Incidental Mutation 'IGL00556:Myo15b'
ID332598
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Myo15b
Ensembl Gene ENSMUSG00000034427
Gene Namemyosin XVB
SynonymsLOC217328, E330039G21Rik, LOC380737
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #IGL00556
Quality Score
Status
Chromosome11
Chromosomal Location115861612-115892592 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 115891916 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 434 (V434A)
Ref Sequence ENSEMBL: ENSMUSP00000129226 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093911] [ENSMUST00000167507]
Predicted Effect unknown
Transcript: ENSMUST00000093911
AA Change: V2956A
SMART Domains Protein: ENSMUSP00000091439
Gene: ENSMUSG00000034427
AA Change: V2956A

DomainStartEndE-ValueType
MYSc 1 640 2.4e-134 SMART
IQ 660 682 1.03e1 SMART
Pfam:MyTH4 837 945 2.1e-23 PFAM
low complexity region 1050 1068 N/A INTRINSIC
low complexity region 1136 1170 N/A INTRINSIC
low complexity region 1207 1246 N/A INTRINSIC
low complexity region 1302 1327 N/A INTRINSIC
low complexity region 1454 1468 N/A INTRINSIC
low complexity region 1489 1509 N/A INTRINSIC
SH3 1735 1792 1.15e-7 SMART
Pfam:MyTH4 1928 2029 8.3e-25 PFAM
B41 2032 2235 6.99e-4 SMART
low complexity region 2243 2253 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132447
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136774
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141947
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144824
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147172
Predicted Effect possibly damaging
Transcript: ENSMUST00000167507
AA Change: V434A

PolyPhen 2 Score 0.558 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000129226
Gene: ENSMUSG00000034427
AA Change: V434A

