Incidental Mutation 'R4515:Vmn2r102'
ID |
332884 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r102
|
Ensembl Gene |
ENSMUSG00000095961 |
Gene Name |
vomeronasal 2, receptor 102 |
Synonyms |
EG224572 |
MMRRC Submission |
041589-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R4515 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
19880661-19915010 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 19901475 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Cysteine
at position 534
(Y534C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126559
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171741]
|
AlphaFold |
L7N279 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000171741
AA Change: Y534C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000126559 Gene: ENSMUSG00000095961 AA Change: Y534C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
448 |
5.2e-38 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
1.1e-21 |
PFAM |
Pfam:7tm_3
|
595 |
830 |
1.8e-53 |
PFAM |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.5%
- 3x: 98.7%
- 10x: 97.1%
- 20x: 94.6%
|
Validation Efficiency |
96% (65/68) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 59 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A430033K04Rik |
G |
T |
5: 138,646,006 (GRCm39) |
K630N |
probably damaging |
Het |
Acss2 |
C |
A |
2: 155,398,283 (GRCm39) |
L335I |
probably benign |
Het |
Alg6 |
A |
T |
4: 99,641,023 (GRCm39) |
|
probably benign |
Het |
Atp8b3 |
C |
T |
10: 80,359,681 (GRCm39) |
M984I |
probably benign |
Het |
Bsn |
G |
T |
9: 107,981,277 (GRCm39) |
|
probably null |
Het |
Ccdc88a |
T |
C |
11: 29,432,651 (GRCm39) |
I1219T |
probably benign |
Het |
Cdhr4 |
G |
A |
9: 107,870,150 (GRCm39) |
E52K |
probably benign |
Het |
Ces1a |
T |
A |
8: 93,747,532 (GRCm39) |
N500Y |
probably damaging |
Het |
Chd3 |
G |
T |
11: 69,240,703 (GRCm39) |
R1579S |
probably benign |
Het |
Chrnb3 |
T |
C |
8: 27,875,118 (GRCm39) |
L39P |
probably damaging |
Het |
Ckm |
A |
G |
7: 19,154,209 (GRCm39) |
K319E |
probably damaging |
Het |
Cnot6 |
C |
T |
11: 49,593,363 (GRCm39) |
|
probably null |
Het |
Copg1 |
A |
G |
6: 87,884,528 (GRCm39) |
|
probably benign |
Het |
Dbn1 |
A |
T |
13: 55,624,042 (GRCm39) |
I350N |
possibly damaging |
Het |
Dnah2 |
A |
G |
11: 69,356,457 (GRCm39) |
S2135P |
possibly damaging |
Het |
Dsg2 |
C |
A |
18: 20,734,444 (GRCm39) |
D807E |
probably benign |
Het |
Foxi1 |
A |
G |
11: 34,157,972 (GRCm39) |
F18L |
probably damaging |
Het |
Galnt3 |
C |
A |
2: 65,923,954 (GRCm39) |
R438L |
probably damaging |
Het |
Glod4 |
T |
A |
11: 76,134,397 (GRCm39) |
D25V |
probably damaging |
Het |
Golga4 |
T |
A |
9: 118,388,076 (GRCm39) |
S1733T |
probably benign |
Het |
H2-M10.3 |
C |
T |
17: 36,678,722 (GRCm39) |
|
probably null |
Het |
Hemgn |
T |
C |
4: 46,396,477 (GRCm39) |
E253G |
probably damaging |
Het |
Itsn1 |
G |
A |
16: 91,696,537 (GRCm39) |
V47M |
probably damaging |
Het |
Kif5b |
A |
G |
18: 6,208,257 (GRCm39) |
V947A |
probably benign |
Het |
Kif9 |
A |
G |
9: 110,318,935 (GRCm39) |
