Incidental Mutation 'R4479:Or10v1'
ID |
331415 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Or10v1
|
Ensembl Gene |
ENSMUSG00000060878 |
Gene Name |
olfactory receptor family 10 subfamily V member 1 |
Synonyms |
Olfr1420, GA_x6K02T2RE5P-2247227-2248156, MOR266-4 |
MMRRC Submission |
041736-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.112)
|
Stock # |
R4479 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
19 |
Chromosomal Location |
11873387-11874316 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 11873922 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Cysteine
at position 179
(Y179C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000149208
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072784]
[ENSMUST00000217281]
|
AlphaFold |
Q8VF55 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000072784
AA Change: Y179C
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000072563 Gene: ENSMUSG00000060878 AA Change: Y179C
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
31 |
308 |
5.3e-54 |
PFAM |
Pfam:7tm_1
|
41 |
291 |
3.4e-23 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215766
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000217281
AA Change: Y179C
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
Meta Mutation Damage Score |
0.1855 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
Validation Efficiency |
95% (36/38) |
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 30 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc6 |
T |
C |
7: 45,654,663 (GRCm39) |
T553A |
possibly damaging |
Het |
Adamts20 |
C |
T |
15: 94,301,326 (GRCm39) |
R66H |
probably damaging |
Het |
Anks1b |
A |
G |
10: 89,885,754 (GRCm39) |
E150G |
probably damaging |
Het |
Chp2 |
A |
G |
7: 121,820,141 (GRCm39) |
D97G |
probably benign |
Het |
Cnbd2 |
T |
C |
2: 156,175,573 (GRCm39) |
|
probably benign |
Het |
D130040H23Rik |
C |
A |
8: 69,755,155 (GRCm39) |
H187N |
possibly damaging |
Het |
Dusp15 |
A |
G |
2: 152,786,102 (GRCm39) |
L135P |
probably damaging |
Het |
Eif4g1 |
G |
T |
16: 20,497,593 (GRCm39) |
|
probably benign |
Het |
Erlin2 |
G |
T |
8: 27,515,127 (GRCm39) |
V10L |
probably benign |
Het |
F830104G03Rik |
A |
G |
3: 56,797,634 (GRCm39) |
S98P |
unknown |
Het |
Fat3 |
G |
A |
9: 15,909,567 (GRCm39) |
S2145F |
probably damaging |
Het |
Gm3159 |
T |
C |
14: 4,398,584 (GRCm38) |
Y92H |
probably damaging |
Het |
Ighv1-22 |
G |
T |
12: 114,710,283 (GRCm39) |
A15E |
possibly damaging |
Het |
Ints4 |
T |
C |
7: 97,134,178 (GRCm39) |
S37P |
probably damaging |
Het |
Irs1 |
G |
A |
1: 82,265,015 (GRCm39) |
T1067I |
probably damaging |
Het |
Lrrc28 |
C |
T |
7: 67,181,362 (GRCm39) |
|
probably null |
Het |
Or4a71 |
A |
G |
2: 89,358,514 (GRCm39) |
I80T |
possibly damaging |
Het |
Or5ac24 |
G |
A |
16: 59,165,230 (GRCm39) |
T278I |
probably damaging |
Het |
Psg18 |
C |
T |
7: 18,084,787 (GRCm39) |
S103N |
probably benign |
Het |
Psma3 |
T |
C |
12: 71,031,555 (GRCm39) |
|
probably benign |
Het |
Slc7a11 |
T |
C |
3: 50,372,412 (GRCm39) |
|
probably benign |
Het |
Tas2r115 |
T |
C |
6: 132,714,495 (GRCm39) |
D152G |
probably damaging |
Het |
Tti1 |
A |
T |
2: 157,850,315 (GRCm39) |
L308Q |
possibly damaging |
Het |
Unc93b1 |
G |
A |
19: 3,985,236 (GRCm39) |
A15T |
probably benign |
Het |
Usp43 |
G |
A |
11: 67,747,233 (GRCm39) |
R820C |
possibly damaging |
Het |
Vmn2r68 |
TCC |
TC |
7: 84,870,758 (GRCm39) |
|
probably null |
Het |
Vps8 |
A |
T |
16: 21,363,986 (GRCm39) |
|
probably benign |
Het |
Wdr73 |
T |
C |
7: 80,542,969 (GRCm39) |
E213G |
probably benign |
Het |
Zfp286 |
C |
G |
11: 62,671,030 (GRCm39) |
G348R |
probably damaging |
Het |
Zkscan5 |
T |
C |
5: 145,147,984 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Or10v1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02419:Or10v1
|
APN |
19 |
11,874,186 (GRCm39) |
missense |
probably benign |
0.06 |
IGL02703:Or10v1
|
APN |
19 |
11,873,606 (GRCm39) |
missense |
possibly damaging |
0.96 |
IGL02948:Or10v1
|
APN |
19 |
11,874,145 (GRCm39) |
nonsense |
probably null |
|
R1514:Or10v1
|
UTSW |
19 |
11,873,978 (GRCm39) |
missense |
probably benign |
|
R1539:Or10v1
|
UTSW |
19 |
11,873,855 (GRCm39) |
missense |
possibly damaging |
0.88 |
R1852:Or10v1
|
UTSW |
19 |
11,874,249 (GRCm39) |
missense |
probably damaging |
1.00 |
R1903:Or10v1
|
UTSW |
19 |
11,873,913 (GRCm39) |
missense |
probably benign |
0.24 |
R2061:Or10v1
|
UTSW |
19 |
11,873,921 (GRCm39) |
missense |
probably damaging |
0.98 |
R3768:Or10v1
|
UTSW |
19 |
11,873,676 (GRCm39) |
missense |
probably damaging |
0.99 |
R3977:Or10v1
|
UTSW |
19 |
11,873,880 (GRCm39) |
missense |
probably damaging |
1.00 |
R4592:Or10v1
|
UTSW |
19 |
11,874,126 (GRCm39) |
missense |
probably benign |
|
R5934:Or10v1
|
UTSW |
19 |
11,874,293 (GRCm39) |
missense |
probably benign |
|
R6058:Or10v1
|
UTSW |
19 |
11,873,388 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R6536:Or10v1
|
UTSW |
19 |
11,873,760 (GRCm39) |
missense |
probably benign |
0.05 |
R7752:Or10v1
|
UTSW |
19 |
11,873,898 (GRCm39) |
missense |
probably benign |
0.01 |
R7901:Or10v1
|
UTSW |
19 |
11,873,898 (GRCm39) |
missense |
probably benign |
0.01 |
R8250:Or10v1
|
UTSW |
19 |
11,873,741 (GRCm39) |
missense |
probably damaging |
1.00 |
R9434:Or10v1
|
UTSW |
19 |
11,873,393 (GRCm39) |
missense |
probably benign |
|
|
Predicted Primers |
PCR Primer
(F):5'- ACGACCGGTTTGTTGCGATC -3'
(R):5'- AGCCATACTGTAGGAGGACCAC -3'
Sequencing Primer
(F):5'- GATCTGCTACCCTCTGAGATACAC -3'
(R):5'- CATACTGTAGGAGGACCACTACGATG -3'
|
Posted On |
2015-07-21 |