Incidental Mutation 'R4491:Zfp648'
ID 330703
Institutional Source Beutler Lab
Gene Symbol Zfp648
Ensembl Gene ENSMUSG00000066797
Gene Name zinc finger protein 648
Synonyms Gm10178, LOC207678
MMRRC Submission 041747-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R4491 (G1)
Quality Score 144
Status Validated
Chromosome 1
Chromosomal Location 154076933-154081435 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 154080873 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 344 (L344R)
Ref Sequence ENSEMBL: ENSMUSP00000083370 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086195]
AlphaFold D3Z0W3
Predicted Effect probably damaging
Transcript: ENSMUST00000086195
AA Change: L344R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000083370
Gene: ENSMUSG00000066797
AA Change: L344R

DomainStartEndE-ValueType
ZnF_C2H2 236 258 1.82e-3 SMART
ZnF_C2H2 264 286 1.28e-3 SMART
ZnF_C2H2 292 315 1.2e-3 SMART
ZnF_C2H2 321 343 1.95e-3 SMART
ZnF_C2H2 349 371 8.94e-3 SMART
ZnF_C2H2 377 399 8.34e-3 SMART
ZnF_C2H2 405 427 4.54e-4 SMART
ZnF_C2H2 433 455 4.47e-3 SMART
ZnF_C2H2 461 483 5.81e-2 SMART
ZnF_C2H2 489 511 1.2e-3 SMART
Meta Mutation Damage Score 0.1234 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 98% (64/65)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik C A 5: 64,055,812 (GRCm39) P183T probably damaging Het
Bcan G A 3: 87,897,540 (GRCm39) R682* probably null Het
Bzw1 T A 1: 58,443,418 (GRCm39) L410Q probably damaging Het
Cdh5 A T 8: 104,839,672 (GRCm39) I48F probably damaging Het
Cdhr5 T C 7: 140,853,970 (GRCm39) N173D possibly damaging Het
Cfap74 T C 4: 155,513,628 (GRCm39) M480T probably benign Het
Col6a5 C T 9: 105,817,211 (GRCm39) A367T unknown Het
Cpsf1 A C 15: 76,481,922 (GRCm39) Y1064D possibly damaging Het
Defb6 A T 8: 19,278,090 (GRCm39) H54L probably benign Het
Dmtf1 A G 5: 9,190,379 (GRCm39) probably benign Het
Dnah12 T C 14: 26,455,758 (GRCm39) L827S possibly damaging Het
Dnai4 T C 4: 102,923,596 (GRCm39) E411G probably benign Het
Dsc3 T C 18: 20,134,922 (GRCm39) T21A probably benign Het
Epb41l1 G T 2: 156,364,088 (GRCm39) D866Y probably benign Het
Epha1 T C 6: 42,337,600 (GRCm39) M860V probably damaging Het
Far2 T C 6: 148,074,907 (GRCm39) L380P possibly damaging Het
Fgd5 A G 6: 91,966,280 (GRCm39) I680V possibly damaging Het
Fnbp4 T C 2: 90,583,312 (GRCm39) probably null Het
Focad G A 4: 88,278,142 (GRCm39) probably null Het
Gm14180 T A 11: 99,621,139 (GRCm39) probably benign Het
Hbb-bh2 T C 7: 103,489,622 (GRCm39) T5A probably benign Het
Ighv7-2 A G 12: 113,876,100 (GRCm39) F2L probably benign Het
Igsf5 A G 16: 96,165,281 (GRCm39) T19A probably benign Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Klb A G 5: 65,533,137 (GRCm39) N482S probably benign Het
Lipo2 A C 19: 33,699,100 (GRCm39) L310R probably damaging Het
Mc3r A G 2: 172,091,123 (GRCm39) H115R possibly damaging Het
Meioc A G 11: 102,565,746 (GRCm39) D398G possibly damaging Het
Or10ag60 G A 2: 87,437,736 (GRCm39) M1I probably null Het
Or56a5 A T 7: 104,792,983 (GRCm39) C172* probably null Het
Or7a37 T C 10: 78,806,151 (GRCm39) S223P probably damaging Het
Pds5a T C 5: 65,792,780 (GRCm39) T718A probably benign Het
Pdzd2 C T 15: 12,385,723 (GRCm39) D1016N possibly damaging Het
Pla2g2c T C 4: 138,461,719 (GRCm39) probably null Het
Plch1 T C 3: 63,648,160 (GRCm39) I404V probably damaging Het
Pou2af3 A G 9: 51,181,955 (GRCm39) F206L probably benign Het
Ppp2r5c A T 12: 110,546,956 (GRCm39) D522V possibly damaging Het
