Incidental Mutation 'R4478:Eif4g1'
ID 331377
Institutional Source Beutler Lab
Gene Symbol Eif4g1
Ensembl Gene ENSMUSG00000045983
Gene Name eukaryotic translation initiation factor 4, gamma 1
Synonyms E030015G23Rik
MMRRC Submission 041735-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.970) question?
Stock # R4478 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 20491457-20511633 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to T at 20497593 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000156280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044783] [ENSMUST00000073840] [ENSMUST00000115457] [ENSMUST00000115460] [ENSMUST00000115461] [ENSMUST00000115463] [ENSMUST00000143939] [ENSMUST00000142344] [ENSMUST00000150333] [ENSMUST00000140576] [ENSMUST00000141034] [ENSMUST00000128840] [ENSMUST00000151679] [ENSMUST00000136713] [ENSMUST00000128594] [ENSMUST00000156226] [ENSMUST00000154594] [ENSMUST00000154950] [ENSMUST00000231618]
AlphaFold Q6NZJ6
Predicted Effect probably benign
Transcript: ENSMUST00000044783
SMART Domains Protein: ENSMUSP00000047678
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 60 81 N/A INTRINSIC
PDB:1LJ2|D 179 206 1e-10 PDB
low complexity region 260 286 N/A INTRINSIC
low complexity region 436 457 N/A INTRINSIC
low complexity region 464 487 N/A INTRINSIC
Blast:MIF4G 638 683 7e-9 BLAST
low complexity region 685 707 N/A INTRINSIC
MIF4G 765 993 5.14e-72 SMART
low complexity region 1035 1047 N/A INTRINSIC
low complexity region 1092 1106 N/A INTRINSIC
low complexity region 1157 1178 N/A INTRINSIC
low complexity region 1186 1201 N/A INTRINSIC
MA3 1242 1354 3.83e-39 SMART
low complexity region 1441 1452 N/A INTRINSIC
eIF5C 1508 1595 3.78e-33 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000073840
SMART Domains Protein: ENSMUSP00000073506
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 53 74 N/A INTRINSIC
PDB:1LJ2|D 172 199 1e-10 PDB
low complexity region 253 279 N/A INTRINSIC
low complexity region 429 450 N/A INTRINSIC
low complexity region 457 480 N/A INTRINSIC
Blast:MIF4G 631 676 7e-9 BLAST
low complexity region 678 700 N/A INTRINSIC
MIF4G 758 986 5.14e-72 SMART
low complexity region 1028 1040 N/A INTRINSIC
low complexity region 1085 1099 N/A INTRINSIC
low complexity region 1150 1171 N/A INTRINSIC
low complexity region 1179 1194 N/A INTRINSIC
MA3 1235 1347 3.83e-39 SMART
low complexity region 1434 1445 N/A INTRINSIC
eIF5C 1501 1588 3.78e-33 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115457
SMART Domains Protein: ENSMUSP00000111117
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 13 34 N/A INTRINSIC
PDB:1LJ2|D 132 159 9e-11 PDB
low complexity region 213 239 N/A INTRINSIC
low complexity region 389 410 N/A INTRINSIC
low complexity region 417 440 N/A INTRINSIC
Blast:MIF4G 591 636 7e-9 BLAST
low complexity region 638 660 N/A INTRINSIC
MIF4G 718 946 5.14e-72 SMART
low complexity region 988 1000 N/A INTRINSIC
low complexity region 1045 1059 N/A INTRINSIC
low complexity region 1110 1131 N/A INTRINSIC
low complexity region 1139 1154 N/A INTRINSIC
MA3 1195 1307 3.83e-39 SMART
low complexity region 1394 1405 N/A INTRINSIC
eIF5C 1461 1548 3.78e-33 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115460
