Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00575:Mrgpra9'

332677

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgpra9

Ensembl Gene

ENSMUSG00000074111

Gene Name

MAS-related GPR, member A9

Synonyms

MrgA9, EG668725

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL00575

Quality Score

Status

Chromosome

Chromosomal Location

46884667-46902627 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 46885053 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 205 (F205I)

Ref Sequence

ENSEMBL: ENSMUSP00000136396 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098436] [ENSMUST00000179005]

AlphaFold

A0A140T8U8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000098436
AA Change: F204I

PolyPhen 2 Score 0.762 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000096035
Gene: ENSMUSG00000074111
AA Change: F204I

Domain	Start	End	E-Value	Type
low complexity region	37	48	N/A	INTRINSIC
Pfam:7tm_1	56	225	1.5e-11	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000179005
AA Change: F205I

PolyPhen 2 Score 0.762 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000136396
Gene: ENSMUSG00000074111
AA Change: F205I

Domain	Start	End	E-Value	Type
Pfam:7tm_1	12	178	3.4e-9	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 9 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Fabp9	A	G	3: 10,258,843 (GRCm39)	V99A	probably damaging	Het
Gramd1b	T	A	9: 40,238,707 (GRCm39)		probably benign	Het
Nav3	A	T	10: 109,600,626 (GRCm39)	S1334T	probably damaging	Het
Pglyrp4	A	T	3: 90,638,098 (GRCm39)	Q137H	probably damaging	Het
Serpinb1c	T	C	13: 33,067,958 (GRCm39)	K213E	probably damaging	Het
Spata31e2	T	A	1: 26,722,013 (GRCm39)	T1056S	possibly damaging	Het
Spata31e3	C	A	13: 50,400,752 (GRCm39)	G525W	probably damaging	Het
Tubb2b	A	G	13: 34,313,244 (GRCm39)	Y51H	probably damaging	Het
Zfp112	A	T	7: 23,825,757 (GRCm39)	Y573F	probably damaging	Het

Other mutations in Mrgpra9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00095:Mrgpra9	APN	7	46,884,839 (GRCm39)	missense	possibly damaging	0.85
IGL01649:Mrgpra9	APN	7	46,884,900 (GRCm39)	missense	probably benign	0.22
IGL03207:Mrgpra9	APN	7	46,885,385 (GRCm39)	missense	possibly damaging	0.68
R0388:Mrgpra9	UTSW	7	46,902,542 (GRCm39)	start codon destroyed	probably null	0.08
R0972:Mrgpra9	UTSW	7	46,885,203 (GRCm39)	missense	probably damaging	0.99
R1270:Mrgpra9	UTSW	7	46,902,531 (GRCm39)	critical splice donor site	probably null
R1381:Mrgpra9	UTSW	7	46,885,050 (GRCm39)	missense	possibly damaging	0.75
R1403:Mrgpra9	UTSW	7	46,885,386 (GRCm39)	missense	probably benign	0.24
R1403:Mrgpra9	UTSW	7	46,885,386 (GRCm39)	missense	probably benign	0.24
R1448:Mrgpra9	UTSW	7	46,885,561 (GRCm39)	missense	probably benign	0.02
R2045:Mrgpra9	UTSW	7	46,885,583 (GRCm39)	missense	probably benign
R2144:Mrgpra9	UTSW	7	46,885,211 (GRCm39)	missense	probably benign	0.31
R2187:Mrgpra9	UTSW	7	46,884,797 (GRCm39)	missense	probably damaging	1.00
R2507:Mrgpra9	UTSW	7	46,885,242 (GRCm39)	missense	possibly damaging	0.63
R2913:Mrgpra9	UTSW	7	46,884,828 (GRCm39)	missense	probably benign
R3810:Mrgpra9	UTSW	7	46,885,527 (GRCm39)	missense	probably damaging	0.98
R4177:Mrgpra9	UTSW	7	46,885,302 (GRCm39)	missense	probably damaging	1.00
R4521:Mrgpra9	UTSW	7	46,884,938 (GRCm39)	missense	probably damaging	1.00
R4781:Mrgpra9	UTSW	7	46,884,795 (GRCm39)	missense	possibly damaging	0.88
R4926:Mrgpra9	UTSW	7	46,884,759 (GRCm39)	missense	possibly damaging	0.62
R6469:Mrgpra9	UTSW	7	46,884,854 (GRCm39)	missense	probably benign	0.02
R6505:Mrgpra9	UTSW	7	46,884,884 (GRCm39)	missense	probably benign	0.00
R6724:Mrgpra9	UTSW	7	46,884,786 (GRCm39)	missense	probably damaging	1.00
R7398:Mrgpra9	UTSW	7	46,885,385 (GRCm39)	missense	possibly damaging	0.68
R8737:Mrgpra9	UTSW	7	46,885,624 (GRCm39)	missense	probably benign	0.00
R8824:Mrgpra9	UTSW	7	46,885,041 (GRCm39)	missense	probably benign	0.06
R8881:Mrgpra9	UTSW	7	46,885,242 (GRCm39)	missense	possibly damaging	0.63
R9320:Mrgpra9	UTSW	7	46,885,392 (GRCm39)	missense	probably benign	0.00

Posted On

2015-08-05