Incidental Mutation 'R4533:Tex14'
ID 333212
Institutional Source Beutler Lab
Gene Symbol Tex14
Ensembl Gene ENSMUSG00000010342
Gene Name testis expressed gene 14
Synonyms
MMRRC Submission 041773-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.159) question?
Stock # R4533 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 87295891-87446649 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 87427655 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 36 (R36*)
Ref Sequence ENSEMBL: ENSMUSP00000117564 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060835] [ENSMUST00000100657] [ENSMUST00000131973]
AlphaFold Q7M6U3
Predicted Effect probably null
Transcript: ENSMUST00000060835
AA Change: R1216*
SMART Domains Protein: ENSMUSP00000054444
Gene: ENSMUSG00000010342
AA Change: R1216*

DomainStartEndE-ValueType
ANK 22 51 7.99e2 SMART
ANK 55 84 6.36e-3 SMART
ANK 88 117 3.49e0 SMART
Pfam:Pkinase 251 504 3.5e-19 PFAM
Pfam:Pkinase_Tyr 254 503 8.1e-28 PFAM
coiled coil region 659 684 N/A INTRINSIC
coiled coil region 740 776 N/A INTRINSIC
low complexity region 1219 1236 N/A INTRINSIC
coiled coil region 1289 1309 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000100657
Predicted Effect probably null
Transcript: ENSMUST00000131973
AA Change: R36*
SMART Domains Protein: ENSMUSP00000117564
Gene: ENSMUSG00000010342
AA Change: R36*

DomainStartEndE-ValueType
low complexity region 39 56 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
PHENOTYPE: Males homozygous for a targeted allele are infertile due to spermatogenic failure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts7 A G 9: 90,062,761 (GRCm39) Y405C probably damaging Het
Ago3 A T 4: 126,239,356 (GRCm39) S832T probably damaging Het
Akap9 T A 5: 4,093,948 (GRCm39) F2157I probably damaging Het
Anapc5 T C 5: 122,929,798 (GRCm39) E561G possibly damaging Het
Art5 T C 7: 101,747,545 (GRCm39) H78R probably benign Het
Blvra T A 2: 126,932,304 (GRCm39) probably null Het
Ccdc171 A G 4: 83,575,579 (GRCm39) T488A possibly damaging Het
Crtc3 A T 7: 80,239,543 (GRCm39) M603K probably damaging Het
Csmd1 T C 8: 15,981,037 (GRCm39) probably null Het
Dbh C A 2: 27,067,343 (GRCm39) H409Q possibly damaging Het
Gm12185 T C 11: 48,798,747 (GRCm39) Y582C probably damaging Het
Gm12185 T C 11: 48,798,921 (GRCm39) N524S possibly damaging Het
Gm7356 A C 17: 14,221,672 (GRCm39) I119R probably damaging Het
Heatr1 T A 13: 12,449,392 (GRCm39) D1963E probably benign Het
Ighv1-37 A T 12: 114,860,147 (GRCm39) V21D probably damaging Het
Itga3 T G 11: 94,948,119 (GRCm39) Q602P probably benign Het
Kcmf1 G A 6: 72,826,574 (GRCm39) R152C probably damaging Het
Lin54 T C 5: 100,633,262 (GRCm39) I141V possibly damaging Het
Mast1 T A 8: 85,647,990 (GRCm39) H497L probably damaging Het
Mrpl44 T C 1: 79,753,971 (GRCm39) F41S possibly damaging Het
Myo18b T C 5: 112,840,891 (GRCm39) R2301G probably damaging Het
Nek1 A T 8: 61,460,247 (GRCm39) M58L possibly damaging Het
Or4k15c T C 14: 50,321,156 (GRCm39) probably null Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
P3h3 A G 6: 124,831,371 (GRCm39) V338A possibly damaging Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Pcdha7 T C 18: 37,108,460 (GRCm39) V495A possibly damaging Het
Plcb3 T C 19: 6,933,640 (GRCm39) E895G probably benign Het
