Incidental Mutation 'R4533:Zfp609'
ID 333207
Institutional Source Beutler Lab
Gene Symbol Zfp609
Ensembl Gene ENSMUSG00000040524
Gene Name zinc finger protein 609
Synonyms
MMRRC Submission 041773-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.620) question?
Stock # R4533 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 65599673-65734846 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 65610890 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 691 (V691G)
Ref Sequence ENSEMBL: ENSMUSP00000124089 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159109]
AlphaFold Q8BZ47
Predicted Effect probably benign
Transcript: ENSMUST00000159109
AA Change: V691G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000124089
Gene: ENSMUSG00000040524
AA Change: V691G

DomainStartEndE-ValueType
low complexity region 83 101 N/A INTRINSIC
low complexity region 125 139 N/A INTRINSIC
low complexity region 155 176 N/A INTRINSIC
low complexity region 259 269 N/A INTRINSIC
low complexity region 365 376 N/A INTRINSIC
low complexity region 386 405 N/A INTRINSIC
ZnF_C2H2 495 520 2.14e0 SMART
low complexity region 629 638 N/A INTRINSIC
low complexity region 657 667 N/A INTRINSIC
low complexity region 724 738 N/A INTRINSIC
low complexity region 1000 1020 N/A INTRINSIC
low complexity region 1210 1219 N/A INTRINSIC
low complexity region 1257 1273 N/A INTRINSIC
low complexity region 1329 1348 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159878
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 100% (54/54)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts7 A G 9: 90,062,761 (GRCm39) Y405C probably damaging Het
Ago3 A T 4: 126,239,356 (GRCm39) S832T probably damaging Het
Akap9 T A 5: 4,093,948 (GRCm39) F2157I probably damaging Het
Anapc5 T C 5: 122,929,798 (GRCm39) E561G possibly damaging Het
Art5 T C 7: 101,747,545 (GRCm39) H78R probably benign Het
Blvra T A 2: 126,932,304 (GRCm39) probably null Het
Ccdc171 A G 4: 83,575,579 (GRCm39) T488A possibly damaging Het
Crtc3 A T 7: 80,239,543 (GRCm39) M603K probably damaging Het
Csmd1 T C 8: 15,981,037 (GRCm39) probably null Het
Dbh C A 2: 27,067,343 (GRCm39) H409Q possibly damaging Het
Gm12185 T C 11: 48,798,747 (GRCm39) Y582C probably damaging Het
Gm12185 T C 11: 48,798,921 (GRCm39) N524S possibly damaging Het
Gm7356 A C 17: 14,221,672 (GRCm39) I119R probably damaging Het
Heatr1 T A 13: 12,449,392 (GRCm39) D1963E probably benign Het
Ighv1-37 A T 12: 114,860,147 (GRCm39) V21D probably damaging Het
Itga3 T G 11: 94,948,119 (GRCm39) Q602P probably benign Het
Kcmf1 G A 6: 72,826,574 (GRCm39) R152C probably damaging Het
Lin54 T C 5: 100,633,262 (GRCm39) I141V possibly damaging Het
Mast1 T A 8: 85,647,990 (GRCm39) H497L probably damaging Het
Mrpl44 T C 1: 79,753,971 (GRCm39) F41S possibly damaging Het
Myo18b T C 5: 112,840,891 (GRCm39) R2301G probably damaging Het
Nek1 A T 8: 61,460,247 (GRCm39) M58L possibly damaging Het
Or4k15c T C 14: 50,321,156 (GRCm39) probably null Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
P3h3 A G 6: 124,831,371 (GRCm39) V338A possibly damaging Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Pcdha7 T C 18: 37,108,460 (GRCm39) V495A possibly damaging Het
Plcb3 T C 19: 6,933,640 (GRCm39) E895G probably benign Het
Plekha5 A G 6: 140,516,057 (GRCm39) E770G probably damaging Het
Ptchd3 C T 11: 121,727,257 (GRCm39) S377F probably damaging Het
Ptprj C T 2: 90,270,299 (GRCm39) D1266N probably damaging Het
Raly A T 2: 154,707,853 (GRCm39) E291V probably damaging Het
Rnf217 C A 10: 31,484,759 (GRCm39) C141F possibly damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Slc12a3 A G 8: 95,083,714 (GRCm39) M914V probably null Het
Tbc1d9 A G 8: 83,997,547 (GRCm39) T1035A probably damaging Het
Tex14 C T 11: 87,427,655 (GRCm39) R36* probably null Het
Tiparp A G 3: 65,453,768 (GRCm39) D172G probably benign Het
Ttc3 T A 16: 94,267,736 (GRCm39) probably benign Het
Uap1 A T 1: 169,970,994 (GRCm39) I466N probably damaging Het
