Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00426:Trav19'

332385

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trav19

Ensembl Gene

ENSMUSG00000076862

Gene Name

T cell receptor alpha variable 19

Synonyms

Gm13893

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

IGL00426

Quality Score

Status

Chromosome

Chromosomal Location

54082779-54083284 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 54083141 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 72 (L72P)

Ref Sequence

ENSEMBL: ENSMUSP00000100451 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103674]

AlphaFold

A0A0B4J1K4

Predicted Effect

probably damaging
Transcript: ENSMUST00000103674
AA Change: L72P

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000100451
Gene: ENSMUSG00000076862
AA Change: L72P

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGv	44	118	4.26e-7	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A830018L16Rik	G	A	1: 11,818,278 (GRCm39)	E313K	probably damaging	Het
Aadacl2fm2	T	A	3: 59,659,542 (GRCm39)	L332I	possibly damaging	Het
Adgrl2	A	G	3: 148,571,244 (GRCm39)	V130A	probably damaging	Het
Arhgef28	G	A	13: 98,124,785 (GRCm39)	A499V	probably benign	Het
Ceacam18	C	T	7: 43,288,780 (GRCm39)	T177I	probably benign	Het
Cspp1	G	A	1: 10,182,776 (GRCm39)		probably benign	Het
Cyp2j7	A	T	4: 96,115,749 (GRCm39)		probably benign	Het
Cyp2j7	C	T	4: 96,115,750 (GRCm39)		probably null	Het
Dip2c	T	C	13: 9,656,551 (GRCm39)	F821L	probably damaging	Het
Lrig3	A	T	10: 125,808,006 (GRCm39)	R85*	probably null	Het
Mcf2l	A	G	8: 13,034,910 (GRCm39)	D106G	probably damaging	Het
Mdn1	T	C	4: 32,719,214 (GRCm39)	V2259A	possibly damaging	Het
Mmp16	C	T	4: 18,011,784 (GRCm39)	P233L	probably benign	Het
Mrpl27	A	G	11: 94,550,523 (GRCm39)	N110S	probably benign	Het
Myom2	T	C	8: 15,119,502 (GRCm39)	M131T	probably benign	Het
Myzap	T	C	9: 71,462,953 (GRCm39)	T198A	probably benign	Het
Nek8	T	C	11: 78,058,653 (GRCm39)	Q549R	probably damaging	Het
Nr1d2	A	G	14: 18,215,502 (GRCm38)		probably benign	Het
Nup155	T	C	15: 8,186,278 (GRCm39)	*1347Q	probably null	Het
Pkd2l1	C	T	19: 44,144,044 (GRCm39)	R343H	probably benign	Het
Ppfibp2	T	A	7: 107,308,012 (GRCm39)	L215H	probably damaging	Het
Ralgds	T	C	2: 28,442,230 (GRCm39)	L137P	probably damaging	Het
Rasa2	C	T	9: 96,426,913 (GRCm39)	D752N	probably damaging	Het
Spg11	T	C	2: 121,896,041 (GRCm39)	K1726E	probably damaging	Het
St6gal1	G	A	16: 23,175,142 (GRCm39)		probably benign	Het
Tmem183a	A	G	1: 134,277,882 (GRCm39)	L294P	probably damaging	Het
Vapa	T	C	17: 65,900,476 (GRCm39)	T99A	possibly damaging	Het

Other mutations in Trav19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01413:Trav19	APN	14	54,083,072 (GRCm39)	missense	probably damaging	1.00
IGL01873:Trav19	APN	14	54,083,173 (GRCm39)	missense	probably benign	0.00
R5725:Trav19	UTSW	14	54,082,999 (GRCm39)	missense	possibly damaging	0.55
R6127:Trav19	UTSW	14	54,082,999 (GRCm39)	missense	probably benign	0.02
R6272:Trav19	UTSW	14	54,083,255 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-08-05