Incidental Mutation 'R4502:Or5k15'
ID 331876
Institutional Source Beutler Lab
Gene Symbol Or5k15
Ensembl Gene ENSMUSG00000044029
Gene Name olfactory receptor family 5 subfamily J member 15
Synonyms MOR184-6, Olfr178, GA_x54KRFPKG5P-55108059-55107100
MMRRC Submission 041754-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R4502 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 58709622-58710581 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58710539 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 15 (I15V)
Ref Sequence ENSEMBL: ENSMUSP00000148922 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058564] [ENSMUST00000206523] [ENSMUST00000215032]
AlphaFold E9Q9T3
Predicted Effect probably benign
Transcript: ENSMUST00000058564
AA Change: I15V

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000049578
Gene: ENSMUSG00000044029
AA Change: I15V

DomainStartEndE-ValueType
Pfam:7tm_4 33 306 1.2e-49 PFAM
Pfam:7TM_GPCR_Srsx 37 262 4.4e-7 PFAM
Pfam:7tm_1 43 312 5.2e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206523
AA Change: I15V

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000215032
AA Change: I15V

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtr1b A C 3: 20,369,962 (GRCm39) Y215D probably damaging Het
Arf5 T C 6: 28,425,775 (GRCm39) V123A possibly damaging Het
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 117,721,122 (GRCm39) probably benign Het
Atm A G 9: 53,407,246 (GRCm39) V1164A possibly damaging Het
Atp6v0d1 A G 8: 106,292,430 (GRCm39) C39R probably damaging Het
Bmp8a T A 4: 123,236,192 (GRCm39) S104C probably damaging Het
Cand1 T C 10: 119,052,572 (GRCm39) T185A probably benign Het
Ccdc171 A G 4: 83,782,560 (GRCm39) E1284G probably damaging Het
Chodl A G 16: 78,728,332 (GRCm39) S26G possibly damaging Het
Cic C T 7: 24,987,892 (GRCm39) P620S probably damaging Het
Col3a1 T C 1: 45,387,837 (GRCm39) probably benign Het
Dpyd G T 3: 118,591,186 (GRCm39) G225C probably damaging Het
Dst G A 1: 34,286,772 (GRCm39) V5560M probably damaging Het
Eea1 G A 10: 95,875,427 (GRCm39) E1233K probably benign Het
Fryl T C 5: 73,245,740 (GRCm39) D1139G probably damaging Het
Gpr39 G A 1: 125,605,728 (GRCm39) V219I probably benign Het
Hc T C 2: 34,896,264 (GRCm39) D1173G probably benign Het
Htr2a T A 14: 74,879,428 (GRCm39) M19K probably benign Het
Kank4 G A 4: 98,665,335 (GRCm39) S653L possibly damaging Het
Kcnt2 G T 1: 140,435,485 (GRCm39) C484F probably damaging Het
Kdm1b C T 13: 47,216,553 (GRCm39) R308W probably damaging Het
Klhl1 A G 14: 96,755,282 (GRCm39) S158P probably benign Het
Ldb2 T C 5: 44,826,749 (GRCm39) D62G probably damaging Het
Ldhb T C 6: 142,436,183 (GRCm39) K329E possibly damaging Het
Mtmr7 T C 8: 41,011,203 (GRCm39) E285G possibly damaging Het
Or2p2 A T 13: 21,256,916 (GRCm39) I185N probably damaging Het
Or6aa1 T A 7: 86,044,485 (GRCm39) T74S possibly damaging Het
Pi4kb T A 3: 94,903,918 (GRCm39) H501Q probably benign Het
Ppargc1b T C 18: 61,435,750 (GRCm39) K910R probably benign Het
Ppp1r12a G T 10: 108,085,339 (GRCm39) R428I probably benign Het
Rbbp8nl G T 2: 179,920,989 (GRCm39) T465N possibly damaging Het
Rpl5 T C 5: 108,052,723 (GRCm39) F223S possibly damaging Het
Scpep1 T C 11: 88,835,211 (GRCm39) K154R probably benign Het
Sil1 T C 18: 35,450,928 (GRCm39) Y249C probably benign Het
Slc12a1 T A 2: 125,067,964 (GRCm39) L1017Q probably damaging Het
Slc2a9 T C 5: 38,556,154 (GRCm39) N264S probably benign Het
Slc49a4 T C 16: 35,539,787 (GRCm39) M345V probably benign Het
