Mutagenetix > Incidental Mutation

Incidental Mutation 'R4544:Ifi205'

333651

Institutional Source

Beutler Lab

Gene Symbol

Ifi205

Ensembl Gene

ENSMUSG00000054203

Gene Name

interferon activated gene 205

Synonyms

MMRRC Submission

041779-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R4544 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

173839564-173859376 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 173854139 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 171 (I171M)

Ref Sequence

ENSEMBL: ENSMUSP00000062409 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059226]

AlphaFold

Q8CGE8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000059226
AA Change: I171M

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000062409
Gene: ENSMUSG00000054203
AA Change: I171M

Domain	Start	End	E-Value	Type
PYRIN	6	84	9.42e-13	SMART
low complexity region	102	112	N/A	INTRINSIC
low complexity region	121	134	N/A	INTRINSIC
low complexity region	168	185	N/A	INTRINSIC
Pfam:HIN	204	372	2e-76	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000192166

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 95.7%

Validation Efficiency

100% (58/58)

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1c20	A	C	13: 4,557,843 (GRCm39)	V201G	probably damaging	Het
Alg9	C	T	9: 50,716,654 (GRCm39)	T409M	possibly damaging	Het
Atf7	A	G	15: 102,442,762 (GRCm39)	V449A	probably benign	Het
C1s1	A	G	6: 124,508,499 (GRCm39)	S497P	probably benign	Het
Ccnyl1	G	T	1: 64,762,735 (GRCm39)	M347I	probably benign	Het
Chil4	C	A	3: 106,117,922 (GRCm39)	R116L	probably damaging	Het
Cmpk2	A	G	12: 26,528,016 (GRCm39)	E411G	probably damaging	Het
Cmya5	G	A	13: 93,228,426 (GRCm39)	R2221*	probably null	Het
Csmd1	A	T	8: 16,760,652 (GRCm39)	F161Y	possibly damaging	Het
Cspg4	T	A	9: 56,795,913 (GRCm39)	L1216Q	possibly damaging	Het
Dppa3	A	G	6: 122,603,726 (GRCm39)		probably benign	Het
Ednra	A	G	8: 78,401,540 (GRCm39)		probably null	Het
Fancd2	A	G	6: 113,549,603 (GRCm39)		probably null	Het
Fastkd1	C	T	2: 69,542,655 (GRCm39)	E51K	probably damaging	Het
Fndc1	T	A	17: 7,992,376 (GRCm39)	D440V	unknown	Het
Gm9934	A	G	7: 92,702,188 (GRCm39)		noncoding transcript	Het
Hdac1-ps	A	T	17: 78,800,388 (GRCm39)	T460S	probably benign	Het
Ifi213	T	C	1: 173,409,693 (GRCm39)		probably null	Het
Insig2	A	T	1: 121,239,921 (GRCm39)		probably benign	Het
Kdm7a	T	C	6: 39,152,406 (GRCm39)	R97G	probably benign	Het
Krt23	G	A	11: 99,369,102 (GRCm39)	T397M	probably benign	Het
Lepr	G	A	4: 101,625,425 (GRCm39)	V527I	possibly damaging	Het
Lmo2	C	T	2: 103,806,382 (GRCm39)	P25L	probably damaging	Het
Lsr	C	T	7: 30,671,401 (GRCm39)	V111M	probably damaging	Het
Mest	T	C	6: 30,740,679 (GRCm39)	W13R	probably damaging	Het
Mfn2	A	G	4: 147,971,909 (GRCm39)	V224A	probably benign	Het
Mkx	T	C	18: 7,000,651 (GRCm39)	Y97C	probably damaging	Het
Mndal	A	T	1: 173,703,230 (GRCm39)	Y58*	probably null	Het
Myo9b	T	C	8: 71,780,585 (GRCm39)	V494A	probably damaging	Het
Nek1	C	T	8: 61,469,338 (GRCm39)	Q132*	probably null	Het
Or2a12	C	T	6: 42,904,348 (GRCm39)	S61L	probably damaging	Het
Or6c5	A	C	10: 129,074,027 (GRCm39)	N3T	probably damaging	Het
Osbpl6	T	C	2: 76,414,836 (GRCm39)	V409A	possibly damaging	Het
Pde8a	A	T	7: 80,977,847 (GRCm39)	R713S	probably damaging	Het
Pex10	T	C	4: 155,154,952 (GRCm39)	Y235H	probably benign	Het
Pik3cb	T	A	9: 98,921,812 (GRCm39)	K1050I	probably damaging	Het
Prss56	A	G	1: 87,112,364 (GRCm39)	D85G	probably damaging	Het
Psg26	T	C	7: 18,212,464 (GRCm39)	N297S	probably damaging	Het
Rdh16f1	T	C	10: 127,626,706 (GRCm39)	L253S	probably benign	Het
Slc15a4	A	G	5: 127,681,600 (GRCm39)		probably null	Het
Slc7a8	C	G	14: 54,973,247 (GRCm39)	G240A	possibly damaging	Het
Slc8b1	G	A	5: 120,669,218 (GRCm39)		probably null	Het
Sorbs1	G	A	19: 40,300,294 (GRCm39)	T575M	probably damaging	Het
Syne3	T	A	12: 104,925,728 (GRCm39)	K313M	probably damaging	Het
Tas2r108	A	G	6: 40,470,742 (GRCm39)	T73A	probably benign	Het
Ttn	T	C	2: 76,652,932 (GRCm39)		probably null	Het
Uba52rt	C	T	4: 3,973,244 (GRCm39)	R106H	probably benign	Het
Ubr3	G	A	2: 69,786,437 (GRCm39)	M850I	probably benign	Het
Vmn2r78	A	T	7: 86,570,399 (GRCm39)	M306L	probably benign	Het
Vmn2r9	T	G	5: 108,995,551 (GRCm39)	M366L	probably benign	Het
Zan	C	G	5: 137,382,096 (GRCm39)	M5150I	unknown	Het