Prex2 T A 1: 11,232,487 (GRCm39) S851R probably benign Het
Rapgef1 C T 2: 29,609,668 (GRCm39) P702S possibly damaging Het
Rasal3 T A 17: 32,610,359 (GRCm39) D976V probably damaging Het
Rasef A C 4: 73,652,740 (GRCm39) L587R probably damaging Het
Rptn A T 3: 93,303,818 (GRCm39) R384* probably null Het
Sema6a G A 18: 47,439,524 (GRCm39) probably benign Het
Sycp2 G T 2: 178,016,778 (GRCm39) T608K probably damaging Het
Syde1 C T 10: 78,426,062 (GRCm39) R35H probably benign Het
Taf1 G T X: 100,586,665 (GRCm39) M313I possibly damaging Het
Taf15 A T 11: 83,375,520 (GRCm39) T31S probably benign Het
Tktl2 T C 8: 66,964,664 (GRCm39) V74A probably damaging Het
Tle4 A G 19: 14,432,229 (GRCm39) V489A probably damaging Het
Tmem30a T C 9: 79,684,567 (GRCm39) H95R probably damaging Het
Trmt9b G A 8: 36,972,760 (GRCm39) C70Y probably damaging Het
Vmn1r75 C A 7: 11,614,909 (GRCm39) Q214K probably damaging Het
Vps13c C T 9: 67,817,475 (GRCm39) T1049M probably benign Het
Zfp37 T C 4: 62,110,365 (GRCm39) Q274R probably benign Het
Other mutations in Zfp648
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Zfp648 APN 1 154,079,935 (GRCm39) missense possibly damaging 0.88
IGL01150:Zfp648 APN 1 154,081,110 (GRCm39) missense probably damaging 1.00
IGL01557:Zfp648 APN 1 154,080,426 (GRCm39) missense probably benign
IGL01757:Zfp648 APN 1 154,080,671 (GRCm39) missense probably damaging 0.98
IGL02247:Zfp648 APN 1 154,079,923 (GRCm39) missense probably benign 0.01
PIT4519001:Zfp648 UTSW 1 154,080,687 (GRCm39) missense probably damaging 0.98
R0001:Zfp648 UTSW 1 154,081,032 (GRCm39) missense probably damaging 1.00
R0256:Zfp648 UTSW 1 154,081,414 (GRCm39) missense probably benign 0.08
R0266:Zfp648 UTSW 1 154,080,632 (GRCm39) missense probably damaging 1.00
R0371:Zfp648 UTSW 1 154,080,413 (GRCm39) missense possibly damaging 0.66
R1498:Zfp648 UTSW 1 154,081,119 (GRCm39) missense probably damaging 1.00
R1562:Zfp648 UTSW 1 154,080,138 (GRCm39) missense probably benign
R1687:Zfp648 UTSW 1 154,079,988 (GRCm39) missense probably benign 0.15
R2128:Zfp648 UTSW 1 154,080,353 (GRCm39) missense probably benign
R2427:Zfp648 UTSW 1 154,080,819 (GRCm39) missense probably damaging 1.00
R2567:Zfp648 UTSW 1 154,080,695 (GRCm39) missense probably damaging 0.98
R2844:Zfp648 UTSW 1 154,080,881 (GRCm39) nonsense probably null
R3711:Zfp648 UTSW 1 154,080,304 (GRCm39) missense probably benign 0.30
R4693:Zfp648 UTSW 1 154,080,152 (GRCm39) missense probably benign 0.01
R5666:Zfp648 UTSW 1 154,079,963 (GRCm39) missense probably benign 0.00
R5670:Zfp648 UTSW 1 154,079,963 (GRCm39) missense probably benign 0.00
R7432:Zfp648 UTSW 1 154,080,783 (GRCm39) missense possibly damaging 0.84
R8069:Zfp648 UTSW 1 154,079,862 (GRCm39) missense probably benign 0.34
R8137:Zfp648 UTSW 1 154,081,110 (GRCm39) missense probably damaging 1.00
R8282:Zfp648 UTSW 1 154,080,535 (GRCm39) missense probably benign 0.25
R9023:Zfp648 UTSW 1 154,080,914 (GRCm39) missense probably damaging 0.98
R9489:Zfp648 UTSW 1 154,080,110 (GRCm39) missense probably benign 0.17
R9520:Zfp648 UTSW 1 154,081,221 (GRCm39) missense probably benign
R9605:Zfp648 UTSW 1 154,080,110 (GRCm39) missense probably benign 0.17
Z1088:Zfp648 UTSW 1 154,080,266 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GATCACCGCAAGCATATCCG -3'
(R):5'- AGCACAAGGAAATGGCCTC -3'

Sequencing Primer
(F):5'- CGCAAGCATATCCGCACTC -3'
(R):5'- AAGGTTACACCGCAGTCG -3'
Posted On 2015-07-21