Incidental Mutation 'R4541:Sost'
ID |
333543 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Sost
|
Ensembl Gene |
ENSMUSG00000001494 |
Gene Name |
sclerostin |
Synonyms |
5430411E23Rik |
MMRRC Submission |
041777-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.174)
|
Stock # |
R4541 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
101853284-101857841 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 101857670 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Proline to Serine
at position 44
(P44S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000001534
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000001534]
[ENSMUST00000003612]
[ENSMUST00000107172]
[ENSMUST00000107173]
[ENSMUST00000151678]
|
AlphaFold |
Q99P68 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000001534
AA Change: P44S
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000001534 Gene: ENSMUSG00000001494 AA Change: P44S
Domain | Start | End | E-Value | Type |
Pfam:Sclerostin
|
1 |
208 |
8e-98 |
PFAM |
Pfam:DAN
|
51 |
168 |
1.2e-23 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000003612
|
SMART Domains |
Protein: ENSMUSP00000003612 Gene: ENSMUSG00000003518
Domain | Start | End | E-Value | Type |
DSPc
|
29 |
176 |
8.04e-58 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000107172
|
SMART Domains |
Protein: ENSMUSP00000102790 Gene: ENSMUSG00000003518
Domain | Start | End | E-Value | Type |
DSPc
|
29 |
176 |
8.04e-58 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000107173
|
SMART Domains |
Protein: ENSMUSP00000102791 Gene: ENSMUSG00000003518
Domain | Start | End | E-Value | Type |
DSPc
|
54 |
201 |
8.04e-58 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000151678
|
SMART Domains |
Protein: ENSMUSP00000135384 Gene: ENSMUSG00000003518
Domain | Start | End | E-Value | Type |
DSPc
|
3 |
108 |
6.99e-26 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176599
|
Meta Mutation Damage Score |
0.3937 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.5%
|
Validation Efficiency |
96% (51/53) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008] PHENOTYPE: Mice homozygous for a null allele exhibit an increase in trabecular and cortical bone volume, mineral density, and formation. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 44 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2810021J22Rik |
C |
T |
11: 58,769,676 (GRCm39) |
P73S |
probably benign |
Het |
4930533L02Rik |
G |
A |
7: 124,917,750 (GRCm39) |
|
noncoding transcript |
Het |
Acot4 |
A |
T |
12: 84,090,022 (GRCm39) |
I240F |
probably benign |
Het |
B4galt6 |
A |
G |
18: 20,878,496 (GRCm39) |
V10A |
probably benign |
Het |
Bag4 |
C |
T |
8: 26,259,516 (GRCm39) |
A228T |
probably benign |
Het |
Ccnb3 |
T |
C |
X: 6,875,308 (GRCm39) |
T424A |
probably benign |
Het |
Cd8a |
A |
T |
6: 71,350,856 (GRCm39) |
D107V |
probably benign |
Het |
Cdca7l |
T |
C |
12: 117,836,098 (GRCm39) |
S190P |
probably damaging |
Het |
Ceacam12 |
G |
A |
7: 17,805,648 (GRCm39) |
M278I |
probably benign |
Het |
Cfap43 |
C |
T |
19: 47,736,454 (GRCm39) |
V1346I |
probably benign |
Het |
Clic5 |
C |
T |
17: 44,552,956 (GRCm39) |
T70M |
probably damaging |
Het |
Dbpht2 |
A |
T |
12: 74,345,934 (GRCm39) |
|
noncoding transcript |
Het |
Ddhd1 |
G |
A |
14: 45,860,313 (GRCm39) |
R140* |
probably null |
Het |
Evpl |
T |
G |
11: 116,123,470 (GRCm39) |
I301L |
probably benign |
Het |
Glul |
T |
A |
1: 153,778,782 (GRCm39) |
Y30* |
probably null |
Het |
Itgad |
A |
T |
7: 127,797,287 (GRCm39) |
H878L |
probably benign |
Het |
Kcnk10 |
A |
G |
12: 98,402,536 (GRCm39) |
I301T |
probably damaging |
Het |
Klhl14 |
A |
T |
18: 21,687,696 (GRCm39) |
Y575* |
probably null |
Het |
Mrps2 |
G |
T |
2: 28,358,412 (GRCm39) |
|
probably benign |
Het |
Mymx |