H133R |
probably benign |
Het |
Lce1l |
T |
C |
3: 92,757,781 (GRCm39) |
T26A |
unknown |
Het |
Macf1 |
T |
C |
4: 123,387,781 (GRCm39) |
E1172G |
probably damaging |
Het |
Nkx3-2 |
C |
T |
5: 41,921,281 (GRCm39) |
V3M |
probably damaging |
Het |
Nr2e1 |
G |
A |
10: 42,454,187 (GRCm39) |
T49I |
probably benign |
Het |
Oc90 |
A |
G |
15: 65,764,242 (GRCm39) |
L138P |
probably damaging |
Het |
Or7g12 |
T |
G |
9: 18,899,278 (GRCm39) |
|
probably null |
Het |
Or8g34 |
C |
T |
9: 39,373,527 (GRCm39) |
R264* |
probably null |
Het |
Orc4 |
G |
A |
2: 48,827,501 (GRCm39) |
P31S |
probably benign |
Het |
Pabir3 |
G |
A |
X: 52,382,376 (GRCm39) |
R94H |
possibly damaging |
Het |
Paqr3 |
T |
A |
5: 97,251,220 (GRCm39) |
N168I |
possibly damaging |
Het |
Pcdhac1 |
T |
A |
18: 37,224,432 (GRCm39) |
I415N |
probably damaging |
Het |
Pdik1l |
T |
C |
4: 134,006,207 (GRCm39) |
N75S |
probably damaging |
Het |
Pik3r4 |
A |
G |
9: 105,549,924 (GRCm39) |
H1005R |
probably damaging |
Het |
Plekhn1 |
T |
C |
4: 156,309,988 (GRCm39) |
S109G |
probably damaging |
Het |
Prkch |
A |
G |
12: 73,749,612 (GRCm39) |
T402A |
possibly damaging |
Het |
Ptger4 |
C |
A |
15: 5,271,860 (GRCm39) |
R253L |
probably damaging |
Het |
Rabac1 |
A |
T |
7: 24,669,585 (GRCm39) |
Y173* |
probably null |
Het |
Rapsn |
G |
A |
2: 90,873,557 (GRCm39) |
V288M |
possibly damaging |
Het |
Rnf26rt |
C |
T |
6: 76,473,792 (GRCm39) |
V275I |
probably benign |
Het |
Sec31a |
A |
G |
5: 100,513,817 (GRCm39) |
S993P |
probably damaging |
Het |
Septin4 |
A |
G |
11: 87,458,883 (GRCm39) |
H419R |
probably benign |
Het |
Serpina9 |
T |
A |
12: 103,967,553 (GRCm39) |
M281L |
probably benign |
Het |
Serpine1 |
G |
A |
5: 137,098,322 (GRCm39) |
A117V |
probably damaging |
Het |
Sh3tc2 |
A |
G |
18: 62,120,764 (GRCm39) |
|
probably null |
Het |
Sipa1l2 |
T |
C |
8: 126,218,965 (GRCm39) |
D124G |
probably benign |
Het |
Slc6a12 |
T |
A |
6: 121,330,489 (GRCm39) |
|
probably null |
Het |
Stk11 |
A |
G |
10: 79,952,435 (GRCm39) |
|
probably benign |
Het |
Tcaf3 |
A |
G |
6: 42,566,930 (GRCm39) |
Y720H |
probably damaging |
Het |
Tmem38a |
C |
T |
8: 73,326,005 (GRCm39) |
P20S |
possibly damaging |
Het |
Tmprss11a |
C |
T |
5: 86,568,055 (GRCm39) |
R224K |
probably damaging |
Het |
Tmprss15 |
C |
T |
16: 78,754,244 (GRCm39) |
S988N |
probably benign |
Het |
Txn2 |
A |
T |
15: 77,799,643 (GRCm39) |
|
probably null |
Het |
Ugt1a10 |
T |
A |
1: 87,983,919 (GRCm39) |
V239E |
probably damaging |
Het |
Vmn2r78 |
A |
T |
7: 86,603,466 (GRCm39) |
D548V |
probably damaging |
Het |
|
Other mutations in Vmn2r102 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00944:Vmn2r102
|
APN |
17 |
19,899,154 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00974:Vmn2r102
|
APN |
17 |
19,897,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL00978:Vmn2r102
|
APN |
17 |
19,899,185 (GRCm39) |
splice site |
probably null |
|
IGL01589:Vmn2r102
|
APN |
17 |
19,899,066 (GRCm39) |
missense |
probably benign |
|
IGL01738:Vmn2r102
|
APN |
17 |
