Incidental Mutation 'R4492:Or13c3'
ID 330770
Institutional Source Beutler Lab
Gene Symbol Or13c3
Ensembl Gene ENSMUSG00000049648
Gene Name olfactory receptor family 13 subfamily C member 3
Synonyms Olfr273, GA_x6K02T2N78B-7137430-7138383, MOR262-8
MMRRC Submission 041581-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R4492 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 52855558-52856511 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 52855764 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 250 (I250V)
Ref Sequence ENSEMBL: ENSMUSP00000149869 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051520] [ENSMUST00000107670] [ENSMUST00000215274]
AlphaFold Q8VG87
Predicted Effect probably benign
Transcript: ENSMUST00000051520
AA Change: I250V

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000052080
Gene: ENSMUSG00000049648
AA Change: I250V

DomainStartEndE-ValueType
Pfam:7tm_4 31 314 1.3e-55 PFAM
Pfam:7tm_1 41 296 1.4e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107670
AA Change: I250V

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000103297
Gene: ENSMUSG00000049648
AA Change: I250V

DomainStartEndE-ValueType
Pfam:7tm_1 41 296 3.2e-37 PFAM
Pfam:7tm_4 139 289 4e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215274
AA Change: I250V

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr6 T G 10: 89,561,676 (GRCm39) I157L probably benign Het
Amph T C 13: 19,333,928 (GRCm39) V663A possibly damaging Het
Anapc16 A G 10: 59,826,724 (GRCm39) S50P possibly damaging Het
Ank3 T A 10: 69,644,755 (GRCm39) V60D probably damaging Het
Btbd9 A G 17: 30,746,545 (GRCm39) Y94H probably damaging Het
Chil3 A G 3: 106,063,017 (GRCm39) I191T probably damaging Het
Clpb T C 7: 101,436,929 (GRCm39) L668P probably damaging Het
Cyp2d22 G A 15: 82,258,571 (GRCm39) H97Y probably benign Het
Dhrs7 A T 12: 72,699,899 (GRCm39) N244K probably damaging Het
Dusp4 C T 8: 35,274,890 (GRCm39) T3M possibly damaging Het
Edc4 GGATTTTAGCCA G 8: 106,611,700 (GRCm39) probably null Het
Etl4 G A 2: 20,811,676 (GRCm39) S1621N possibly damaging Het
Fam174a T C 1: 95,241,701 (GRCm39) S54P probably benign Het
Fdxacb1 T C 9: 50,681,547 (GRCm39) F7S probably damaging Het
Focad G A 4: 88,278,142 (GRCm39) probably null Het
Gpr156 T A 16: 37,812,468 (GRCm39) L268H probably damaging Het
Gpr17 A T 18: 32,080,304 (GRCm39) I253N possibly damaging Het
H2-T23 A T 17: 36,343,058 (GRCm39) N106K probably damaging Het
Hspa4 T C 11: 53,171,296 (GRCm39) R303G probably damaging Het
Irgm1 G A 11: 48,756,955 (GRCm39) silent Het
Jph1 A C 1: 17,067,770 (GRCm39) I114S probably damaging Het
Kcna1 C T 6: 126,619,238 (GRCm39) D361N possibly damaging Het
Kcna4 G A 2: 107,126,436 (GRCm39) R390Q probably damaging Het
Lum C A 10: 97,404,300 (GRCm39) P65H probably damaging Het
Mc4r A G 18: 66,992,711 (GRCm39) L134P probably benign Het
Mroh8 A T 2: 157,099,960 (GRCm39) I248N probably damaging Het
Nos2 A G 11: 78,840,921 (GRCm39) T677A probably benign Het