Other mutations in Ifi205

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Ifi205	APN	1	173,854,899 (GRCm39)	splice site	probably benign
IGL02419:Ifi205	APN	1	173,845,180 (GRCm39)	missense	probably damaging	0.99
IGL02476:Ifi205	APN	1	173,842,627 (GRCm39)	missense	probably damaging	1.00
IGL03128:Ifi205	APN	1	173,842,652 (GRCm39)	missense	probably damaging	0.99
IGL03154:Ifi205	APN	1	173,845,232 (GRCm39)	splice site	probably benign
R0211:Ifi205	UTSW	1	173,855,994 (GRCm39)	missense	probably benign
R1932:Ifi205	UTSW	1	173,855,980 (GRCm39)	missense	possibly damaging	0.47
R2397:Ifi205	UTSW	1	173,845,141 (GRCm39)	missense	possibly damaging	0.64
R3115:Ifi205	UTSW	1	173,855,901 (GRCm39)	missense	possibly damaging	0.95
R4534:Ifi205	UTSW	1	173,845,207 (GRCm39)	missense	probably benign	0.16
R4715:Ifi205	UTSW	1	173,855,887 (GRCm39)	missense	possibly damaging	0.51
R4977:Ifi205	UTSW	1	173,842,574 (GRCm39)	missense	probably benign	0.07
R5844:Ifi205	UTSW	1	173,854,258 (GRCm39)	splice site	probably null
R6061:Ifi205	UTSW	1	173,854,830 (GRCm39)	missense	possibly damaging	0.91
R6510:Ifi205	UTSW	1	173,845,131 (GRCm39)	missense	probably damaging	1.00
R7032:Ifi205	UTSW	1	173,855,916 (GRCm39)	missense	possibly damaging	0.80
R7196:Ifi205	UTSW	1	173,854,109 (GRCm39)	missense	probably damaging	0.96
R7244:Ifi205	UTSW	1	173,845,210 (GRCm39)	nonsense	probably null
R7419:Ifi205	UTSW	1	173,855,874 (GRCm39)	missense	possibly damaging	0.71
R7431:Ifi205	UTSW	1	173,855,943 (GRCm39)	missense	probably benign
R7660:Ifi205	UTSW	1	173,855,814 (GRCm39)	missense	probably benign	0.27
R7787:Ifi205	UTSW	1	173,842,644 (GRCm39)	missense	probably damaging	1.00
R7787:Ifi205	UTSW	1	173,842,640 (GRCm39)	missense	probably damaging	1.00
R9069:Ifi205	UTSW	1	173,855,841 (GRCm39)	missense	probably benign
R9163:Ifi205	UTSW	1	173,844,988 (GRCm39)	missense	possibly damaging	0.88
R9348:Ifi205	UTSW	1	173,844,997 (GRCm39)	missense	probably benign	0.24
R9376:Ifi205	UTSW	1	173,854,221 (GRCm39)	missense	probably benign
R9477:Ifi205	UTSW	1	173,854,155 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- AAAGGTTGTGTATGAGTCAGCC -3'
(R):5'- GAAAATGCACTCTGCTCAACTG -3'

Sequencing Primer
(F):5'- AAGGTTGTGTATGAGTCAGCCAATTC -3'
(R):5'- ATGCACTCTGCTCAACTGATTAGAC -3'

Posted On

2015-08-18