GCC |
GC |
17: 45,912,519 (GRCm39) |
|
probably null |
Het |
Napb |
G |
A |
2: 148,551,229 (GRCm39) |
|
probably benign |
Het |
Nlrp1c-ps |
A |
G |
11: 71,171,706 (GRCm39) |
|
noncoding transcript |
Het |
Or10g9b |
A |
C |
9: 39,917,589 (GRCm39) |
S219A |
possibly damaging |
Het |
Or4f15 |
A |
G |
2: 111,813,981 (GRCm39) |
I146T |
probably benign |
Het |
Piwil4 |
C |
A |
9: 14,629,612 (GRCm39) |
M438I |
probably damaging |
Het |
Pla2r1 |
C |
T |
2: 60,258,082 (GRCm39) |
D1199N |
probably damaging |
Het |
Pmpca |
T |
G |
2: 26,280,201 (GRCm39) |
|
probably benign |
Het |
Prkcq |
G |
T |
2: 11,288,623 (GRCm39) |
M525I |
possibly damaging |
Het |
Rnf225 |
T |
C |
7: 12,662,520 (GRCm39) |
|
probably null |
Het |
Sco1 |
G |
T |
11: 66,943,668 (GRCm39) |
A50S |
probably benign |
Het |
Slc12a2 |
T |
A |
18: 58,046,037 (GRCm39) |
|
probably null |
Het |
Slc36a1 |
T |
C |
11: 55,112,849 (GRCm39) |
V148A |
probably benign |
Het |
Tbc1d10c |
G |
T |
19: 4,239,473 (GRCm39) |
R96S |
probably damaging |
Het |
Tbc1d2b |
A |
T |
9: 90,087,222 (GRCm39) |
I919N |
probably damaging |
Het |
Tcea1 |
T |
C |
1: 4,963,659 (GRCm39) |
L233P |
probably damaging |
Het |
Tlcd4 |
A |
G |
3: 121,028,884 (GRCm39) |
M1T |
probably null |
Het |
Tmem231 |
T |
C |
8: 112,641,224 (GRCm39) |
T223A |
probably benign |
Het |
Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
Tomm34 |
A |
G |
2: 163,896,719 (GRCm39) |
Y243H |
probably benign |
Het |
Tubgcp4 |
A |
T |
2: 121,025,907 (GRCm39) |
N584I |
probably benign |
Het |
Vldlr |
T |
C |
19: 27,216,192 (GRCm39) |
C7R |
probably damaging |
Het |
Vmn1r42 |
A |
T |
6: 89,822,533 (GRCm39) |
M12K |
probably benign |
Het |
Vsig10 |
C |
T |
5: 117,490,881 (GRCm39) |
|
probably benign |
Het |
Zfp974 |
C |
G |
7: 27,625,829 (GRCm39) |
V14L |
probably damaging |
Het |
|
Other mutations in Sost |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00335:Sost
|
APN |
11 |
101,857,705 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02487:Sost
|
APN |
11 |
101,857,633 (GRCm39) |
missense |
possibly damaging |
0.64 |
IGL02967:Sost
|
APN |
11 |
101,855,084 (GRCm39) |
missense |
possibly damaging |
0.50 |
R0724:Sost
|
UTSW |
11 |
101,857,744 (GRCm39) |
missense |
probably benign |
0.04 |
R1873:Sost
|
UTSW |
11 |
101,855,069 (GRCm39) |
missense |
probably damaging |
1.00 |
R2182:Sost
|
UTSW |
11 |
101,854,676 (GRCm39) |
missense |
probably damaging |
1.00 |
R3429:Sost
|
UTSW |
11 |
101,854,865 (GRCm39) |
missense |
probably damaging |
1.00 |
R4428:Sost
|
UTSW |
11 |
101,857,670 (GRCm39) |
missense |
probably damaging |
0.97 |
R4430:Sost
|
UTSW |
11 |
101,857,670 (GRCm39) |
missense |
probably damaging |
0.97 |
R4464:Sost
|
UTSW |
11 |
101,857,670 (GRCm39) |
missense |
probably damaging |
0.97 |
R4537:Sost
|
UTSW |
11 |
101,857,670 (GRCm39) |
missense |
probably damaging |
0.97 |
R4539:Sost
|
UTSW |
11 |
101,857,670 (GRCm39) |
missense |
probably damaging |
0.97 |
R4540:Sost
|
UTSW |
11 |
101,857,670 (GRCm39) |
missense |
probably damaging |
0.97 |
R4542:Sost
|
UTSW |
11 |
101,857,670 (GRCm39) |
missense |
probably damaging |
0.97 |
R4710:Sost
|
UTSW |
11 |
101,857,670 (GRCm39) |
missense |
probably damaging |
0.97 |
R5125:Sost
|
UTSW |
11 |
101,854,767 (GRCm39) |
missense |
probably damaging |
1.00 |
R7297:Sost
|
UTSW |
11 |
101,854,929 (GRCm39) |
missense |
probably damaging |
1.00 |
R7779:Sost
|
UTSW |
11 |
101,857,675 (GRCm39) |
missense |
possibly damaging |
0.75 |
R9617:Sost
|
UTSW |
11 |
101,854,892 (GRCm39) |
missense |
possibly damaging |
0.85 |
RF013:Sost
|
UTSW |
11 |
101,854,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AAATGTGTCCCTGCCCTGATG -3'
(R):5'- ACCGTATCTAGGCTGGACAC -3'
Sequencing Primer
(F):5'- TGCCCTGATGTAGCAGAGG -3'
(R):5'- TATCTAGGCTGGACACTGGAGC -3'
|
Posted On |
2015-08-18 |