Incidental Mutation 'R4496:Gpr158'
ID 330963
Institutional Source Beutler Lab
Gene Symbol Gpr158
Ensembl Gene ENSMUSG00000045967
Gene Name G protein-coupled receptor 158
Synonyms 5330427M13Rik
MMRRC Submission 041749-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4496 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 21372378-21835355 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 21831810 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 970 (M970K)
Ref Sequence ENSEMBL: ENSMUSP00000049708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055946]
AlphaFold Q8C419
Predicted Effect probably damaging
Transcript: ENSMUST00000055946
AA Change: M970K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000049708
Gene: ENSMUSG00000045967
AA Change: M970K

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 110 125 N/A INTRINSIC
SCOP:d1edmb_ 313 359 5e-4 SMART
Blast:EGF 318 365 2e-27 BLAST
Pfam:7tm_3 426 669 1.2e-35 PFAM
low complexity region 840 863 N/A INTRINSIC
Meta Mutation Damage Score 0.1418 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 100% (50/50)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T A 17: 24,602,947 (GRCm39) L514H possibly damaging Het
Abca7 T C 10: 79,838,768 (GRCm39) F647S probably damaging Het
Ahi1 A G 10: 20,841,444 (GRCm39) K244E probably benign Het
Ankhd1 G A 18: 36,693,839 (GRCm39) D17N probably damaging Het
Arvcf G T 16: 18,223,932 (GRCm39) K890N probably damaging Het
Atosa T A 9: 74,938,813 (GRCm39) S1038T probably damaging Het
Atp11c T C X: 59,326,104 (GRCm39) D478G probably damaging Het
Clasrp C A 7: 19,319,165 (GRCm39) probably benign Het
Clca3a2 C T 3: 144,797,926 (GRCm39) D180N possibly damaging Het
Comt T C 16: 18,230,437 (GRCm39) probably null Het
Cylc2 C G 4: 51,229,651 (GRCm39) T331R unknown Het
Cyp2d11 C T 15: 82,276,149 (GRCm39) probably benign Het
Fam169b G T 7: 68,007,954 (GRCm39) C289F possibly damaging Het
Fastkd5 T C 2: 130,458,501 (GRCm39) T30A probably benign Het
Fchsd2 A C 7: 100,931,702 (GRCm39) T753P probably benign Het
Gatd3a T C 10: 77,999,377 (GRCm39) I145V probably damaging Het
Glis3 G A 19: 28,643,527 (GRCm39) S5L possibly damaging Het
Gpt A T 15: 76,582,663 (GRCm39) Q276L probably damaging Het
Gtf3c3 G T 1: 54,463,291 (GRCm39) S302R probably benign Het
Hnrnpc A G 14: 52,312,888 (GRCm39) S229P probably benign Het
Ikzf5 T C 7: 130,998,393 (GRCm39) probably null Het
Mal2 T C 15: 54,461,835 (GRCm39) V110A probably damaging Het
Mideas C T 12: 84,203,245 (GRCm39) G886S probably benign Het
Myo3b A G 2: 70,084,748 (GRCm39) D702G probably benign Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Nat10 T A 2: 103,588,084 (GRCm39) I14F probably damaging Het
Nat14 C T 7: 4,926,918 (GRCm39) T30M probably damaging Het
Ndst4 C A 3: 125,476,922 (GRCm39) A49D probably damaging Het
Nnt A T 13: 119,518,301 (GRCm39) M292K probably damaging Het
Obox7 C T 7: 14,399,299 (GRCm39) T175I probably benign Het
Or2t26 T A 11: 49,039,214 (GRCm39) N43K possibly damaging Het
Or6c5c T G 10: 129,299,430 (GRCm39) V295G possibly damaging Het
Plekhm3 T C 1: 64,900,395 (GRCm39) E634G probably damaging Het
Plxdc2 T A 2: 16,517,040 (GRCm39) I107K probably damaging Het
Psmb10 T A 8: 106,662,660 (GRCm39) R226S probably damaging Het
Ptprr T A 10: 116,065,407 (GRCm39) V160E possibly damaging Het
Sema5a T A 15: 32,641,133 (GRCm39) L649H probably damaging Het