DomainStartEndE-ValueType
Pfam:MyTH4 100 205 3.1e-24 PFAM
B41 207 410 6.99e-4 SMART
low complexity region 418 428 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402H24Rik T C 2: 130,784,457 D356G probably benign Het
Abca12 T C 1: 71,353,757 I108V probably benign Het
Atad2 A G 15: 58,100,080 I1047T probably damaging Het
Cct4 T A 11: 22,997,656 V233E possibly damaging Het
Ces1a A G 8: 93,045,059 Y37H probably benign Het
Cgnl1 C T 9: 71,656,056 R863Q probably benign Het
Fam13b T C 18: 34,497,435 D90G probably damaging Het
Fhdc1 A T 3: 84,457,242 D232E possibly damaging Het
Gm6370 A G 5: 146,493,913 T303A probably benign Het
Gsdmc2 A G 15: 63,828,271 probably benign Het
Kif13b T A 14: 64,744,888 N516K probably damaging Het
Med1 A G 11: 98,155,684 S1429P unknown Het
Med4 T C 14: 73,517,267 M190T probably damaging Het
Neb T C 2: 52,191,949 R1722G probably benign Het
Obp2b A T 2: 25,738,581 I116F probably damaging Het
Rims2 A G 15: 39,456,674 probably null Het
Siglecg A T 7: 43,411,795 I431F probably benign Het
Thap12 T A 7: 98,716,137 V504D possibly damaging Het
Tlr7 A C X: 167,308,475 M5R possibly damaging Het
Tubgcp6 A G 15: 89,100,962 V1641A probably damaging Het
Ugt2b1 T A 5: 86,926,196 L101F probably benign Het
Xdh A T 17: 73,884,435 *1336R probably null Het
Other mutations in Myo15b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01409:Myo15b APN 11 115869504 nonsense probably null
IGL01539:Myo15b APN 11 115863473 missense unknown 0.00
IGL01895:Myo15b APN 11 115883498 missense probably benign 0.21
IGL02254:Myo15b APN 11 115886283 missense probably damaging 1.00
IGL02343:Myo15b APN 11 115873400 unclassified noncoding transcript
IGL02349:Myo15b APN 11 115863105 unclassified 0.00
IGL02368:Myo15b APN 11 115877002 unclassified noncoding transcript
IGL02576:Myo15b APN 11 115890053 missense probably null 0.96
IGL02650:Myo15b APN 11 115886511 unclassified probably null
IGL02661:Myo15b APN 11 115884069 missense probably benign
IGL02716:Myo15b APN 11 115883709 missense probably benign 0.00
IGL02733:Myo15b APN 11 115884250 missense probably benign
IGL02951:Myo15b APN 11 115881301 missense probably damaging 1.00
IGL03017:Myo15b APN 11 115887917 missense possibly damaging 0.86
IGL03029:Myo15b APN 11 115871643 missense unknown 0.00
ANU74:Myo15b UTSW 11 115878413 missense noncoding transcript
R0092:Myo15b UTSW 11 115862986 missense possibly damaging 0.94
R0255:Myo15b UTSW 11 115886283 missense probably damaging 1.00
R0325:Myo15b UTSW 11 115884265 missense probably damaging 1.00
R0614:Myo15b UTSW 11 115882913 missense probably damaging 1.00
R0652:Myo15b UTSW 11 115864642 missense possibly damaging 0.90
R0711:Myo15b UTSW 11 115883838 missense probably damaging 0.97
R0815:Myo15b UTSW 11 115866336 splice site probably benign
R0961:Myo15b UTSW 11 115882454 missense probably benign 0.00
R1066:Myo15b UTSW 11 115879751 missense noncoding transcript
R1221:Myo15b UTSW 11 115886720 missense possibly damaging 0.84
R1240:Myo15b UTSW 11 115880501 missense probably benign 0.18
R1275:Myo15b UTSW 11 115883492 small deletion probably benign
R1313:Myo15b UTSW 11 115885129 missense probably benign 0.17
R1313:Myo15b UTSW 11 115885129 missense probably benign 0.17
R1317:Myo15b UTSW 11 115883634 missense probably null 0.02
R1491:Myo15b UTSW 11 115886857 splice site probably null
R1552:Myo15b UTSW 11 115866635 missense probably damaging 1.00
R1731:Myo15b UTSW 11 115891560 missense possibly damaging 0.57
R1800:Myo15b UTSW 11 115880509 critical splice donor site probably null
R1843:Myo15b UTSW 11 115869586 missense probably benign 0.26
R1888:Myo15b UTSW 11 115887073 missense probably damaging 1.00
R1888:Myo15b UTSW 11 115887073 missense probably damaging 1.00
R1894:Myo15b UTSW 11 115887073 missense probably damaging 1.00
R1917:Myo15b UTSW 11 115882254 missense probably benign 0.19
R1934:Myo15b UTSW 11 115863484 missense probably damaging 0.96
R1939:Myo15b UTSW 11 115887703 missense probably benign 0.00
R1945:Myo15b UTSW 11 115878398 missense noncoding transcript
R1986:Myo15b UTSW 11 115882875 missense probably benign 0.01
R2130:Myo15b UTSW 11 115871643 missense probably benign 0.06
R2138:Myo15b UTSW 11 115883807 missense probably benign
R2176:Myo15b UTSW 11 115866572 missense probably damaging 0.99
R2415:Myo15b UTSW 11 115879564 missense probably benign 0.00
R2483:Myo15b UTSW 11 115864739 missense possibly damaging 0.59
R3620:Myo15b UTSW 11 115871187 missense probably benign 0.08
R3716:Myo15b UTSW 11 115863413 missense probably damaging 0.99
R4013:Myo15b UTSW 11 115871456 nonsense probably null
R4021:Myo15b UTSW 11 115873505 missense noncoding transcript
R4119:Myo15b UTSW 11 115873492 missense noncoding transcript
R4120:Myo15b UTSW 11 115873492 missense noncoding transcript
R4499:Myo15b UTSW 11 115890952 missense probably benign 0.00
R4653:Myo15b UTSW 11 115879987 critical splice donor site probably null
R4655:Myo15b UTSW 11 115890697 missense probably damaging 1.00
R4700:Myo15b UTSW 11 115861935 missense probably benign 0.03
R4702:Myo15b UTSW 11 115884008 missense probably benign
R4777:Myo15b UTSW 11 115879652 missense noncoding transcript
R4833:Myo15b UTSW 11 115887602 missense probably null 0.51
R5083:Myo15b UTSW 11 115866656 missense not run
R5121:Myo15b UTSW 11 115886054 missense probably damaging 1.00
R5146:Myo15b UTSW 11 115891198 missense probably benign 0.00
R5535:Myo15b UTSW 11 115881301 missense probably damaging 1.00
R5647:Myo15b UTSW 11 115871511 missense not run
R5849:Myo15b UTSW 11 115881933 missense probably damaging 1.00
R5882:Myo15b UTSW 11 115869596 missense not run
R5956:Myo15b UTSW 11 115873757 missense not run
R6273:Myo15b UTSW 11 115862799 missense not run
R6302:Myo15b UTSW 11 115886239 missense not run
R6318:Myo15b UTSW 11 115890831 missense probably damaging 1.00
R6462:Myo15b UTSW 11 115859442 missense not run
X0020:Myo15b UTSW 11 115871799 critical splice acceptor site probably null
Posted OnAug 05, 2015