Incidental Mutation 'R4514:Cylc2'
ID 332780
Institutional Source Beutler Lab
Gene Symbol Cylc2
Ensembl Gene ENSMUSG00000039555
Gene Name cylicin, basic protein of sperm head cytoskeleton 2
Synonyms 4930488P18Rik
MMRRC Submission 041588-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R4514 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 51216678-51250622 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 51229651 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Arginine at position 331 (T331R)
Ref Sequence ENSEMBL: ENSMUSP00000125758 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041392] [ENSMUST00000166749]
AlphaFold A0A571BEE2
Predicted Effect unknown
Transcript: ENSMUST00000041392
AA Change: T331R
SMART Domains Protein: ENSMUSP00000039750
Gene: ENSMUSG00000039555
AA Change: T331R

DomainStartEndE-ValueType
Pfam:Cylicin_N 7 115 1.1e-43 PFAM
low complexity region 122 131 N/A INTRINSIC
low complexity region 174 220 N/A INTRINSIC
low complexity region 224 245 N/A INTRINSIC
low complexity region 249 272 N/A INTRINSIC
low complexity region 278 300 N/A INTRINSIC
low complexity region 312 329 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156384
Predicted Effect unknown
Transcript: ENSMUST00000166749
AA Change: T331R
SMART Domains Protein: ENSMUSP00000125758
Gene: ENSMUSG00000039555
AA Change: T331R