SMART Domains Protein: ENSMUSP00000111120
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 60 81 N/A INTRINSIC
PDB:1LJ2|D 179 206 1e-10 PDB
low complexity region 260 286 N/A INTRINSIC
low complexity region 436 457 N/A INTRINSIC
low complexity region 464 487 N/A INTRINSIC
Blast:MIF4G 638 683 7e-9 BLAST
low complexity region 685 707 N/A INTRINSIC
MIF4G 765 993 5.14e-72 SMART
low complexity region 1035 1047 N/A INTRINSIC
low complexity region 1092 1106 N/A INTRINSIC
low complexity region 1157 1178 N/A INTRINSIC
low complexity region 1186 1201 N/A INTRINSIC
MA3 1242 1354 3.83e-39 SMART
low complexity region 1441 1452 N/A INTRINSIC
eIF5C 1508 1595 3.78e-33 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115461
SMART Domains Protein: ENSMUSP00000111121
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 53 74 N/A INTRINSIC
PDB:1LJ2|D 172 199 1e-10 PDB
low complexity region 253 279 N/A INTRINSIC
low complexity region 429 450 N/A INTRINSIC
low complexity region 457 480 N/A INTRINSIC
Blast:MIF4G 631 676 8e-9 BLAST
low complexity region 678 693 N/A INTRINSIC
MIF4G 759 987 5.14e-72 SMART
low complexity region 1029 1041 N/A INTRINSIC
low complexity region 1086 1100 N/A INTRINSIC
low complexity region 1151 1172 N/A INTRINSIC
low complexity region 1180 1195 N/A INTRINSIC
MA3 1236 1348 3.83e-39 SMART
low complexity region 1435 1446 N/A INTRINSIC
eIF5C 1502 1589 3.78e-33 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115463
SMART Domains Protein: ENSMUSP00000111123
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 53 74 N/A INTRINSIC
PDB:1LJ2|D 172 199 1e-10 PDB
low complexity region 253 279 N/A INTRINSIC
low complexity region 429 450 N/A INTRINSIC
low complexity region 457 480 N/A INTRINSIC
Blast:MIF4G 631 676 7e-9 BLAST
low complexity region 678 700 N/A INTRINSIC
MIF4G 758 986 5.14e-72 SMART
low complexity region 1030 1036 N/A INTRINSIC
low complexity region 1078 1092 N/A INTRINSIC
low complexity region 1143 1164 N/A INTRINSIC
low complexity region 1172 1187 N/A INTRINSIC
MA3 1228 1340 3.83e-39 SMART
low complexity region 1427 1438 N/A INTRINSIC
eIF5C 1494 1581 3.78e-33 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000143939
SMART Domains Protein: ENSMUSP00000144320
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 139 160 N/A INTRINSIC
low complexity region 167 190 N/A INTRINSIC
Blast:MIF4G 341 386 6e-9 BLAST
low complexity region 388 410 N/A INTRINSIC
MIF4G 468 696 2.2e-74 SMART
low complexity region 738 750 N/A INTRINSIC
low complexity region 795 809 N/A INTRINSIC
low complexity region 860 881 N/A INTRINSIC
low complexity region 889 904 N/A INTRINSIC
MA3 945 1057 1.7e-41 SMART
low complexity region 1144 1155 N/A INTRINSIC
eIF5C 1211 1298 1.8e-35 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137690
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136106
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132320
Predicted Effect probably benign
Transcript: ENSMUST00000142344
SMART Domains Protein: ENSMUSP00000116029
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 53 74 N/A INTRINSIC
PDB:1LJ2|D 172 199 5e-11 PDB
low complexity region 253 279 N/A INTRINSIC
low complexity region 429 450 N/A INTRINSIC
low complexity region 457 480 N/A INTRINSIC