Sephs1 T A 2: 4,911,494 (GRCm39) I356K probably benign Het
Serpinb3d C T 1: 107,007,022 (GRCm39) V229M probably damaging Het
Slc7a4 T C 16: 17,393,676 (GRCm39) D41G probably damaging Het
Sort1 T C 3: 108,217,461 (GRCm39) V121A probably benign Het
Tcf20 C A 15: 82,739,185 (GRCm39) Q755H probably damaging Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Ttll13 A T 7: 79,906,667 (GRCm39) Y445F probably benign Het
Usp40 T C 1: 87,923,459 (GRCm39) I271V possibly damaging Het
Vmn1r72 A G 7: 11,403,791 (GRCm39) I219T probably damaging Het
Other mutations in Gpr158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Gpr158 APN 2 21,373,494 (GRCm39) missense probably damaging 1.00
IGL00469:Gpr158 APN 2 21,751,606 (GRCm39) splice site probably benign
IGL00706:Gpr158 APN 2 21,751,584 (GRCm39) missense probably damaging 1.00
IGL00780:Gpr158 APN 2 21,831,629 (GRCm39) nonsense probably null
IGL00885:Gpr158 APN 2 21,653,832 (GRCm39) missense probably damaging 1.00
IGL01339:Gpr158 APN 2 21,373,842 (GRCm39) missense possibly damaging 0.73
IGL01368:Gpr158 APN 2 21,831,909 (GRCm39) missense probably damaging 1.00
IGL02141:Gpr158 APN 2 21,788,101 (GRCm39) missense probably damaging 0.99
IGL02455:Gpr158 APN 2 21,373,511 (GRCm39) missense probably benign 0.00
IGL02554:Gpr158 APN 2 21,831,407 (GRCm39) missense probably benign
IGL02681:Gpr158 APN 2 21,820,441 (GRCm39) missense probably damaging 1.00
IGL02752:Gpr158 APN 2 21,831,638 (GRCm39) missense possibly damaging 0.95
IGL02756:Gpr158 APN 2 21,831,890 (GRCm39) missense possibly damaging 0.47
IGL03181:Gpr158 APN 2 21,787,972 (GRCm39) missense probably benign 0.02
IGL03258:Gpr158 APN 2 21,830,085 (GRCm39) missense probably damaging 1.00
IGL03386:Gpr158 APN 2 21,831,057 (GRCm39) missense probably damaging 1.00
PIT4810001:Gpr158 UTSW 2 21,831,682 (GRCm39) missense probably benign 0.01
R0071:Gpr158 UTSW 2 21,815,479 (GRCm39) missense probably benign 0.08
R0081:Gpr158 UTSW 2 21,831,528 (GRCm39) missense probably damaging 1.00
R0528:Gpr158 UTSW 2 21,830,019 (GRCm39) missense probably damaging 1.00
R0560:Gpr158 UTSW 2 21,830,085 (GRCm39) missense probably damaging 1.00
R0603:Gpr158 UTSW 2 21,820,480 (GRCm39) missense possibly damaging 0.67
R1560:Gpr158 UTSW 2 21,831,125 (GRCm39) missense probably damaging 1.00
R1561:Gpr158 UTSW 2 21,820,505 (GRCm39) splice site probably null
R1609:Gpr158 UTSW 2 21,788,104 (GRCm39) missense possibly damaging 0.61
R1741:Gpr158 UTSW 2 21,832,359 (GRCm39) missense probably benign 0.00
R1827:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R1854:Gpr158 UTSW 2 21,373,935 (GRCm39) missense probably damaging 1.00
R1871:Gpr158 UTSW 2 21,820,426 (GRCm39) missense probably damaging 1.00
R2151:Gpr158 UTSW 2 21,832,325 (GRCm39) missense possibly damaging 0.82
R2273:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R2275:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R3004:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R3151:Gpr158 UTSW 2 21,581,771 (GRCm39) missense possibly damaging 0.68
R3943:Gpr158 UTSW 2 21,373,370 (GRCm39) missense possibly damaging 0.65
R4238:Gpr158 UTSW 2 21,373,362 (GRCm39) missense probably damaging 1.00
R4379:Gpr158 UTSW 2 21,830,025 (GRCm39) missense probably damaging 1.00
R4381:Gpr158 UTSW 2 21,832,403 (GRCm39) missense probably damaging 1.00
