Incidental Mutation 'R4492:Cyp2d22'
ID 330804
Institutional Source Beutler Lab
Gene Symbol Cyp2d22
Ensembl Gene ENSMUSG00000061740
Gene Name cytochrome P450, family 2, subfamily d, polypeptide 22
Synonyms 2D22
MMRRC Submission 041581-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R4492 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 82254728-82264461 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 82258571 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 97 (H97Y)
Ref Sequence ENSEMBL: ENSMUSP00000023083 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023083] [ENSMUST00000228986]
AlphaFold Q9JKY7
Predicted Effect probably benign
Transcript: ENSMUST00000023083
AA Change: H97Y

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000023083
Gene: ENSMUSG00000061740
AA Change: H97Y

DomainStartEndE-ValueType
transmembrane domain 9 28 N/A INTRINSIC
Pfam:p450 37 497 8.1e-139 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000228986
AA Change: H70Y
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229438
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229599
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230370
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230663
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr6 T G 10: 89,561,676 (GRCm39) I157L probably benign Het
Amph T C 13: 19,333,928 (GRCm39) V663A possibly damaging Het
Anapc16 A G 10: 59,826,724 (GRCm39) S50P possibly damaging Het
Ank3 T A 10: 69,644,755 (GRCm39) V60D probably damaging Het
Btbd9 A G 17: 30,746,545 (GRCm39) Y94H probably damaging Het
Chil3 A G 3: 106,063,017 (GRCm39) I191T probably damaging Het
Clpb T C 7: 101,436,929 (GRCm39) L668P probably damaging Het
Dhrs7 A T 12: 72,699,899 (GRCm39) N244K probably damaging Het
Dusp4 C T 8: 35,274,890 (GRCm39) T3M possibly damaging Het
Edc4 GGATTTTAGCCA G 8: 106,611,700 (GRCm39) probably null Het
Etl4 G A 2: 20,811,676 (GRCm39) S1621N possibly damaging Het
Fam174a T C 1: 95,241,701 (GRCm39) S54P probably benign Het
Fdxacb1 T C 9: 50,681,547 (GRCm39) F7S probably damaging Het
Focad G A 4: 88,278,142 (GRCm39) probably null Het
Gpr156 T A 16: 37,812,468 (GRCm39) L268H probably damaging Het
Gpr17 A T 18: 32,080,304 (GRCm39) I253N possibly damaging Het
H2-T23 A T 17: 36,343,058 (GRCm39) N106K probably damaging Het
Hspa4 T C 11: 53,171,296 (GRCm39) R303G probably damaging Het
Irgm1 G A 11: 48,756,955 (GRCm39) silent Het
Jph1 A C 1: 17,067,770 (GRCm39) I114S probably damaging Het
Kcna1 C T 6: 126,619,238 (GRCm39) D361N possibly damaging Het
Kcna4 G A 2: 107,126,436 (GRCm39) R390Q probably damaging Het
Lum C A 10: 97,404,300 (GRCm39) P65H probably damaging Het
Mc4r A G 18: 66,992,711 (GRCm39) L134P probably benign Het
Mroh8 A T 2: 157,099,960 (GRCm39) I248N probably damaging Het
Nos2 A G 11: 78,840,921 (GRCm39) T677A probably benign Het
Nup37 T A 10: 88,010,791 (GRCm39) F257I possibly damaging Het
Or13c3 T C 4: 52,855,764 (GRCm39) I250V probably benign Het
Or6k6 C T 1: 173,944,770 (GRCm39) V271I probably benign Het
Pdzd2 C T 15: 12,385,723 (GRCm39) D1016N possibly damaging Het
Pdzd2 A C 15: 12,419,567 (GRCm39) M501R possibly damaging Het
Pitx1 T C 13: 55,976,465 (GRCm39) K65E probably benign Het
Pla1a C T 16: 38,229,972 (GRCm39) A247T probably benign Het
Prex2 T A 1: 11,232,487 (GRCm39) S851R probably benign Het
Prss8 A G 7: 127,528,979 (GRCm39) S26P probably damaging Het
Rasef A C 4: 73,652,740 (GRCm39) L587R probably damaging Het