Plekha5 A G 6: 140,516,057 (GRCm39) E770G probably damaging Het
Ptchd3 C T 11: 121,727,257 (GRCm39) S377F probably damaging Het
Ptprj C T 2: 90,270,299 (GRCm39) D1266N probably damaging Het
Raly A T 2: 154,707,853 (GRCm39) E291V probably damaging Het
Rnf217 C A 10: 31,484,759 (GRCm39) C141F possibly damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Slc12a3 A G 8: 95,083,714 (GRCm39) M914V probably null Het
Tbc1d9 A G 8: 83,997,547 (GRCm39) T1035A probably damaging Het
Tiparp A G 3: 65,453,768 (GRCm39) D172G probably benign Het
Ttc3 T A 16: 94,267,736 (GRCm39) probably benign Het
Uap1 A T 1: 169,970,994 (GRCm39) I466N probably damaging Het
Ubr1 T C 2: 120,772,963 (GRCm39) T426A possibly damaging Het
Vmn1r77 T A 7: 11,775,756 (GRCm39) H177Q probably benign Het
Vmn2r72 T A 7: 85,401,134 (GRCm39) H95L probably benign Het
Vwc2l G A 1: 70,921,298 (GRCm39) C151Y probably damaging Het
Wdr12 T C 1: 60,117,354 (GRCm39) Y414C probably benign Het
Zfp609 A C 9: 65,610,890 (GRCm39) V691G probably benign Het
Zmiz1 T C 14: 25,646,084 (GRCm39) Y254H probably damaging Het
Other mutations in Tex14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00272:Tex14 APN 11 87,426,469 (GRCm39) missense probably damaging 0.98
IGL00494:Tex14 APN 11 87,446,310 (GRCm39) missense probably damaging 1.00
IGL01604:Tex14 APN 11 87,400,524 (GRCm39) missense possibly damaging 0.63
IGL02690:Tex14 APN 11 87,377,100 (GRCm39) missense probably benign 0.11
IGL02888:Tex14 APN 11 87,418,738 (GRCm39) critical splice donor site probably null
IGL03073:Tex14 APN 11 87,426,435 (GRCm39) missense probably damaging 0.99
IGL03109:Tex14 APN 11 87,434,191 (GRCm39) missense probably damaging 1.00
IGL03047:Tex14 UTSW 11 87,427,530 (GRCm39) missense probably damaging 1.00
R0141:Tex14 UTSW 11 87,383,857 (GRCm39) splice site probably null
R0455:Tex14 UTSW 11 87,405,131 (GRCm39) missense possibly damaging 0.93
R0624:Tex14 UTSW 11 87,411,525 (GRCm39) missense probably benign 0.19
R0718:Tex14 UTSW 11 87,390,439 (GRCm39) missense probably benign 0.20
R1077:Tex14 UTSW 11 87,410,571 (GRCm39) splice site probably benign
R1118:Tex14 UTSW 11 87,413,343 (GRCm39) missense probably benign 0.07
R1120:Tex14 UTSW 11 87,429,502 (GRCm39) splice site probably benign
R1168:Tex14 UTSW 11 87,427,568 (GRCm39) missense probably benign 0.11
R1190:Tex14 UTSW 11 87,385,934 (GRCm39) splice site probably null
R1470:Tex14 UTSW 11 87,440,355 (GRCm39) splice site probably benign
R1563:Tex14 UTSW 11 87,427,634 (GRCm39) missense probably damaging 0.99
R1607:Tex14 UTSW 11 87,445,754 (GRCm39) missense probably damaging 1.00
R1696:Tex14 UTSW 11 87,402,371 (GRCm39) missense possibly damaging 0.49
R1873:Tex14 UTSW 11 87,390,431 (GRCm39) missense probably damaging 1.00
R1894:Tex14 UTSW 11 87,365,274 (GRCm39) missense probably damaging 1.00
R1911:Tex14 UTSW 11 87,385,861 (GRCm39) missense probably damaging 1.00
R1955:Tex14 UTSW 11 87,400,447 (GRCm39) missense probably damaging 1.00
R1971:Tex14 UTSW 11 87,402,431 (GRCm39) missense probably damaging 1.00
R1990:Tex14 UTSW 11 87,440,296 (GRCm39) missense probably damaging 1.00
R1991:Tex14 UTSW 11 87,440,296 (GRCm39) missense probably damaging 1.00
R1993:Tex14 UTSW 11 87,427,581 (GRCm39) missense possibly damaging 0.57
