Incidental Mutation 'R4479:Tas2r115'
ID |
331392 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tas2r115
|
Ensembl Gene |
ENSMUSG00000071149 |
Gene Name |
taste receptor, type 2, member 115 |
Synonyms |
T2R15, mt2r49, Tas2r15, mGR15 |
MMRRC Submission |
041736-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.053)
|
Stock # |
R4479 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
6 |
Chromosomal Location |
132714017-132714949 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 132714495 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Glycine
at position 152
(D152G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000093043
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095394]
|
AlphaFold |
Q7M719 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000095394
AA Change: D152G
PolyPhen 2
Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000093043 Gene: ENSMUSG00000071149 AA Change: D152G
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
1 |
299 |
2.2e-84 |
PFAM |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
Validation Efficiency |
95% (36/38) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 30 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc6 |
T |
C |
7: 45,654,663 (GRCm39) |
T553A |
possibly damaging |
Het |
Adamts20 |
C |
T |
15: 94,301,326 (GRCm39) |
R66H |
probably damaging |
Het |
Anks1b |
A |
G |
10: 89,885,754 (GRCm39) |
E150G |
probably damaging |
Het |
Chp2 |
A |
G |
7: 121,820,141 (GRCm39) |
D97G |
probably benign |
Het |
Cnbd2 |
T |
C |
2: 156,175,573 (GRCm39) |
|
probably benign |
Het |
D130040H23Rik |
C |
A |
8: 69,755,155 (GRCm39) |
H187N |
possibly damaging |
Het |
Dusp15 |
A |
G |
2: 152,786,102 (GRCm39) |
L135P |
probably damaging |
Het |
Eif4g1 |
G |
T |
16: 20,497,593 (GRCm39) |
|
probably benign |
Het |
Erlin2 |
G |
T |
8: 27,515,127 (GRCm39) |
V10L |
probably benign |
Het |
F830104G03Rik |
A |
G |
3: 56,797,634 (GRCm39) |
S98P |
unknown |
Het |
Fat3 |
G |
A |
9: 15,909,567 (GRCm39) |
S2145F |
probably damaging |
Het |
Gm3159 |
T |
C |
14: 4,398,584 (GRCm38) |
Y92H |
probably damaging |
Het |
Ighv1-22 |
G |
T |
12: 114,710,283 (GRCm39) |
A15E |
possibly damaging |
Het |
Ints4 |
T |
C |
7: 97,134,178 (GRCm39) |
S37P |
probably damaging |
Het |
Irs1 |
G |
A |
1: 82,265,015 (GRCm39) |
T1067I |
probably damaging |
Het |
Lrrc28 |
C |
T |
7: 67,181,362 (GRCm39) |
|
probably null |
Het |
Or10v1 |
A |
G |
19: 11,873,922 (GRCm39) |
Y179C |
probably damaging |
Het |
Or4a71 |
A |
G |
2: 89,358,514 (GRCm39) |
I80T |
possibly damaging |
Het |
Or5ac24 |
G |
A |
16: 59,165,230 (GRCm39) |
T278I |
probably damaging |
Het |
Psg18 |
C |
T |
7: 18,084,787 (GRCm39) |
S103N |
probably benign |
Het |
Psma3 |
T |
C |
12: 71,031,555 (GRCm39) |
|
probably benign |
Het |
Slc7a11 |
T |
C |
3: 50,372,412 (GRCm39) |
|
probably benign |
Het |
Tti1 |
A |
T |
2: 157,850,315 (GRCm39) |
L308Q |
possibly damaging |
Het |
Unc93b1 |
G |
A |
19: 3,985,236 (GRCm39) |
A15T |
probably benign |
Het |
Usp43 |
G |
A |
11: 67,747,233 (GRCm39) |
R820C |
possibly damaging |
Het |
Vmn2r68 |
TCC |
TC |
7: 84,870,758 (GRCm39) |
|
probably null |
Het |
Vps8 |
A |
T |
16: 21,363,986 (GRCm39) |
