Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00465:Zfp658'

332122

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp658

Ensembl Gene

ENSMUSG00000056592

Gene Name

zinc finger protein 658

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00465

Quality Score

Status

Chromosome

Chromosomal Location

43211680-43224885 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 43216780 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 50 (D50G)

Ref Sequence

ENSEMBL: ENSMUSP00000103606 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000005597] [ENSMUST00000107972]

AlphaFold

Q5PPQ4

Predicted Effect

probably benign
Transcript: ENSMUST00000005597
AA Change: D50G

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000005597
Gene: ENSMUSG00000056592
AA Change: D50G

Domain	Start	End	E-Value	Type
KRAB	23	83	3.7e-27	SMART
ZnF_C2H2	276	295	8.84e1	SMART
ZnF_C2H2	301	323	5.81e-2	SMART
ZnF_C2H2	328	350	1.5e-4	SMART
ZnF_C2H2	356	378	1.84e-4	SMART
ZnF_C2H2	384	406	3.16e-3	SMART
ZnF_C2H2	412	434	1.45e-2	SMART
ZnF_C2H2	440	462	4.87e-4	SMART
ZnF_C2H2	468	490	4.87e-4	SMART
ZnF_C2H2	496	518	6.88e-4	SMART
ZnF_C2H2	524	546	1.69e-3	SMART
ZnF_C2H2	552	574	9.73e-4	SMART
ZnF_C2H2	580	602	1.82e-3	SMART
ZnF_C2H2	608	630	3.16e-3	SMART
ZnF_C2H2	636	658	8.94e-3	SMART
ZnF_C2H2	664	686	3.74e-5	SMART
ZnF_C2H2	692	714	2.99e-4	SMART
ZnF_C2H2	720	742	5.21e-4	SMART
ZnF_C2H2	748	770	2.79e-4	SMART
ZnF_C2H2	776	798	1.58e-3	SMART
ZnF_C2H2	804	826	3.44e-4	SMART
ZnF_C2H2	832	854	5.59e-4	SMART
ZnF_C2H2	860	882	5.81e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000107972
AA Change: D50G

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000103606
Gene: ENSMUSG00000056592
AA Change: D50G

Domain	Start	End	E-Value	Type
KRAB	23	83	3.7e-27	SMART
ZnF_C2H2	276	295	8.84e1	SMART
ZnF_C2H2	301	323	5.81e-2	SMART
ZnF_C2H2	328	350	1.5e-4	SMART
ZnF_C2H2	356	378	1.84e-4	SMART
ZnF_C2H2	384	406	3.16e-3	SMART
ZnF_C2H2	412	434	1.45e-2	SMART
ZnF_C2H2	440	462	4.87e-4	SMART
ZnF_C2H2	468	490	4.87e-4	SMART
ZnF_C2H2	496	518	6.88e-4	SMART
ZnF_C2H2	524	546	1.69e-3	SMART
ZnF_C2H2	552	574	9.73e-4	SMART
ZnF_C2H2	580	602	1.82e-3	SMART
ZnF_C2H2	608	630	3.16e-3	SMART
ZnF_C2H2	636	658	8.94e-3	SMART
ZnF_C2H2	664	686	3.74e-5	SMART
ZnF_C2H2	692	714	2.99e-4	SMART
ZnF_C2H2	720	742	5.21e-4	SMART
ZnF_C2H2	748	770	2.79e-4	SMART
ZnF_C2H2	776	798	1.58e-3	SMART
ZnF_C2H2	804	826	3.44e-4	SMART
ZnF_C2H2	832	854	5.59e-4	SMART
ZnF_C2H2	860	882	5.81e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1bg	A	T	15: 60,793,102 (GRCm39)	S2T	probably damaging	Het
Adamts13	T	A	2: 26,863,567 (GRCm39)	W7R	probably benign	Het
Anks6	T	A	4: 47,046,054 (GRCm39)	D279V	probably damaging	Het
C4bp	A	T	1: 130,566,871 (GRCm39)	L335Q	probably damaging	Het
Cd109	A	T	9: 78,568,216 (GRCm39)	K299*	probably null	Het
Cd200r2	A	T	16: 44,729,651 (GRCm39)	H102L	probably damaging	Het
Col12a1	A	G	9: 79,604,863 (GRCm39)	Y662H	probably damaging	Het
Cyp2c37	T	C	19: 39,990,441 (GRCm39)	F380L	probably benign	Het
Deup1	A	G	9: 15,472,666 (GRCm39)	S549P	probably damaging	Het
Dysf	G	T	6: 84,176,830 (GRCm39)		probably null	Het
Etaa1	A	T	11: 17,897,825 (GRCm39)	C166*	probably null	Het
Fam227b	T	C	2: 125,986,245 (GRCm39)		probably null	Het
Gucy1b2	T	G	14: 62,640,649 (GRCm39)	Q752P	probably benign	Het
Hal	T	C	10: 93,325,931 (GRCm39)		probably null	Het
Hao1	C	A	2: 134,396,190 (GRCm39)	K21N	probably damaging	Het
Itga4	T	C	2: 79,122,394 (GRCm39)	F536L	probably benign	Het
Lmod3	A	T	6: 97,224,822 (GRCm39)	I333N	probably damaging	Het
Mgme1	T	A	2: 144,121,436 (GRCm39)	D297E	probably damaging	Het
Myh2	G	T	11: 67,069,659 (GRCm39)		probably benign	Het
Myo7a	A	G	7: 97,751,833 (GRCm39)	M70T	probably damaging	Het
Nav3	T	C	10: 109,688,607 (GRCm39)	T557A	probably damaging	Het
Nif3l1	C	A	1: 58,494,845 (GRCm39)	H271Q	possibly damaging	Het
Nostrin	A	G	2: 69,015,898 (GRCm39)		probably benign	Het
Nxn	C	A	11: 76,165,481 (GRCm39)		probably benign	Het
Pcdhb22	A	T	18: 37,653,185 (GRCm39)	D551V	probably damaging	Het
Pde4d	A	G	13: 110,073,221 (GRCm39)	D339G	possibly damaging	Het
Pkp4	T	A	2: 59,169,099 (GRCm39)	S408T	probably damaging	Het
Pxmp2	T	C	5: 110,431,582 (GRCm39)	T54A	probably benign	Het
Rif1	T	A	2: 52,011,019 (GRCm39)	V2362E	probably damaging	Het
Rps6kl1	A	G	12: 85,186,203 (GRCm39)	S276P	probably benign	Het
Scaf4	C	A	16: 90,044,169 (GRCm39)	M601I	unknown	Het
Scart2	A	G	7: 139,874,755 (GRCm39)	Y411C	probably damaging	Het
Setd7	T	A	3: 51,457,729 (GRCm39)	T33S	probably benign	Het
Shroom1	T	A	11: 53,354,921 (GRCm39)	D280E	probably benign	Het
Slc35f2	G	T	9: 53,705,298 (GRCm39)		probably null	Het
Slitrk3	T	A	3: 72,958,436 (GRCm39)	N112I	probably damaging	Het
Spag1	A	G	15: 36,183,967 (GRCm39)		probably benign	Het
Stx6	C	T	1: 155,077,679 (GRCm39)		probably benign	Het
Sun1	A	T	5: 139,220,440 (GRCm39)		probably null	Het
Tbl1xr1	G	A	3: 22,246,432 (GRCm39)		probably null	Het
Tmc2	T	C	2: 130,103,224 (GRCm39)	S787P	possibly damaging	Het
Traf3ip3	C	T	1: 192,877,128 (GRCm39)		probably benign	Het
Trip12	T	G	1: 84,741,582 (GRCm39)	H559P	probably damaging	Het
Trpm1	G	T	7: 63,897,215 (GRCm39)	M272I	possibly damaging	Het
Ttc21b	T	C	2: 66,073,119 (GRCm39)	E189G	probably benign	Het
Tubd1	T	C	11: 86,445,894 (GRCm39)		probably benign	Het
Vps13a	T	A	19: 16,729,539 (GRCm39)	T167S	probably damaging	Het
Zbtb3	A	G	19: 8,781,029 (GRCm39)	D214G	possibly damaging	Het
Zfp976	T	A	7: 42,263,109 (GRCm39)	I243L	unknown	Het

