Incidental Mutation 'R4502:Usp25'
ID 331877
Institutional Source Beutler Lab
Gene Symbol Usp25
Ensembl Gene ENSMUSG00000022867
Gene Name ubiquitin specific peptidase 25
Synonyms
MMRRC Submission 041754-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4502 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 76810594-76913668 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 76912284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 1001 (L1001P)
Ref Sequence ENSEMBL: ENSMUSP00000023580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023580]
AlphaFold P57080
PDB Structure Solution Structure of RSGI RUH-013, a UBA domain in Mouse cDNA [SOLUTION NMR]
Predicted Effect probably damaging
Transcript: ENSMUST00000023580
AA Change: L1001P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023580
Gene: ENSMUSG00000022867
AA Change: L1001P

DomainStartEndE-ValueType
PDB:1VDL|A 1 67 2e-35 PDB
Blast:UBA 17 56 9e-16 BLAST
UIM 97 116 5.27e-3 SMART
Pfam:UIM 124 140 6.7e-3 PFAM
Pfam:UCH 168 655 9.3e-55 PFAM
Pfam:UCH_1 169 632 3.1e-14 PFAM
coiled coil region 685 714 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased severity of IL17-induced pulmonary inflammation and MOG-induced experimental autoimmune encephalomyelitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtr1b A C 3: 20,369,962 (GRCm39) Y215D probably damaging Het
Arf5 T C 6: 28,425,775 (GRCm39) V123A possibly damaging Het
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 117,721,122 (GRCm39) probably benign Het
Atm A G 9: 53,407,246 (GRCm39) V1164A possibly damaging Het
Atp6v0d1 A G 8: 106,292,430 (GRCm39) C39R probably damaging Het
Bmp8a T A 4: 123,236,192 (GRCm39) S104C probably damaging Het
Cand1 T C 10: 119,052,572 (GRCm39) T185A probably benign Het
Ccdc171 A G 4: 83,782,560 (GRCm39) E1284G probably damaging Het
Chodl A G 16: 78,728,332 (GRCm39) S26G possibly damaging Het
Cic C T 7: 24,987,892 (GRCm39) P620S probably damaging Het
Col3a1 T C 1: 45,387,837 (GRCm39) probably benign Het
Dpyd G T 3: 118,591,186 (GRCm39) G225C probably damaging Het
Dst G A 1: 34,286,772 (GRCm39) V5560M probably damaging Het
Eea1 G A 10: 95,875,427 (GRCm39) E1233K probably benign Het
Fryl T C 5: 73,245,740 (GRCm39) D1139G probably damaging Het
Gpr39 G A 1: 125,605,728 (GRCm39) V219I probably benign Het
Hc T C 2: 34,896,264 (GRCm39) D1173G probably benign Het
Htr2a T A 14: 74,879,428 (GRCm39) M19K probably benign Het
Kank4 G A 4: 98,665,335 (GRCm39) S653L possibly damaging Het
Kcnt2 G T 1: 140,435,485 (GRCm39) C484F probably damaging Het
Kdm1b C T 13: 47,216,553 (GRCm39) R308W probably damaging Het
Klhl1 A G 14: 96,755,282 (GRCm39) S158P probably benign Het
Ldb2 T C 5: 44,826,749 (GRCm39) D62G probably damaging Het
Ldhb T C 6: 142,436,183 (GRCm39) K329E possibly damaging Het
Mtmr7 T C 8: 41,011,203 (GRCm39) E285G possibly damaging Het
Or2p2 A T 13: 21,256,916 (GRCm39) I185N probably damaging Het
Or5k15 T C 16: 58,710,539 (GRCm39) I15V probably benign Het
Or6aa1 T A 7: 86,044,485 (GRCm39) T74S possibly damaging Het
Pi4kb T A 3: 94,903,918 (GRCm39) H501Q probably benign Het
Ppargc1b T C 18: 61,435,750 (GRCm39) K910R probably benign Het
Ppp1r12a G T 10: 108,085,339 (GRCm39) R428I probably benign Het
