Incidental Mutation 'R4486:Cnga2'
ID 331640
Institutional Source Beutler Lab
Gene Symbol Cnga2
Ensembl Gene ENSMUSG00000005864
Gene Name cyclic nucleotide gated channel alpha 2
Synonyms Cnca, Cncg4, OCNC1
MMRRC Submission 041742-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4486 (G1)
Quality Score 222
Status Validated
Chromosome X
Chromosomal Location 71035455-71053824 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 71049733 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 133 (F133I)
Ref Sequence ENSEMBL: ENSMUSP00000006020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006020]
AlphaFold Q62398
Predicted Effect possibly damaging
Transcript: ENSMUST00000006020
AA Change: F133I

PolyPhen 2 Score 0.576 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000006020
Gene: ENSMUSG00000005864
AA Change: F133I

DomainStartEndE-ValueType
low complexity region 11 24 N/A INTRINSIC
low complexity region 62 79 N/A INTRINSIC
low complexity region 113 129 N/A INTRINSIC
Pfam:Ion_trans 142 385 2.8e-30 PFAM
cNMP 456 580 4.54e-23 SMART
PDB:3SWY|C 599 642 2e-9 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145642
Meta Mutation Damage Score 0.1095 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency 94% (45/48)
MGI Phenotype FUNCTION: This gene encodes a transmembrane protein that is a subunit of the nucleotide-gated olfactory ion channel. Knock out of this gene affects development of the olfactory epithelium and olfactory bulb. [provided by RefSeq, May 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality within 2 days of birth, growth retardation, and abnormal olfactory neuron response to forskolin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 A G 15: 91,062,486 (GRCm39) V484A probably damaging Het
Adam22 A T 5: 8,230,227 (GRCm39) probably benign Het
Adamts18 G T 8: 114,439,825 (GRCm39) P923T probably benign Het
Ank3 C T 10: 69,837,804 (GRCm39) T1604I possibly damaging Het
Armc10 A G 5: 21,858,432 (GRCm39) Q159R probably damaging Het
Arnt2 T A 7: 83,924,553 (GRCm39) T425S probably benign Het
B4galt3 A G 1: 171,099,343 (GRCm39) T36A possibly damaging Het
Bbx A G 16: 50,020,777 (GRCm39) V799A probably damaging Het
Bud23 T C 5: 135,092,779 (GRCm39) probably null Het
Crispld1 A G 1: 17,823,102 (GRCm39) T390A probably benign Het
Cyp4f39 T A 17: 32,702,428 (GRCm39) D308E probably damaging Het
Dnah6 A G 6: 73,015,729 (GRCm39) V3584A probably damaging Het
Ecpas A G 4: 58,820,086 (GRCm39) probably benign Het
Frk T C 10: 34,484,377 (GRCm39) I450T probably benign Het
Grm6 T C 11: 50,750,816 (GRCm39) S660P probably damaging Het
Hao2 T A 3: 98,789,341 (GRCm39) I116F probably damaging Het
Hyi G A 4: 118,219,674 (GRCm39) G237D probably damaging Het
Jrkl T C 9: 13,245,376 (GRCm39) N95S probably benign Het
Kifbp A G 10: 62,398,806 (GRCm39) probably benign Het
Nanog T C 6: 122,689,676 (GRCm39) probably null Het
Ngf G A 3: 102,428,015 (GRCm39) D255N probably damaging Het
Nlrp4e A G 7: 23,020,652 (GRCm39) I380V probably benign Het
Or52e7 T C 7: 104,684,510 (GRCm39) F35S probably benign Het
Or6c76b T C 10: 129,692,567 (GRCm39) F60S probably damaging Het
Pcdha3 T C 18: 37,080,404 (GRCm39) V382A probably damaging Het
Pla2g4c T A 7: 13,071,676 (GRCm39) N165K probably benign Het
Rexo5 T C 7: 119,424,800 (GRCm39) I362T probably benign Het
Rpl7a-ps3 G A 15: 36,308,429 (GRCm39) noncoding transcript Het
Rpusd2 T C 2: 118,865,705 (GRCm39) V134A probably damaging Het
Serpina1c T A 12: 103,863,259 (GRCm39) probably null Het
Slc6a19 A T 13: 73,829,836 (GRCm39) I606N probably damaging Het
Smchd1 T C 17: 71,714,230 (GRCm39) T878A probably benign Het
Tas2r143 A G 6: 42,377,628 (GRCm39) M153V probably benign Het
Thrb G T 14: 17,925,640 (GRCm38) M1I probably null Het
Trbc2 A G 6: 41,523,814 (GRCm39) probably benign Het
Trim37 T A 11: 87,087,651 (GRCm39) S587R probably benign Het
Ulbp1 T A 10: 7,397,397 (GRCm39) H151L probably benign Het
Vmn2r54 A T 7: 12,366,199 (GRCm39) L245* probably null Het
Vmn2r78 A C 7: 86,569,959 (GRCm39) probably null Het
Xlr5b T C X: 72,201,504 (GRCm39) probably null Het
Xrcc4 A C 13: 90,140,707 (GRCm39) S167R possibly damaging Het
Zfp994 C T 17: 22,420,541 (GRCm39) C136Y probably damaging Het
Other mutations in Cnga2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02512:Cnga2 APN X 71,052,531 (GRCm39) missense probably damaging 1.00
IGL02633:Cnga2 APN X 71,048,655 (GRCm39) splice site probably benign
IGL03059:Cnga2 APN X 71,051,878 (GRCm39) missense probably damaging 1.00
IGL03215:Cnga2 APN X 71,052,772 (GRCm39) missense probably damaging 1.00
IGL03332:Cnga2 APN X 71,049,800 (GRCm39) missense probably damaging 1.00
R2128:Cnga2 UTSW X 71,051,394 (GRCm39) missense possibly damaging 0.95
R4487:Cnga2 UTSW X 71,049,733 (GRCm39) missense possibly damaging 0.58
R4489:Cnga2 UTSW X 71,049,733 (GRCm39) missense possibly damaging 0.58
Predicted Primers PCR Primer
(F):5'- ATGATCAGAATGGTTCAGAGGC -3'
(R):5'- GGAAAAGCACTGGGTTATTGC -3'

Sequencing Primer
(F):5'- AGAATGGTTCAGAGGCCTGGTATTTG -3'
(R):5'- CATACTCCCTGTCTAGAGGTGAG -3'
Posted On 2015-07-21