Incidental Mutation 'R4479:Or10v1'
ID 331415
Institutional Source Beutler Lab
Gene Symbol Or10v1
Ensembl Gene ENSMUSG00000060878
Gene Name olfactory receptor family 10 subfamily V member 1
Synonyms Olfr1420, GA_x6K02T2RE5P-2247227-2248156, MOR266-4
MMRRC Submission 041736-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R4479 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 11873387-11874316 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 11873922 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 179 (Y179C)
Ref Sequence ENSEMBL: ENSMUSP00000149208 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072784] [ENSMUST00000217281]
AlphaFold Q8VF55
Predicted Effect probably damaging
Transcript: ENSMUST00000072784
AA Change: Y179C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000072563
Gene: ENSMUSG00000060878
AA Change: Y179C

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.3e-54 PFAM
Pfam:7tm_1 41 291 3.4e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215766
Predicted Effect probably damaging
Transcript: ENSMUST00000217281
AA Change: Y179C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Meta Mutation Damage Score 0.1855 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency 95% (36/38)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 45,654,663 (GRCm39) T553A possibly damaging Het
Adamts20 C T 15: 94,301,326 (GRCm39) R66H probably damaging Het
Anks1b A G 10: 89,885,754 (GRCm39) E150G probably damaging Het
Chp2 A G 7: 121,820,141 (GRCm39) D97G probably benign Het
Cnbd2 T C 2: 156,175,573 (GRCm39) probably benign Het
D130040H23Rik C A 8: 69,755,155 (GRCm39) H187N possibly damaging Het
Dusp15 A G 2: 152,786,102 (GRCm39) L135P probably damaging Het
Eif4g1 G T 16: 20,497,593 (GRCm39) probably benign Het
Erlin2 G T 8: 27,515,127 (GRCm39) V10L probably benign Het
F830104G03Rik A G 3: 56,797,634 (GRCm39) S98P unknown Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Gm3159 T C 14: 4,398,584 (GRCm38) Y92H probably damaging Het
Ighv1-22 G T 12: 114,710,283 (GRCm39) A15E possibly damaging Het
Ints4 T C 7: 97,134,178 (GRCm39) S37P probably damaging Het
Irs1 G A 1: 82,265,015 (GRCm39) T1067I probably damaging Het
Lrrc28 C T 7: 67,181,362 (GRCm39) probably null Het
Or4a71 A G 2: 89,358,514 (GRCm39) I80T possibly damaging Het
Or5ac24 G A 16: 59,165,230 (GRCm39) T278I probably damaging Het
Psg18 C T 7: 18,084,787 (GRCm39) S103N probably benign Het
Psma3 T C 12: 71,031,555 (GRCm39) probably benign Het
Slc7a11 T C 3: 50,372,412 (GRCm39) probably benign Het
Tas2r115 T C 6: 132,714,495 (GRCm39) D152G probably damaging Het
Tti1 A T 2: 157,850,315 (GRCm39) L308Q possibly damaging Het
Unc93b1 G A 19: 3,985,236 (GRCm39) A15T probably benign Het
Usp43 G A 11: 67,747,233 (GRCm39) R820C possibly damaging Het
Vmn2r68 TCC TC 7: 84,870,758 (GRCm39) probably null Het
Vps8 A T 16: 21,363,986 (GRCm39) probably benign Het
Wdr73 T C 7: 80,542,969 (GRCm39) E213G probably benign Het
Zfp286 C G 11: 62,671,030 (GRCm39) G348R probably damaging Het
Zkscan5 T C 5: 145,147,984 (GRCm39) probably benign Het
Other mutations in Or10v1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02419:Or10v1 APN 19 11,874,186 (GRCm39) missense probably benign 0.06
IGL02703:Or10v1 APN 19 11,873,606 (GRCm39) missense possibly damaging 0.96
IGL02948:Or10v1 APN 19 11,874,145 (GRCm39) nonsense probably null
R1514:Or10v1 UTSW 19 11,873,978 (GRCm39) missense probably benign
R1539:Or10v1 UTSW 19 11,873,855 (GRCm39) missense possibly damaging 0.88
R1852:Or10v1 UTSW 19 11,874,249 (GRCm39) missense probably damaging 1.00
R1903:Or10v1 UTSW 19 11,873,913 (GRCm39) missense probably benign 0.24
R2061:Or10v1 UTSW 19 11,873,921 (GRCm39) missense probably damaging 0.98
R3768:Or10v1 UTSW 19 11,873,676 (GRCm39) missense probably damaging 0.99
R3977:Or10v1 UTSW 19 11,873,880 (GRCm39) missense probably damaging 1.00
R4592:Or10v1 UTSW 19 11,874,126 (GRCm39) missense probably benign
R5934:Or10v1 UTSW 19 11,874,293 (GRCm39) missense probably benign
R6058:Or10v1 UTSW 19 11,873,388 (GRCm39) start codon destroyed probably null 1.00
R6536:Or10v1 UTSW 19 11,873,760 (GRCm39) missense probably benign 0.05
R7752:Or10v1 UTSW 19 11,873,898 (GRCm39) missense probably benign 0.01
R7901:Or10v1 UTSW 19 11,873,898 (GRCm39) missense probably benign 0.01
R8250:Or10v1 UTSW 19 11,873,741 (GRCm39) missense probably damaging 1.00
R9434:Or10v1 UTSW 19 11,873,393 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACGACCGGTTTGTTGCGATC -3'
(R):5'- AGCCATACTGTAGGAGGACCAC -3'

Sequencing Primer
(F):5'- GATCTGCTACCCTCTGAGATACAC -3'
(R):5'- CATACTGTAGGAGGACCACTACGATG -3'
Posted On 2015-07-21