Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00565:Map4'

332629

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Map4

Ensembl Gene

ENSMUSG00000032479

Gene Name

microtubule-associated protein 4

Synonyms

MAP 4, Mtap4

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00565

Quality Score

Status

Chromosome

Chromosomal Location

109760528-109913023 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 109901672 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143408 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035055] [ENSMUST00000163979] [ENSMUST00000164930] [ENSMUST00000165876] [ENSMUST00000198511] [ENSMUST00000199548] [ENSMUST00000199161] [ENSMUST00000199461] [ENSMUST00000199498]

AlphaFold

P27546

Predicted Effect

probably benign
Transcript: ENSMUST00000035055

SMART Domains

Protein: ENSMUSP00000035055
Gene: ENSMUSG00000032479

Domain	Start	End	E-Value	Type
low complexity region	254	265	N/A	INTRINSIC
internal_repeat_1	266	379	4.96e-7	PROSPERO
low complexity region	401	420	N/A	INTRINSIC
internal_repeat_1	439	550	4.96e-7	PROSPERO
low complexity region	659	674	N/A	INTRINSIC
low complexity region	720	742	N/A	INTRINSIC
low complexity region	760	775	N/A	INTRINSIC
low complexity region	879	889	N/A	INTRINSIC
Pfam:Tubulin-binding	903	926	2e-12	PFAM
Pfam:Tubulin-binding	965	995	4.9e-18	PFAM
Pfam:Tubulin-binding	996	1026	7.4e-18	PFAM
Pfam:Tubulin-binding	1027	1058	4.4e-15	PFAM
low complexity region	1093	1108	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000163190

Predicted Effect

probably benign
Transcript: ENSMUST00000163979

SMART Domains

Protein: ENSMUSP00000129362
Gene: ENSMUSG00000032479

Domain	Start	End	E-Value	Type
low complexity region	9	17	N/A	INTRINSIC
low complexity region	324	341	N/A	INTRINSIC
low complexity region	365	376	N/A	INTRINSIC
low complexity region	506	521	N/A	INTRINSIC
low complexity region	567	589	N/A	INTRINSIC
low complexity region	607	622	N/A	INTRINSIC
low complexity region	726	736	N/A	INTRINSIC
Pfam:Tubulin-binding	743	773	5.8e-16	PFAM
Pfam:Tubulin-binding	774	804	2.2e-18	PFAM
Pfam:Tubulin-binding	805	836	1.6e-11	PFAM
low complexity region	871	886	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000164930

SMART Domains

Protein: ENSMUSP00000131285
Gene: ENSMUSG00000032479

Domain	Start	End	E-Value	Type
low complexity region	9	17	N/A	INTRINSIC
low complexity region	324	341	N/A	INTRINSIC
low complexity region	365	376	N/A	INTRINSIC
low complexity region	506	521	N/A	INTRINSIC
low complexity region	567	589	N/A	INTRINSIC
low complexity region	607	622	N/A	INTRINSIC
low complexity region	726	736	N/A	INTRINSIC
Pfam:Tubulin-binding	743	773	6e-16	PFAM
Pfam:Tubulin-binding	774	804	4.5e-19	PFAM
Pfam:Tubulin-binding	805	835	2.3e-18	PFAM
Pfam:Tubulin-binding	836	867	1.6e-11	PFAM
low complexity region	902	917	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000165876

SMART Domains

Protein: ENSMUSP00000132662
Gene: ENSMUSG00000032479

Domain	Start	End	E-Value	Type
low complexity region	254	265	N/A	INTRINSIC
internal_repeat_1	266	379	4.95e-7	PROSPERO
low complexity region	401	420	N/A	INTRINSIC
internal_repeat_1	439	550	4.95e-7	PROSPERO
low complexity region	659	674	N/A	INTRINSIC
low complexity region	720	742	N/A	INTRINSIC
low complexity region	760	775	N/A	INTRINSIC
low complexity region	879	889	N/A	INTRINSIC
Pfam:Tubulin-binding	896	926	8.5e-16	PFAM
Pfam:Tubulin-binding	965	995	6.4e-19	PFAM
Pfam:Tubulin-binding	996	1026	3.3e-18	PFAM
Pfam:Tubulin-binding	1027	1058	2.3e-11	PFAM
low complexity region	1093	1108	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196763

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198185

Predicted Effect

probably benign
Transcript: ENSMUST00000198511

SMART Domains

Protein: ENSMUSP00000142558
Gene: ENSMUSG00000032479

Domain	Start	End	E-Value	Type
low complexity region	7	17	N/A	INTRINSIC
Pfam:Tubulin-binding	24	54	7.3e-14	PFAM
Pfam:Tubulin-binding	55	85	5.3e-17	PFAM
Pfam:Tubulin-binding	86	116	2.8e-16	PFAM
Pfam:Tubulin-binding	117	148	1.9e-9	PFAM
low complexity region	183	198	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000199548