Rbbp8nl G T 2: 179,920,989 (GRCm39) T465N possibly damaging Het
Rpl5 T C 5: 108,052,723 (GRCm39) F223S possibly damaging Het
Scpep1 T C 11: 88,835,211 (GRCm39) K154R probably benign Het
Sil1 T C 18: 35,450,928 (GRCm39) Y249C probably benign Het
Slc12a1 T A 2: 125,067,964 (GRCm39) L1017Q probably damaging Het
Slc2a9 T C 5: 38,556,154 (GRCm39) N264S probably benign Het
Slc49a4 T C 16: 35,539,787 (GRCm39) M345V probably benign Het
Tdrd5 T A 1: 156,128,334 (GRCm39) M141L probably benign Het
Tdrd9 T C 12: 111,960,259 (GRCm39) C182R probably damaging Het
Thap4 T C 1: 93,678,709 (GRCm39) probably null Het
Tmem131 T C 1: 36,864,560 (GRCm39) T558A probably benign Het
Tnks1bp1 C T 2: 84,892,991 (GRCm39) R973* probably null Het
Ulk3 A G 9: 57,500,512 (GRCm39) Y307C probably damaging Het
Vmn2r80 A T 10: 78,984,764 (GRCm39) T39S probably benign Het
Vps33b G A 7: 79,937,655 (GRCm39) A468T possibly damaging Het
Wnt9a T C 11: 59,219,363 (GRCm39) S130P probably damaging Het
Zfp236 T C 18: 82,655,079 (GRCm39) E730G probably benign Het
Zfp689 C A 7: 127,047,925 (GRCm39) V36L probably benign Het
Zfp938 A G 10: 82,062,105 (GRCm39) S172P possibly damaging Het
Other mutations in Usp25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00846:Usp25 APN 16 76,859,293 (GRCm39) missense probably damaging 1.00
IGL01359:Usp25 APN 16 76,856,141 (GRCm39) missense probably damaging 1.00
IGL01380:Usp25 APN 16 76,890,566 (GRCm39) missense probably benign 0.06
IGL01614:Usp25 APN 16 76,874,005 (GRCm39) missense probably damaging 1.00
IGL02065:Usp25 APN 16 76,880,670 (GRCm39) missense probably benign 0.06
IGL02271:Usp25 APN 16 76,912,335 (GRCm39) missense probably damaging 1.00
IGL03184:Usp25 APN 16 76,878,541 (GRCm39) missense probably damaging 1.00
IGL03046:Usp25 UTSW 16 76,871,754 (GRCm39) missense probably damaging 1.00
R0433:Usp25 UTSW 16 76,906,105 (GRCm39) missense probably benign 0.02
R0741:Usp25 UTSW 16 76,868,596 (GRCm39) missense possibly damaging 0.80
R0944:Usp25 UTSW 16 76,878,335 (GRCm39) splice site probably benign
R1324:Usp25 UTSW 16 76,877,275 (GRCm39) missense probably damaging 0.98
R1341:Usp25 UTSW 16 76,912,331 (GRCm39) missense probably benign
R1373:Usp25 UTSW 16 76,859,273 (GRCm39) splice site probably benign
R1641:Usp25 UTSW 16 76,868,559 (GRCm39) missense possibly damaging 0.89
R1777:Usp25 UTSW 16 76,878,442 (GRCm39) missense probably damaging 1.00
R1813:Usp25 UTSW 16 76,911,838 (GRCm39) missense probably benign 0.00
R1960:Usp25 UTSW 16 76,873,259 (GRCm39) missense probably damaging 1.00
R2256:Usp25 UTSW 16 76,910,682 (GRCm39) missense probably benign
R2271:Usp25 UTSW 16 76,873,317 (GRCm39) missense probably damaging 0.97
R4404:Usp25 UTSW 16 76,912,341 (GRCm39) missense probably damaging 1.00
R4408:Usp25 UTSW 16 76,912,341 (GRCm39) missense probably damaging 1.00
R4604:Usp25 UTSW 16 76,912,303 (GRCm39) missense probably damaging 1.00
R4612:Usp25 UTSW 16 76,830,833 (GRCm39) missense possibly damaging 0.92
R4744:Usp25 UTSW 16 76,911,877 (GRCm39) missense probably damaging 1.00
R4867:Usp25 UTSW 16 76,847,355 (GRCm39) missense probably damaging 1.00
R4932:Usp25 UTSW 16 76,830,870 (GRCm39) critical splice donor site probably null
