Incidental Mutation 'R4536:Syt10'
ID 333343
Institutional Source Beutler Lab
Gene Symbol Syt10
Ensembl Gene ENSMUSG00000063260
Gene Name synaptotagmin X
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R4536 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 89666596-89726063 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 89666825 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 509 (D509N)
Ref Sequence ENSEMBL: ENSMUSP00000029441 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029441]
AlphaFold Q9R0N4
Predicted Effect probably damaging
Transcript: ENSMUST00000029441
AA Change: D509N

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000029441
Gene: ENSMUSG00000063260
AA Change: D509N

DomainStartEndE-ValueType
transmembrane domain 55 77 N/A INTRINSIC
low complexity region 105 126 N/A INTRINSIC
C2 247 350 1.22e-19 SMART
C2 379 493 7.73e-22 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-in allele exhibit minor circadian rhythm impairments. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amot A G X: 144,263,138 (GRCm39) S398P probably benign Het
Arhgef17 G C 7: 100,579,061 (GRCm39) S629C probably damaging Het
Atg5lrt G A 10: 95,972,564 (GRCm39) A34T probably benign Het
Atp5if1 A C 4: 132,260,870 (GRCm39) S4A possibly damaging Het
Atp8b2 G A 3: 89,849,091 (GRCm39) A1081V probably benign Het
Atr A G 9: 95,756,471 (GRCm39) D867G probably benign Het
C1qtnf3 G A 15: 10,972,113 (GRCm39) S206N probably damaging Het
Cep152 A C 2: 125,444,867 (GRCm39) probably null Het
Cetn1 T C 18: 9,618,998 (GRCm39) E141G probably damaging Het
Dennd2b A T 7: 109,130,363 (GRCm39) S879R probably damaging Het
Erbb4 A T 1: 68,385,781 (GRCm39) N269K probably damaging Het
Exoc4 C T 6: 33,254,179 (GRCm39) R112C probably damaging Het
Frmd4b T A 6: 97,287,693 (GRCm39) Q241L possibly damaging Het
Fyco1 A G 9: 123,667,953 (GRCm39) V91A probably damaging Het
Gls2 G A 10: 128,036,806 (GRCm39) V196I probably benign Het
Hormad1 T C 3: 95,492,452 (GRCm39) V343A probably benign Het
Incenp T C 19: 9,861,303 (GRCm39) N450S unknown Het
Klhl1 A C 14: 96,374,019 (GRCm39) probably null Het
Mettl4 C A 17: 95,042,933 (GRCm39) S301I possibly damaging Het
Mlxip G A 5: 123,588,566 (GRCm39) D819N probably damaging Het
Or10d5 A T 9: 39,861,731 (GRCm39) L112Q probably damaging Het
Pam T A 1: 97,772,424 (GRCm39) K440* probably null Het
Phldb2 T C 16: 45,591,044 (GRCm39) M996V probably benign Het
Pira13 T A 7: 3,825,251 (GRCm39) M464L probably benign Het
Rad51ap2 A G 12: 11,507,850 (GRCm39) S591G possibly damaging Het
Rfx6 A G 10: 51,599,880 (GRCm39) N542S probably benign Het
Slc44a4 T A 17: 35,142,815 (GRCm39) C254S probably damaging Het
Sptbn2 C T 19: 4,782,630 (GRCm39) A522V probably damaging Het
Tango2 A G 16: 18,142,219 (GRCm39) probably null Het
Tfpi2 T C 6: 3,968,044 (GRCm39) N32S possibly damaging Het
Trafd1 T C 5: 121,517,746 (GRCm39) probably null Het
Ttll2 A T 17: 7,619,120 (GRCm39) I269N probably benign Het
Tysnd1 G A 10: 61,531,832 (GRCm39) W161* probably null Het
