Incidental Mutation 'R4541:Zfp974'
ID 333533
Institutional Source Beutler Lab
Gene Symbol Zfp974
Ensembl Gene ENSMUSG00000070709
Gene Name zinc finger protein 974
Synonyms 1700049G17Rik
MMRRC Submission 041777-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R4541 (G1)
Quality Score 213
Status Validated
Chromosome 7
Chromosomal Location 27606817-27628885 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 27625829 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 14 (V14L)
Ref Sequence ENSEMBL: ENSMUSP00000115940 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098639] [ENSMUST00000129341]
AlphaFold Q3UVF6
Predicted Effect probably benign
Transcript: ENSMUST00000098639
SMART Domains Protein: ENSMUSP00000096238
Gene: ENSMUSG00000070709

DomainStartEndE-ValueType
ZnF_C2H2 99 121 8.81e-2 SMART
ZnF_C2H2 127 149 1.82e-3 SMART
ZnF_C2H2 155 177 3.11e-2 SMART
ZnF_C2H2 201 223 2.15e-5 SMART
ZnF_C2H2 229 251 1.18e-2 SMART
ZnF_C2H2 257 279 1.47e-3 SMART
ZnF_C2H2 285 307 1.79e-2 SMART
ZnF_C2H2 313 335 2.24e-3 SMART
ZnF_C2H2 341 363 9.73e-4 SMART
ZnF_C2H2 369 391 7.26e-3 SMART
ZnF_C2H2 397 419 6.42e-4 SMART
ZnF_C2H2 425 447 3.63e-3 SMART
ZnF_C2H2 453 475 1.28e-3 SMART
ZnF_C2H2 481 503 1.26e-2 SMART
ZnF_C2H2 509 531 1.38e-3 SMART
ZnF_C2H2 537 559 3.83e-2 SMART
ZnF_C2H2 565 587 1.95e-3 SMART
ZnF_C2H2 593 615 4.61e-5 SMART
ZnF_C2H2 621 643 1.95e-3 SMART
ZnF_C2H2 649 671 1.03e-2 SMART
ZnF_C2H2 677 699 5.5e-3 SMART
ZnF_C2H2 705 727 2.37e2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000129341
AA Change: V14L

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000115940
Gene: ENSMUSG00000070709
AA Change: V14L

