Incidental Mutation 'R4529:Inmt'
ID 333029
Institutional Source Beutler Lab
Gene Symbol Inmt
Ensembl Gene ENSMUSG00000003477
Gene Name indolethylamine N-methyltransferase
Synonyms Temt
MMRRC Submission 041592-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.049) question?
Stock # R4529 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 55147612-55151975 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 55148012 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 206 (M206V)
Ref Sequence ENSEMBL: ENSMUSP00000003569 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003569]
AlphaFold P40936
Predicted Effect probably benign
Transcript: ENSMUST00000003569
AA Change: M206V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000003569
Gene: ENSMUSG00000003477
AA Change: M206V

DomainStartEndE-ValueType
Pfam:NNMT_PNMT_TEMT 1 260 4.9e-113 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152720
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204585
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre1 A G 17: 57,727,519 (GRCm39) Y483C possibly damaging Het
Akap9 T A 5: 4,093,948 (GRCm39) F2157I probably damaging Het
Aldh1a3 T C 7: 66,051,742 (GRCm39) N404D probably benign Het
Ankrd2 A T 19: 42,032,240 (GRCm39) I231F probably benign Het
Apba1 A G 19: 23,913,899 (GRCm39) N641D probably damaging Het
C1qbp T C 11: 70,869,550 (GRCm39) T178A probably benign Het
Chtf18 T C 17: 25,939,592 (GRCm39) Y64C probably damaging Het
Cyp1a1 A G 9: 57,608,962 (GRCm39) H281R probably benign Het
Ehmt2 A G 17: 35,132,707 (GRCm39) I1235V probably damaging Het
Fcamr A G 1: 130,732,313 (GRCm39) H44R probably damaging Het
Gm12185 T C 11: 48,798,747 (GRCm39) Y582C probably damaging Het
Gm12185 T C 11: 48,798,921 (GRCm39) N524S possibly damaging Het
Gm5460 A C 14: 33,767,769 (GRCm39) D459A probably damaging Het
H2-Q6 C T 17: 35,644,820 (GRCm39) T203I probably null Het
Khdc3 T C 9: 73,011,301 (GRCm39) S360P possibly damaging Het
Lin54 G A 5: 100,594,419 (GRCm39) T582I possibly damaging Het
Ltbp1 T G 17: 75,458,355 (GRCm39) V312G probably benign Het
Nlrp9a T C 7: 26,270,832 (GRCm39) L899P probably damaging Het
Or6c1b T C 10: 129,273,287 (GRCm39) V202A probably benign Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Pappa A G 4: 65,149,419 (GRCm39) I920V probably benign Het
Parp1 T A 1: 180,418,877 (GRCm39) V679E probably damaging Het
Pla2g4f C T 2: 120,131,100 (GRCm39) R785Q probably damaging Het
Plbd1 T A 6: 136,628,823 (GRCm39) I82F probably benign Het
Plekhm3 A G 1: 64,976,984 (GRCm39) V162A probably benign Het
Plin4 A G 17: 56,411,274 (GRCm39) L919P probably damaging Het
Plxna4 C T 6: 32,473,831 (GRCm39) probably null Het
Pou3f3 C A 1: 42,737,714 (GRCm39) T470K probably benign Het
Prss38 T C 11: 59,264,325 (GRCm39) Y214C probably damaging Het
Retreg1 T A 15: 25,968,600 (GRCm39) Y109N probably damaging Het
Slco1c1 A G 6: 141,500,907 (GRCm39) Y413C probably damaging Het
Stk32a T C 18: 43,376,044 (GRCm39) C38R possibly damaging Het
Themis T C 10: 28,658,331 (GRCm39) F453L possibly damaging Het
Tmem38a C T 8: 73,326,005 (GRCm39) P20S possibly damaging Het
Tubgcp3 G T 8: 12,713,932 (GRCm39) L62I probably damaging Het
Ubqlnl C T 7: 103,798,925 (GRCm39) V191M probably benign Het
Xpo7 G A 14: 70,906,188 (GRCm39) T986M probably damaging Het
Zfp51 C T 17: 21,684,998 (GRCm39) L538F probably damaging Het
Zfy1 A G Y: 726,511 (GRCm39) L418S possibly damaging Het
Other mutations in Inmt
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01520:Inmt APN 6 55,148,213 (GRCm39) missense probably damaging 1.00
IGL02404:Inmt APN 6 55,148,095 (GRCm39) missense possibly damaging 0.67
IGL02478:Inmt APN 6 55,150,355 (GRCm39) missense probably damaging 1.00
IGL02585:Inmt APN 6 55,150,431 (GRCm39) missense probably damaging 1.00
R0639:Inmt UTSW 6 55,148,212 (GRCm39) missense probably damaging 1.00
R0673:Inmt UTSW 6 55,148,212 (GRCm39) missense probably damaging 1.00
R1818:Inmt UTSW 6 55,150,404 (GRCm39) missense possibly damaging 0.92
R1862:Inmt UTSW 6 55,151,868 (GRCm39) missense probably damaging 1.00
R4383:Inmt UTSW 6 55,148,203 (GRCm39) missense probably damaging 1.00
R5057:Inmt UTSW 6 55,151,883 (GRCm39) missense probably benign 0.00
R5999:Inmt UTSW 6 55,151,933 (GRCm39) nonsense probably null
R7135:Inmt UTSW 6 55,148,013 (GRCm39) nonsense probably null
R9242:Inmt UTSW 6 55,150,270 (GRCm39) critical splice donor site probably null
R9353:Inmt UTSW 6 55,151,984 (GRCm39) start gained probably benign
R9476:Inmt UTSW 6 55,147,990 (GRCm39) missense possibly damaging 0.95
R9510:Inmt UTSW 6 55,147,990 (GRCm39) missense possibly damaging 0.95
X0021:Inmt UTSW 6 55,150,281 (GRCm39) missense probably damaging 0.98
X0022:Inmt UTSW 6 55,150,460 (GRCm39) missense probably benign 0.40
Predicted Primers PCR Primer
(F):5'- ATAACTTTCCCAGGGAAGGCG -3'
(R):5'- GTGTGATGTGACCAAGACACCC -3'

Sequencing Primer
(F):5'- TTTCCCAGGGAAGGCGATTCG -3'
(R):5'- CAAGACACCCCCGCTGG -3'
Posted On 2015-08-18