Blast:MIF4G 631 672 6e-8 BLAST
low complexity region 678 693 N/A INTRINSIC
MIF4G 759 958 5.49e-49 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000150333
SMART Domains Protein: ENSMUSP00000144107
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
PDB:1LJ2|D 113 140 5e-11 PDB
low complexity region 194 220 N/A INTRINSIC
low complexity region 370 391 N/A INTRINSIC
low complexity region 398 421 N/A INTRINSIC
Blast:MIF4G 572 613 9e-8 BLAST
low complexity region 619 641 N/A INTRINSIC
MIF4G 699 900 1.1e-52 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000140576
SMART Domains Protein: ENSMUSP00000117587
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 20 41 N/A INTRINSIC
PDB:1LJ2|D 129 156 3e-12 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000141034
SMART Domains Protein: ENSMUSP00000120035
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 60 81 N/A INTRINSIC
PDB:4F02|F 175 200 4e-11 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000128840
SMART Domains Protein: ENSMUSP00000143861
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
PDB:1LJ2|D 85 112 5e-13 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000151679
SMART Domains Protein: ENSMUSP00000120698
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 13 34 N/A INTRINSIC
PDB:1LJ2|D 132 159 8e-13 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000136713
SMART Domains Protein: ENSMUSP00000143999
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
PDB:1LJ2|D 85 112 3e-13 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000128594
SMART Domains Protein: ENSMUSP00000144594
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
PDB:1LJ2|D 8 35 5e-11 PDB
low complexity region 89 115 N/A INTRINSIC
low complexity region 265 286 N/A INTRINSIC
low complexity region 293 316 N/A INTRINSIC
Blast:MIF4G 467 512 4e-9 BLAST
low complexity region 514 536 N/A INTRINSIC
MIF4G 594 795 1.1e-52 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000156226
SMART Domains Protein: ENSMUSP00000119215
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 53 74 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231477
Predicted Effect probably benign
Transcript: ENSMUST00000154594
SMART Domains Protein: ENSMUSP00000144233
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
PDB:1LJ2|D 8 35 3e-12 PDB
low complexity region 89 115 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000154950
SMART Domains Protein: ENSMUSP00000115230
Gene: ENSMUSG00000045983

DomainStartEndE-ValueType
low complexity region 60 81 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000231618
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 94% (46/49)
MGI Phenotype FUNCTION: This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]
PHENOTYPE: Mice homozygous for an amino acid substitution (R1207H) are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 T C 8: 25,185,171 (GRCm39) D509G probably benign Het
Ank1 C T 8: 23,610,594 (GRCm39) T1379I probably benign Het
Ap1m2 A G 9: 21,209,509 (GRCm39) V389A probably benign Het
Cdh15 A G 8: 123,591,415 (GRCm39) H517R probably benign Het
Chd9 T C 8: 91,760,659 (GRCm39) probably benign Het
Chp2 A G 7: 121,820,141 (GRCm39) D97G probably benign Het