19,898,020 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01994:Vmn2r102
|
APN |
17 |
19,880,731 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02066:Vmn2r102
|
APN |
17 |
19,914,191 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02525:Vmn2r102
|
APN |
17 |
19,901,447 (GRCm39) |
missense |
probably benign |
|
IGL02589:Vmn2r102
|
APN |
17 |
19,901,480 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02814:Vmn2r102
|
APN |
17 |
19,898,170 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03028:Vmn2r102
|
APN |
17 |
19,914,328 (GRCm39) |
missense |
possibly damaging |
0.92 |
IGL03162:Vmn2r102
|
APN |
17 |
19,914,286 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4431001:Vmn2r102
|
UTSW |
17 |
19,896,958 (GRCm39) |
missense |
possibly damaging |
0.68 |
R0042:Vmn2r102
|
UTSW |
17 |
19,880,851 (GRCm39) |
missense |
probably damaging |
0.98 |
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
R0132:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
R0268:Vmn2r102
|
UTSW |
17 |
19,898,112 (GRCm39) |
missense |
probably benign |
0.00 |
R0441:Vmn2r102
|
UTSW |
17 |
19,914,630 (GRCm39) |
missense |
probably damaging |
1.00 |
R0583:Vmn2r102
|
UTSW |
17 |
19,897,043 (GRCm39) |
missense |
probably benign |
0.01 |
R0600:Vmn2r102
|
UTSW |
17 |
19,898,277 (GRCm39) |
missense |
probably benign |
0.00 |
R0606:Vmn2r102
|
UTSW |
17 |
19,899,106 (GRCm39) |
missense |
possibly damaging |
0.93 |
R0674:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
R0709:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
R0879:Vmn2r102
|
UTSW |
17 |
19,914,454 (GRCm39) |
missense |
probably damaging |
1.00 |
R1349:Vmn2r102
|
UTSW |
17 |
19,880,887 (GRCm39) |
splice site |
probably benign |
|
R1473:Vmn2r102
|
UTSW |
17 |
19,914,843 (GRCm39) |
missense |
probably benign |
0.00 |
R1630:Vmn2r102
|
UTSW |
17 |
19,899,032 (GRCm39) |
missense |
possibly damaging |
0.60 |
R1727:Vmn2r102
|
UTSW |
17 |
19,897,770 (GRCm39) |
missense |
probably damaging |
0.99 |
R1759:Vmn2r102
|
UTSW |
17 |
19,914,755 (GRCm39) |
missense |
probably damaging |
1.00 |
R1809:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
R2013:Vmn2r102
|
UTSW |
17 |
19,897,006 (GRCm39) |
missense |
probably benign |
0.03 |
R2086:Vmn2r102
|
UTSW |
17 |
19,896,949 (GRCm39) |
missense |
probably damaging |
1.00 |
R2241:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
R2378:Vmn2r102
|
UTSW |
17 |
19,914,930 (GRCm39) |
missense |
probably damaging |
1.00 |
R3814:Vmn2r102
|
UTSW |
17 |
19,899,093 (GRCm39) |
missense |
probably damaging |
0.98 |
R3827:Vmn2r102
|
UTSW |
17 |
19,914,787 (GRCm39) |
missense |
probably damaging |
1.00 |
R4159:Vmn2r102
|
UTSW |
17 |
19,898,088 (GRCm39) |
missense |
probably damaging |
1.00 |
R4505:Vmn2r102
|
UTSW |
17 |
19,880,845 (GRCm39) |
missense |
probably benign |
0.00 |
R4517:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
R4534:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
R4535:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
R4662:Vmn2r102
|
UTSW |
17 |
19,901,424 (GRCm39) |
missense |
probably damaging |