R5087:Usp25 UTSW 16 76,874,007 (GRCm39) missense probably benign 0.00
R5165:Usp25 UTSW 16 76,873,293 (GRCm39) missense possibly damaging 0.85
R5184:Usp25 UTSW 16 76,906,115 (GRCm39) missense probably benign 0.00
R5307:Usp25 UTSW 16 76,890,594 (GRCm39) missense probably benign
R5331:Usp25 UTSW 16 76,847,446 (GRCm39) missense probably damaging 1.00
R5355:Usp25 UTSW 16 76,847,342 (GRCm39) missense probably damaging 1.00
R5479:Usp25 UTSW 16 76,904,801 (GRCm39) missense possibly damaging 0.51
R5619:Usp25 UTSW 16 76,830,833 (GRCm39) missense probably benign 0.22
R5646:Usp25 UTSW 16 76,847,360 (GRCm39) missense probably benign 0.34
R5946:Usp25 UTSW 16 76,911,942 (GRCm39) nonsense probably null
R6013:Usp25 UTSW 16 76,873,909 (GRCm39) missense probably benign 0.00
R6418:Usp25 UTSW 16 76,859,330 (GRCm39) missense probably damaging 1.00
R6653:Usp25 UTSW 16 76,856,176 (GRCm39) missense probably benign 0.29
R6709:Usp25 UTSW 16 76,880,820 (GRCm39) missense probably benign
R6987:Usp25 UTSW 16 76,874,068 (GRCm39) missense probably damaging 1.00
R7418:Usp25 UTSW 16 76,910,730 (GRCm39) nonsense probably null
R7500:Usp25 UTSW 16 76,874,089 (GRCm39) missense probably damaging 1.00
R7886:Usp25 UTSW 16 76,910,659 (GRCm39) missense probably damaging 0.99
R7961:Usp25 UTSW 16 76,856,150 (GRCm39) missense probably damaging 1.00
R8005:Usp25 UTSW 16 76,873,956 (GRCm39) missense probably benign
R8046:Usp25 UTSW 16 76,906,063 (GRCm39) missense probably damaging 1.00
R8069:Usp25 UTSW 16 76,865,943 (GRCm39) missense possibly damaging 0.58
R8140:Usp25 UTSW 16 76,868,569 (GRCm39) nonsense probably null
R8167:Usp25 UTSW 16 76,904,819 (GRCm39) missense probably damaging 1.00
R8437:Usp25 UTSW 16 76,830,800 (GRCm39) missense probably damaging 1.00
R8704:Usp25 UTSW 16 76,856,178 (GRCm39) missense probably benign 0.00
R8903:Usp25 UTSW 16 76,878,421 (GRCm39) missense probably damaging 1.00
R9123:Usp25 UTSW 16 76,911,969 (GRCm39) critical splice donor site probably null
R9276:Usp25 UTSW 16 76,910,721 (GRCm39) missense probably benign 0.09
R9286:Usp25 UTSW 16 76,904,864 (GRCm39) missense probably damaging 1.00
R9368:Usp25 UTSW 16 76,904,843 (GRCm39) missense probably damaging 1.00
R9489:Usp25 UTSW 16 76,874,046 (GRCm39) missense probably damaging 1.00
R9515:Usp25 UTSW 16 76,852,076 (GRCm39) missense probably damaging 1.00
R9516:Usp25 UTSW 16 76,852,076 (GRCm39) missense probably damaging 1.00
R9580:Usp25 UTSW 16 76,880,682 (GRCm39) missense probably benign 0.00
R9605:Usp25 UTSW 16 76,874,046 (GRCm39) missense probably damaging 1.00
R9667:Usp25 UTSW 16 76,874,123 (GRCm39) critical splice donor site probably null
X0065:Usp25 UTSW 16 76,878,444 (GRCm39) missense probably damaging 1.00
Z1176:Usp25 UTSW 16 76,878,409 (GRCm39) missense probably damaging 1.00
Z1176:Usp25 UTSW 16 76,868,680 (GRCm39) missense possibly damaging 0.93
Z1176:Usp25 UTSW 16 76,868,679 (GRCm39) missense probably damaging 0.98
Z1176:Usp25 UTSW 16 76,910,718 (GRCm39) missense probably benign
Z1176:Usp25 UTSW 16 76,880,801 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CCGTTACAAGCTAGCAAGTGC -3'
(R):5'- TGAGAACAGAGTTTCTATGGTGACC -3'

Sequencing Primer
(F):5'- AGCAAGTGCACATTTCCGTTG -3'
(R):5'- CTATGGTGACCCTGGGAAGTC -3'
Posted On 2015-07-21