Incidental Mutation 'R4531:Zmynd12'
ID 333105
Institutional Source Beutler Lab
Gene Symbol Zmynd12
Ensembl Gene ENSMUSG00000070806
Gene Name zinc finger, MYND domain containing 12
Synonyms
MMRRC Submission 041771-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R4531 (G1)
Quality Score 179
Status Validated
Chromosome 4
Chromosomal Location 119279881-119311096 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 119280194 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000092414 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030385] [ENSMUST00000094819] [ENSMUST00000106316]
AlphaFold A2BGJ5
Predicted Effect probably benign
Transcript: ENSMUST00000030385
SMART Domains Protein: ENSMUSP00000030385
Gene: ENSMUSG00000028636

DomainStartEndE-ValueType
Pfam:DFP 33 96 1.2e-9 PFAM
Pfam:DFP 117 276 8.5e-14 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000094819
SMART Domains Protein: ENSMUSP00000092414
Gene: ENSMUSG00000070806

DomainStartEndE-ValueType
Pfam:zf-MYND 17 54 1.2e-10 PFAM
low complexity region 70 87 N/A INTRINSIC
Blast:TPR 88 121 2e-14 BLAST
Pfam:TPR_8 130 157 3.9e-3 PFAM
Pfam:TPR_8 172 196 1.5e-2 PFAM
Blast:TPR 214 247 2e-13 BLAST
low complexity region 305 319 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106316
SMART Domains Protein: ENSMUSP00000101923
Gene: ENSMUSG00000028636

DomainStartEndE-ValueType
Pfam:DFP 1 107 5.2e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134147
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140641
Meta Mutation Damage Score 0.9494 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 97% (35/36)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad12 T C 5: 121,736,962 (GRCm39) T526A probably benign Het
Acad12 T C 5: 121,736,964 (GRCm39) Q525R probably benign Het
Cnot3 T C 7: 3,661,073 (GRCm39) V558A probably benign Het
Cntnap4 G A 8: 113,537,240 (GRCm39) V704M possibly damaging Het
Col22a1 T C 15: 71,878,998 (GRCm39) D53G probably damaging Het
Cspp1 T A 1: 10,137,072 (GRCm39) probably benign Het
Cyp2d10 T A 15: 82,289,462 (GRCm39) T217S probably benign Het
Dcaf6 T C 1: 165,239,036 (GRCm39) T229A probably damaging Het
E4f1 A T 17: 24,664,961 (GRCm39) S408T possibly damaging Het
Eif1ad19 G A 12: 87,740,314 (GRCm39) Q82* probably null Het
Gpr149 A G 3: 62,510,099 (GRCm39) F339L probably benign Het
Hmbox1 A T 14: 65,062,938 (GRCm39) C413S probably benign Het
Kmo T C 1: 175,487,273 (GRCm39) probably null Het
Lin54 G A 5: 100,594,419 (GRCm39) T582I possibly damaging Het
Lrpprc T C 17: 85,020,215 (GRCm39) I1157V probably benign Het
Obscn A G 11: 58,898,700 (GRCm39) probably benign Het
Or14c40 T A 7: 86,313,479 (GRCm39) L203H probably benign Het
Or8k23 A T 2: 86,186,318 (GRCm39) M136K probably damaging Het
Pclo A G 5: 14,825,422 (GRCm39) D4657G unknown Het
Pgd T C 4: 149,241,234 (GRCm39) K225R probably benign Het
Poli A T 18: 70,650,548 (GRCm39) H297Q probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Slc24a2 T C 4: 86,909,715 (GRCm39) I668V possibly damaging Het
Tdrd6 A G 17: 43,939,645 (GRCm39) S468P probably damaging Het
Trav6-4 A G 14: 53,691,790 (GRCm39) T3A probably benign Het
Trpc2 G T 7: 101,745,205 (GRCm39) R807L probably damaging Het
Ttc3 T A 16: 94,267,736 (GRCm39) probably benign Het
Tubgcp3 G T 8: 12,713,932 (GRCm39) L62I probably damaging Het
Ubqlnl C T 7: 103,798,925 (GRCm39) V191M probably benign Het
Vwce A C 19: 10,641,710 (GRCm39) E812A probably benign Het
Other mutations in Zmynd12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01603:Zmynd12 APN 4 119,299,117 (GRCm39) critical splice donor site probably null
IGL02113:Zmynd12 APN 4 119,291,194 (GRCm39) missense probably damaging 1.00
IGL02701:Zmynd12 APN 4 119,301,952 (GRCm39) splice site probably benign
IGL03287:Zmynd12 APN 4 119,310,776 (GRCm39) missense probably damaging 1.00
IGL03138:Zmynd12 UTSW 4 119,280,186 (GRCm39) missense probably damaging 1.00
R5078:Zmynd12 UTSW 4 119,302,047 (GRCm39) missense probably damaging 1.00
R5687:Zmynd12 UTSW 4 119,299,098 (GRCm39) missense probably damaging 0.96
R6995:Zmynd12 UTSW 4 119,310,772 (GRCm39) missense probably benign 0.00
R7707:Zmynd12 UTSW 4 119,302,063 (GRCm39) missense probably damaging 1.00
R8393:Zmynd12 UTSW 4 119,305,352 (GRCm39) missense probably damaging 1.00
R8911:Zmynd12 UTSW 4 119,294,286 (GRCm39) missense probably damaging 1.00
R8952:Zmynd12 UTSW 4 119,302,081 (GRCm39) critical splice donor site probably null
X0019:Zmynd12 UTSW 4 119,307,565 (GRCm39) missense probably benign 0.04
Z1176:Zmynd12 UTSW 4 119,280,074 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- TTGCCCTTGAAATCCCGAC -3'
(R):5'- ACAGTAACAGTAGGAGCCCC -3'

Sequencing Primer
(F):5'- TTGAAATCCCGACGTCCG -3'
(R):5'- GTAGGAGCCCCGCAAAACATC -3'
Posted On 2015-08-18