Rock2 T A 12: 17,027,684 (GRCm39) C1334S probably damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,130 (GRCm39) probably benign Het
Serpina6 A G 12: 103,613,146 (GRCm39) W385R probably damaging Het
Slc12a5 T C 2: 164,821,263 (GRCm39) M249T probably benign Het
Srsf9 T A 5: 115,470,651 (GRCm39) I117N probably damaging Het
Taf1 G T X: 100,586,665 (GRCm39) M313I possibly damaging Het
Tmem30a T C 9: 79,684,567 (GRCm39) H95R probably damaging Het
Top2b T G 14: 16,409,189 (GRCm38) I777M probably damaging Het
Ttc21a T C 9: 119,770,346 (GRCm39) V139A probably benign Het
Zfp236 A T 18: 82,648,125 (GRCm39) V1012D probably damaging Het
Zfp612 C A 8: 110,815,929 (GRCm39) Q379K probably damaging Het
Zfp930 C T 8: 69,680,898 (GRCm39) Q198* probably null Het
Other mutations in Cyp2d22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01305:Cyp2d22 APN 15 82,255,869 (GRCm39) missense probably damaging 1.00
IGL01750:Cyp2d22 APN 15 82,258,570 (GRCm39) missense probably benign 0.12
IGL01801:Cyp2d22 APN 15 82,257,046 (GRCm39) missense probably benign 0.41
IGL02449:Cyp2d22 APN 15 82,257,442 (GRCm39) missense probably benign 0.00
ANU22:Cyp2d22 UTSW 15 82,255,869 (GRCm39) missense probably damaging 1.00
R0165:Cyp2d22 UTSW 15 82,257,481 (GRCm39) missense probably benign 0.06
R0294:Cyp2d22 UTSW 15 82,258,646 (GRCm39) missense possibly damaging 0.86
R1381:Cyp2d22 UTSW 15 82,256,709 (GRCm39) missense probably benign 0.00
R1479:Cyp2d22 UTSW 15 82,256,137 (GRCm39) missense probably damaging 0.97
R1562:Cyp2d22 UTSW 15 82,258,179 (GRCm39) missense probably damaging 0.99
R1968:Cyp2d22 UTSW 15 82,257,373 (GRCm39) missense probably benign 0.04
R1972:Cyp2d22 UTSW 15 82,260,028 (GRCm39) missense probably benign 0.11
R4575:Cyp2d22 UTSW 15 82,256,133 (GRCm39) missense possibly damaging 0.94
R4702:Cyp2d22 UTSW 15 82,260,118 (GRCm39) missense probably damaging 1.00
R4703:Cyp2d22 UTSW 15 82,260,118 (GRCm39) missense probably damaging 1.00
R5344:Cyp2d22 UTSW 15 82,255,839 (GRCm39) missense possibly damaging 0.95
R5523:Cyp2d22 UTSW 15 82,256,772 (GRCm39) missense probably damaging 1.00
R5888:Cyp2d22 UTSW 15 82,258,014 (GRCm39) missense probably benign
R6060:Cyp2d22 UTSW 15 82,260,086 (GRCm39) missense probably benign 0.00
R6108:Cyp2d22 UTSW 15 82,256,106 (GRCm39) missense possibly damaging 0.59
R6146:Cyp2d22 UTSW 15 82,258,036 (GRCm39) critical splice acceptor site probably null
R6279:Cyp2d22 UTSW 15 82,258,169 (GRCm39) missense probably damaging 1.00
R6563:Cyp2d22 UTSW 15 82,256,113 (GRCm39) missense probably damaging 1.00
R7597:Cyp2d22 UTSW 15 82,260,053 (GRCm39) missense probably damaging 1.00
R7709:Cyp2d22 UTSW 15 82,258,612 (GRCm39) missense possibly damaging 0.88
R7839:Cyp2d22 UTSW 15 82,256,772 (GRCm39) missense probably damaging 1.00
R8094:Cyp2d22 UTSW 15 82,258,556 (GRCm39) missense probably benign 0.19
R8302:Cyp2d22 UTSW 15 82,256,021 (GRCm39) critical splice donor site probably null
R8515:Cyp2d22 UTSW 15 82,258,113 (GRCm39) missense probably benign 0.27
R9245:Cyp2d22 UTSW 15 82,256,748 (GRCm39) missense probably damaging 0.97
R9323:Cyp2d22 UTSW 15 82,258,207 (GRCm39) missense probably damaging 1.00
R9521:Cyp2d22 UTSW 15 82,256,688 (GRCm39) missense probably damaging 1.00
Z1186:Cyp2d22 UTSW 15 82,260,086 (GRCm39) missense probably benign 0.00
Z1190:Cyp2d22 UTSW 15 82,260,086 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCCCATCACTACTGTAAGATCC -3'
(R):5'- TGCCAAGTCCTATCCGGTAC -3'

Sequencing Primer
(F):5'- ATCACTACTGTAAGATCCTCTGTC -3'
(R):5'- AGTCCTATCCGGTACAGCTAAGTG -3'
Posted On 2015-07-21