SMART Domains

Protein: ENSMUSP00000143408
Gene: ENSMUSG00000032479

Domain	Start	End	E-Value	Type
low complexity region	99	109	N/A	INTRINSIC
Pfam:Tubulin-binding	116	146	1.1e-13	PFAM
Pfam:Tubulin-binding	147	177	7.9e-17	PFAM
Pfam:Tubulin-binding	178	208	4.1e-16	PFAM
Pfam:Tubulin-binding	209	240	2.8e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000199161

SMART Domains

Protein: ENSMUSP00000143205
Gene: ENSMUSG00000032479

Domain	Start	End	E-Value	Type
Pfam:Tubulin-binding	16	46	6.7e-14	PFAM
Pfam:Tubulin-binding	47	77	4.9e-17	PFAM
Pfam:Tubulin-binding	78	108	2.5e-16	PFAM
Pfam:Tubulin-binding	109	140	1.7e-9	PFAM
low complexity region	176	191	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000199461

SMART Domains

Protein: ENSMUSP00000143296
Gene: ENSMUSG00000032479

Domain	Start	End	E-Value	Type
low complexity region	99	109	N/A	INTRINSIC
Pfam:Tubulin-binding	116	146	1e-13	PFAM
Pfam:Tubulin-binding	147	177	3.8e-16	PFAM
Pfam:Tubulin-binding	178	209	2.6e-9	PFAM
low complexity region	244	259	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000199498

SMART Domains

Protein: ENSMUSP00000142439
Gene: ENSMUSG00000032479

Domain	Start	End	E-Value	Type
low complexity region	9	17	N/A	INTRINSIC
low complexity region	324	341	N/A	INTRINSIC
low complexity region	365	376	N/A	INTRINSIC
low complexity region	506	521	N/A	INTRINSIC
low complexity region	567	589	N/A	INTRINSIC
low complexity region	607	622	N/A	INTRINSIC
low complexity region	726	736	N/A	INTRINSIC
Pfam:Tubulin-binding	743	773	5.8e-16	PFAM
Pfam:Tubulin-binding	774	804	2.2e-18	PFAM
Pfam:Tubulin-binding	805	836	1.6e-11	PFAM
low complexity region	871	886	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
PHENOTYPE: Mice homozygous for a gene trapped allele are viable and do not display any overt phenotypic abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610021A01Rik	C	A	7: 41,274,996 (GRCm39)	T233K	possibly damaging	Het
Adamts9	A	T	6: 92,836,883 (GRCm39)	M623K	possibly damaging	Het
Arid1a	T	G	4: 133,412,793 (GRCm39)	D1467A	unknown	Het
Cdhr2	A	G	13: 54,866,112 (GRCm39)	D304G	probably damaging	Het
Cenpj	C	T	14: 56,790,487 (GRCm39)	V521I	probably benign	Het
Ciao2a	A	T	9: 66,039,898 (GRCm39)	I72L	probably benign	Het
Csf2rb	G	T	15: 78,232,714 (GRCm39)	E674*	probably null	Het
Dnai3	T	C	3: 145,750,674 (GRCm39)		probably benign	Het
Edaradd	C	T	13: 12,498,480 (GRCm39)		probably null	Het
Emilin2	A	G	17: 71,559,854 (GRCm39)	V1041A	possibly damaging	Het
Fam135b	A	G	15: 71,343,361 (GRCm39)	V418A	probably benign	Het
Gnas	T	A	2: 174,183,504 (GRCm39)		probably benign	Het
Grxcr1	A	T	5: 68,189,540 (GRCm39)	N104Y	possibly damaging	Het
Gtf2a1l	T	A	17: 89,001,723 (GRCm39)	L146Q	probably damaging	Het
Hectd1	T	A	12: 51,837,181 (GRCm39)	E791D	probably damaging	Het
Ifi203	A	G	1: 173,765,306 (GRCm39)		probably null	Het
Klk1b11	A	G	7: 43,649,243 (GRCm39)	N260S	probably damaging	Het
LTO1	G	T	7: 144,470,220 (GRCm39)	V50F	probably damaging	Het
Marveld2	C	T	13: 100,737,401 (GRCm39)	V163M	possibly damaging	Het
Med14	T	C	X: 12,613,003 (GRCm39)		probably benign	Het
Mex3b	A	T	7: 82,518,116 (GRCm39)	I144F	probably damaging	Het
Pde2a	T	A	7: 101,133,796 (GRCm39)	C92*	probably null	Het
Phf6	T	A	X: 52,020,516 (GRCm39)	Y103N	probably damaging	Het
Ptprt	A	G	2: 161,402,111 (GRCm39)	I1039T	probably damaging	Het
Rftn2	C	A	1: 55,243,444 (GRCm39)	V275F	probably damaging	Het
Skap1	C	A	11: 96,621,971 (GRCm39)	Q296K	probably damaging	Het
Skap1	T	A	11: 96,622,016 (GRCm39)	F311I	probably damaging	Het
Tas2r115	A	G	6: 132,714,741 (GRCm39)	I70T	probably benign	Het
Vav2	T	C	2: 27,167,250 (GRCm39)	D613G	probably benign	Het
Zranb3	T	C	1: 127,943,877 (GRCm39)	E290G	probably benign	Het