R4464:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4467:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4506:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4530:Gpr158 UTSW 2 21,373,811 (GRCm39) missense probably benign 0.03
R4646:Gpr158 UTSW 2 21,831,864 (GRCm39) missense probably benign
R4798:Gpr158 UTSW 2 21,787,993 (GRCm39) missense probably damaging 1.00
R4882:Gpr158 UTSW 2 21,830,059 (GRCm39) missense probably damaging 0.98
R4943:Gpr158 UTSW 2 21,831,968 (GRCm39) missense probably damaging 1.00
R5334:Gpr158 UTSW 2 21,832,316 (GRCm39) missense probably benign 0.01
R5560:Gpr158 UTSW 2 21,831,101 (GRCm39) missense possibly damaging 0.67
R5600:Gpr158 UTSW 2 21,832,046 (GRCm39) missense probably benign
R5637:Gpr158 UTSW 2 21,788,083 (GRCm39) missense probably benign 0.00
R5701:Gpr158 UTSW 2 21,751,520 (GRCm39) missense probably damaging 1.00
R5744:Gpr158 UTSW 2 21,373,331 (GRCm39) missense probably damaging 1.00
R5911:Gpr158 UTSW 2 21,373,932 (GRCm39) missense possibly damaging 0.95
R5991:Gpr158 UTSW 2 21,373,319 (GRCm39) missense probably damaging 0.99
R6200:Gpr158 UTSW 2 21,404,227 (GRCm39) missense probably damaging 0.97
R6306:Gpr158 UTSW 2 21,820,422 (GRCm39) missense possibly damaging 0.84
R6324:Gpr158 UTSW 2 21,815,365 (GRCm39) missense probably damaging 1.00
R6384:Gpr158 UTSW 2 21,831,099 (GRCm39) missense probably damaging 1.00
R6698:Gpr158 UTSW 2 21,831,921 (GRCm39) missense probably damaging 1.00
R6997:Gpr158 UTSW 2 21,653,802 (GRCm39) missense possibly damaging 0.46
R7086:Gpr158 UTSW 2 21,831,386 (GRCm39) missense probably benign 0.01
R7175:Gpr158 UTSW 2 21,373,113 (GRCm39) missense probably benign 0.13
R7197:Gpr158 UTSW 2 21,815,412 (GRCm39) missense probably damaging 0.99
R7293:Gpr158 UTSW 2 21,581,750 (GRCm39) missense possibly damaging 0.47
R7427:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R7515:Gpr158 UTSW 2 21,373,092 (GRCm39) missense probably damaging 1.00
R7730:Gpr158 UTSW 2 21,831,158 (GRCm39) missense probably damaging 1.00
R8122:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R8311:Gpr158 UTSW 2 21,373,701 (GRCm39) missense probably benign 0.00
R8754:Gpr158 UTSW 2 21,581,693 (GRCm39) missense probably benign 0.00
R8782:Gpr158 UTSW 2 21,404,149 (GRCm39) missense probably damaging 1.00
R8792:Gpr158 UTSW 2 21,558,137 (GRCm39) missense probably damaging 1.00
R8842:Gpr158 UTSW 2 21,581,751 (GRCm39) missense possibly damaging 0.88
R9009:Gpr158 UTSW 2 21,581,760 (GRCm39) missense probably damaging 1.00
R9102:Gpr158 UTSW 2 21,830,078 (GRCm39) missense probably damaging 1.00
R9150:Gpr158 UTSW 2 21,831,251 (GRCm39) missense probably benign 0.17
R9254:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9317:Gpr158 UTSW 2 21,832,037 (GRCm39) missense probably benign
R9379:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9428:Gpr158 UTSW 2 21,787,972 (GRCm39) missense probably benign
R9497:Gpr158 UTSW 2 21,831,825 (GRCm39) missense probably benign 0.00
R9667:Gpr158 UTSW 2 21,830,054 (GRCm39) missense probably damaging 0.99
R9681:Gpr158 UTSW 2 21,831,315 (GRCm39) missense probably damaging 0.99
X0062:Gpr158 UTSW 2 21,831,180 (GRCm39) missense probably damaging 1.00
Z1176:Gpr158 UTSW 2 21,815,501 (GRCm39) critical splice donor site probably null
Z1177:Gpr158 UTSW 2 21,832,083 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- TGTCATTGCAAGTGCCAAGG -3'
(R):5'- AAACGAAGCAGGGTTTTGTTC -3'

Sequencing Primer
(F):5'- GAGAAGACACTTGGCCTGGC -3'
(R):5'- CACTTCAGAAGCTGCGATTG -3'
Posted On 2015-07-21