Nup37 T A 10: 88,010,791 (GRCm39) F257I possibly damaging Het
Or6k6 C T 1: 173,944,770 (GRCm39) V271I probably benign Het
Pdzd2 C T 15: 12,385,723 (GRCm39) D1016N possibly damaging Het
Pdzd2 A C 15: 12,419,567 (GRCm39) M501R possibly damaging Het
Pitx1 T C 13: 55,976,465 (GRCm39) K65E probably benign Het
Pla1a C T 16: 38,229,972 (GRCm39) A247T probably benign Het
Prex2 T A 1: 11,232,487 (GRCm39) S851R probably benign Het
Prss8 A G 7: 127,528,979 (GRCm39) S26P probably damaging Het
Rasef A C 4: 73,652,740 (GRCm39) L587R probably damaging Het
Rock2 T A 12: 17,027,684 (GRCm39) C1334S probably damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,130 (GRCm39) probably benign Het
Serpina6 A G 12: 103,613,146 (GRCm39) W385R probably damaging Het
Slc12a5 T C 2: 164,821,263 (GRCm39) M249T probably benign Het
Srsf9 T A 5: 115,470,651 (GRCm39) I117N probably damaging Het
Taf1 G T X: 100,586,665 (GRCm39) M313I possibly damaging Het
Tmem30a T C 9: 79,684,567 (GRCm39) H95R probably damaging Het
Top2b T G 14: 16,409,189 (GRCm38) I777M probably damaging Het
Ttc21a T C 9: 119,770,346 (GRCm39) V139A probably benign Het
Zfp236 A T 18: 82,648,125 (GRCm39) V1012D probably damaging Het
Zfp612 C A 8: 110,815,929 (GRCm39) Q379K probably damaging Het
Zfp930 C T 8: 69,680,898 (GRCm39) Q198* probably null Het
Other mutations in Or13c3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02114:Or13c3 APN 4 52,856,144 (GRCm39) missense probably damaging 1.00
R0048:Or13c3 UTSW 4 52,856,196 (GRCm39) missense probably damaging 1.00
R0048:Or13c3 UTSW 4 52,856,196 (GRCm39) missense probably damaging 1.00
R0826:Or13c3 UTSW 4 52,855,566 (GRCm39) missense probably benign
R0831:Or13c3 UTSW 4 52,855,764 (GRCm39) missense possibly damaging 0.46
R1772:Or13c3 UTSW 4 52,855,730 (GRCm39) missense probably benign 0.30
R1774:Or13c3 UTSW 4 52,855,674 (GRCm39) missense probably benign 0.01
R1861:Or13c3 UTSW 4 52,856,373 (GRCm39) missense probably benign 0.00
R2080:Or13c3 UTSW 4 52,855,568 (GRCm39) missense probably benign 0.20
R2242:Or13c3 UTSW 4 52,855,769 (GRCm39) missense probably damaging 1.00
R3777:Or13c3 UTSW 4 52,855,636 (GRCm39) missense probably damaging 1.00
R4748:Or13c3 UTSW 4 52,856,076 (GRCm39) missense possibly damaging 0.95
R4880:Or13c3 UTSW 4 52,856,411 (GRCm39) missense probably damaging 1.00
R4905:Or13c3 UTSW 4 52,855,613 (GRCm39) missense probably damaging 0.99
R5856:Or13c3 UTSW 4 52,856,516 (GRCm39) start gained probably benign
R6585:Or13c3 UTSW 4 52,856,192 (GRCm39) missense possibly damaging 0.84
R6862:Or13c3 UTSW 4 52,855,695 (GRCm39) missense probably benign
R7378:Or13c3 UTSW 4 52,856,421 (GRCm39) missense probably benign
R7649:Or13c3 UTSW 4 52,855,692 (GRCm39) nonsense probably null
R8793:Or13c3 UTSW 4 52,856,490 (GRCm39) missense probably benign
R9169:Or13c3 UTSW 4 52,856,052 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TGCTGATGTCTCTAAGGAACGTAC -3'
(R):5'- TGTCCTCAAGCTAGCATGTG -3'

Sequencing Primer
(F):5'- GATGTCTCTAAGGAACGTACTTTTG -3'
(R):5'- CAAATATGGCCTTCCTGG -3'
Posted On 2015-07-21