Other mutations in Map4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01331:Map4	APN	9	109,863,869 (GRCm39)	missense	probably benign	0.04
IGL01599:Map4	APN	9	109,863,836 (GRCm39)	missense	probably benign	0.26
IGL01631:Map4	APN	9	109,892,201 (GRCm39)	unclassified	probably benign
IGL02208:Map4	APN	9	109,807,938 (GRCm39)	start codon destroyed	probably null	1.00
IGL02455:Map4	APN	9	109,828,901 (GRCm39)	missense	probably benign	0.15
IGL02625:Map4	APN	9	109,893,485 (GRCm39)	missense	probably damaging	1.00
PIT4486001:Map4	UTSW	9	109,901,682 (GRCm39)	missense	probably damaging	1.00
R0149:Map4	UTSW	9	109,896,692 (GRCm39)	missense	probably damaging	0.96
R0384:Map4	UTSW	9	109,863,696 (GRCm39)	missense	probably damaging	0.99
R0392:Map4	UTSW	9	109,907,113 (GRCm39)	missense	probably damaging	1.00
R0496:Map4	UTSW	9	109,868,918 (GRCm39)	intron	probably benign
R0526:Map4	UTSW	9	109,866,346 (GRCm39)	splice site	probably null
R0555:Map4	UTSW	9	109,808,171 (GRCm39)	splice site	probably benign
R0571:Map4	UTSW	9	109,865,834 (GRCm39)	missense	probably benign	0.00
R0698:Map4	UTSW	9	109,897,856 (GRCm39)	nonsense	probably null
R0762:Map4	UTSW	9	109,867,546 (GRCm39)	intron	probably benign
R0862:Map4	UTSW	9	109,808,037 (GRCm39)	missense	probably damaging	1.00
R0864:Map4	UTSW	9	109,808,037 (GRCm39)	missense	probably damaging	1.00
R1168:Map4	UTSW	9	109,864,032 (GRCm39)	missense	probably benign	0.00
R1238:Map4	UTSW	9	109,897,648 (GRCm39)	missense	probably benign	0.00
R1735:Map4	UTSW	9	109,864,023 (GRCm39)	missense	probably benign	0.00
R1869:Map4	UTSW	9	109,897,996 (GRCm39)	missense	possibly damaging	0.95
R1869:Map4	UTSW	9	109,864,032 (GRCm39)	missense	probably benign	0.00
R2196:Map4	UTSW	9	109,900,116 (GRCm39)	missense	probably damaging	1.00
R2264:Map4	UTSW	9	109,910,525 (GRCm39)	missense	probably damaging	1.00
R2507:Map4	UTSW	9	109,866,551 (GRCm39)	intron	probably benign
R2512:Map4	UTSW	9	109,863,770 (GRCm39)	missense	possibly damaging	0.48
R3087:Map4	UTSW	9	109,882,257 (GRCm39)	missense	possibly damaging	0.84
R3154:Map4	UTSW	9	109,828,860 (GRCm39)	missense	probably benign	0.19
R3498:Map4	UTSW	9	109,864,280 (GRCm39)	missense	probably benign	0.03
R3547:Map4	UTSW	9	109,881,266 (GRCm39)	missense	possibly damaging	0.61
R3751:Map4	UTSW	9	109,867,742 (GRCm39)	intron	probably benign
R4036:Map4	UTSW	9	109,861,283 (GRCm39)	missense	possibly damaging	0.47
R4423:Map4	UTSW	9	109,896,662 (GRCm39)	missense	probably damaging	1.00
R4505:Map4	UTSW	9	109,861,253 (GRCm39)	missense	probably benign	0.01
R4561:Map4	UTSW	9	109,881,439 (GRCm39)	missense	possibly damaging	0.91
R4577:Map4	UTSW	9	109,910,489 (GRCm39)	missense	possibly damaging	0.48
R4601:Map4	UTSW	9	109,881,887 (GRCm39)	missense	possibly damaging	0.75
R4795:Map4	UTSW	9	109,864,331 (GRCm39)	missense	probably benign	0.00
R4801:Map4	UTSW	9	109,864,325 (GRCm39)	missense	probably benign	0.15