DomainStartEndE-ValueType
Pfam:Cylicin_N 8 113 4.6e-46 PFAM
low complexity region 122 131 N/A INTRINSIC
low complexity region 174 220 N/A INTRINSIC
low complexity region 224 245 N/A INTRINSIC
low complexity region 249 272 N/A INTRINSIC
low complexity region 278 300 N/A INTRINSIC
low complexity region 312 329 N/A INTRINSIC
low complexity region 338 420 N/A INTRINSIC
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 T G 8: 25,308,152 (GRCm39) T51P probably damaging Het
Akr1c20 A C 13: 4,557,843 (GRCm39) V201G probably damaging Het
Alg9 C T 9: 50,716,654 (GRCm39) T409M possibly damaging Het
Arpp21 T A 9: 112,006,745 (GRCm39) T155S probably damaging Het
Atm T A 9: 53,404,339 (GRCm39) Q1334L probably damaging Het
Bptf G A 11: 106,968,518 (GRCm39) T1055M probably damaging Het
Cd3g C A 9: 44,884,882 (GRCm39) A121S possibly damaging Het
Cenpn A G 8: 117,660,135 (GRCm39) Y68C probably damaging Het
Clock A G 5: 76,378,046 (GRCm39) I618T probably benign Het
Cp A G 3: 20,042,177 (GRCm39) M982V probably damaging Het
Csf3r T A 4: 125,933,653 (GRCm39) S611T possibly damaging Het
Csn3 A G 5: 88,077,997 (GRCm39) T168A unknown Het
D630003M21Rik T C 2: 158,046,722 (GRCm39) T752A probably benign Het
Defb34 A T 8: 19,176,522 (GRCm39) D71V probably damaging Het
Dync1h1 T A 12: 110,623,573 (GRCm39) D3615E possibly damaging Het
Etl4 A T 2: 20,666,709 (GRCm39) T167S probably damaging Het
F5 T A 1: 163,979,566 (GRCm39) probably benign Het
Got1l1 C T 8: 27,688,513 (GRCm39) M279I probably benign Het
Grm7 A G 6: 111,335,265 (GRCm39) T559A possibly damaging Het
Ifit1 A T 19: 34,625,913 (GRCm39) R350* probably null Het
Ighv2-5 T C 12: 113,649,216 (GRCm39) N79S possibly damaging Het
Igkv17-127 A G 6: 67,838,498 (GRCm39) I70V possibly damaging Het
Itga8 T C 2: 12,187,547 (GRCm39) S711G probably benign Het
Kndc1 A G 7: 139,490,202 (GRCm39) T235A probably benign Het
Lct T C 1: 128,228,251 (GRCm39) I1081V probably benign Het
Lrrc8b G T 5: 105,627,819 (GRCm39) C55F probably damaging Het
Lrwd1 T C 5: 136,160,402 (GRCm39) T311A probably benign Het
Mapk14 T C 17: 28,943,798 (GRCm39) F129S probably damaging Het
Mdga2 A G 12: 66,763,496 (GRCm39) I200T probably damaging Het
Mocos T A 18: 24,816,269 (GRCm39) S615R probably damaging Het
Myh4 T C 11: 67,146,395 (GRCm39) V1456A probably benign Het
Myh9 T C 15: 77,648,200 (GRCm39) I1759V probably benign Het
Nat8f5 G A 6: 85,794,405 (GRCm39) T185I possibly damaging Het
Nav3 T C 10: 109,529,943 (GRCm39) I2133V possibly damaging Het
Ncam2 T A 16: 81,309,884 (GRCm39) M458K probably benign Het
Nphp1 T C 2: 127,590,007 (GRCm39) S532G probably benign Het
Oplah A G 15: 76,182,155 (GRCm39) L1035P probably damaging Het
Or4p22 T C 2: 88,317,709 (GRCm39) V211A probably benign Het
Or52h2 C T 7: 103,838,598 (GRCm39) R272H probably benign Het
Pask T A 1: 93,249,855 (GRCm39) Q515L probably benign Het
Poglut1 A T 16: 38,369,778 (GRCm39) F35I probably benign Het
Ppp1ca T G 19: 4,245,054 (GRCm39) I319S probably benign Het
Psg25 T A 7: 18,263,533 (GRCm39) R97* probably null Het
Sars2 T C 7: 28,441,709 (GRCm39) probably null Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Slc16a7 T G 10: 125,069,308 (GRCm39) probably null Het
Slc7a8 C G 14: 54,973,247 (GRCm39) G240A possibly damaging Het
St6gal2 A T 17: 55,790,018 (GRCm39) N351Y probably benign Het
Susd5 T C 9: 113,924,992 (GRCm39) F292L probably benign Het
Tmco5 T A 2: 116,710,795 (GRCm39) D38E probably damaging Het
Tubgcp2 G A 7: 139,575,984 (GRCm39) P893L possibly damaging Het
Uncx A G 5: 139,532,522 (GRCm39) I196V possibly damaging Het
Zeb1 G A 18: 5,759,007 (GRCm39) C138Y probably damaging Het
Zfp609 A G 9: 65,610,977 (GRCm39) I662T possibly damaging Het
Zfp985 G A 4: 147,668,020 (GRCm39) C296Y probably damaging Het
Other mutations in Cylc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00476:Cylc2 APN 4 51,228,157 (GRCm39) missense probably damaging 1.00
IGL01669:Cylc2 APN 4 51,228,360 (GRCm39) missense probably benign 0.01
IGL02662:Cylc2 APN 4 51,216,698 (GRCm39) utr 5 prime probably benign
R0277:Cylc2 UTSW 4 51,228,477 (GRCm39) missense unknown
R0323:Cylc2 UTSW 4 51,228,477 (GRCm39) missense unknown
R0968:Cylc2 UTSW 4 51,216,706 (GRCm39) start codon destroyed probably null 0.50
R1395:Cylc2 UTSW 4 51,228,366 (GRCm39) missense possibly damaging 0.53
R1639:Cylc2 UTSW 4 51,228,310 (GRCm39) missense probably benign 0.23
R1643:Cylc2 UTSW 4 51,225,173 (GRCm39) missense probably benign 0.38
R2829:Cylc2 UTSW 4 51,229,798 (GRCm39) missense unknown
R4464:Cylc2 UTSW 4 51,229,651 (GRCm39) missense unknown
R4467:Cylc2 UTSW 4 51,229,651 (GRCm39) missense unknown
R4496:Cylc2 UTSW 4 51,229,651 (GRCm39) missense unknown
R4505:Cylc2 UTSW 4 51,229,651 (GRCm39) missense unknown
R4546:Cylc2 UTSW 4 51,229,840 (GRCm39) missense unknown
R4546:Cylc2 UTSW 4 51,229,651 (GRCm39) missense unknown
R4654:Cylc2 UTSW 4 51,228,279 (GRCm39) missense probably benign 0.00
R4949:Cylc2 UTSW 4 51,229,804 (GRCm39) missense unknown
R5141:Cylc2 UTSW 4 51,228,587 (GRCm39) intron probably benign
R5176:Cylc2 UTSW 4 51,228,587 (GRCm39) intron probably benign
R5177:Cylc2 UTSW 4 51,228,587 (GRCm39) intron probably benign
R5179:Cylc2 UTSW 4 51,228,587 (GRCm39) intron probably benign
R7469:Cylc2 UTSW 4 51,227,970 (GRCm39) splice site probably null
R7508:Cylc2 UTSW 4 51,229,256 (GRCm39) splice site probably null
R7699:Cylc2 UTSW 4 51,229,335 (GRCm39) missense unknown
R8685:Cylc2 UTSW 4 51,229,651 (GRCm39) missense unknown
R8686:Cylc2 UTSW 4 51,229,651 (GRCm39) missense unknown
R8951:Cylc2 UTSW 4 51,229,469 (GRCm39) missense unknown
R9801:Cylc2 UTSW 4 51,228,466 (GRCm39) missense probably null
Predicted Primers PCR Primer
(F):5'- GTCAGCCACAGAATCTGGAG -3'
(R):5'- TTGAACCAAGACCTACTTCTCC -3'

Sequencing Primer
(F):5'- ATCTGGAGGTGAAAAGGCTGGTTC -3'
(R):5'- AACCAAGACCTACTTCTCCTACTTTG -3'
Posted On 2015-08-18