Uggt2 A T 14: 119,256,970 (GRCm39) M1088K probably benign Het
Other mutations in Syt10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02718:Syt10 APN 15 89,698,282 (GRCm39) missense probably damaging 1.00
IGL02976:Syt10 APN 15 89,698,682 (GRCm39) missense probably benign 0.26
R0200:Syt10 UTSW 15 89,711,144 (GRCm39) missense probably benign 0.01
R0306:Syt10 UTSW 15 89,711,191 (GRCm39) missense probably benign 0.02
R0580:Syt10 UTSW 15 89,711,379 (GRCm39) missense probably benign 0.15
R0608:Syt10 UTSW 15 89,711,144 (GRCm39) missense probably benign 0.01
R1705:Syt10 UTSW 15 89,674,979 (GRCm39) missense probably damaging 1.00
R1706:Syt10 UTSW 15 89,674,979 (GRCm39) missense probably damaging 1.00
R1921:Syt10 UTSW 15 89,674,979 (GRCm39) missense probably damaging 1.00
R1922:Syt10 UTSW 15 89,674,979 (GRCm39) missense probably damaging 1.00
R2072:Syt10 UTSW 15 89,674,979 (GRCm39) missense probably damaging 1.00
R2074:Syt10 UTSW 15 89,674,979 (GRCm39) missense probably damaging 1.00
R2119:Syt10 UTSW 15 89,674,979 (GRCm39) missense probably damaging 1.00
R2120:Syt10 UTSW 15 89,674,979 (GRCm39) missense probably damaging 1.00
R2121:Syt10 UTSW 15 89,674,979 (GRCm39) missense probably damaging 1.00
R3812:Syt10 UTSW 15 89,675,000 (GRCm39) missense probably benign
R4029:Syt10 UTSW 15 89,698,741 (GRCm39) missense probably benign
R4270:Syt10 UTSW 15 89,675,095 (GRCm39) missense probably benign 0.39
R5333:Syt10 UTSW 15 89,725,932 (GRCm39) missense probably benign 0.00
R6042:Syt10 UTSW 15 89,725,824 (GRCm39) missense probably benign 0.13
R6104:Syt10 UTSW 15 89,711,067 (GRCm39) missense probably benign 0.02
R6445:Syt10 UTSW 15 89,698,471 (GRCm39) missense probably damaging 1.00
R6470:Syt10 UTSW 15 89,676,804 (GRCm39) missense probably damaging 1.00
R6472:Syt10 UTSW 15 89,698,761 (GRCm39) missense probably benign
R6679:Syt10 UTSW 15 89,698,574 (GRCm39) missense probably damaging 1.00
R7048:Syt10 UTSW 15 89,675,008 (GRCm39) missense probably damaging 1.00
R7128:Syt10 UTSW 15 89,698,314 (GRCm39) missense probably damaging 1.00
R7315:Syt10 UTSW 15 89,698,541 (GRCm39) missense probably damaging 0.99
R7352:Syt10 UTSW 15 89,698,659 (GRCm39) missense probably benign 0.42
R7686:Syt10 UTSW 15 89,698,360 (GRCm39) missense probably damaging 1.00
R7789:Syt10 UTSW 15 89,711,101 (GRCm39) missense probably damaging 1.00
R7937:Syt10 UTSW 15 89,666,820 (GRCm39) missense probably damaging 1.00
R8532:Syt10 UTSW 15 89,676,889 (GRCm39) missense probably damaging 1.00
R9578:Syt10 UTSW 15 89,675,122 (GRCm39) missense possibly damaging 0.80
R9668:Syt10 UTSW 15 89,711,135 (GRCm39) missense probably damaging 1.00
X0057:Syt10 UTSW 15 89,711,131 (GRCm39) missense probably damaging 1.00
Z1088:Syt10 UTSW 15 89,725,842 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTAAGGGCCATTAGTACTCAAGTAG -3'
(R):5'- CCTTGGAAGGTAAGTTCTGATGAAC -3'

Sequencing Primer
(F):5'- TGCTCAAAGTTGAAGACAAATAAGCC -3'
(R):5'- ACATGGAGGTTACATAGATCATCAC -3'
Posted On 2015-08-18