Cpne5 T C 17: 29,428,450 (GRCm39) T118A probably damaging Het
D130040H23Rik C A 8: 69,755,155 (GRCm39) H187N possibly damaging Het
Dag1 G C 9: 108,085,929 (GRCm39) T404R probably damaging Het
Dnah3 T G 7: 119,671,086 (GRCm39) H599P probably benign Het
Fabp9 T C 3: 10,262,166 (GRCm39) Y30C probably damaging Het
Fnbp1 G A 2: 30,995,266 (GRCm39) A56V probably damaging Het
Hid1 G A 11: 115,252,481 (GRCm39) A67V probably damaging Het
Il6ra T A 3: 89,797,597 (GRCm39) Y90F probably damaging Het
Kcnk18 T C 19: 59,223,676 (GRCm39) S274P probably damaging Het
Kndc1 A T 7: 139,500,600 (GRCm39) D655V probably damaging Het
Lrrk2 G A 15: 91,607,391 (GRCm39) A585T probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Myo9b A T 8: 71,743,725 (GRCm39) K262M probably damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or10aa1 C T 1: 173,870,182 (GRCm39) T222I probably benign Het
Or6c6b C T 10: 129,147,645 (GRCm39) L90F possibly damaging Het
Or8h10 G T 2: 86,808,562 (GRCm39) R193S probably benign Het
Plxna4 A T 6: 32,173,068 (GRCm39) C1288S possibly damaging Het
Ptpn22 T C 3: 103,809,380 (GRCm39) probably benign Het
Rab11fip3 C T 17: 26,235,057 (GRCm39) E619K probably damaging Het
Robo2 C A 16: 73,812,761 (GRCm39) R311L probably damaging Het
S2bpcox16 T C 12: 81,535,990 (GRCm39) probably benign Het
Sdad1 A G 5: 92,445,019 (GRCm39) M315T probably damaging Het
Slc39a12 T A 2: 14,424,990 (GRCm39) L407* probably null Het
Snap29 T C 16: 17,246,019 (GRCm39) V213A probably benign Het
Spef1l A T 7: 139,555,773 (GRCm39) probably null Het
Stard7 T A 2: 127,126,179 (GRCm39) L77Q probably damaging Het
Stat5b A G 11: 100,678,110 (GRCm39) Y668H probably benign Het
Tgfb2 A G 1: 186,364,696 (GRCm39) I266T probably damaging Het
Tmem87a C T 2: 120,199,824 (GRCm39) W440* probably null Het
Tnr T A 1: 159,712,326 (GRCm39) probably null Het
Ubl3 C T 5: 148,448,787 (GRCm39) S18N probably benign Het
Vmn2r68 TCC TC 7: 84,870,758 (GRCm39) probably null Het
Vmn2r9 T C 5: 108,994,143 (GRCm39) E502G probably benign Het
Vps8 A T 16: 21,363,986 (GRCm39) probably benign Het
Vwa8 T A 14: 79,106,241 (GRCm39) D61E probably benign Het
Wdr73 T C 7: 80,542,969 (GRCm39) E213G probably benign Het
Zfp1 A G 8: 112,397,175 (GRCm39) R366G probably damaging Het
Zfp282 A T 6: 47,867,630 (GRCm39) R269* probably null Het
Other mutations in Eif4g1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00584:Eif4g1 APN 16 20,505,504 (GRCm39) intron probably benign
IGL00707:Eif4g1 APN 16 20,507,764 (GRCm39) missense probably damaging 1.00
IGL00950:Eif4g1 APN 16 20,502,378 (GRCm39) missense probably damaging 1.00
IGL01397:Eif4g1 APN 16 20,498,425 (GRCm39) missense probably damaging 0.98
IGL01657:Eif4g1 APN 16 20,500,966 (GRCm39) missense possibly damaging 0.94
IGL01875:Eif4g1 APN 16 20,499,790 (GRCm39) missense probably damaging 0.96
IGL02728:Eif4g1 APN 16 20,505,502 (GRCm39) intron probably benign
IGL03155:Eif4g1 APN 16 20,511,167 (GRCm39) missense probably damaging 1.00
IGL03339:Eif4g1 APN 16 20,499,734 (GRCm39) missense possibly damaging 0.72
R0032:Eif4g1 UTSW 16 20,504,648 (GRCm39) missense probably damaging 1.00
R0032:Eif4g1 UTSW 16 20,504,648 (GRCm39) missense probably damaging 1.00