|
probably benign |
Het |
Wdr73 |
T |
C |
7: 80,542,969 (GRCm39) |
E213G |
probably benign |
Het |
Zfp286 |
C |
G |
11: 62,671,030 (GRCm39) |
G348R |
probably damaging |
Het |
Zkscan5 |
T |
C |
5: 145,147,984 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Tas2r115 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00565:Tas2r115
|
APN |
6 |
132,714,741 (GRCm39) |
missense |
probably benign |
0.11 |
IGL01285:Tas2r115
|
APN |
6 |
132,714,641 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01516:Tas2r115
|
APN |
6 |
132,714,576 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01637:Tas2r115
|
APN |
6 |
132,714,592 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02041:Tas2r115
|
APN |
6 |
132,714,430 (GRCm39) |
missense |
probably benign |
0.13 |
IGL02178:Tas2r115
|
APN |
6 |
132,714,271 (GRCm39) |
missense |
probably benign |
0.11 |
R0467:Tas2r115
|
UTSW |
6 |
132,714,682 (GRCm39) |
missense |
probably benign |
0.02 |
R0553:Tas2r115
|
UTSW |
6 |
132,714,922 (GRCm39) |
missense |
probably benign |
0.18 |
R1425:Tas2r115
|
UTSW |
6 |
132,714,442 (GRCm39) |
missense |
probably benign |
0.02 |
R1770:Tas2r115
|
UTSW |
6 |
132,714,934 (GRCm39) |
missense |
probably damaging |
1.00 |
R2120:Tas2r115
|
UTSW |
6 |
132,714,470 (GRCm39) |
missense |
possibly damaging |
0.51 |
R2136:Tas2r115
|
UTSW |
6 |
132,714,309 (GRCm39) |
missense |
probably damaging |
0.99 |
R2141:Tas2r115
|
UTSW |
6 |
132,714,321 (GRCm39) |
missense |
probably benign |
0.43 |
R2142:Tas2r115
|
UTSW |
6 |
132,714,321 (GRCm39) |
missense |
probably benign |
0.43 |
R4687:Tas2r115
|
UTSW |
6 |
132,714,247 (GRCm39) |
missense |
possibly damaging |
0.80 |
R4948:Tas2r115
|
UTSW |
6 |
132,714,124 (GRCm39) |
missense |
probably damaging |
1.00 |
R5097:Tas2r115
|
UTSW |
6 |
132,714,216 (GRCm39) |
missense |
probably damaging |
1.00 |
R5856:Tas2r115
|
UTSW |
6 |
132,714,501 (GRCm39) |
missense |
possibly damaging |
0.86 |
R6927:Tas2r115
|
UTSW |
6 |
132,714,895 (GRCm39) |
missense |
probably damaging |
1.00 |
R7473:Tas2r115
|
UTSW |
6 |
132,714,214 (GRCm39) |
missense |
probably damaging |
1.00 |
R7688:Tas2r115
|
UTSW |
6 |
132,714,643 (GRCm39) |
missense |
probably damaging |
1.00 |
R8415:Tas2r115
|
UTSW |
6 |
132,714,798 (GRCm39) |
missense |
probably damaging |
1.00 |
R8495:Tas2r115
|
UTSW |
6 |
132,714,887 (GRCm39) |
missense |
probably damaging |
1.00 |
R9032:Tas2r115
|
UTSW |
6 |
132,714,327 (GRCm39) |
missense |
probably benign |
0.37 |
R9085:Tas2r115
|
UTSW |
6 |
132,714,327 (GRCm39) |
missense |
probably benign |
0.37 |
R9318:Tas2r115
|
UTSW |
6 |
132,714,472 (GRCm39) |
missense |
probably benign |
0.01 |
R9665:Tas2r115
|
UTSW |
6 |
132,714,390 (GRCm39) |
missense |
probably benign |
0.31 |
R9751:Tas2r115
|
UTSW |
6 |
132,714,918 (GRCm39) |
missense |
possibly damaging |
0.85 |
Z1088:Tas2r115
|
UTSW |
6 |
132,714,044 (GRCm39) |
nonsense |
probably null |
|
Z1176:Tas2r115
|
UTSW |
6 |
132,714,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GTGTAGTACTGCATCTTCCTTACATG -3'
(R):5'- AGACTGATTCAGACTGCCTGG -3'
Sequencing Primer
(F):5'- GCATCTTCCTTACATGTTTCATAAGG -3'
(R):5'- TCAGACTGCCTGGAATATAAGC -3'
|
Posted On |
2015-07-21 |