DomainStartEndE-ValueType
KRAB 14 75 7.5e-37 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137668
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138583
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145674
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152330
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181644
Meta Mutation Damage Score 0.2157 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency 96% (51/53)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik C T 11: 58,769,676 (GRCm39) P73S probably benign Het
4930533L02Rik G A 7: 124,917,750 (GRCm39) noncoding transcript Het
Acot4 A T 12: 84,090,022 (GRCm39) I240F probably benign Het
B4galt6 A G 18: 20,878,496 (GRCm39) V10A probably benign Het
Bag4 C T 8: 26,259,516 (GRCm39) A228T probably benign Het
Ccnb3 T C X: 6,875,308 (GRCm39) T424A probably benign Het
Cd8a A T 6: 71,350,856 (GRCm39) D107V probably benign Het
Cdca7l T C 12: 117,836,098 (GRCm39) S190P probably damaging Het
Ceacam12 G A 7: 17,805,648 (GRCm39) M278I probably benign Het
Cfap43 C T 19: 47,736,454 (GRCm39) V1346I probably benign Het
Clic5 C T 17: 44,552,956 (GRCm39) T70M probably damaging Het
Dbpht2 A T 12: 74,345,934 (GRCm39) noncoding transcript Het
Ddhd1 G A 14: 45,860,313 (GRCm39) R140* probably null Het
Evpl T G 11: 116,123,470 (GRCm39) I301L probably benign Het
Glul T A 1: 153,778,782 (GRCm39) Y30* probably null Het
Itgad A T 7: 127,797,287 (GRCm39) H878L probably benign Het
Kcnk10 A G 12: 98,402,536 (GRCm39) I301T probably damaging Het
Klhl14 A T 18: 21,687,696 (GRCm39) Y575* probably null Het
Mrps2 G T 2: 28,358,412 (GRCm39) probably benign Het
Mymx GCC GC 17: 45,912,519 (GRCm39) probably null Het
Napb G A 2: 148,551,229 (GRCm39) probably benign Het
Nlrp1c-ps A G 11: 71,171,706 (GRCm39) noncoding transcript Het
Or10g9b A C 9: 39,917,589 (GRCm39) S219A possibly damaging Het
Or4f15 A G 2: 111,813,981 (GRCm39) I146T probably benign Het
Piwil4 C A 9: 14,629,612 (GRCm39) M438I probably damaging Het
Pla2r1 C T 2: 60,258,082 (GRCm39) D1199N probably damaging Het
Pmpca T G 2: 26,280,201 (GRCm39) probably benign Het
Prkcq G T 2: 11,288,623 (GRCm39) M525I possibly damaging Het
Rnf225 T C 7: 12,662,520 (GRCm39) probably null Het
Sco1 G T 11: 66,943,668 (GRCm39) A50S probably benign Het
Slc12a2 T A 18: 58,046,037 (GRCm39) probably null Het
Slc36a1 T C 11: 55,112,849 (GRCm39) V148A probably benign Het
Sost G A 11: 101,857,670 (GRCm39) P44S probably damaging Het
Tbc1d10c G T 19: 4,239,473 (GRCm39) R96S probably damaging Het
Tbc1d2b A T 9: 90,087,222 (GRCm39) I919N probably damaging Het
Tcea1 T C 1: 4,963,659 (GRCm39) L233P probably damaging Het
Tlcd4 A G 3: 121,028,884 (GRCm39) M1T probably null Het
Tmem231 T C 8: 112,641,224 (GRCm39) T223A probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Tomm34 A G 2: 163,896,719 (GRCm39) Y243H probably benign Het
Tubgcp4 A T 2: 121,025,907 (GRCm39) N584I probably benign Het
Vldlr T C 19: 27,216,192 (GRCm39) C7R probably damaging Het
Vmn1r42 A T 6: 89,822,533 (GRCm39) M12K probably benign Het
Vsig10 C T 5: 117,490,881 (GRCm39) probably benign Het
Other mutations in Zfp974
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00836:Zfp974 APN 7 27,610,315 (GRCm39) missense possibly damaging 0.83
IGL01805:Zfp974 APN 7 27,611,689 (GRCm39) splice site probably benign
IGL02313:Zfp974 APN 7 27,611,678 (GRCm39) missense possibly damaging 0.53
IGL02449:Zfp974 APN 7 27,611,152 (GRCm39) missense probably benign
R0362:Zfp974 UTSW 7 27,626,819 (GRCm39) splice site probably benign
R0372:Zfp974 UTSW 7 27,620,120 (GRCm39) critical splice donor site probably null
R0379:Zfp974 UTSW 7 27,610,357 (GRCm39) missense probably damaging 0.98
R0699:Zfp974 UTSW 7 27,611,416 (GRCm39) missense possibly damaging 0.56
R0791:Zfp974 UTSW 7 27,609,510 (GRCm39) nonsense probably null
R1411:Zfp974 UTSW 7 27,610,634 (GRCm39) missense probably benign 0.00
R1567:Zfp974 UTSW 7 27,610,148 (GRCm39) missense probably damaging 0.99
R1747:Zfp974 UTSW 7 27,610,506 (GRCm39) missense possibly damaging 0.61
R1837:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R1838:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R1839:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R2311:Zfp974 UTSW 7 27,609,866 (GRCm39) missense possibly damaging 0.73
R4006:Zfp974 UTSW 7 27,611,677 (GRCm39) missense possibly damaging 0.86
R4303:Zfp974 UTSW 7 27,609,657 (GRCm39) missense possibly damaging 0.85
R4771:Zfp974 UTSW 7 27,625,733 (GRCm39) missense probably damaging 0.96
R4889:Zfp974 UTSW 7 27,610,244 (GRCm39) missense possibly damaging 0.86
R5332:Zfp974 UTSW 7 27,625,715 (GRCm39) missense probably benign 0.01
R5537:Zfp974 UTSW 7 27,611,671 (GRCm39) critical splice acceptor site probably benign
R5906:Zfp974 UTSW 7 27,610,230 (GRCm39) missense possibly damaging 0.72
R5908:Zfp974 UTSW 7 27,610,382 (GRCm39) missense probably benign 0.01
R6419:Zfp974 UTSW 7 27,610,940 (GRCm39) missense possibly damaging 0.72
R6654:Zfp974 UTSW 7 27,625,828 (GRCm39) missense probably damaging 1.00
R6731:Zfp974 UTSW 7 27,611,074 (GRCm39) missense possibly damaging 0.93
R7162:Zfp974 UTSW 7 27,610,944 (GRCm39) missense possibly damaging 0.71
R7316:Zfp974 UTSW 7 27,609,863 (GRCm39) missense possibly damaging 0.93
R7484:Zfp974 UTSW 7 27,611,559 (GRCm39) missense possibly damaging 0.72
R7663:Zfp974 UTSW 7 27,611,110 (GRCm39) missense possibly damaging 0.74
R7664:Zfp974 UTSW 7 27,610,137 (GRCm39) missense possibly damaging 0.86
R8052:Zfp974 UTSW 7 27,610,697 (GRCm39) missense probably damaging 1.00
R8698:Zfp974 UTSW 7 27,610,361 (GRCm39) missense possibly damaging 0.90
R8700:Zfp974 UTSW 7 27,609,472 (GRCm39) missense possibly damaging 0.86
R8938:Zfp974 UTSW 7 27,610,311 (GRCm39) missense possibly damaging 0.74
R8972:Zfp974 UTSW 7 27,610,589 (GRCm39) missense probably benign 0.06
R9212:Zfp974 UTSW 7 27,610,052 (GRCm39) missense possibly damaging 0.86
R9236:Zfp974 UTSW 7 27,610,342 (GRCm39) missense possibly damaging 0.51
R9335:Zfp974 UTSW 7 27,611,476 (GRCm39) missense probably benign 0.02
R9436:Zfp974 UTSW 7 27,611,094 (GRCm39) missense probably benign 0.24
R9740:Zfp974 UTSW 7 27,610,025 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAGAGTGAGGAAAGCCCAC -3'
(R):5'- CCTTCTGTGGGTATAGCCTGAG -3'

Sequencing Primer
(F):5'- AGCCCACAGTGTAGAGGAC -3'
(R):5'- AGAGGCACAGGTATTGGCTATG -3'
Posted On 2015-08-18