R2106:Tex14 UTSW 11 87,377,076 (GRCm39) missense possibly damaging 0.47
R2118:Tex14 UTSW 11 87,410,569 (GRCm39) splice site probably benign
R2860:Tex14 UTSW 11 87,365,243 (GRCm39) missense probably damaging 1.00
R2861:Tex14 UTSW 11 87,365,243 (GRCm39) missense probably damaging 1.00
R4016:Tex14 UTSW 11 87,429,449 (GRCm39) splice site probably null
R4089:Tex14 UTSW 11 87,403,029 (GRCm39) missense probably damaging 1.00
R4158:Tex14 UTSW 11 87,407,595 (GRCm39) missense probably benign 0.06
R4713:Tex14 UTSW 11 87,427,691 (GRCm39) missense probably damaging 0.99
R4758:Tex14 UTSW 11 87,405,311 (GRCm39) missense probably benign 0.00
R4880:Tex14 UTSW 11 87,377,121 (GRCm39) missense possibly damaging 0.95
R4953:Tex14 UTSW 11 87,427,727 (GRCm39) critical splice donor site probably null
R5092:Tex14 UTSW 11 87,405,668 (GRCm39) missense probably benign 0.03
R5119:Tex14 UTSW 11 87,324,639 (GRCm39) missense probably damaging 1.00
R5322:Tex14 UTSW 11 87,402,298 (GRCm39) missense probably benign 0.04
R5470:Tex14 UTSW 11 87,442,430 (GRCm39) missense probably damaging 0.99
R5607:Tex14 UTSW 11 87,413,404 (GRCm39) missense probably benign 0.00
R5642:Tex14 UTSW 11 87,405,046 (GRCm39) missense probably benign
R5643:Tex14 UTSW 11 87,426,452 (GRCm39) missense probably damaging 1.00
R5786:Tex14 UTSW 11 87,405,121 (GRCm39) missense probably damaging 0.97
R6478:Tex14 UTSW 11 87,405,199 (GRCm39) missense probably benign
R6560:Tex14 UTSW 11 87,388,688 (GRCm39) missense possibly damaging 0.95
R6661:Tex14 UTSW 11 87,385,842 (GRCm39) missense probably damaging 1.00
R7037:Tex14 UTSW 11 87,388,741 (GRCm39) missense probably damaging 1.00
R7156:Tex14 UTSW 11 87,375,545 (GRCm39) missense probably damaging 0.99
R7465:Tex14 UTSW 11 87,405,256 (GRCm39) missense possibly damaging 0.48
R7675:Tex14 UTSW 11 87,400,504 (GRCm39) missense probably damaging 1.00
R7725:Tex14 UTSW 11 87,385,868 (GRCm39) missense probably damaging 0.99
R7911:Tex14 UTSW 11 87,424,428 (GRCm39) critical splice donor site probably null
R8015:Tex14 UTSW 11 87,400,426 (GRCm39) missense probably benign 0.13
R8226:Tex14 UTSW 11 87,375,585 (GRCm39) missense probably damaging 0.96
R8283:Tex14 UTSW 11 87,365,241 (GRCm39) missense probably damaging 1.00
R8292:Tex14 UTSW 11 87,388,664 (GRCm39) missense probably damaging 1.00
R8833:Tex14 UTSW 11 87,383,878 (GRCm39) missense probably benign 0.22
R8932:Tex14 UTSW 11 87,324,675 (GRCm39) missense possibly damaging 0.65
R9023:Tex14 UTSW 11 87,365,239 (GRCm39) missense
R9144:Tex14 UTSW 11 87,413,423 (GRCm39) critical splice donor site probably null
R9610:Tex14 UTSW 11 87,377,084 (GRCm39) missense probably damaging 1.00
R9611:Tex14 UTSW 11 87,377,084 (GRCm39) missense probably damaging 1.00
RF018:Tex14 UTSW 11 87,405,572 (GRCm39) missense probably benign 0.01
X0017:Tex14 UTSW 11 87,426,375 (GRCm39) nonsense probably null
Z1176:Tex14 UTSW 11 87,390,419 (GRCm39) missense possibly damaging 0.95
Z1176:Tex14 UTSW 11 87,375,633 (GRCm39) missense probably benign 0.08
Z1177:Tex14 UTSW 11 87,404,981 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- AGCTGTCTCAGATTCATGGTTG -3'
(R):5'- CCATGTTTCTCAACAAATCTGGAG -3'

Sequencing Primer
(F):5'- CTGTCTCAGATTCATGGTTGTTTCAG -3'
(R):5'- TGGAGAAACCTTAGCCCTTTCAG -3'
Posted On 2015-08-18