Incidental Mutation 'R4533:Vmn1r77'
ID |
333197 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r77
|
Ensembl Gene |
ENSMUSG00000095864 |
Gene Name |
vomeronasal 1 receptor 77 |
Synonyms |
Gm6935 |
MMRRC Submission |
041773-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.055)
|
Stock # |
R4533 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
11775226-11776146 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 11775756 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Histidine to Glutamine
at position 177
(H177Q)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000153872
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164446]
[ENSMUST00000226525]
[ENSMUST00000227320]
[ENSMUST00000228213]
|
AlphaFold |
E9PY60 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000164446
AA Change: H177Q
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
SMART Domains |
Protein: ENSMUSP00000130869 Gene: ENSMUSG00000095864 AA Change: H177Q
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
1 |
300 |
1.9e-12 |
PFAM |
Pfam:V1R
|
35 |
299 |
5.3e-26 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000226525
AA Change: H109Q
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000227320
AA Change: H177Q
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000228213
AA Change: H109Q
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.8%
|
Validation Efficiency |
100% (54/54) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 46 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adamts7 |
A |
G |
9: 90,062,761 (GRCm39) |
Y405C |
probably damaging |
Het |
Ago3 |
A |
T |
4: 126,239,356 (GRCm39) |
S832T |
probably damaging |
Het |
Akap9 |
T |
A |
5: 4,093,948 (GRCm39) |
F2157I |
probably damaging |
Het |
Anapc5 |
T |
C |
5: 122,929,798 (GRCm39) |
E561G |
possibly damaging |
Het |
Art5 |
T |
C |
7: 101,747,545 (GRCm39) |
H78R |
probably benign |
Het |
Blvra |
T |
A |
2: 126,932,304 (GRCm39) |
|
probably null |
Het |
Ccdc171 |
A |
G |
4: 83,575,579 (GRCm39) |
T488A |
possibly damaging |
Het |
Crtc3 |
A |
T |
7: 80,239,543 (GRCm39) |
M603K |
probably damaging |
Het |
Csmd1 |
T |
C |
8: 15,981,037 (GRCm39) |
|
probably null |
Het |
Dbh |
C |
A |
2: 27,067,343 (GRCm39) |
H409Q |
possibly damaging |
Het |
Gm12185 |
T |
C |
11: 48,798,747 (GRCm39) |
Y582C |
probably damaging |
Het |
Gm12185 |
T |
C |
11: 48,798,921 (GRCm39) |
N524S |
possibly damaging |
Het |
Gm7356 |
A |
C |
17: 14,221,672 (GRCm39) |
I119R |
probably damaging |
Het |
Heatr1 |
T |
A |
13: 12,449,392 (GRCm39) |
D1963E |
probably benign |
Het |
Ighv1-37 |
A |
T |
12: 114,860,147 (GRCm39) |
V21D |
probably damaging |
Het |
Itga3 |
T |
G |
11: 94,948,119 (GRCm39) |
Q602P |
probably benign |
Het |
Kcmf1 |
G |
A |
6: 72,826,574 (GRCm39) |
R152C |
probably damaging |
Het |
Lin54 |
T |
C |
5: 100,633,262 (GRCm39) |
I141V |
possibly damaging |
Het |
Mast1 |
T |
A |
8: 85,647,990 (GRCm39) |
H497L |
probably damaging |
Het |
Mrpl44 |
T |
C |
1: 79,753,971 (GRCm39) |
F41S |
possibly damaging |
Het |
Myo18b |
T |
C |
5: 112,840,891 (GRCm39) |
R2301G |
probably damaging |
Het |
Nek1 |
A |
T |
8: 61,460,247 (GRCm39) |
M58L |
possibly damaging |
Het |
Or4k15c |
T |
C |
14: 50,321,156 (GRCm39) |
|
probably null |
Het |
Orc4 |
G |
A |
2: 48,827,501 (GRCm39) |
P31S |
probably benign |
Het |
P3h3 |
A |
G |
6: 124,831,371 (GRCm39) |
V338A |
possibly damaging |
Het |
Pabir3 |
G |
A |
X: 52,382,376 (GRCm39) |
R94H |
possibly damaging |
Het |
Pcdha7 |
T |
C |
18: 37,108,460 (GRCm39) |
V495A |
possibly damaging |
Het |
Plcb3 |
T |
C |
19: 6,933,640 (GRCm39) |
E895G |
probably benign |
Het |
Plekha5 |
A |
G |
6: 140,516,057 (GRCm39) |
E770G |
probably damaging |
Het |
Ptchd3 |
C |
T |
11: 121,727,257 (GRCm39) |
S377F |
probably damaging |
Het |
Ptprj |
C |
T |
2: 90,270,299 (GRCm39) |
D1266N |
probably damaging |
Het |
Raly |
A |
T |
2: 154,707,853 (GRCm39) |
E291V |
probably damaging |
Het |
Rnf217 |
C |
A |
10: 31,484,759 (GRCm39) |
C141F |
possibly damaging |