1.00 |
R4708:Vmn2r102
|
UTSW |
17 |
19,914,576 (GRCm39) |
missense |
probably benign |
0.00 |
R4734:Vmn2r102
|
UTSW |
17 |
19,897,795 (GRCm39) |
missense |
probably damaging |
1.00 |
R4834:Vmn2r102
|
UTSW |
17 |
19,898,203 (GRCm39) |
missense |
probably damaging |
0.99 |
R4927:Vmn2r102
|
UTSW |
17 |
19,880,661 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
R5077:Vmn2r102
|
UTSW |
17 |
19,897,834 (GRCm39) |
missense |
probably benign |
0.20 |
R5181:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
R5277:Vmn2r102
|
UTSW |
17 |
19,914,393 (GRCm39) |
missense |
possibly damaging |
0.49 |
R5418:Vmn2r102
|
UTSW |
17 |
19,914,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R5810:Vmn2r102
|
UTSW |
17 |
19,897,804 (GRCm39) |
missense |
probably benign |
0.20 |
R5864:Vmn2r102
|
UTSW |
17 |
19,914,943 (GRCm39) |
missense |
possibly damaging |
0.55 |
R6168:Vmn2r102
|
UTSW |
17 |
19,914,402 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6266:Vmn2r102
|
UTSW |
17 |
19,899,007 (GRCm39) |
missense |
probably benign |
|
R6432:Vmn2r102
|
UTSW |
17 |
19,901,483 (GRCm39) |
missense |
possibly damaging |
0.61 |
R6487:Vmn2r102
|
UTSW |
17 |
19,898,169 (GRCm39) |
missense |
probably damaging |
1.00 |
R6597:Vmn2r102
|
UTSW |
17 |
19,914,450 (GRCm39) |
missense |
probably damaging |
0.99 |
R6797:Vmn2r102
|
UTSW |
17 |
19,880,694 (GRCm39) |
nonsense |
probably null |
|
R7009:Vmn2r102
|
UTSW |
17 |
19,914,456 (GRCm39) |
missense |
probably damaging |
0.99 |
R7098:Vmn2r102
|
UTSW |
17 |
19,914,670 (GRCm39) |
missense |
probably damaging |
1.00 |
R7134:Vmn2r102
|
UTSW |
17 |
19,897,749 (GRCm39) |
missense |
probably benign |
0.01 |
R7463:Vmn2r102
|
UTSW |
17 |
19,896,886 (GRCm39) |
missense |
probably damaging |
1.00 |
R7511:Vmn2r102
|
UTSW |
17 |
19,901,405 (GRCm39) |
missense |
probably damaging |
1.00 |
R7512:Vmn2r102
|
UTSW |
17 |
19,914,363 (GRCm39) |
missense |
probably damaging |
1.00 |
R7556:Vmn2r102
|
UTSW |
17 |
19,898,093 (GRCm39) |
missense |
probably benign |
|
R8126:Vmn2r102
|
UTSW |
17 |
19,880,712 (GRCm39) |
missense |
probably benign |
0.02 |
R8385:Vmn2r102
|
UTSW |
17 |
19,914,088 (GRCm39) |
missense |
possibly damaging |
0.89 |
R8410:Vmn2r102
|
UTSW |
17 |
19,898,196 (GRCm39) |
missense |
possibly damaging |
0.85 |
R9045:Vmn2r102
|
UTSW |
17 |
19,880,841 (GRCm39) |
missense |
probably benign |
0.00 |
R9267:Vmn2r102
|
UTSW |
17 |
19,896,928 (GRCm39) |
missense |
probably damaging |
1.00 |
R9325:Vmn2r102
|
UTSW |
17 |
19,897,558 (GRCm39) |
missense |
probably damaging |
1.00 |
R9363:Vmn2r102
|
UTSW |
17 |
19,897,614 (GRCm39) |
missense |
probably benign |
0.04 |
R9524:Vmn2r102
|
UTSW |
17 |
19,897,564 (GRCm39) |
missense |
possibly damaging |
0.74 |
R9747:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
Z1176:Vmn2r102
|
UTSW |
17 |
19,914,305 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- AGGGATGAATACAATACTCCTGCC -3'
(R):5'- ACTCAGGTCTTCTCTACTCAGG -3'
Sequencing Primer
(F):5'- GATGAATACAATACTCCTGCCTTCTG -3'
(R):5'- GGATATCATCCTTAGTGAGGTAACCC -3'
|
Posted On |
2015-08-18 |