Tdrd5 T A 1: 156,128,334 (GRCm39) M141L probably benign Het
Tdrd9 T C 12: 111,960,259 (GRCm39) C182R probably damaging Het
Thap4 T C 1: 93,678,709 (GRCm39) probably null Het
Tmem131 T C 1: 36,864,560 (GRCm39) T558A probably benign Het
Tnks1bp1 C T 2: 84,892,991 (GRCm39) R973* probably null Het
Ulk3 A G 9: 57,500,512 (GRCm39) Y307C probably damaging Het
Usp25 T C 16: 76,912,284 (GRCm39) L1001P probably damaging Het
Vmn2r80 A T 10: 78,984,764 (GRCm39) T39S probably benign Het
Vps33b G A 7: 79,937,655 (GRCm39) A468T possibly damaging Het
Wnt9a T C 11: 59,219,363 (GRCm39) S130P probably damaging Het
Zfp236 T C 18: 82,655,079 (GRCm39) E730G probably benign Het
Zfp689 C A 7: 127,047,925 (GRCm39) V36L probably benign Het
Zfp938 A G 10: 82,062,105 (GRCm39) S172P possibly damaging Het
Other mutations in Or5k15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Or5k15 APN 16 58,710,048 (GRCm39) missense probably damaging 0.97
IGL01964:Or5k15 APN 16 58,709,827 (GRCm39) missense probably damaging 0.97
IGL02122:Or5k15 APN 16 58,710,134 (GRCm39) missense probably benign
IGL02183:Or5k15 APN 16 58,710,184 (GRCm39) missense probably benign 0.00
IGL03143:Or5k15 APN 16 58,709,824 (GRCm39) missense probably damaging 1.00
R1566:Or5k15 UTSW 16 58,709,903 (GRCm39) missense probably damaging 1.00
R2324:Or5k15 UTSW 16 58,710,503 (GRCm39) missense probably benign
R2420:Or5k15 UTSW 16 58,710,328 (GRCm39) missense probably benign 0.00
R2421:Or5k15 UTSW 16 58,710,328 (GRCm39) missense probably benign 0.00
R2422:Or5k15 UTSW 16 58,710,328 (GRCm39) missense probably benign 0.00
R4256:Or5k15 UTSW 16 58,710,143 (GRCm39) missense probably benign 0.21
R4374:Or5k15 UTSW 16 58,710,242 (GRCm39) missense probably benign 0.13
R4503:Or5k15 UTSW 16 58,710,539 (GRCm39) missense probably benign 0.02
R4662:Or5k15 UTSW 16 58,710,287 (GRCm39) missense probably damaging 1.00
R4967:Or5k15 UTSW 16 58,709,957 (GRCm39) missense possibly damaging 0.48
R5206:Or5k15 UTSW 16 58,710,381 (GRCm39) missense probably damaging 0.99
R5285:Or5k15 UTSW 16 58,710,471 (GRCm39) nonsense probably null
R5477:Or5k15 UTSW 16 58,710,107 (GRCm39) missense probably benign 0.10
R5554:Or5k15 UTSW 16 58,710,169 (GRCm39) missense possibly damaging 0.95
R5723:Or5k15 UTSW 16 58,709,976 (GRCm39) nonsense probably null
R5725:Or5k15 UTSW 16 58,710,250 (GRCm39) missense possibly damaging 0.64
R6853:Or5k15 UTSW 16 58,710,122 (GRCm39) missense probably damaging 0.99
R6853:Or5k15 UTSW 16 58,710,121 (GRCm39) missense possibly damaging 0.64
R7238:Or5k15 UTSW 16 58,710,252 (GRCm39) missense probably damaging 1.00
R7554:Or5k15 UTSW 16 58,709,769 (GRCm39) missense probably benign 0.27
R7577:Or5k15 UTSW 16 58,709,629 (GRCm39) missense probably benign 0.22
R7787:Or5k15 UTSW 16 58,709,953 (GRCm39) missense probably benign
R8008:Or5k15 UTSW 16 58,710,251 (GRCm39) missense probably benign 0.13
R8140:Or5k15 UTSW 16 58,709,948 (GRCm39) missense probably benign 0.10
R8928:Or5k15 UTSW 16 58,709,750 (GRCm39) missense possibly damaging 0.75
R9082:Or5k15 UTSW 16 58,709,834 (GRCm39) missense probably damaging 1.00
R9285:Or5k15 UTSW 16 58,710,569 (GRCm39) nonsense probably null
R9414:Or5k15 UTSW 16 58,710,565 (GRCm39) missense probably benign 0.03
R9627:Or5k15 UTSW 16 58,709,771 (GRCm39) missense probably benign 0.01
R9745:Or5k15 UTSW 16 58,710,265 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTCCATCAGAGCCAGGTTG -3'
(R):5'- ACAATACCCATCTGTGCAATCTATG -3'

Sequencing Primer
(F):5'- CCAGGTTGCCCAGAAAGATGTAC -3'
(R):5'- ACCCATCTGTGCAATCTATGTATGG -3'
Posted On 2015-07-21