Incidental Mutation 'R4487:Vmn1r61'
| ID |
331657 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r61
|
| Ensembl Gene |
ENSMUSG00000094313 |
| Gene Name |
vomeronasal 1 receptor 61 |
| Synonyms |
Gm7186 |
| MMRRC Submission |
041743-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R4487 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
5613410-5614312 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 5613924 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Phenylalanine
at position 130
(C130F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128012
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164880]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000164880
AA Change: C130F
PolyPhen 2
Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000128012
Gene: ENSMUSG00000094313
AA Change: C130F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
294 |
5.3e-12 |
PFAM |
|
Pfam:7tm_1
|
20 |
279 |
5e-9 |
PFAM |
|
Pfam:V1R
|
31 |
299 |
9.5e-21 |
PFAM |
|
| Meta Mutation Damage Score |
0.4246 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
100% (41/41) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310030G06Rik |
A |
G |
9: 50,651,931 (GRCm39) |
L99P |
probably damaging |
Het |
| Abcd2 |
A |
G |
15: 91,062,486 (GRCm39) |
V484A |
probably damaging |
Het |
| Adgrv1 |
A |
G |
13: 81,588,185 (GRCm39) |
I4467T |
probably damaging |
Het |
| Ash1l |
T |
A |
3: 88,892,622 (GRCm39) |
D1500E |
possibly damaging |
Het |
| C1ql2 |
A |
T |
1: 120,269,409 (GRCm39) |
Y188F |
possibly damaging |
Het |
| Cnga2 |
T |
A |
X: 71,049,733 (GRCm39) |
F133I |
possibly damaging |
Het |
| Crybg2 |
T |
C |
4: 133,801,512 (GRCm39) |
S891P |
probably benign |
Het |
| Hao2 |
T |
A |
3: 98,789,341 (GRCm39) |
I116F |
probably damaging |
Het |
| Htr1b |
A |
T |
9: 81,513,592 (GRCm39) |
D338E |
probably benign |
Het |
| Kalrn |
C |
T |
16: 33,810,180 (GRCm39) |
D2525N |
possibly damaging |
Het |
| Kif9 |
A |
G |
9: 110,323,552 (GRCm39) |
E225G |
probably null |
Het |
| Krt76 |
T |
C |
15: 101,798,917 (GRCm39) |
K256R |
possibly damaging |
Het |
| Mapk4 |
T |
C |
18: 74,064,046 (GRCm39) |
D392G |
probably damaging |
Het |
| Mthfr |
A |
G |
4: 148,135,884 (GRCm39) |
K278R |
probably benign |
Het |
| Mup4 |
T |
A |
4: 59,960,547 (GRCm39) |
E18V |
probably damaging |
Het |
| Nepro |
A |
G |
16: 44,556,089 (GRCm39) |
K416E |
probably damaging |
Het |
| Ngf |
G |
A |
3: 102,428,015 (GRCm39) |
D255N |
probably damaging |
Het |
| Nmu |
A |
G |
5: 76,491,909 (GRCm39) |
|
probably null |
Het |
| Nt5m |
A |
G |
11: 59,739,173 (GRCm39) |
Y73C |
probably damaging |
Het |
| Oaz3 |
A |
T |
3: 94,342,437 (GRCm39) |
|
probably null |
Het |
| Pgap1 |
A |
G |
1: 54,567,751 (GRCm39) |
S365P |
probably benign |
Het |
| Plxna2 |
C |
T |
1: 194,431,625 (GRCm39) |
S538F |
probably damaging |
Het |
| Pus7l |
A |
G |
15: 94,429,498 (GRCm39) |
I440T |
possibly damaging |
Het |
| Raph1 |
C |
T |
1: 60,542,028 (GRCm39) |
S362N |
possibly damaging |
Het |
| Rftn2 |
A |
G |
1: 55,241,311 (GRCm39) |
Y330H |
possibly damaging |
Het |
| Rhot2 |
G |
A |
17: 26,058,467 (GRCm39) |
H580Y |
probably benign |
Het |
| Rnase2a |
A |
T |
14: 51,493,302 (GRCm39) |
M21K |
unknown |
Het |
| Rusf1 |
T |
C |
7: 127,887,530 (GRCm39) |
D24G |
probably damaging |
Het |
| Smchd1 |
T |
C |
17: 71,714,230 (GRCm39) |
T878A |
probably benign |
Het |
| Snx1 |
A |
T |
9: 65,996,877 (GRCm39) |
V459E |
possibly damaging |
Het |
| Suz12 |
A |
G |
11: 79,922,939 (GRCm39) |
T694A |
probably benign |
Het |
| Tg |
G |
A |
15: 66,543,245 (GRCm39) |
C53Y |
probably damaging |
Het |
| Tor1aip1 |
G |
T |
1: 155,882,870 (GRCm39) |
T326K |
probably damaging |
Het |
| Xlr5b |
T |
C |
X: 72,201,504 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn1r61 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01700:Vmn1r61
|
APN |
7 |
5,614,202 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02859:Vmn1r61
|
APN |
7 |
5,614,288 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL03344:Vmn1r61
|
APN |
7 |
5,613,493 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0189:Vmn1r61
|
UTSW |
7 |
5,613,699 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0336:Vmn1r61
|
UTSW |
7 |
5,614,066 (GRCm39) |
missense |
probably benign |
|
|
R0616:Vmn1r61
|
UTSW |
7 |
5,613,998 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1490:Vmn1r61
|
UTSW |
7 |
5,614,242 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1737:Vmn1r61
|
UTSW |
7 |
5,614,060 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1755:Vmn1r61
|
UTSW |
7 |
5,614,302 (GRCm39) |
nonsense |
probably null |
|
|
R1795:Vmn1r61
|
UTSW |
7 |
5,614,324 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R3929:Vmn1r61
|
UTSW |
7 |
5,614,176 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4629:Vmn1r61
|
UTSW |
7 |
5,614,249 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4785:Vmn1r61
|
UTSW |
7 |
5,614,126 (GRCm39) |
missense |
probably benign |
|
|
R4785:Vmn1r61
|
UTSW |
7 |
5,614,124 (GRCm39) |
nonsense |
probably null |
|
|
R5108:Vmn1r61
|
UTSW |
7 |
5,613,519 (GRCm39) |
missense |
probably benign |
|
|
R5305:Vmn1r61
|
UTSW |
7 |
5,613,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5914:Vmn1r61
|
UTSW |
7 |
5,613,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6150:Vmn1r61
|
UTSW |
7 |
5,613,678 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6232:Vmn1r61
|
UTSW |
7 |
5,613,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6722:Vmn1r61
|
UTSW |
7 |
5,613,687 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7488:Vmn1r61
|
UTSW |
7 |
5,613,767 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7496:Vmn1r61
|
UTSW |
7 |
5,613,430 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8353:Vmn1r61
|
UTSW |
7 |
5,613,886 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8453:Vmn1r61
|
UTSW |
7 |
5,613,886 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8847:Vmn1r61
|
UTSW |
7 |
5,613,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9549:Vmn1r61
|
UTSW |
7 |
5,614,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9559:Vmn1r61
|
UTSW |
7 |
5,613,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTCCAGGCCATGATGCTTAG -3'
(R):5'- GCTGTAGCCAATGCAATCATGC -3'
Sequencing Primer
(F):5'- TCCAGGCCATGATGCTTAGGAATATG -3'
(R):5'- ATTGATTTTGTTCCCAGGAAGCC -3'
|
| Posted On |
2015-07-21 |
Incidental Mutation