Other mutations in Zfp658

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00475:Zfp658	APN	7	43,223,500 (GRCm39)	missense	possibly damaging	0.68
IGL01972:Zfp658	APN	7	43,222,134 (GRCm39)	nonsense	probably null
IGL03223:Zfp658	APN	7	43,216,735 (GRCm39)	missense	possibly damaging	0.85
R0135:Zfp658	UTSW	7	43,223,019 (GRCm39)	nonsense	probably null
R1863:Zfp658	UTSW	7	43,223,323 (GRCm39)	missense	possibly damaging	0.78
R1962:Zfp658	UTSW	7	43,223,245 (GRCm39)	missense	possibly damaging	0.93
R2698:Zfp658	UTSW	7	43,222,969 (GRCm39)	missense	possibly damaging	0.53
R3781:Zfp658	UTSW	7	43,223,270 (GRCm39)	missense	probably benign
R4791:Zfp658	UTSW	7	43,223,890 (GRCm39)	missense	possibly damaging	0.93
R5392:Zfp658	UTSW	7	43,222,355 (GRCm39)	missense	probably benign	0.07
R6092:Zfp658	UTSW	7	43,223,951 (GRCm39)	missense	possibly damaging	0.73
R6594:Zfp658	UTSW	7	43,216,701 (GRCm39)	missense	possibly damaging	0.86
R7003:Zfp658	UTSW	7	43,224,172 (GRCm39)	missense	possibly damaging	0.85
R7008:Zfp658	UTSW	7	43,223,336 (GRCm39)	missense	possibly damaging	0.95
R7077:Zfp658	UTSW	7	43,223,413 (GRCm39)	missense	probably benign	0.32
R7689:Zfp658	UTSW	7	43,224,102 (GRCm39)	missense	probably benign	0.00
R7793:Zfp658	UTSW	7	43,224,108 (GRCm39)	missense	possibly damaging	0.74
R7939:Zfp658	UTSW	7	43,224,301 (GRCm39)	missense	possibly damaging	0.73
R8672:Zfp658	UTSW	7	43,222,919 (GRCm39)	missense	possibly damaging	0.52
R8828:Zfp658	UTSW	7	43,222,240 (GRCm39)	missense	probably benign
R8995:Zfp658	UTSW	7	43,222,798 (GRCm39)	missense	possibly damaging	0.93
R9021:Zfp658	UTSW	7	43,223,381 (GRCm39)	missense	possibly damaging	0.71
R9259:Zfp658	UTSW	7	43,224,280 (GRCm39)	missense	probably benign	0.02
R9551:Zfp658	UTSW	7	43,222,567 (GRCm39)	missense	probably benign	0.00
R9552:Zfp658	UTSW	7	43,222,567 (GRCm39)	missense	probably benign	0.00
R9571:Zfp658	UTSW	7	43,222,139 (GRCm39)	missense	possibly damaging	0.85
Z1176:Zfp658	UTSW	7	43,222,641 (GRCm39)	missense	possibly damaging	0.72

Posted On

2015-08-05