Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00473:Zfp978'

332439

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp978

Ensembl Gene

ENSMUSG00000078497

Gene Name

zinc finger protein 978

Synonyms

Gm13145

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL00473

Quality Score

Status

Chromosome

Chromosomal Location

147445760-147475461 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 147475317 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 288 (N288S)

Ref Sequence

ENSEMBL: ENSMUSP00000114248 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000133078] [ENSMUST00000154154]

AlphaFold

A2A7I1

Predicted Effect

probably benign
Transcript: ENSMUST00000133078

SMART Domains

Protein: ENSMUSP00000115135
Gene: ENSMUSG00000078497

Domain	Start	End	E-Value	Type
KRAB	28	88	5.93e-17	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000154154
AA Change: N288S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000114248
Gene: ENSMUSG00000078497
AA Change: N288S

Domain	Start	End	E-Value	Type
KRAB	28	88	5.93e-17	SMART
low complexity region	104	116	N/A	INTRINSIC
internal_repeat_1	129	223	3.63e-6	PROSPERO
ZnF_C2H2	257	279	7.9e-4	SMART
ZnF_C2H2	285	307	3.49e-5	SMART
ZnF_C2H2	313	335	1.03e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181486

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181752

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arcn1	A	G	9: 44,668,444 (GRCm39)	V264A	probably benign	Het
Asap1	T	C	15: 64,045,064 (GRCm39)		probably benign	Het
Brpf1	A	C	6: 113,293,645 (GRCm39)	Q571H	probably damaging	Het
C9orf72	C	T	4: 35,213,616 (GRCm39)	G178E	possibly damaging	Het
Creb3	G	T	4: 43,565,517 (GRCm39)	R232L	probably benign	Het
Cst5	G	T	2: 149,247,293 (GRCm39)	S3I	unknown	Het
Cyp4a14	A	G	4: 115,347,149 (GRCm39)		probably benign	Het
Daxx	C	T	17: 34,130,581 (GRCm39)	Q199*	probably null	Het
Eml5	A	G	12: 98,771,751 (GRCm39)		probably benign	Het
Gbp6	T	A	5: 105,422,145 (GRCm39)	K520*	probably null	Het
Gcfc2	T	A	6: 81,921,355 (GRCm39)	C454S	probably damaging	Het
Gm9894	T	A	13: 67,913,236 (GRCm39)		noncoding transcript	Het
Gpr15	C	T	16: 58,538,441 (GRCm39)	C216Y	probably damaging	Het
Gzmn	T	C	14: 56,404,436 (GRCm39)	K134E	probably benign	Het
Kat2b	T	G	17: 53,970,651 (GRCm39)	I679S	possibly damaging	Het
Klhl10	A	G	11: 100,347,240 (GRCm39)	Y478C	probably damaging	Het
Mapt	A	G	11: 104,178,009 (GRCm39)	D54G	probably damaging	Het
Mocs1	A	G	17: 49,740,229 (GRCm39)	E52G	probably benign	Het
Plekhn1	T	G	4: 156,307,820 (GRCm39)	T369P	probably damaging	Het
Prdm6	T	A	18: 53,673,357 (GRCm39)	F172L	probably benign	Het
Prl7b1	A	T	13: 27,788,573 (GRCm39)	V94D	probably damaging	Het
Rasal2	T	C	1: 156,975,387 (GRCm39)	T1116A	probably benign	Het
Rreb1	A	T	13: 38,114,767 (GRCm39)	K709*	probably null	Het
Ruvbl1	A	T	6: 88,468,550 (GRCm39)	R357W	probably damaging	Het
Slc4a5	T	C	6: 83,273,579 (GRCm39)	L973P	probably damaging	Het
Srp72	A	G	5: 77,132,023 (GRCm39)	Y234C	probably damaging	Het
Synrg	G	A	11: 83,930,072 (GRCm39)	M1070I	probably damaging	Het
Zan	A	T	5: 137,462,512 (GRCm39)	I889K	possibly damaging	Het
Zbtb40	G	A	4: 136,714,651 (GRCm39)	T1046M	probably damaging	Het
Zfpm2	A	T	15: 40,962,683 (GRCm39)	K247M	probably damaging	Het

Other mutations in Zfp978

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
FR4449:Zfp978	UTSW	4	147,475,401 (GRCm39)	missense	probably benign	0.00
R5157:Zfp978	UTSW	4	147,475,437 (GRCm39)	missense	probably damaging	1.00
R6806:Zfp978	UTSW	4	147,475,284 (GRCm39)	missense	probably benign	0.44
R7778:Zfp978	UTSW	4	147,469,760 (GRCm39)	critical splice donor site	probably null

Posted On

2015-08-05