R4802:Map4	UTSW	9	109,864,325 (GRCm39)	missense	probably benign	0.15
R4999:Map4	UTSW	9	109,867,445 (GRCm39)	intron	probably benign
R5020:Map4	UTSW	9	109,897,868 (GRCm39)	missense	probably benign	0.02
R5021:Map4	UTSW	9	109,867,157 (GRCm39)	nonsense	probably null
R5049:Map4	UTSW	9	109,908,882 (GRCm39)	nonsense	probably null
R5451:Map4	UTSW	9	109,866,851 (GRCm39)	intron	probably benign
R5452:Map4	UTSW	9	109,866,851 (GRCm39)	intron	probably benign
R5453:Map4	UTSW	9	109,866,851 (GRCm39)	intron	probably benign
R5492:Map4	UTSW	9	109,881,450 (GRCm39)	missense	possibly damaging	0.68
R5532:Map4	UTSW	9	109,863,746 (GRCm39)	missense	probably benign	0.24
R5602:Map4	UTSW	9	109,881,768 (GRCm39)	missense	possibly damaging	0.84
R5628:Map4	UTSW	9	109,910,915 (GRCm39)	missense	probably benign	0.04
R5896:Map4	UTSW	9	109,901,702 (GRCm39)	missense	possibly damaging	0.91
R6017:Map4	UTSW	9	109,863,687 (GRCm39)	missense	probably benign	0.00
R6084:Map4	UTSW	9	109,893,360 (GRCm39)	missense	probably damaging	1.00
R6294:Map4	UTSW	9	109,831,814 (GRCm39)	missense	possibly damaging	0.82
R6397:Map4	UTSW	9	109,856,784 (GRCm39)	missense	possibly damaging	0.78
R6773:Map4	UTSW	9	109,863,993 (GRCm39)	missense	probably benign	0.00
R6997:Map4	UTSW	9	109,881,982 (GRCm39)	missense	probably benign	0.35
R7141:Map4	UTSW	9	109,807,938 (GRCm39)	start codon destroyed	probably null	1.00
R7187:Map4	UTSW	9	109,882,201 (GRCm39)	missense	probably benign	0.03
R7320:Map4	UTSW	9	109,910,585 (GRCm39)	missense	probably benign	0.24
R7469:Map4	UTSW	9	109,856,865 (GRCm39)	splice site	probably null
R7479:Map4	UTSW	9	109,897,892 (GRCm39)	missense	possibly damaging	0.94
R7487:Map4	UTSW	9	109,856,783 (GRCm39)	missense	probably damaging	1.00
R7690:Map4	UTSW	9	109,828,861 (GRCm39)	missense	probably damaging	0.99
R7780:Map4	UTSW	9	109,863,720 (GRCm39)	missense	probably benign	0.00
R7998:Map4	UTSW	9	109,908,929 (GRCm39)	missense	probably damaging	1.00
R8028:Map4	UTSW	9	109,897,812 (GRCm39)	missense	probably damaging	1.00
R8557:Map4	UTSW	9	109,893,370 (GRCm39)	splice site	probably null
R8950:Map4	UTSW	9	109,901,702 (GRCm39)	missense	possibly damaging	0.91
R8972:Map4	UTSW	9	109,864,185 (GRCm39)	missense	probably benign
R9145:Map4	UTSW	9	109,855,268 (GRCm39)	missense	probably damaging	0.99
R9297:Map4	UTSW	9	109,882,480 (GRCm39)	missense	probably benign	0.02
R9332:Map4	UTSW	9	109,864,223 (GRCm39)	missense	probably benign	0.00
R9354:Map4	UTSW	9	109,897,847 (GRCm39)	missense	probably benign
R9419:Map4	UTSW	9	109,882,029 (GRCm39)	missense	possibly damaging	0.92
R9430:Map4	UTSW	9	109,863,760 (GRCm39)	missense	probably benign	0.41
R9437:Map4	UTSW	9	109,864,155 (GRCm39)	missense	possibly damaging	0.46
R9718:Map4	UTSW	9	109,901,774 (GRCm39)	critical splice donor site	probably null
Z1177:Map4	UTSW	9	109,897,591 (GRCm39)	critical splice acceptor site	probably null

Posted On

2015-08-05