Incidental Mutation 'R4480:Fpr2'
ID 331448
Institutional Source Beutler Lab
Gene Symbol Fpr2
Ensembl Gene ENSMUSG00000052270
Gene Name formyl peptide receptor 2
Synonyms Fpr-rs2, E330010I07Rik
MMRRC Submission 041737-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R4480 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 18108086-18114214 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 18114015 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 337 (T337I)
Ref Sequence ENSEMBL: ENSMUSP00000065799 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054871] [ENSMUST00000064068] [ENSMUST00000149944]
AlphaFold O88536
Predicted Effect probably benign
Transcript: ENSMUST00000054871
SMART Domains Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 2.2e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000064068
AA Change: T337I

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000065799
Gene: ENSMUSG00000052270
AA Change: T337I

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 4.3e-36 PFAM
low complexity region 326 341 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000149944
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 95% (40/42)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted reporter allele exhibit altered leukocyte responses and experimentally induced inflammation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 45,654,663 (GRCm39) T553A possibly damaging Het
Adgrb3 A T 1: 25,150,829 (GRCm39) F1135I probably damaging Het
Arfgef3 A T 10: 18,476,348 (GRCm39) F1490L probably damaging Het
Begain A G 12: 109,000,049 (GRCm39) Y446H probably damaging Het
Cdh15 A G 8: 123,591,415 (GRCm39) H517R probably benign Het
Cemip2 A G 19: 21,792,853 (GRCm39) Q703R probably benign Het
D130040H23Rik C A 8: 69,755,155 (GRCm39) H187N possibly damaging Het
Dip2b C T 15: 100,084,182 (GRCm39) T935M probably damaging Het
Eif2s2 T C 2: 154,730,190 (GRCm39) T36A probably benign Het
Eif4g1 G T 16: 20,497,593 (GRCm39) probably benign Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Fbxo10 T C 4: 45,048,470 (GRCm39) Y555C probably damaging Het
Frem3 A T 8: 81,337,986 (GRCm39) Q93L probably benign Het
Gapdh A G 6: 125,140,145 (GRCm39) V119A possibly damaging Het
Gm3159 T C 14: 4,398,584 (GRCm38) Y92H probably damaging Het
Hkdc1 T C 10: 62,227,151 (GRCm39) I769V probably benign Het
Ifne T C 4: 88,797,838 (GRCm39) *193W probably null Het
Katna1 T C 10: 7,614,594 (GRCm39) V32A probably damaging Het
Nup107 T C 10: 117,597,237 (GRCm39) I673V probably benign Het
Nup188 T A 2: 30,212,141 (GRCm39) probably benign Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or10g1 G A 14: 52,647,765 (GRCm39) A188V probably damaging Het
Or2t48 G T 11: 58,420,627 (GRCm39) P62T probably damaging Het
Pcdhb5 T A 18: 37,453,805 (GRCm39) S62T probably benign Het
Plekha5 T C 6: 140,472,205 (GRCm39) V44A probably damaging Het
Psg18 C T 7: 18,084,787 (GRCm39) S103N probably benign Het
Ptprcap A G 19: 4,206,223 (GRCm39) E102G probably benign Het
Ptprs A G 17: 56,733,404 (GRCm39) V804A possibly damaging Het
Rab35 C A 5: 115,775,823 (GRCm39) S34* probably null Het
Slco6d1 T A 1: 98,435,299 (GRCm39) Y671* probably null Het
Sostdc1 A G 12: 36,367,165 (GRCm39) I114V probably damaging Het
Tecta A G 9: 42,284,529 (GRCm39) F852S possibly damaging Het
Tmem179 T C 12: 112,469,737 (GRCm39) E21G probably benign Het
Usp17la T A 7: 104,509,897 (GRCm39) H167Q probably benign Het
Vps8 A T 16: 21,363,986 (GRCm39) probably benign Het
Wdr17 A G 8: 55,117,999 (GRCm39) probably null Het
Wdr73 T C 7: 80,542,969 (GRCm39) E213G probably benign Het
Zfp985 A G 4: 147,668,536 (GRCm39) D468G probably benign Het
Other mutations in Fpr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Fpr2 APN 17 18,113,034 (GRCm39) missense probably damaging 0.98
IGL01481:Fpr2 APN 17 18,113,025 (GRCm39) missense probably benign 0.01
IGL02320:Fpr2 APN 17 18,113,608 (GRCm39) missense probably benign 0.05
IGL02479:Fpr2 APN 17 18,113,074 (GRCm39) missense probably benign 0.01
R1553:Fpr2 UTSW 17 18,113,856 (GRCm39) missense possibly damaging 0.87
R3906:Fpr2 UTSW 17 18,113,811 (GRCm39) missense probably benign 0.03
R4424:Fpr2 UTSW 17 18,113,394 (GRCm39) missense probably damaging 1.00
R4521:Fpr2 UTSW 17 18,113,509 (GRCm39) missense probably benign 0.01
R4718:Fpr2 UTSW 17 18,113,598 (GRCm39) missense probably benign 0.00
R5385:Fpr2 UTSW 17 18,113,309 (GRCm39) missense probably benign 0.00
R7184:Fpr2 UTSW 17 18,113,533 (GRCm39) missense unknown
R7233:Fpr2 UTSW 17 18,113,766 (GRCm39) missense probably damaging 1.00
R8902:Fpr2 UTSW 17 18,113,190 (GRCm39) missense probably benign 0.04
R8927:Fpr2 UTSW 17 18,113,724 (GRCm39) missense possibly damaging 0.77
R8928:Fpr2 UTSW 17 18,113,724 (GRCm39) missense possibly damaging 0.77
R8939:Fpr2 UTSW 17 18,113,883 (GRCm39) missense probably damaging 1.00
R9410:Fpr2 UTSW 17 18,113,604 (GRCm39) missense probably benign
R9651:Fpr2 UTSW 17 18,113,484 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGGGCACAGTCTGGTTTAAAG -3'
(R):5'- TTCCAGATTCAGGGGACACAG -3'

Sequencing Primer
(F):5'- CACAGTCTGGTTTAAAGAGACATTGC -3'
(R):5'- GAAGTGGAATGAAAACCATCC -3'
Posted On 2015-07-21