Incidental Mutation 'R4479:Tas2r115'
ID 331392
Institutional Source Beutler Lab
Gene Symbol Tas2r115
Ensembl Gene ENSMUSG00000071149
Gene Name taste receptor, type 2, member 115
Synonyms T2R15, mt2r49, Tas2r15, mGR15
MMRRC Submission 041736-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R4479 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 132714017-132714949 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 132714495 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 152 (D152G)
Ref Sequence ENSEMBL: ENSMUSP00000093043 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095394]
AlphaFold Q7M719
Predicted Effect probably damaging
Transcript: ENSMUST00000095394
AA Change: D152G

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000093043
Gene: ENSMUSG00000071149
AA Change: D152G

DomainStartEndE-ValueType
Pfam:TAS2R 1 299 2.2e-84 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency 95% (36/38)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 45,654,663 (GRCm39) T553A possibly damaging Het
Adamts20 C T 15: 94,301,326 (GRCm39) R66H probably damaging Het
Anks1b A G 10: 89,885,754 (GRCm39) E150G probably damaging Het
Chp2 A G 7: 121,820,141 (GRCm39) D97G probably benign Het
Cnbd2 T C 2: 156,175,573 (GRCm39) probably benign Het
D130040H23Rik C A 8: 69,755,155 (GRCm39) H187N possibly damaging Het
Dusp15 A G 2: 152,786,102 (GRCm39) L135P probably damaging Het
Eif4g1 G T 16: 20,497,593 (GRCm39) probably benign Het
Erlin2 G T 8: 27,515,127 (GRCm39) V10L probably benign Het
F830104G03Rik A G 3: 56,797,634 (GRCm39) S98P unknown Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Gm3159 T C 14: 4,398,584 (GRCm38) Y92H probably damaging Het
Ighv1-22 G T 12: 114,710,283 (GRCm39) A15E possibly damaging Het
Ints4 T C 7: 97,134,178 (GRCm39) S37P probably damaging Het
Irs1 G A 1: 82,265,015 (GRCm39) T1067I probably damaging Het
Lrrc28 C T 7: 67,181,362 (GRCm39) probably null Het
Or10v1 A G 19: 11,873,922 (GRCm39) Y179C probably damaging Het
Or4a71 A G 2: 89,358,514 (GRCm39) I80T possibly damaging Het
Or5ac24 G A 16: 59,165,230 (GRCm39) T278I probably damaging Het
Psg18 C T 7: 18,084,787 (GRCm39) S103N probably benign Het
Psma3 T C 12: 71,031,555 (GRCm39) probably benign Het
Slc7a11 T C 3: 50,372,412 (GRCm39) probably benign Het
Tti1 A T 2: 157,850,315 (GRCm39) L308Q possibly damaging Het
Unc93b1 G A 19: 3,985,236 (GRCm39) A15T probably benign Het
Usp43 G A 11: 67,747,233 (GRCm39) R820C possibly damaging Het
Vmn2r68 TCC TC 7: 84,870,758 (GRCm39) probably null Het
Vps8 A T 16: 21,363,986 (GRCm39) probably benign Het
Wdr73 T C 7: 80,542,969 (GRCm39) E213G probably benign Het
Zfp286 C G 11: 62,671,030 (GRCm39) G348R probably damaging Het
Zkscan5 T C 5: 145,147,984 (GRCm39) probably benign Het
Other mutations in Tas2r115
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00565:Tas2r115 APN 6 132,714,741 (GRCm39) missense probably benign 0.11
IGL01285:Tas2r115 APN 6 132,714,641 (GRCm39) missense probably damaging 1.00
IGL01516:Tas2r115 APN 6 132,714,576 (GRCm39) missense probably damaging 0.98
IGL01637:Tas2r115 APN 6 132,714,592 (GRCm39) missense probably damaging 0.99
IGL02041:Tas2r115 APN 6 132,714,430 (GRCm39) missense probably benign 0.13
IGL02178:Tas2r115 APN 6 132,714,271 (GRCm39) missense probably benign 0.11
R0467:Tas2r115 UTSW 6 132,714,682 (GRCm39) missense probably benign 0.02
R0553:Tas2r115 UTSW 6 132,714,922 (GRCm39) missense probably benign 0.18
R1425:Tas2r115 UTSW 6 132,714,442 (GRCm39) missense probably benign 0.02
R1770:Tas2r115 UTSW 6 132,714,934 (GRCm39) missense probably damaging 1.00
R2120:Tas2r115 UTSW 6 132,714,470 (GRCm39) missense possibly damaging 0.51
R2136:Tas2r115 UTSW 6 132,714,309 (GRCm39) missense probably damaging 0.99
R2141:Tas2r115 UTSW 6 132,714,321 (GRCm39) missense probably benign 0.43
R2142:Tas2r115 UTSW 6 132,714,321 (GRCm39) missense probably benign 0.43
R4687:Tas2r115 UTSW 6 132,714,247 (GRCm39) missense possibly damaging 0.80
R4948:Tas2r115 UTSW 6 132,714,124 (GRCm39) missense probably damaging 1.00
R5097:Tas2r115 UTSW 6 132,714,216 (GRCm39) missense probably damaging 1.00
R5856:Tas2r115 UTSW 6 132,714,501 (GRCm39) missense possibly damaging 0.86
R6927:Tas2r115 UTSW 6 132,714,895 (GRCm39) missense probably damaging 1.00
R7473:Tas2r115 UTSW 6 132,714,214 (GRCm39) missense probably damaging 1.00
R7688:Tas2r115 UTSW 6 132,714,643 (GRCm39) missense probably damaging 1.00
R8415:Tas2r115 UTSW 6 132,714,798 (GRCm39) missense probably damaging 1.00
R8495:Tas2r115 UTSW 6 132,714,887 (GRCm39) missense probably damaging 1.00
R9032:Tas2r115 UTSW 6 132,714,327 (GRCm39) missense probably benign 0.37
R9085:Tas2r115 UTSW 6 132,714,327 (GRCm39) missense probably benign 0.37
R9318:Tas2r115 UTSW 6 132,714,472 (GRCm39) missense probably benign 0.01
R9665:Tas2r115 UTSW 6 132,714,390 (GRCm39) missense probably benign 0.31
R9751:Tas2r115 UTSW 6 132,714,918 (GRCm39) missense possibly damaging 0.85
Z1088:Tas2r115 UTSW 6 132,714,044 (GRCm39) nonsense probably null
Z1176:Tas2r115 UTSW 6 132,714,819 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGTAGTACTGCATCTTCCTTACATG -3'
(R):5'- AGACTGATTCAGACTGCCTGG -3'

Sequencing Primer
(F):5'- GCATCTTCCTTACATGTTTCATAAGG -3'
(R):5'- TCAGACTGCCTGGAATATAAGC -3'
Posted On 2015-07-21