) splice site probably benign
IGL03059:Cnga2 APN X 71,051,878 (GRCm39) missense probably damaging 1.00
IGL03215:Cnga2 APN X 71,052,772 (GRCm39) missense probably damaging 1.00
IGL03332:Cnga2 APN X 71,049,800 (GRCm39) missense probably damaging 1.00
R2128:Cnga2 UTSW X 71,051,394 (GRCm39) missense possibly damaging 0.95
R4486:Cnga2 UTSW X 71,049,733 (GRCm39) missense possibly damaging 0.58
R4487:Cnga2 UTSW X 71,049,733 (GRCm39) missense possibly damaging 0.58
Predicted Primers PCR Primer
(F):5'- TCAGAATGGTTCAGAGGCCTG -3'
(R):5'- TTAGGAAAAGCACTGGGTTATTGC -3'

Sequencing Primer
(F):5'- AGAATGGTTCAGAGGCCTGGTATTTG -3'
(R):5'- CATACTCCCTGTCTAGAGGTGAG -3'
Posted On 2015-07-21