R0138:Eif4g1 UTSW 16 20,494,095 (GRCm39) missense probably damaging 0.99
R0556:Eif4g1 UTSW 16 20,494,544 (GRCm39) missense probably damaging 0.99
R0576:Eif4g1 UTSW 16 20,502,818 (GRCm39) missense probably damaging 0.98
R1424:Eif4g1 UTSW 16 20,497,692 (GRCm39) missense probably benign 0.03
R1469:Eif4g1 UTSW 16 20,498,758 (GRCm39) missense possibly damaging 0.86
R1469:Eif4g1 UTSW 16 20,498,758 (GRCm39) missense possibly damaging 0.86
R1487:Eif4g1 UTSW 16 20,497,623 (GRCm39) unclassified probably benign
R1659:Eif4g1 UTSW 16 20,499,811 (GRCm39) missense probably damaging 0.99
R1697:Eif4g1 UTSW 16 20,498,530 (GRCm39) missense probably damaging 0.99
R1848:Eif4g1 UTSW 16 20,500,617 (GRCm39) missense probably damaging 1.00
R1855:Eif4g1 UTSW 16 20,505,911 (GRCm39) missense possibly damaging 0.77
R1865:Eif4g1 UTSW 16 20,497,398 (GRCm39) missense probably damaging 0.99
R3001:Eif4g1 UTSW 16 20,511,134 (GRCm39) missense probably damaging 1.00
R3002:Eif4g1 UTSW 16 20,511,134 (GRCm39) missense probably damaging 1.00
R4402:Eif4g1 UTSW 16 20,497,593 (GRCm39) unclassified probably benign
R4477:Eif4g1 UTSW 16 20,497,593 (GRCm39) unclassified probably benign
R4479:Eif4g1 UTSW 16 20,497,593 (GRCm39) unclassified probably benign
R4480:Eif4g1 UTSW 16 20,497,593 (GRCm39) unclassified probably benign
R4623:Eif4g1 UTSW 16 20,500,095 (GRCm39) unclassified probably benign
R4658:Eif4g1 UTSW 16 20,504,684 (GRCm39) missense possibly damaging 0.78
R4751:Eif4g1 UTSW 16 20,505,265 (GRCm39) missense possibly damaging 0.89
R4859:Eif4g1 UTSW 16 20,500,923 (GRCm39) missense probably benign 0.44
R5267:Eif4g1 UTSW 16 20,504,283 (GRCm39) missense probably damaging 0.99
R5376:Eif4g1 UTSW 16 20,502,577 (GRCm39) missense probably damaging 1.00
R5560:Eif4g1 UTSW 16 20,505,645 (GRCm39) missense probably benign
R5719:Eif4g1 UTSW 16 20,507,761 (GRCm39) missense probably damaging 1.00
R6632:Eif4g1 UTSW 16 20,504,270 (GRCm39) missense probably damaging 0.99
R6849:Eif4g1 UTSW 16 20,499,495 (GRCm39) missense probably benign 0.08
R7134:Eif4g1 UTSW 16 20,500,252 (GRCm39) missense probably damaging 1.00
R7793:Eif4g1 UTSW 16 20,507,364 (GRCm39) missense probably benign 0.00
R7861:Eif4g1 UTSW 16 20,498,452 (GRCm39) missense probably benign
R8309:Eif4g1 UTSW 16 20,507,578 (GRCm39) missense probably benign 0.19
R8365:Eif4g1 UTSW 16 20,502,277 (GRCm39) missense probably damaging 1.00
R8726:Eif4g1 UTSW 16 20,494,232 (GRCm39) missense probably damaging 1.00
R8778:Eif4g1 UTSW 16 20,492,196 (GRCm39) intron probably benign
R9604:Eif4g1 UTSW 16 20,500,255 (GRCm39) missense possibly damaging 0.90
R9658:Eif4g1 UTSW 16 20,502,863 (GRCm39) missense probably benign 0.01
R9779:Eif4g1 UTSW 16 20,498,251 (GRCm39) missense probably damaging 0.97
X0062:Eif4g1 UTSW 16 20,503,251 (GRCm39) missense probably damaging 1.00
X0065:Eif4g1 UTSW 16 20,501,476 (GRCm39) missense probably damaging 1.00
Z1176:Eif4g1 UTSW 16 20,492,158 (GRCm39) intron probably benign
Z1177:Eif4g1 UTSW 16 20,505,116 (GRCm39) frame shift probably null
Z1177:Eif4g1 UTSW 16 20,502,655 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- AAGAGATCATGTCTGGGGCC -3'
(R):5'- ACTCAGTTTGAATCACTCCTTCAAG -3'

Sequencing Primer
(F):5'- ATGTCTGGGGCCCGCAC -3'
(R):5'- GAATCACTCCTTCAAGTGTAAATCC -3'
Posted On 2015-07-21