Het |
Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
Slc12a3 |
A |
G |
8: 95,083,714 (GRCm39) |
M914V |
probably null |
Het |
Tbc1d9 |
A |
G |
8: 83,997,547 (GRCm39) |
T1035A |
probably damaging |
Het |
Tex14 |
C |
T |
11: 87,427,655 (GRCm39) |
R36* |
probably null |
Het |
Tiparp |
A |
G |
3: 65,453,768 (GRCm39) |
D172G |
probably benign |
Het |
Ttc3 |
T |
A |
16: 94,267,736 (GRCm39) |
|
probably benign |
Het |
Uap1 |
A |
T |
1: 169,970,994 (GRCm39) |
I466N |
probably damaging |
Het |
Ubr1 |
T |
C |
2: 120,772,963 (GRCm39) |
T426A |
possibly damaging |
Het |
Vmn2r72 |
T |
A |
7: 85,401,134 (GRCm39) |
H95L |
probably benign |
Het |
Vwc2l |
G |
A |
1: 70,921,298 (GRCm39) |
C151Y |
probably damaging |
Het |
Wdr12 |
T |
C |
1: 60,117,354 (GRCm39) |
Y414C |
probably benign |
Het |
Zfp609 |
A |
C |
9: 65,610,890 (GRCm39) |
V691G |
probably benign |
Het |
Zmiz1 |
T |
C |
14: 25,646,084 (GRCm39) |
Y254H |
probably damaging |
Het |
|
Other mutations in Vmn1r77 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00965:Vmn1r77
|
APN |
7 |
11,775,223 (GRCm39) |
critical splice acceptor site |
probably null |
|
IGL00990:Vmn1r77
|
APN |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
IGL00990:Vmn1r77
|
APN |
7 |
11,775,403 (GRCm39) |
missense |
probably benign |
0.05 |
IGL01304:Vmn1r77
|
APN |
7 |
11,775,962 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01360:Vmn1r77
|
APN |
7 |
11,775,315 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01714:Vmn1r77
|
APN |
7 |
11,775,277 (GRCm39) |
missense |
probably benign |
0.03 |
IGL01829:Vmn1r77
|
APN |
7 |
11,775,358 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02336:Vmn1r77
|
APN |
7 |
11,775,223 (GRCm39) |
critical splice acceptor site |
probably null |
|
R0456:Vmn1r77
|
UTSW |
7 |
11,775,665 (GRCm39) |
nonsense |
probably null |
|
R0622:Vmn1r77
|
UTSW |
7 |
11,775,315 (GRCm39) |
missense |
probably benign |
0.06 |
R1244:Vmn1r77
|
UTSW |
7 |
11,775,847 (GRCm39) |
missense |
possibly damaging |
0.59 |
R1696:Vmn1r77
|
UTSW |
7 |
11,775,547 (GRCm39) |
nonsense |
probably null |
|
R1836:Vmn1r77
|
UTSW |
7 |
11,775,338 (GRCm39) |
missense |
probably benign |
0.00 |
R1898:Vmn1r77
|
UTSW |
7 |
11,775,550 (GRCm39) |
missense |
probably damaging |
1.00 |
R4668:Vmn1r77
|
UTSW |
7 |
11,775,358 (GRCm39) |
missense |
probably damaging |
1.00 |
R5381:Vmn1r77
|
UTSW |
7 |
11,775,952 (GRCm39) |
missense |
probably damaging |
1.00 |
R6290:Vmn1r77
|
UTSW |
7 |
11,775,736 (GRCm39) |
missense |
probably damaging |
1.00 |
R6675:Vmn1r77
|
UTSW |
7 |
11,775,382 (GRCm39) |
missense |
probably damaging |
1.00 |
R7032:Vmn1r77
|
UTSW |
7 |
11,776,017 (GRCm39) |
nonsense |
probably null |
|
R7044:Vmn1r77
|
UTSW |
7 |
11,775,761 (GRCm39) |
missense |
probably benign |
0.06 |
R7302:Vmn1r77
|
UTSW |
7 |
11,775,983 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7417:Vmn1r77
|
UTSW |
7 |
11,775,611 (GRCm39) |
missense |
probably damaging |
1.00 |
R7436:Vmn1r77
|
UTSW |
7 |
11,775,694 (GRCm39) |
missense |
probably benign |
0.01 |
R8487:Vmn1r77
|
UTSW |
7 |
11,775,514 (GRCm39) |
missense |
probably damaging |
1.00 |
R8862:Vmn1r77
|
UTSW |
7 |
11,776,060 (GRCm39) |
missense |
probably benign |
0.19 |
R9614:Vmn1r77
|
UTSW |
7 |
11,775,766 (GRCm39) |
missense |
probably benign |
0.43 |
R9753:Vmn1r77
|
UTSW |
7 |
11,775,659 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,674 (GRCm39) |
missense |
|
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,524 (GRCm39) |
missense |
probably benign |
0.36 |
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,508 (GRCm39) |
missense |
|
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,674 (GRCm39) |
missense |
|
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,524 (GRCm39) |
missense |
probably benign |
0.36 |
|
Predicted Primers |
PCR Primer
(F):5'- GCCACATGCATATTGAGTTGTTTTC -3'
(R):5'- GATGCTCTGTCTTCAGGTGAGAC -3'
Sequencing Primer
(F):5'- TCCAGCAACTTCAAGTGGATG -3'
(R):5'- CTTCAGGTGAGACTTTCTGAAAG -3'
|
Posted On |
2015-08-18 |