Ubr1 T C 2: 120,772,963 (GRCm39) T426A possibly damaging Het
Vmn1r77 T A 7: 11,775,756 (GRCm39) H177Q probably benign Het
Vmn2r72 T A 7: 85,401,134 (GRCm39) H95L probably benign Het
Vwc2l G A 1: 70,921,298 (GRCm39) C151Y probably damaging Het
Wdr12 T C 1: 60,117,354 (GRCm39) Y414C probably benign Het
Zmiz1 T C 14: 25,646,084 (GRCm39) Y254H probably damaging Het
Other mutations in Zfp609
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00956:Zfp609 APN 9 65,610,045 (GRCm39) missense probably benign 0.18
IGL01688:Zfp609 APN 9 65,611,307 (GRCm39) missense probably benign
IGL01718:Zfp609 APN 9 65,609,682 (GRCm39) nonsense probably null
IGL01860:Zfp609 APN 9 65,610,116 (GRCm39) missense possibly damaging 0.82
IGL02441:Zfp609 APN 9 65,610,611 (GRCm39) missense possibly damaging 0.92
IGL02490:Zfp609 APN 9 65,611,250 (GRCm39) missense possibly damaging 0.92
IGL02614:Zfp609 APN 9 65,610,072 (GRCm39) missense probably damaging 0.96
IGL02794:Zfp609 APN 9 65,611,602 (GRCm39) missense possibly damaging 0.83
IGL02959:Zfp609 APN 9 65,610,675 (GRCm39) missense probably benign
IGL02967:Zfp609 APN 9 65,604,901 (GRCm39) missense possibly damaging 0.83
IGL03036:Zfp609 APN 9 65,609,927 (GRCm39) missense possibly damaging 0.89
IGL03182:Zfp609 APN 9 65,608,287 (GRCm39) missense probably benign 0.02
H8441:Zfp609 UTSW 9 65,702,169 (GRCm39) missense possibly damaging 0.82
R0304:Zfp609 UTSW 9 65,608,470 (GRCm39) missense possibly damaging 0.89
R0487:Zfp609 UTSW 9 65,609,916 (GRCm39) missense unknown
R0505:Zfp609 UTSW 9 65,610,744 (GRCm39) missense possibly damaging 0.92
R0684:Zfp609 UTSW 9 65,638,483 (GRCm39) missense probably benign 0.01
R1480:Zfp609 UTSW 9 65,610,593 (GRCm39) missense possibly damaging 0.82
R1507:Zfp609 UTSW 9 65,702,059 (GRCm39) missense possibly damaging 0.92
R1579:Zfp609 UTSW 9 65,611,754 (GRCm39) missense possibly damaging 0.90
R1655:Zfp609 UTSW 9 65,610,836 (GRCm39) missense possibly damaging 0.46
R1692:Zfp609 UTSW 9 65,702,593 (GRCm39) missense probably damaging 0.98
R1701:Zfp609 UTSW 9 65,638,282 (GRCm39) missense probably benign 0.05
R1735:Zfp609 UTSW 9 65,610,374 (GRCm39) nonsense probably null
R1883:Zfp609 UTSW 9 65,702,040 (GRCm39) missense probably benign
R1970:Zfp609 UTSW 9 65,702,559 (GRCm39) missense probably damaging 0.96
R2059:Zfp609 UTSW 9 65,611,716 (GRCm39) missense possibly damaging 0.83
R2302:Zfp609 UTSW 9 65,702,179 (GRCm39) missense possibly damaging 0.66
R3404:Zfp609 UTSW 9 65,608,454 (GRCm39) missense possibly damaging 0.68
R3405:Zfp609 UTSW 9 65,608,454 (GRCm39) missense possibly damaging 0.68
R4514:Zfp609 UTSW 9 65,610,977 (GRCm39) missense possibly damaging 0.46
R5043:Zfp609 UTSW 9 65,608,109 (GRCm39) missense probably damaging 0.97
R5499:Zfp609 UTSW 9 65,610,137 (GRCm39) missense probably benign 0.00
R7081:Zfp609 UTSW 9 65,609,723 (GRCm39) missense possibly damaging 0.46
R7514:Zfp609 UTSW 9 65,613,418 (GRCm39) missense probably benign 0.05
R7677:Zfp609 UTSW 9 65,604,456 (GRCm39) missense possibly damaging 0.61
R7684:Zfp609 UTSW 9 65,638,362 (GRCm39) missense possibly damaging 0.66
R8229:Zfp609 UTSW 9 65,610,782 (GRCm39) missense possibly damaging 0.66
R8266:Zfp609 UTSW 9 65,610,996 (GRCm39) missense possibly damaging 0.66
R8278:Zfp609 UTSW 9 65,604,804 (GRCm39) missense possibly damaging 0.90
R8934:Zfp609 UTSW 9 65,610,561 (GRCm39) missense possibly damaging 0.90
R8938:Zfp609 UTSW 9 65,610,561 (GRCm39) missense possibly damaging 0.90
R8940:Zfp609 UTSW 9 65,610,561 (GRCm39) missense possibly damaging 0.90
R8986:Zfp609 UTSW 9 65,610,561 (GRCm39) missense possibly damaging 0.90
R9267:Zfp609 UTSW 9 65,608,328 (GRCm39) missense possibly damaging 0.90
R9456:Zfp609 UTSW 9 65,611,125 (GRCm39) missense
R9561:Zfp609 UTSW 9 65,604,512 (GRCm39) nonsense probably null
X0028:Zfp609 UTSW 9 65,604,362 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- TCTCTGAACGGGCTCTTACC -3'
(R):5'- GCCTTTGACTCTTTGGAAAGG -3'

Sequencing Primer
(F):5'- GCTCGGCATACCTTCCCAG -3'
(R):5'- CCTTTGACTCTTTGGAAAGGAAGTG -3'
Posted On 2015-08-18